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Article ; Online: Kritikus állapotú, szeptikus felnőtt betegek antibiotikumkezelésének farmakokinetikai és farmakodinamikai megfontolásai.

Holub, Lili / Szabó, Bálint Gergely / Závorszky, Lőrinc / Hümpfner, Rózsa / Andréka, Péter / Karvaly, Gellért Balázs / Lakatos, Botond

Orvosi hetilap

2024 Volume 165, Issue 11, Page(s) 403–415

Title translation	Pharmacokinetic and pharmacodynamic considerations of antibiotic therapy among critically ill adult patients with sepsis.
MeSH term(s)	Adult ; Humans ; Critical Illness/therapy ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Sepsis/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	Hungarian
Publishing date	2024-03-17
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2024.33001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Characteristics of Enterococcus species bloodstream infections among adults with and without onco-hematological malignancies: Experiences from the national center of Hungary.

Marosi, Bence / Kádár, Béla / Bruzsa, Anna / Kocsis, Laura / Kamotsay, Katalin / Sinkó, János / Szabó, Bálint Gergely / Lakatos, Botond

European journal of microbiology & immunology

2024

Abstract: Introduction: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and ... ...

Abstract	Introduction: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and long-term outcomes of BSIs caused by Enterococcus spp. in adult patients with and without active onco-hematological malignancies hospitalized at a national referral institute. Methods: A prospective analysis of consecutive enterococcal BSI cases was conducted in the National Institute of Hematology and Infectious Diseases (Budapest, Hungary) between December 2019 and April 2022. We compared characteristics and outcomes at 30-days and 1 year after diagnosis among patients with and without onco-hematological malignancies. Results: In total, 141 patients were included (median age 68 ± 21 years, female sex 36.9%), 37% (52/141) had active onco-hematological malignancies. The distribution of species was as follows: 50.4% Enterococcus faecalis, 46.1% Enterococcus faecium, 1.4% Enterococcus avium and Enterococcus gallinarum, and 0.7% Enterococcus raffinosus. No statistically significant differences in all-cause mortality rates were observed between patient subgroups at 30 days (32.7 vs. 28.1%; P = 0.57) and 1 year (75.0 vs. 60.7%; P = 0.09). Conclusion: Enterococcal bloodstream infections yielded a relevant burden of morbidity, but with no statistical difference in long-term outcomes of adult patients with and without active onco-hematological malignancies.
Language	English
Publishing date	2024-03-27
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2652327-9
ISSN	2062-8633 ; 2062-509X
ISSN (online)	2062-8633
ISSN	2062-509X
DOI	10.1556/1886.2024.00011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: TreeSwap

Nagy, Attila / Lakatos, Dorina / Barta, Botond / Ács, Judit

Data Augmentation for Machine Translation via Dependency Subtree Swapping

2023

Abstract: Data augmentation methods for neural machine translation are particularly useful when limited amount of training data is available, which is often the case when dealing with low-resource languages. We introduce a novel augmentation method, which ... ...

Abstract	Data augmentation methods for neural machine translation are particularly useful when limited amount of training data is available, which is often the case when dealing with low-resource languages. We introduce a novel augmentation method, which generates new sentences by swapping objects and subjects across bisentences. This is performed simultaneously based on the dependency parse trees of the source and target sentences. We name this method TreeSwap. Our results show that TreeSwap achieves consistent improvements over baseline models in 4 language pairs in both directions on resource-constrained datasets. We also explore domain-specific corpora, but find that our method does not make significant improvements on law, medical and IT data. We report the scores of similar augmentation methods and find that TreeSwap performs comparably. We also analyze the generated sentences qualitatively and find that the augmentation produces a correct translation in most cases. Our code is available on Github.
Keywords	Computer Science - Computation and Language
Subject code	410
Publishing date	2023-11-04
Publishing country	us
Document type	Book ; Online
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Article ; Online: A C-reaktívprotein- és -prokalcitoninszintek szérumkinetikája és a klinikai kimenetellel való kapcsolata közösségben szerzett szepszisben.

Marosi, Bence / Kiss, Rebeka / Lakatos, Botond / Szabó, Bálint Gergely

Orvosi hetilap

2022 Volume 163, Issue 43, Page(s) 1713–1720

Abstract: Introduction and objective: Community-acquired sepsis is a life-threatening systemic reaction to infection starting 72 hours within hospital admittance. Data concerning kinetics of serum C-reactive protein (CRP) and procalcitonin (PCT) levels during ... ...

Abstract	Introduction and objective: Community-acquired sepsis is a life-threatening systemic reaction to infection starting 72 hours within hospital admittance. Data concerning kinetics of serum C-reactive protein (CRP) and procalcitonin (PCT) levels during disease progression are sparse. Our aim was to analyze kinetics of CRP and PCT among adults with community-acquired sepsis. Methods: We analyzed data of consecutive patients hospitalized with community-acquired sepsis at our centre during 2016. Sepsis was defined according to ACCP/SCCM criteria, community-acquisition was ascertained by a priori exclusion criteria. CRP and PCT values of days 1-14 were collected. Primary outcomes were in-hospital all-cause mortality, intensive care unit admission, secondary outcomes were septic source and the causative microorganism. Absolute (ΔabsCRP, ΔabsPCT) and relative (Δ%CRP, Δ%PCT) differences were calculated between values at the time of diagnosis and control values within 24 hours of empirical antimicrobial therapy initiation. Results: 193 patients were included. In-hospital all-cause mortality was 13.9%, intensive care unit admittance was 25.9%. Patients who died had significantly smaller median Δ%PCT decrements (-7.7 ± 127.9% vs. -45.7 ± 88.8%, p = 0.01), compared to survivors. During hospital stay, daily absolute values of PCT on days 2-14, while those of CRP on days 5-14 were significantly higher among patients who died. Patients admitted to the intensive care unit also had smaller median Δ%PCT decrements (-19.6 ± 72.5% vs. -49.8 ± 100.8%, p = 0.01), compared to non-admitted patients. Calculated parameters did not show significant correlations with septic focus or causative microorganisms. Discussion, conclusion: Our findings suggest that specific fluctuations of CRP and PCT are observable, and Δ%PCT might be a favourable parameter for outcome prediction among adults with community-acquired sepsis. Orv Hetil. 2022; 163(43): 1713-1720.
MeSH term(s)	Adult ; Humans ; Procalcitonin ; C-Reactive Protein/metabolism ; Sepsis/drug therapy ; Sepsis/diagnosis ; Intensive Care Units ; Hospital Mortality ; Prognosis ; Biomarkers ; ROC Curve
Chemical Substances	Procalcitonin ; C-Reactive Protein (9007-41-4) ; Biomarkers
Language	English
Publishing date	2022-10-23
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2022.32618
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Extracorporeal Photopheresis as a Possible Therapeutic Approach for Adults with Severe and Critical COVID-19 Non-Responsive to Standard Treatment: A Pilot Investigational Study.

Szabó, Bálint Gergely / Reményi, Péter / Tasnády, Szabolcs / Korózs, Dorina / Gopcsa, László / Réti, Marienn / Várkonyi, Andrea / Sinkó, János / Lakatos, Botond / Szlávik, János / Bekő, Gabriella / Bobek, Ilona / Vályi-Nagy, István

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155000
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Article ; Online: Infekciók kockázatának csökkentése veleszületett és szerzett komplementdefektusokban.

Karászi, Éva / Onozó, Beáta / Kulcsár, Andrea / Szlávik, János / Goda, Vera / Kriván, Gergely / Prohászka, Zoltán / Lakatos, Botond

Orvosi hetilap

2023 Volume 164, Issue 25, Page(s) 971–980

Abstract: Hereditary complement deficiencies are relatively rare worldwide, they account for about 1-10% of primary immunodeficiencies. Acquired complement deficiencies are more prevalent and with the more frequent use of complement inhibitor therapy, the ... ...

Title translation	Reducing the risk of infections in hereditary and acquired complement deficiencies.
Abstract	Hereditary complement deficiencies are relatively rare worldwide, they account for about 1-10% of primary immunodeficiencies. Acquired complement deficiencies are more prevalent and with the more frequent use of complement inhibitor therapy, the incidence of patients with iatrogenic complement deficiency is increasing. Alike in the inherited forms, patients have a high risk of severe and life-threatening infections caused by encapsulated bacteria (sepsis, meningitis). The most frequent pathogens are Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae. C5 and C3 complement inhibitor therapies are available in Hungary, which are mostly indicated in the treatment of paroxysmal nocturnal hemoglobinuria, myasthenia gravis, neuromyelitis optica and atypical haemolytic uremic syndrome. It is of utmost importance to prevent severe, potentially life-threatening bacterial infections in this group of patients. Nevertheless, there is no Hungarian guidance to decrease the risk of infections, preventive measures are incomplete and not standardized posing potential risk of infections for these patients, so far. In this review, we aim to summarize the international clinical practices and guidance on the infection prevention in complement deficient patients. This recommendation might be a source of an evidence-based Hungarian guideline regarding vaccination and antibiotic prophylaxis in this specifically vulnerable group of patients. Orv Hetil. 2023; 164(25): 971-980.
MeSH term(s)	Humans ; Complement System Proteins ; Bacterial Infections/epidemiology ; Immunologic Factors ; Complement Inactivating Agents/therapeutic use ; Streptococcus pneumoniae
Chemical Substances	Complement System Proteins (9007-36-7) ; Immunologic Factors ; Complement Inactivating Agents
Language	Hungarian
Publishing date	2023-06-25
Publishing country	Hungary
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2023.32798
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Béta-laktám antibiotikumok terápiás gyógyszerszint-monitorozása kritikus állapotú felnőtt betegekben: egycentrumos, prospektív, obszervációs pilotvizsgálat.

Závorszky, Lőrinc / Rádler, Andrea / Galgóczi, Júlia / Tóth, Bence / Csomós, Ákos / Erőss, Attila / Farkas, Róbert / Karvaly, Gellért / Holub, Lili / Szabó, Bálint Gergely / Lakatos, Botond

Orvosi hetilap

2023 Volume 164, Issue 48, Page(s) 1904–1911

Title translation	Therapeutic drug monitoring of beta-lactam antibiotics in critically ill adult patients.
MeSH term(s)	Humans ; Adult ; Critical Illness/therapy ; Drug Monitoring ; Anti-Bacterial Agents/therapeutic use ; beta-Lactams/therapeutic use ; Monobactams/therapeutic use ; Sepsis
Chemical Substances	Anti-Bacterial Agents ; beta-Lactams ; Monobactams
Language	Hungarian
Publishing date	2023-12-03
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2023.32896
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Article ; Online: Secondary infections and long-term outcomes among hospitalized elderly and non-elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and treated with baricitinib: a comparative study from the national centre of Hungary.

Gáspár, Zsófia / Szabó, Bálint Gergely / Andrikovics, Hajnalka / Ceglédi, Andrea / Rajmon, Martin / Ábrahám, Anita / Várnai, Zsuzsanna / Kiss-Dala, Noémi / Szlávik, János / Sinkó, János / Vályi-Nagy, István / Lakatos, Botond

GeroScience

2024 Volume 46, Issue 3, Page(s) 2863–2877

Abstract: Baricitinib is considered a first-line treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected adult patients with an associated cytokine storm syndrome (CSS). Our objective was to compare rates of secondary infections and ... ...

Abstract	Baricitinib is considered a first-line treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected adult patients with an associated cytokine storm syndrome (CSS). Our objective was to compare rates of secondary infections and long-term outcomes of elderly and non-elderly patients who received baricitinib for COVID-19. We conducted a single-centre observational study between November 2020 and September 2023, focusing on hospitalized adult SARS-CoV-2 patients with CSS, categorized as elderly (≥ 65 years) and non-elderly (< 65 years). Enrolment, severity stratification, and diagnosis of infectious complications followed predefined criteria. Outcomes of all-cause mortality and rates of non-severe and severe secondary infections were assessed at 1-year post-treatment initiation. Kaplan-Meier analysis was performed for survival analysis. In total, 490 patients were enrolled (median age 65 ± 23 (21-100) years (years, median ± IQR, min-max); 49.18% elderly; 59.59% male). Elderly patients were admitted to the hospital significantly earlier (7 ± 5 days vs. 8 ± 4 days; p = 0.02), experienced a higher occurrence of severe COVID-19 (121/241, 50.21% vs. 98/249, 39.36%; p = 0.02), and required the use of non-invasive ventilation at baseline (167/225, 74.22% vs. 153/236, 64.83%; p = 0.03). At 1 year, all-cause mortality was significantly higher in the elderly subgroup (111/241, 46.06% vs. 29/249, 11.65%; p < 0.01). At 90 days and 1 year, rates of any severe secondary infection were also more prevalent among the elderly (56/241, 23.24% vs. 37/249 14.86%; p = 0.02 and 58/241, 24.07% vs. 39/249, 15.66%; p = 0.02). In conclusion, elderly SARS-CoV-2-infected patients experience a more severe clinical course, higher secondary infection rates, and increased risk for long-term mortality, regardless of immunomodulatory therapy.
MeSH term(s)	Humans ; Male ; Aged ; Middle Aged ; Aged, 80 and over ; Female ; SARS-CoV-2 ; COVID-19 ; Coinfection ; Hungary ; COVID-19 Drug Treatment ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides
Chemical Substances	baricitinib (ISP4442I3Y) ; Azetidines ; Purines ; Pyrazoles ; Sulfonamides
Language	English
Publishing date	2024-02-17
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-024-01099-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: HunSum-1

Barta, Botond / Lakatos, Dorina / Nagy, Attila / Nyist, Milán Konor / Ács, Judit

an Abstractive Summarization Dataset for Hungarian

2023

Abstract: We introduce HunSum-1: a dataset for Hungarian abstractive summarization, consisting of 1.14M news articles. The dataset is built by collecting, cleaning and deduplicating data from 9 major Hungarian news sites through CommonCrawl. Using this dataset, we ...

Abstract	We introduce HunSum-1: a dataset for Hungarian abstractive summarization, consisting of 1.14M news articles. The dataset is built by collecting, cleaning and deduplicating data from 9 major Hungarian news sites through CommonCrawl. Using this dataset, we build abstractive summarizer models based on huBERT and mT5. We demonstrate the value of the created dataset by performing a quantitative and qualitative analysis on the models' results. The HunSum-1 dataset, all models used in our experiments and our code are available open source.
Keywords	Computer Science - Computation and Language
Publishing date	2023-02-01
Publishing country	us
Document type	Book ; Online
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Book ; Online: Data Augmentation for Machine Translation via Dependency Subtree Swapping

Nagy, Attila / Lakatos, Dorina Petra / Barta, Botond / Nanys, Patrick / Ács, Judit

2023

Abstract: We present a generic framework for data augmentation via dependency subtree swapping that is applicable to machine translation. We extract corresponding subtrees from the dependency parse trees of the source and target sentences and swap these across ... ...

Abstract	We present a generic framework for data augmentation via dependency subtree swapping that is applicable to machine translation. We extract corresponding subtrees from the dependency parse trees of the source and target sentences and swap these across bisentences to create augmented samples. We perform thorough filtering based on graphbased similarities of the dependency trees and additional heuristics to ensure that extracted subtrees correspond to the same meaning. We conduct resource-constrained experiments on 4 language pairs in both directions using the IWSLT text translation datasets and the Hunglish2 corpus. The results demonstrate consistent improvements in BLEU score over our baseline models in 3 out of 4 language pairs. Our code is available on GitHub.
Keywords	Computer Science - Computation and Language
Publishing date	2023-07-13
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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