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  1. Article: Optimizing Vaccination in Adult Patients With Liver Disease and Liver Transplantation.

    Rhee, Yoona / Sha, Beverly E / Santos, Carlos A Q

    Clinical liver disease

    2020  Volume 15, Issue 2, Page(s) 63–68

    Abstract: ... rhee a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002 ... ISSN)2046-2484/video/15-2-interview-rhee an interview with the author. ...

    Abstract http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-2-reading-rhee a video presentation of this article http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2046-2484/video/15-2-interview-rhee an interview with the author.
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparison of Daily versus Admission and Discharge Surveillance Cultures for Multidrug-Resistant Organism Detection in an Intensive Care Unit.

    Sansom, Sarah E / Shimasaki, Teppei / Dangana, Thelma / Lin, Michael Y / Schoeny, Michael E / Fukuda, Christine / Moore, Nicholas M / Yelin, Rachel D / Bassis, Christine M / Rhee, Yoona / Cornejo Cisneros, Enrique / Bell, Pamela / Lolans, Karen / Aboushaala, Khaled / Young, Vincent B / Hayden, Mary K

    The Journal of infectious diseases

    2024  

    Abstract: Background: Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a traditional approach to active surveillance, but its sensitivity for detecting colonization is uncertain.: ... ...

    Abstract Background: Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a traditional approach to active surveillance, but its sensitivity for detecting colonization is uncertain.
    Methods: Daily rectal or fecal swab samples and clinical data were collected over 12 months from patients in one 25-bed intensive care unit (ICU) in Chicago, IL USA and tested for the following multidrug-resistant organisms (MDROs): vancomycin-resistant enterococci (VRE); third-generation cephalosporin-resistant Enterobacterales, including extended-spectrum β-lactamase-producing Enterobacterales (ESBL); and carbapenem-resistant Enterobacterales (CRE). MDRO detection by (1) admission/discharge surveillance cultures or (2) clinical cultures were compared to daily surveillance cultures. Samples underwent 16S rRNA gene sequencing to measure the relative abundance of operational taxonomic units (OTUs) corresponding to each MDRO.
    Results: Compared with daily surveillance cultures, admission/discharge cultures detected 91% of prevalent MDRO colonization and 63% of incident MDRO colonization among medical ICU patients. Only a minority (7%) of MDRO carriers were identified by clinical cultures. Higher relative abundance of MDRO-associated OTUs and specific antibiotic exposures were independently associated with higher probability of MDRO detection by culture.
    Conclusion: Admission and discharge surveillance cultures underestimated MDRO acquisitions in an ICU. These limitations should be considered when designing sampling strategies for epidemiologic studies that use culture-based surveillance.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae162
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  3. Article: Fatal COVID-19 in a Patient with End-Stage Liver Disease Wait-Listed for Liver Transplantation: An Evidence-Based Review of COVID-19 Screening Modalities Prior to Transplant.

    Rhee, Yoona / Chan, Edie L / Eswaran, Sheila L / Aloman, Costica / Hertl, Martin / Santos, Carlos A Q

    Clinical liver disease

    2020  Volume 15, Issue 6, Page(s) 246–250

    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.990
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  4. Article: Make Sure You Have a Safety Net: Updates in the Prevention and Management of Infectious Complications in Stem Cell Transplant Recipients.

    Santos, Carlos A Q / Rhee, Yoona / Czapka, Michael T / Kazi, Aamir S / Proia, Laurie A

    Journal of clinical medicine

    2020  Volume 9, Issue 3

    Abstract: Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive ... ...

    Abstract Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive medications; and placement of invasive catheters. The prevention and management of infections in these vulnerable hosts is of utmost importance and a key "safety net" in stem cell transplantation. In this review, we provide updates on the prevention and management of CMV infection; invasive fungal infections; bacterial infections;
    Language English
    Publishing date 2020-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9030865
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  5. Article ; Online: Indwelling medical devices and skin microorganisms on ICU patients bathed with chlorhexidine gluconate

    Yoona Rhee / Mary Hayden / Michael Schoeny / Christine Fukuda / Pamela B. Bell / Andrew Simms / Beverly Sha / Carlos Santos / Michael Lin

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol 2, Pp s43-s

    2022  Volume 44

    Abstract: Background: Bathing ICU patients with chlorhexidine gluconate (CHG) decreases bloodstream infections and multidrug-resistant organism transmission. The efficacy of CHG bathing on skin microorganism reduction may be influenced by patient-level clinical ... ...

    Abstract Background: Bathing ICU patients with chlorhexidine gluconate (CHG) decreases bloodstream infections and multidrug-resistant organism transmission. The efficacy of CHG bathing on skin microorganism reduction may be influenced by patient-level clinical factors. We assessed the impact of clinical factors on the recovery of microorganisms from the skin of patients admitted to an ICU who were receiving routine CHG bathing. Methods: We analyzed data obtained from 6 single-day point-prevalence surveys of adult ICU patients between January and October 2018 at 1 medical ICU, in the context of a CHG bathing quality initiative. Demographics and covariates were collected at the bedside and by chart review. Skin swabs were collected from neck, axilla, and inguinal regions and were plated to selective and nonselective media. Standard microbiologic methods were used for species identification and susceptibilities. Multivariable models included patients who received a CHG bath and accounted for clustering of body sites within patients. Results: Across all time points, 144 patients participated, yielding 429 skin swab samples. Mean age was 57 years (SD, 17); 49% were male; 44% had a central venous catheter; and 15% had a tracheostomy Also, 140 patients (97%) had >1 CHG bath prior to skin swab collection, with a median of 9 hours since their last CHG bath (IQR, 6–13 hours). Gram-positive bacteria were more commonly recovered than gram-negative or Candida spp across all skin sites (Table 1). Variation by body site was detected only for gram-positive bacteria, with recovery more common from the neck compared to axilla or groin sites. On multivariate logistic regression (Table 2), presence of central venous catheter was associated with lower odds of gram-positive bacteria recovery among those who received a CHG bath. Presence of tracheostomy was associated with a significantly higher odds of gram-negative bacteria detection on skin. No clinical factors were independently associated with recovery of Candida spp. Conclusions: ...
    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 616
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Comparative incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients versus kidney or kidney-pancreas waitlisted patients: A single-center study.

    Santos, Carlos A Q / Rhee, Yoona / Hollinger, Edward F / Olaitan, Oyedolamu K / Schadde, Erik / Peev, Vasil / Saltzberg, Samuel N / Hertl, Martin

    Clinical transplantation

    2021  Volume 35, Issue 8, Page(s) e14362

    Abstract: Background: COVID-19 epidemiologic studies comparing immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressants on outcomes.: Methods: In this retrospective cohort study, we assembled kidney or kidney- ... ...

    Abstract Background: COVID-19 epidemiologic studies comparing immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressants on outcomes.
    Methods: In this retrospective cohort study, we assembled kidney or kidney-pancreas transplant recipients who underwent transplant from January 1, 2010, to June 30, 2020, and kidney or kidney-pancreas waitlisted patients who were ever on the waitlist from January 1, 2019, to June 30, 2020. We identified laboratory-confirmed COVID-19 until January 31, 2021, and tracked its outcomes by leveraging informatics infrastructure developed for an outcomes research network.
    Results: COVID-19 was identified in 62 of 887 kidney or kidney-pancreas transplant recipients and 20 of 434 kidney or kidney-pancreas waitlisted patients (7.0% vs. 4.6%, p = .092). Of these patients with COVID-19, hospitalization occurred in 48 of 62 transplant recipients and 8 of 20 waitlisted patients (77% vs. 40%, p = .002); intensive care unit admission occurred in 18 of 62 transplant recipients and 2 of 20 waitlisted patients (29% vs. 10%, p = .085); and 7 transplant recipients were mechanically ventilated and died, whereas no waitlisted patients were mechanically ventilated or died (11% vs. 0%, p = .116).
    Conclusions: Our study provides single-center data and an informatics approach that can be used to inform the design of multicenter studies.
    MeSH term(s) COVID-19 ; Humans ; Incidence ; Kidney ; Kidney Transplantation ; Pancreas ; Retrospective Studies ; SARS-CoV-2 ; Transplant Recipients
    Language English
    Publishing date 2021-05-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14362
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Impact of measurement and feedback on chlorhexidine gluconate bathing among intensive care unit patients: A multicenter study.

    Rhee, Yoona / Hayden, Mary K / Schoeny, Michael / Baker, Arthur W / Baker, Meghan A / Gohil, Shruti / Rhee, Chanu / Talati, Naasha J / Warren, David K / Welbel, Sharon / Lolans, Karen / Bahadori, Bardia / Bell, Pamela B / Bravo, Heilen / Dangana, Thelma / Fukuda, Christine / Habrock Bach, Tracey / Nelson, Alicia / Simms, Andrew T /
    Tolomeo, Pam / Wolf, Robert / Yelin, Rachel / Lin, Michael Y

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 9, Page(s) 1375–1380

    Abstract: Objective: To assess whether measurement and feedback of chlorhexidine gluconate (CHG) skin concentrations can improve CHG bathing practice across multiple intensive care units (ICUs).: Design: A before-and-after quality improvement study measuring ... ...

    Abstract Objective: To assess whether measurement and feedback of chlorhexidine gluconate (CHG) skin concentrations can improve CHG bathing practice across multiple intensive care units (ICUs).
    Design: A before-and-after quality improvement study measuring patient CHG skin concentrations during 6 point-prevalence surveys (3 surveys each during baseline and intervention periods).
    Setting: The study was conducted across 7 geographically diverse ICUs with routine CHG bathing.
    Participants: Adult patients in the medical ICU.
    Methods: CHG skin concentrations were measured at the neck, axilla, and inguinal region using a semiquantitative colorimetric assay. Aggregate unit-level CHG skin concentration measurements from the baseline period and each intervention period survey were reported back to ICU leadership, which then used routine education and quality improvement activities to improve CHG bathing practice. We used multilevel linear models to assess the impact of intervention on CHG skin concentrations.
    Results: We enrolled 681 (93%) of 736 eligible patients; 92% received a CHG bath prior to survey. At baseline, CHG skin concentrations were lowest on the neck, compared to axillary or inguinal regions (
    Conclusions: Routine CHG bathing performance in the ICU varied across multiple hospitals. Measurement and feedback of CHG skin concentrations can be an important tool to improve CHG bathing practice.
    MeSH term(s) Adult ; Humans ; Feedback ; Critical Care ; Intensive Care Units ; Chlorhexidine
    Chemical Substances chlorhexidine gluconate (MOR84MUD8E) ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.177
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    Zs.A 1714: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Fatal COVID-19 in a Patient with End-Stage Liver Disease Wait-Listed for Liver Transplantation: An Evidence-Based Review of COVID-19 Screening Modalities Prior to Transplant

    Rhee, Yoona / Chan, Edie L. / Eswaran, Sheila L. / Aloman, Costica / Hertl, Martin / Santos, Carlos A.Q.

    Clin. Liver Dis.

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #630584
    Database COVID19

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  9. Article ; Online: Fatal COVID‐19 in a Patient with End‐Stage Liver Disease Wait‐Listed for Liver Transplantation

    Rhee, Yoona / Chan, Edie L. / Eswaran, Sheila L. / Aloman, Costica / Hertl, Martin / Santos, Carlos A.Q.

    Clinical Liver Disease

    An Evidence‐Based Review of COVID‐19 Screening Modalities Prior to Transplant

    2020  Volume 15, Issue 6, Page(s) 246–250

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.990
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Make Sure You Have a Safety Net

    Carlos A. Q. Santos / Yoona Rhee / Michael T. Czapka / Aamir S. Kazi / Laurie A. Proia

    Journal of Clinical Medicine, Vol 9, Iss 3, p

    Updates in the Prevention and Management of Infectious Complications in Stem Cell Transplant Recipients

    2020  Volume 865

    Abstract: Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive ... ...

    Abstract Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive medications; and placement of invasive catheters. The prevention and management of infections in these vulnerable hosts is of utmost importance and a key “safety net” in stem cell transplantation. In this review, we provide updates on the prevention and management of CMV infection; invasive fungal infections; bacterial infections; Clostridium difficile infection; and EBV, HHV-6, adenovirus and BK infections. We discuss novel drugs, such as letermovir, isavuconazole, meropenem-vaborbactam and bezlotoxumab; weigh the pros and cons of using fluoroquinolone prophylaxis during neutropenia after stem cell transplantation; and provide updates on important viral infections after hematopoietic stem cell transplant (HSCT). Optimizing the prevention and management of infectious diseases by using the best available evidence will contribute to better outcomes for stem cell transplant recipients, and provide the best possible “safety net” for these immunocompromised hosts.
    Keywords infectious complications ; cytomegalovirus ; invasive fungal infections ; antibacterial prophylaxis ; antibacterial treatment ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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