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Article: Allocation of aid for health institutions in Ukraine: implications from a case study of Chornobyl (Chernobyl) area hospitals.

Konrad, Renata / Bezchlibnyk-Butler, Kalyna / Wodoslawsky, Marika Dubyk

International journal of health services : planning, administration, evaluation

2009 Volume 39, Issue 4, Page(s) 623–641

Abstract: Over the past two decades, numerous non-governmental organizations have sought to improve the health status of populations struggling with the lingering effects of the Chornobyl (Chernobyl) nuclear disaster. Political and economic features of Ukraine's ... ...

Abstract	Over the past two decades, numerous non-governmental organizations have sought to improve the health status of populations struggling with the lingering effects of the Chornobyl (Chernobyl) nuclear disaster. Political and economic features of Ukraine's government produced a health system unable to provide services required by its population. To compensate somewhat for these shortcomings, Ukraine's health institutions rely on foreign donations. However, to effectively target foreign aid efforts, a more thorough understanding of the administration of health institutions in Ukraine is needed. This study investigates the organizational structures, care delivery, and legislative and financial regulations in the country's health system and their implications for patient care. Through an exhaustive study of four representative health institutions across Ukraine, the authors identify how donor organizations can achieve their aid objectives and work within the country's health infrastructure.
MeSH term(s)	Chernobyl Nuclear Accident ; Financial Support ; Health Facilities/economics ; Health Facility Administration ; Health Services Needs and Demand ; International Cooperation ; Interviews as Topic ; Organizational Case Studies ; Ukraine
Language	English
Publishing date	2009
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184936-0
ISSN	1541-4469 ; 0020-7314
ISSN (online)	1541-4469
ISSN	0020-7314
DOI	10.2190/HS.39.4.b
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Article: Comment: effect on dissolution from halving methylphenidate extended-release tablets.

Ly, J / Bezchlibnyk-Butler, K

The Annals of pharmacotherapy

1998 Volume 32, Issue 12, Page(s) 1372–1373

MeSH term(s)	Child ; Delayed-Action Preparations/pharmacokinetics ; Humans ; Male ; Methylphenidate/administration & dosage ; Methylphenidate/pharmacokinetics ; Solubility ; Sympathomimetics/administration & dosage ; Sympathomimetics/pharmacokinetics
Chemical Substances	Delayed-Action Preparations ; Sympathomimetics ; Methylphenidate (207ZZ9QZ49)
Language	English
Publishing date	1998-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/106002809803201201
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Article: Citalopram--a review of pharmacological and clinical effects.

Bezchlibnyk-Butler, K / Aleksic, I / Kennedy, S H

Journal of psychiatry & neuroscience : JPN

2000 Volume 25, Issue 3, Page(s) 241–254

Abstract: Objective: To provide clinicians with a critical evaluation of citalopram, a selective serotonin reuptake inhibitor (SSRI) that has been available in Canada since March 1999.: Data sources: Commercial searches (MEDLINE and BiblioTech) and an "in- ... ...

Abstract	Objective: To provide clinicians with a critical evaluation of citalopram, a selective serotonin reuptake inhibitor (SSRI) that has been available in Canada since March 1999. Data sources: Commercial searches (MEDLINE and BiblioTech) and an "in-house" search (InfoDrug) were used to find published English-language references for clinical and preclinical publications. There was no restriction of publication dates. Primary index terms used were: pharmacological properties, receptors, pharmacological selectivity, pharmacokinetics, age-related pharmacokinetics, sex-related pharmacokinetics, renal dysfunction, hepatic dysfunction, cytochrome activity, drug interactions, adverse reactions, antidepressant switching, precautions, overdose, drug discontinuation, children, geriatric, depression, combination therapy, placebo control, refractory depression, anxiety disorders and medical disorders. Study selection: A total of 74 studies were reviewed. Twenty-one of these studies specifically examined the clinical efficacy and tolerability of citalopram in depressive disorders as well as other disorders. In depressive disorders, clinical studies were required to have either placebo or active comparison controls for a minimum of 3 weeks. For other disorders, in the absence of double-blind trials, open-label studies were included. Pharmacological studies were limited to animal studies focusing on citalopram's selectivity and receptor specificity, and positron emission tomography studies were incorporated to include human pharmacological data. Pharmacokinetic studies focused on the metabolism, safety and tolerability of citalopram, specifically with reference to adverse reactions, drug interactions and overdose in addition to citalopram's effect on vulnerable populations, such as children, the elderly and patients with metabolic diseases. Data extraction: Data on clinical studies were summarized according to test measures, study duration and outcome of study. Pharmacokinetic and pharmacodynamic studies were summarized according to properties and interactions. Adverse reactions were extracted to outline citalopram's safety profile. Data synthesis: Citalopram is an SSRI antidepressant with a more specific and selective pharmacological profile than other antidepressants of its class. It is well tolerated, and drug interactions are not a significant concern. It is also reasonably safe for populations vulnerable to pharmacokinetic effects, such as the elderly and patients with metabolic diseases. In addition to its tolerability, citalopram is effective in the treatment of major depression, other depressive disorders and panic disorder. It has the potential to effectively treat other anxiety disorders and substance-use disorders; in addition, it may be useful in several medical conditions. Conclusions: There is evidence to support the role of citalopram as a well-tolerated and effective SSRI antidepressant. There is a need for further evaluation of its role in psychiatric disorders other than major depressive disorder.
MeSH term(s)	Aged ; Child ; Child, Preschool ; Citalopram/pharmacology ; Citalopram/therapeutic use ; Depressive Disorder, Major/drug therapy ; Drug Interactions ; Humans ; Serotonin Uptake Inhibitors/pharmacology ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V)
Language	English
Publishing date	2000-05
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	1077443-9
ISSN	1180-4882
ISSN	1180-4882
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neuroleptic dosing in chronic schizophrenia: a 10-year follow-up.

Remington, G J / Prendergast, P / Bezchlibnyk-Butler, K Z

Canadian journal of psychiatry. Revue canadienne de psychiatrie

1997 Volume 42, Issue 1, Page(s) 53–57

Abstract: Objective: To evaluate neuroleptic dosing patterns in individuals with schizophrenia over a 10-year interval.: Method: Changes in neuroleptic dosing between 1980 and 1990 were followed in 65 patients with a diagnosis of chronic schizophrenia.: ... ...

Abstract	Objective: To evaluate neuroleptic dosing patterns in individuals with schizophrenia over a 10-year interval. Method: Changes in neuroleptic dosing between 1980 and 1990 were followed in 65 patients with a diagnosis of chronic schizophrenia. Results: According to more recent dosing guidelines, doses were already high at the time of initial evaluation, yet overall they continued to increase during the next decade of treatment for both males and females. Patients were almost equally divided, however, by those who underwent an increase (n = 33) and those whose dose remained stable (n = 4) or was decreased (n = 28). Conclusion: A considerable number of patients with schizophrenia appear to receive progressively higher neuroleptic doses over the course of their illness, despite a lack of empirical data to support such an approach. Results are discussed in terms of current dosing recommendations and factors influencing dose changes.
MeSH term(s)	Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Chlorpromazine/administration & dosage ; Chlorpromazine/adverse effects ; Chronic Disease ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenic Psychology
Chemical Substances	Antipsychotic Agents ; Delayed-Action Preparations ; Chlorpromazine (U42B7VYA4P)
Language	English
Publishing date	1997-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	304227-3
ISSN	1497-0015 ; 0706-7437 ; 0008-4824
ISSN (online)	1497-0015
ISSN	0706-7437 ; 0008-4824
DOI	10.1177/070674379704200108
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Article: Use of cytokines in clozapine-induced agranulocytosis.

Chin-Yee, I / Bezchlibnyk-Butler, K / Wong, L

Canadian journal of psychiatry. Revue canadienne de psychiatrie

1996 Volume 41, Issue 5, Page(s) 280–284

Abstract: Objective: To report and review the use of cytokines for the treatment of clozapine-induced neutropenia.: Method: Case report and review of literature.: Results: Cytokines, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage ... ...

Abstract	Objective: To report and review the use of cytokines for the treatment of clozapine-induced neutropenia. Method: Case report and review of literature. Results: Cytokines, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), appear to shorten the duration of clozapine-induced neutropenia. Conclusions: G-CSF or GM-CSF therapy should be considered in patients with profound neutropenia of prolonged duration (high-risk neutropenia).
MeSH term(s)	Adult ; Agranulocytosis/chemically induced ; Agranulocytosis/therapy ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Clozapine/adverse effects ; Clozapine/therapeutic use ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocytes/drug effects ; Humans ; Injections, Subcutaneous ; Leukocyte Count/drug effects ; Male ; Neutropenia/chemically induced ; Neutropenia/therapy ; Schizophrenia/drug therapy ; Schizophrenic Psychology
Chemical Substances	Antipsychotic Agents ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Clozapine (J60AR2IKIC)
Language	English
Publishing date	1996-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	304227-3
ISSN	1497-0015 ; 0706-7437 ; 0008-4824
ISSN (online)	1497-0015
ISSN	0706-7437 ; 0008-4824
DOI	10.1177/070674379604100504
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Article: Ineffective sublingual lorazepam: considerations.

Remington, G / Bezchlibnyk-Butler, K

Journal of clinical psychopharmacology

1987 Volume 7, Issue 5, Page(s) 365–367

MeSH term(s)	Administration, Sublingual ; Anxiety/drug therapy ; Female ; Humans ; Lorazepam/administration & dosage ; Middle Aged
Chemical Substances	Lorazepam (O26FZP769L)
Language	English
Publishing date	1987-10
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
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Article: Effect of clozapine on polypharmacy.

Chong, S A / Remington, G J / Bezchlibnyk-Butler, K Z

Psychiatric services (Washington, D.C.)

2000 Volume 51, Issue 2, Page(s) 250–252

Abstract: Prescribing patterns for a group of outpatients with schizophrenia were surveyed for changes after the initiation of clozapine. Data were drawn from computerized pharmacy records, direct case record reviews, and interviews with the attending ... ...

Abstract	Prescribing patterns for a group of outpatients with schizophrenia were surveyed for changes after the initiation of clozapine. Data were drawn from computerized pharmacy records, direct case record reviews, and interviews with the attending psychiatrists. The number of patients with two or more psychotropic drugs decreased by 31 percent after the initiation of clozapine, and a trend toward the use of clozapine without additional neuroleptics was detected. Decreases occurred in the use of anticholinergic agents, carbamazepine, and benzodiazepines, but selective serotonin reuptake inhibitors and sodium valproate were more likely to be prescribed concomitantly with clozapine.
MeSH term(s)	Adult ; Antipsychotic Agents/therapeutic use ; Canada ; Clozapine/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Polypharmacy ; Practice Patterns, Physicians' ; Sampling Studies ; Schizophrenia/drug therapy ; Serotonin Antagonists/therapeutic use
Chemical Substances	Antipsychotic Agents ; Serotonin Antagonists ; Clozapine (J60AR2IKIC)
Language	English
Publishing date	2000-02
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.51.2.250
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Article: Antiparkinsonian drugs in the treatment of neuroleptic-induced extrapyramidal symptoms.

Bezchlibnyk-Butler, K Z / Remington, G J

Canadian journal of psychiatry. Revue canadienne de psychiatrie

1994 Volume 39, Issue 2, Page(s) 74–84

Abstract: Most patients on neuroleptic therapy experience extrapyramidal symptoms in one form or another during treatment. While the risk of extrapyramidal symptoms appears diminished with the newer and "atypical" neuroleptics (for example, risperidone, ... ...

Abstract	Most patients on neuroleptic therapy experience extrapyramidal symptoms in one form or another during treatment. While the risk of extrapyramidal symptoms appears diminished with the newer and "atypical" neuroleptics (for example, risperidone, remoxipride, clozapine), it is not eliminated. It is essential that the treating clinician monitor for such side effects since if they are left untreated they can be an ongoing source of discomfort to the patient and may affect compliance with therapy. Antiparkinsonian medication represents the mainstay of treatment for neuroleptic-induced extrapyramidal symptoms. Their clinical use is reviewed here with reference to mode of action, indications, choice, side-effects and precautions.
MeSH term(s)	Antiparkinson Agents/adverse effects ; Antiparkinson Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Basal Ganglia Diseases/chemically induced ; Basal Ganglia Diseases/drug therapy ; Dyskinesia, Drug-Induced/drug therapy ; Humans ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/drug therapy ; Treatment Outcome
Chemical Substances	Antiparkinson Agents ; Antipsychotic Agents
Language	English
Publishing date	1994-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	304227-3
ISSN	1497-0015 ; 0706-7437 ; 0008-4824
ISSN (online)	1497-0015
ISSN	0706-7437 ; 0008-4824
DOI	10.1177/070674379403900203
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Article: Dosaging patterns in schizophrenia with depot, oral and combined neuroleptic therapy.

Remington, G J / Prendergast, P / Bezchlibnyk-Butler, K Z

Canadian journal of psychiatry. Revue canadienne de psychiatrie

1993 Volume 38, Issue 3, Page(s) 159–161

Abstract: A group of patients with chronic schizophrenia were evaluated according to the form of neuroleptic treatment they were receiving: depot, oral or combined (depot/oral or oral/oral). The patients treated with the combined therapy received significantly ... ...

Abstract	A group of patients with chronic schizophrenia were evaluated according to the form of neuroleptic treatment they were receiving: depot, oral or combined (depot/oral or oral/oral). The patients treated with the combined therapy received significantly higher dosages of neuroleptic than those treated with either depot or oral therapy, which did not differ from each other. Daily maintenance dosages were generally well above recent guidelines.
MeSH term(s)	Administration, Oral ; Adult ; Antipsychotic Agents/administration & dosage ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Humans ; Injections, Intramuscular ; Male ; Schizophrenia/drug therapy ; Schizophrenic Psychology
Chemical Substances	Antipsychotic Agents ; Delayed-Action Preparations
Language	English
Publishing date	1993-04
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	304227-3
ISSN	1497-0015 ; 0706-7437 ; 0008-4824
ISSN (online)	1497-0015
ISSN	0706-7437 ; 0008-4824
DOI	10.1177/070674379303800301
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Article: Amenorrhea and galactorrhea associated with fluvoxamine in a loxapine-treated patient.

Jeffries, J / Bezchlibnyk-Butler, K / Remington, G

Journal of clinical psychopharmacology

1992 Volume 12, Issue 4, Page(s) 296–297

MeSH term(s)	Adult ; Amenorrhea/chemically induced ; Bipolar Disorder/drug therapy ; Female ; Fluvoxamine/adverse effects ; Galactorrhea/chemically induced ; Humans ; Loxapine/therapeutic use
Chemical Substances	Loxapine (LER583670J) ; Fluvoxamine (O4L1XPO44W)
Language	English
Publishing date	1992-08
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/00004714-199208000-00024
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