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  1. Article: Editorial: The Non-Coding Transcriptome as a New Player in Intercellular Communication.

    Devaux, Yvan / Pinet, Florence / de Gonzalo-Calvo, David

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 858702

    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.858702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Methodological considerations for circulating long noncoding RNA quantification.

    de Gonzalo-Calvo, David / Sopić, Miron / Devaux, Yvan

    Trends in molecular medicine

    2022  Volume 28, Issue 8, Page(s) 616–618

    Abstract: In the past decade, significant resources have been invested in long noncoding RNA (lncRNA) research. Despite the knowledge available, we are far from incorporation of lncRNA into clinical practice. Here, we emphasize the technical challenges in the ... ...

    Abstract In the past decade, significant resources have been invested in long noncoding RNA (lncRNA) research. Despite the knowledge available, we are far from incorporation of lncRNA into clinical practice. Here, we emphasize the technical challenges in the field, hoping to provoke a response leading to new consensus and guidelines.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2022.05.011
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    Zs.A 4345: Show issues Location:
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  3. Article ; Online: Searching for New Biomarkers in Respiratory Medicine: Present and Future of miRNAs.

    Dodani, Krish / de Gonzalo-Calvo, David / Sánchez-de-la-Torre, Manuel

    Archivos de bronconeumologia

    2023  Volume 60, Issue 3, Page(s) 125–128

    MeSH term(s) Humans ; MicroRNAs ; Pulmonary Medicine ; Biomarkers
    Chemical Substances MicroRNAs ; Biomarkers
    Language Spanish
    Publishing date 2023-10-20
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.09.018
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  4. Article ; Online: microRNA Expression Profile in Obesity-Induced Kidney Disease Driven by High-Fat Diet in Mice.

    Eritja, Àuria / Caus, Maite / Belmonte, Thalia / de Gonzalo-Calvo, David / García-Carrasco, Alicia / Martinez, Ana / Martínez, Montserrat / Bozic, Milica

    Nutrients

    2024  Volume 16, Issue 5

    Abstract: Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney ... ...

    Abstract Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney microRNA (miRNA) expression profile in a model of obesity-induced kidney disease in C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led to notable structural alterations in tubular and glomerular regions of the kidney, increased renal expression of proinflammatory and profibrotic genes, as well as an elevated renal expression of genes involved in cellular lipid metabolism. The miRNA sequencing analysis identified a set of nine miRNAs differentially expressed in the kidney upon HFD feeding, with miR-5099, miR-551b-3p, miR-223-3p, miR-146a-3p and miR-21a-3p showing the most significant differential expression between standard diet (STD) and HFD mice. A validation analysis showed that the expression levels of miR-5099, miR-551b-3p and miR-146a-3p were consistent with NGS results, while Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses revealed that these three validated miRNAs modulated target genes involved in metabolic and adipocytokine pathways, fatty acid and lipid metabolism, and inflammatory, senescence and profibrotic pathways. Our results suggest that differentially expressed miRNAs play pivotal roles in the intricate pathophysiology of obesity-associated kidney disease and could potentially create novel treatment strategies to counteract the deleterious effects of obesity on kidney function.
    MeSH term(s) Mice ; Animals ; Diet, High-Fat ; Mice, Inbred C57BL ; Obesity/metabolism ; MicroRNAs/metabolism ; Renal Insufficiency, Chronic/complications
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16050691
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  5. Article ; Online: MicroRNAs to guide medical decision-making in obstructive sleep apnea: A review.

    Pinilla, Lucía / Barbé, Ferran / de Gonzalo-Calvo, David

    Sleep medicine reviews

    2021  Volume 59, Page(s) 101458

    Abstract: Obstructive sleep apnea (OSA) is a common and frequently underdiagnosed sleep disorder tightly associated with a wide range of morbidities and an elevated risk of the main causes of mortality. This condition represents a major public health concern due ... ...

    Abstract Obstructive sleep apnea (OSA) is a common and frequently underdiagnosed sleep disorder tightly associated with a wide range of morbidities and an elevated risk of the main causes of mortality. This condition represents a major public health concern due to its increasing worldwide prevalence and its serious pathological consequences. Current clinical guidelines support the importance of effective diagnosis and treatment of OSA and emphasize the unmet need for biomarkers to guide medical decision-making. In recent years, the noncoding transcriptome has emerged as a new opportunity for biomarker discovery. In this review, we provide a brief overview of the current understanding of noncoding RNAs, specifically microRNAs (miRNAs). Then, we carefully address the potential role of miRNAs as novel indicators for the management of both pediatric and adult OSA, highlighting their translational applicability, particularly for diagnosis and therapy allocation. Finally, we identify the gaps in the research state-of-art, discuss current methodological and conceptual limitations and propose future key steps and perspectives for the incorporation of miRNAs into routine clinical practice.
    MeSH term(s) Adult ; Biomarkers ; Child ; Clinical Decision-Making ; Humans ; MicroRNAs/genetics ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/genetics ; Sleep Apnea, Obstructive/therapy
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1414211-9
    ISSN 1532-2955 ; 1087-0792
    ISSN (online) 1532-2955
    ISSN 1087-0792
    DOI 10.1016/j.smrv.2021.101458
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    Zs.A 5901: Show issues Location:
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  6. Article ; Online: Going the Long Noncoding RNA Way Toward Cardiac Regeneration: Mapping Candidate Long Noncoding RNA Controllers of Regeneration.

    de Gonzalo-Calvo, David / Bär, Christian

    The Canadian journal of cardiology

    2020  Volume 37, Issue 3, Page(s) 374–376

    MeSH term(s) Animals ; Myocytes, Cardiac ; RNA, Long Noncoding/genetics ; Regeneration ; Zebrafish
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2020-09-16
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2020.09.007
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    Zs.A 2150: Show issues Location:
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  7. Article: MicroRNA-centered theranostics for pulmoprotection in critical COVID-19.

    Perez-Pons, Manel / Molinero, Marta / Benítez, Iván D / García-Hidalgo, María C / Chatterjee, Shambhabi / Bär, Christian / González, Jessica / Torres, Antoni / Barbé, Ferran / de Gonzalo-Calvo, David

    Molecular therapy. Nucleic acids

    2024  Volume 35, Issue 1, Page(s) 102118

    Abstract: Elucidating the pathobiological mechanisms underlying post-acute pulmonary sequelae following SARS-CoV-2 infection is essential for early interventions and patient stratification. Here, we investigated the potential of microRNAs (miRNAs) as theranostic ... ...

    Abstract Elucidating the pathobiological mechanisms underlying post-acute pulmonary sequelae following SARS-CoV-2 infection is essential for early interventions and patient stratification. Here, we investigated the potential of microRNAs (miRNAs) as theranostic agents for pulmoprotection in critical illness survivors. Multicenter study including 172 ICU survivors. Diffusion impairment was defined as a lung-diffusing capacity for carbon monoxide (D
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2024.102118
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  8. Article ; Online: Circulating miRNAs as mediators in cell-to-cell communication.

    Bär, Christian / Thum, Thomas / de Gonzalo-Calvo, David

    Epigenomics

    2019  Volume 11, Issue 2, Page(s) 111–113

    MeSH term(s) Animals ; Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Circulating MicroRNA/metabolism ; Humans ; Paracrine Communication
    Chemical Substances Circulating MicroRNA
    Language English
    Publishing date 2019-01-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ISSN 1750-192X
    ISSN (online) 1750-192X
    DOI 10.2217/epi-2018-0183
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  9. Article ; Online: Circulating non-coding RNAs as biomarkers to predict and monitor the response to exercise: chances and hurdles.

    de Gonzalo-Calvo, David / Thum, Thomas

    European heart journal

    2018  Volume 39, Issue 38, Page(s) 3552

    MeSH term(s) Biomarkers ; Exercise ; Precision Medicine ; RNA, Untranslated
    Chemical Substances Biomarkers ; RNA, Untranslated
    Language English
    Publishing date 2018-12-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy457
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    Zs.A 1563: Show issues Location:
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  10. Article ; Online: Sleep and Circadian Health of Critical Survivors: A 12-Month Follow-Up Study.

    Henríquez-Beltrán, Mario / Vaca, Rafaela / Benítez, Iván D / González, Jessica / Santisteve, Sally / Aguilà, Maria / Minguez, Olga / Moncusí-Moix, Anna / Gort-Paniello, Clara / Torres, Gerard / Labarca, Gonzalo / Caballero, Jesús / Barberà, Carme / Torres, Antoni / de Gonzalo-Calvo, David / Barbé, Ferran / Targa, Adriano D S

    Critical care medicine

    2024  

    Abstract: Objectives: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge and to evaluate a possible effect of the severity of the disease within this context.: Design: Observational, prospective study.: ... ...

    Abstract Objectives: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge and to evaluate a possible effect of the severity of the disease within this context.
    Design: Observational, prospective study.
    Setting: Single-center study.
    Patients: Two hundred sixty patients admitted to the ICU due to severe acute respiratory syndrome coronavirus 2 infection.
    Interventions: None.
    Measurements and main results: The cohort was composed of 260 patients (69.2% males), with a median (quartile 1-quartile 3) age of 61.5 years (52.0-67.0 yr). The median length of ICU stay was 11.0 days (6.00-21.8 d), where 56.2% of the patients required invasive mechanical ventilation (IMV). The Pittsburgh Sleep Quality Index (PSQI) revealed that 43.1% of the cohort presented poor sleep quality 12 months after hospital discharge. Actigraphy data indicated an influence of the disease severity on the fragmentation of the circadian rest-activity rhythm at the 3- and 6-month follow-ups, which was no longer significant in the long term. Still, the length of the ICU stay and the duration of IMV predicted a higher fragmentation of the rhythm at the 12-month follow-up with effect sizes (95% CI) of 0.248 (0.078-0.418) and 0.182 (0.005-0.359), respectively. Relevant associations between the PSQI and the Hospital Anxiety and Depression Scale (rho = 0.55, anxiety; rho = 0.5, depression) as well as between the fragmentation of the rhythm and the diffusing lung capacity for carbon monoxide (rho = -0.35) were observed at this time point.
    Conclusions: Our findings reveal a great prevalence of critical survivors presenting poor sleep quality 12 months after hospital discharge. Actigraphy data indicated the persistence of circadian alterations and a possible impact of the disease severity on the fragmentation of the circadian rest-activity rhythm, which was attenuated at the 12-month follow-up. This altogether highlights the relevance of considering the sleep and circadian health of critical survivors in the long term.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006298
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