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  1. Article ; Online: Photobiomodulation effects on cancer cells through modifications of their bioelectric properties: Comment on "The distinguishing electrical properties of cancer cells" by E. di Gregorio, S. Israel, M. Staelens, et al.

    Lim, Lew

    Physics of life reviews

    2023  Volume 46, Page(s) 283–285

    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2023.08.008
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  2. Article ; Online: Nucleocytoplasmic trafficking of G2/M regulators in yeast.

    Keaton, Mignon A / Szkotnicki, Lee / Marquitz, Aron R / Harrison, Jake / Zyla, Trevin R / Lew, Daniel J

    Molecular biology of the cell

    2008  Volume 19, Issue 9, Page(s) 4006–4018

    Abstract: Nucleocytoplasmic shuttling is prevalent among many cell cycle regulators controlling the G2/M ...

    Abstract Nucleocytoplasmic shuttling is prevalent among many cell cycle regulators controlling the G2/M transition. Shuttling of cyclin/cyclin-dependent kinase (CDK) complexes is thought to provide access to substrates stably located in either compartment. Because cyclin/CDK shuttles between cellular compartments, an upstream regulator that is fixed in one compartment could in principle affect the entire cyclin/CDK pool. Alternatively, the regulators themselves may need to shuttle to effectively regulate their moving target. Here, we identify localization motifs in the budding yeast Swe1p (Wee1) and Mih1p (Cdc25) cell cycle regulators. Replacement of endogenous Swe1p or Mih1p with mutants impaired in nuclear import or export revealed that the nuclear pools of Swe1p and Mih1p were more effective in CDK regulation than were the cytoplasmic pools. Nevertheless, shuttling of cyclin/CDK complexes was sufficiently rapid to coordinate nuclear and cytoplasmic events even when Swe1p or Mih1p were restricted to one compartment. Additionally, we found that Swe1p nuclear export was important for its degradation. Because Swe1p degradation is regulated by cytoskeletal stress, shuttling of Swe1p between nucleus and cytoplasm serves to couple cytoplasmic stress to nuclear cyclin/CDK inhibition.
    MeSH term(s) Active Transport, Cell Nucleus ; Alleles ; Amino Acid Sequence ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Division ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; G2 Phase ; Gene Expression Regulation, Fungal ; Molecular Sequence Data ; Mutation ; Oligonucleotides/chemistry ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Homology, Amino Acid ; Time Factors ; ras-GRF1
    Chemical Substances CDC25 protein, S cerevisiae ; Cell Cycle Proteins ; Oligonucleotides ; Saccharomyces cerevisiae Proteins ; ras-GRF1 ; SWE1 protein, S cerevisiae (EC 2.7.1.-) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2008-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E08-03-0286
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  3. Article: The separation of M. leprae from tissues by enzyme digestion.

    LEW, J / CARPENTER, C M

    American review of tuberculosis

    2001  Volume 74, Issue 1, Page(s) 152

    MeSH term(s) Leprosy/immunology ; Mycobacterium leprae
    Language English
    Publishing date 2001-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 422518-1
    ISSN 0096-0381
    ISSN 0096-0381
    DOI 10.1164/artpd.1956.74.1.152
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  4. Article: Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.

    Keaton, Mignon A / Bardes, Elaine S G / Marquitz, Aron R / Freel, Christopher D / Zyla, Trevin R / Rudolph, Johannes / Lew, Daniel J

    Current biology : CB

    2007  Volume 17, Issue 14, Page(s) 1181–1189

    Abstract: Background: Several checkpoint pathways employ Wee1-mediated inhibitory tyrosine phosphorylation of cyclin-dependent kinases (CDKs) to restrain cell-cycle progression. Whereas in vertebrates this strategy can delay both DNA replication and mitosis, in ... ...

    Abstract Background: Several checkpoint pathways employ Wee1-mediated inhibitory tyrosine phosphorylation of cyclin-dependent kinases (CDKs) to restrain cell-cycle progression. Whereas in vertebrates this strategy can delay both DNA replication and mitosis, in yeast cells only mitosis is delayed. This is particularly surprising because yeasts, unlike vertebrates, employ a single family of cyclins (B type) and the same CDK to promote both S phase and mitosis. The G2-specific arrest could be explained in two fundamentally different ways: tyrosine phosphorylation of cyclin/CDK complexes could leave sufficient residual activity to promote S phase, or S phase-promoting cyclin/CDK complexes could somehow be protected from checkpoint-induced tyrosine phosphorylation.
    Results: We demonstrate that in Saccharomyces cerevisiae, several cyclin/CDK complexes are protected from inhibitory tyrosine phosphorylation, allowing Clb5,6p to promote DNA replication and Clb3,4p to promote spindle assembly, even under checkpoint-inducing conditions that block nuclear division. In vivo, S phase-promoting Clb5p/Cdc28p complexes were phosphorylated more slowly and dephosphorylated more effectively than were mitosis-promoting Clb2p/Cdc28p complexes. Moreover, we show that the CDK inhibitor (CKI) Sic1p protects bound Clb5p/Cdc28p complexes from tyrosine phosphorylation, allowing the accumulation of unphosphorylated complexes that are unleashed when Sic1p is degraded to promote S phase. The vertebrate CKI p27(Kip1) similarly protects Cyclin A/Cdk2 complexes from Wee1, suggesting that the antagonism between CKIs and Wee1 is evolutionarily conserved.
    Conclusions: In yeast cells, the combination of CKI binding and preferential phosphorylation/dephosphorylation of different B cyclin/CDK complexes renders S phase progression immune from checkpoints acting via CDK tyrosine phosphorylation.
    MeSH term(s) Actins/antagonists & inhibitors ; Actins/metabolism ; Bridged Bicyclo Compounds, Heterocyclic ; CDC28 Protein Kinase, S cerevisiae/metabolism ; Cell Cycle Proteins/metabolism ; Cyclin B/metabolism ; Cyclin-Dependent Kinase Inhibitor Proteins ; DNA Replication/physiology ; Mitosis/physiology ; Multiprotein Complexes/metabolism ; Phosphorylation ; Protein Tyrosine Phosphatases/metabolism ; Protein-Tyrosine Kinases/metabolism ; S Phase/physiology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Spindle Apparatus/metabolism ; Thiazolidines ; Tyrosine/metabolism ; ras-GRF1
    Chemical Substances Actins ; Bridged Bicyclo Compounds, Heterocyclic ; CDC25 protein, S cerevisiae ; CLB5 protein, S cerevisiae ; Cell Cycle Proteins ; Cyclin B ; Cyclin-Dependent Kinase Inhibitor Proteins ; Multiprotein Complexes ; SIC1 protein, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Thiazolidines ; ras-GRF1 ; Tyrosine (42HK56048U) ; SWE1 protein, S cerevisiae (EC 2.7.1.-) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; CDC28 Protein Kinase, S cerevisiae (EC 2.7.11.22) ; Protein Tyrosine Phosphatases (EC 3.1.3.48) ; latrunculin A (SRQ9WWM084)
    Language English
    Publishing date 2007-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2007.05.075
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  5. Article: Le C.M.P.P. L'administratif: une réalité.

    Lew, R

    Soins. Psychiatrie

    1990  , Issue 114, Page(s) 5–7

    Title translation Medico-psycho-pedagogical centers. Administration: a reality.
    MeSH term(s) Child Health Services/economics ; Child Health Services/organization & administration ; Community Mental Health Centers/organization & administration ; France ; Humans
    Language French
    Publishing date 1990-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 632590-7
    ISSN 0241-6972
    ISSN 0241-6972
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  6. Article: La psychanalyse au C.M.P.P. d'Ivry.

    Lew, R

    Soins. Psychiatrie

    1990  , Issue 114, Page(s) 23–25

    Title translation Psychoanalysis at the medico-psycho-pedagogical center of Ivry.
    MeSH term(s) Child ; Community Mental Health Centers ; Humans ; Psychoanalysis
    Language French
    Publishing date 1990-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 632590-7
    ISSN 0241-6972
    ISSN 0241-6972
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  7. Article: Le C.M.P.P. Les raisons de consulter.

    Lew, R

    Soins. Psychiatrie

    1990  , Issue 114, Page(s) 8–10

    Title translation Medico-psycho-pedagogical centers. Reasons for consultations.
    MeSH term(s) Adolescent ; Adult ; Child ; Child Behavior Disorders/diagnosis ; Culture ; Humans ; Parent-Child Relations ; Psychology, Child
    Language French
    Publishing date 1990-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 632590-7
    ISSN 0241-6972
    ISSN 0241-6972
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  8. Article ; Online: Recent studies on non-invasive biomarkers useful in biliary atresia - a literature review.

    Lew-Tusk, Anna / Pęksa, Marta / Stachowicz-Stencel, Teresa

    Acta biochimica Polonica

    2023  Volume 70, Issue 3, Page(s) 475–480

    Abstract: The aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven ... ...

    Abstract The aim of this review is to specify new potential reliable and non-invasive methods for the diagnosis of biliary atresia (BA) that could shorten the way to diagnose BA, and finally the surgical treatment. Apart from the biomarkers that have been proven helpful and are used nowadays in neonatal wards, there are several new potential biomarkers that researchers have found to be helpful in the diagnosis of biliary atresia. Circulating microRNAs, matrix metalloproteinase-7, stool proteins, interleukin-33, Th17-associated cytokines, urinary metabolomics, anti-smooth muscle antibodies, heat shock proteins 90 and positive biliary epithelial cells CD56 are among those presented in this summary. These markers may play a new significant role in BA diagnosis. The described methods include Nomogram, Circulating microRNAs (miRNAs), Matrix metalloproteinase-7 (MMP-7), Stool proteins, Interleukin-33 (IL-33), Th17-associated cytokines, Alpha-aminoadipic acid and N-acetyl-d-mannosamine in urine, Anti-smooth muscle antibodies (ASMA), Heat shock proteins 90 (HSP90), Positive biliary epithelial cells CD56.
    MeSH term(s) Infant, Newborn ; Humans ; Biliary Atresia/diagnosis ; HSP90 Heat-Shock Proteins ; Interleukin-33 ; Matrix Metalloproteinase 7 ; Autoantibodies ; Biomarkers ; Cytokines ; MicroRNAs
    Chemical Substances HSP90 Heat-Shock Proteins ; Interleukin-33 ; Matrix Metalloproteinase 7 (EC 3.4.24.23) ; Autoantibodies ; Biomarkers ; Cytokines ; MicroRNAs
    Language English
    Publishing date 2023-08-24
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 595762-x
    ISSN 1734-154X ; 0001-527X
    ISSN (online) 1734-154X
    ISSN 0001-527X
    DOI 10.18388/abp.2020_6858
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  9. Article ; Online: Towards optimal point spread function design for resolving closely spaced emitters in three dimensions.

    Jusuf, James M / Lew, Matthew D

    Optics express

    2022  Volume 30, Issue 20, Page(s) 37154–37174

    Abstract: The past decade has brought many innovations in optical design for 3D super-resolution imaging of point-like emitters, but these methods often focus on single-emitter localization precision as a performance metric. Here, we propose a simple heuristic for ...

    Abstract The past decade has brought many innovations in optical design for 3D super-resolution imaging of point-like emitters, but these methods often focus on single-emitter localization precision as a performance metric. Here, we propose a simple heuristic for designing a point spread function (PSF) that allows for precise measurement of the distance between two emitters. We discover that there are two types of PSFs that achieve high performance for resolving emitters in 3D, as quantified by the Cramér-Rao bounds for estimating the separation between two closely spaced emitters. One PSF is very similar to the existing Tetrapod PSFs; the other is a rotating single-spot PSF, which we call the crescent PSF. The latter exhibits excellent performance for localizing single emitters throughout a 1-µm focal volume (localization precisions of 7.3 nm in x, 7.7 nm in y, and 18.3 nm in z using 1000 detected photons), and it distinguishes between one and two closely spaced emitters with superior accuracy (25-53% lower error rates than the best-performing Tetrapod PSF, averaged throughout a 1-µm focal volume). Our study provides additional insights into optimal strategies for encoding 3D spatial information into optical PSFs.
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.472067
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  10. Article ; Online: A game of raids: Expanding on a game theoretical approach utilising the prisoner's dilemma and ethnography in situ.

    Jeffries, Emily M L / Wright, Sarah E / Lew-Levy, Sheina

    The Behavioral and brain sciences

    2024  Volume 47, Page(s) e14

    Abstract: In this commentary, we set out the specifics of how Glowacki's game theoretical framework for the evolution of peace could be incorporated within broader cultural evolutionary approaches. We outline a formal proposal for prisoner's dilemma games ... ...

    Abstract In this commentary, we set out the specifics of how Glowacki's game theoretical framework for the evolution of peace could be incorporated within broader cultural evolutionary approaches. We outline a formal proposal for prisoner's dilemma games investigating raid-based conflict. We also centre an ethnographic lens to understand the norms surrounding war and peace in intergroup interactions in small-scale communities.
    MeSH term(s) Humans ; Prisoner Dilemma ; Cooperative Behavior ; Game Theory ; Anthropology, Cultural ; Cultural Evolution
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X23002510
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