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  1. Article ; Online: "Selective" serotonin 5-HT

    Casey, Austen B / Cui, Meng / Booth, Raymond G / Canal, Clinton E

    Biochemical pharmacology

    2022  Volume 200, Page(s) 115028

    Abstract: Blockade of the serotonin 5- ... ...

    Abstract Blockade of the serotonin 5-HT
    MeSH term(s) Depressive Disorder, Major ; Hallucinogens/pharmacology ; Humans ; Receptor, Serotonin, 5-HT2A ; Serotonin ; Serotonin 5-HT2 Receptor Agonists/pharmacology ; Serotonin 5-HT2 Receptor Agonists/therapeutic use
    Chemical Substances Hallucinogens ; Receptor, Serotonin, 5-HT2A ; Serotonin 5-HT2 Receptor Agonists ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.115028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
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  2. Article ; Online: Classics in Chemical Neuroscience: Aripiprazole.

    Casey, Austen B / Canal, Clinton E

    ACS chemical neuroscience

    2017  Volume 8, Issue 6, Page(s) 1135–1146

    Abstract: Aripiprazole was the first antipsychotic developed to possess agonist properties at dopamine ... ...

    Abstract Aripiprazole was the first antipsychotic developed to possess agonist properties at dopamine D
    MeSH term(s) Antipsychotic Agents ; Aripiprazole
    Chemical Substances Antipsychotic Agents ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2017--21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.7b00087
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  3. Article: Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in mice.

    Pomrenze, Matthew B / Vaillancourt, Sam / Llorach, Pierre / Rijsketic, Daniel Ryskamp / Casey, Austen B / Gregory, Nicholas / Salgado, Juliana S / Malenka, Robert C / Heifets, Boris D

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear whether naltrexone ...

    Abstract Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear whether naltrexone blocks a direct effect of ketamine at ORs, or whether normal functioning of the OR system is required to realize the full antidepressant effects of treatment. In mice, the effect of ketamine on locomotion, but not analgesia or the forced swim test, was sensitive to naltrexone and was therefore used as a behavioral readout to localize the effect of naltrexone in the brain. We performed whole-brain imaging of cFos expression in ketamine-treated mice, pretreated with naltrexone or vehicle, and identified the central amygdala (CeA) as the area with greatest difference in cFos intensity. CeA neurons expressing both μOR (MOR) and PKCμ were strongly activated by naltrexone but not ketamine, and selectively interrupting MOR function in the CeA either pharmacologically or genetically blocked the locomotor effects of ketamine. These data suggest that MORs expressed in CeA neurons gate behavioral effects of ketamine but are not direct targets of ketamine.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.03.583196
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  4. Article ; Online: UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.

    Rijsketic, Daniel Ryskamp / Casey, Austen B / Barbosa, Daniel A N / Zhang, Xue / Hietamies, Tuuli M / Ramirez-Ovalle, Grecia / Pomrenze, Matthew B / Halpern, Casey H / Williams, Leanne M / Malenka, Robert C / Heifets, Boris D

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2023  Volume 48, Issue 12, Page(s) 1798–1807

    Abstract: The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in their ...

    Abstract The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in their home cage or an enriched environment, immunofluorescently-labeled brain-wide c-Fos, and imaged iDISCO+ cleared tissue with light sheet fluorescence microscopy (LSFM) to examine the impact of environmental context on psilocybin-elicited neural activity at cellular resolution. Voxel-wise analysis of c-Fos-immunofluorescence revealed clusters of neural activity associated with main effects of context and psilocybin-treatment, which were validated with c-Fos
    MeSH term(s) Mice ; Humans ; Animals ; Psilocybin/pharmacology ; Genes, Immediate-Early ; Brain/metabolism ; Hallucinogens/pharmacology ; Proto-Oncogene Proteins c-fos/metabolism
    Chemical Substances Psilocybin (2RV7212BP0) ; Hallucinogens ; Proto-Oncogene Proteins c-fos
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-023-01613-4
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    Zs.A 2379: Show issues Location:
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  5. Article: UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.

    Rijsketic, Daniel Ryskamp / Casey, Austen B / Barbosa, Daniel A N / Zhang, Xue / Hietamies, Tuuli M / Ramirez-Ovalle, Grecia / Pomrenze, Matthew / Halpern, Casey H / Williams, Leanne M / Malenka, Robert C / Heifets, Boris D

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in their ...

    Abstract The effects of context on the subjective experience of serotonergic psychedelics have not been fully examined in human neuroimaging studies, partly due to limitations of the imaging environment. Here, we administered saline or psilocybin to mice in their home cage or an enriched environment, immunofluorescently-labeled brain-wide c-Fos, and imaged cleared tissue with light sheet microscopy to examine the impact of context on psilocybin-elicited neural activity at cellular resolution. Voxel-wise analysis of c-Fos-immunofluorescence revealed differential neural activity, which we validated with c-Fos
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.19.528997
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  6. Article ; Online: A new class of 5-HT

    Casey, Austen B / Mukherjee, Munmun / McGlynn, Ryan P / Cui, Meng / Kohut, Stephen J / Booth, Raymond G

    British journal of pharmacology

    2022  Volume 179, Issue 11, Page(s) 2610–2630

    Abstract: Background and purpose: The 5-HT receptor subtypes 5-HT: Experimental approach: We synthesized 42 novel 4-PATs with halogen or aryl moieties at the C(4)-phenyl meta-position. Affinity, function, molecular modeling and 5-HT: Key results: Most 4-PAT ...

    Abstract Background and purpose: The 5-HT receptor subtypes 5-HT
    Experimental approach: We synthesized 42 novel 4-PATs with halogen or aryl moieties at the C(4)-phenyl meta-position. Affinity, function, molecular modeling and 5-HT
    Key results: Most 4-PAT diastereomers in the (2S,4R)-configuration bound non-selectively to 5-HT
    Conclusions and implications: The novel 4-PAT chemotype can yield selective 5-HT
    MeSH term(s) Animals ; Antipsychotic Agents ; Mice ; Receptor, Serotonin, 5-HT2A ; Receptor, Serotonin, 5-HT2C ; Serotonin ; Serotonin 5-HT2 Receptor Agonists/pharmacology ; Tetrahydronaphthalenes/pharmacology
    Chemical Substances Antipsychotic Agents ; Receptor, Serotonin, 5-HT2A ; Receptor, Serotonin, 5-HT2C ; Serotonin 5-HT2 Receptor Agonists ; Tetrahydronaphthalenes ; 2-aminotetralin (2954-50-9) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15756
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  7. Article ; Online: Molecular identification of the Trypanosoma (Herpetosoma) lewisi clade in black rats (Rattus rattus) from Australia.

    Egan, Siobhon L / Taylor, Casey L / Austen, Jill M / Banks, Peter B / Ahlstrom, Liisa A / Ryan, Una M / Irwin, Peter J / Oskam, Charlotte L

    Parasitology research

    2020  Volume 119, Issue 5, Page(s) 1691–1696

    Abstract: Invasive rodent species are known hosts for a diverse range of infectious microorganisms and have long been associated with the spread of disease globally. The present study describes molecular evidence for the presence of a Trypanosoma sp. from black ... ...

    Abstract Invasive rodent species are known hosts for a diverse range of infectious microorganisms and have long been associated with the spread of disease globally. The present study describes molecular evidence for the presence of a Trypanosoma sp. from black rats (Rattus rattus) in northern Sydney, Australia. Sequences of the 18S ribosomal RNA (rRNA) locus were obtained in two out of eleven (18%) blood samples with subsequent phylogenetic analysis confirming the identity within the Trypanosoma lewisi clade.
    MeSH term(s) Animals ; Australia ; Introduced Species ; Phylogeny ; RNA, Ribosomal, 18S/genetics ; Rats ; Rodentia/parasitology ; Trypanosoma lewisi/classification ; Trypanosoma lewisi/genetics ; Trypanosomiasis/diagnosis ; Trypanosomiasis/veterinary
    Chemical Substances RNA, Ribosomal, 18S
    Language English
    Publishing date 2020-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-020-06653-z
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  8. Article ; Online: Haemoprotozoan surveillance in peri-urban native and introduced wildlife from Australia.

    Egan, Siobhon L / Taylor, Casey L / Austen, Jill M / Banks, Peter B / Northover, Amy S / Ahlstrom, Liisa A / Ryan, Una M / Irwin, Peter J / Oskam, Charlotte L

    Current research in parasitology & vector-borne diseases

    2021  Volume 1, Page(s) 100052

    Abstract: Vector-borne haemoprotozoans comprise a diverse group of eukaryote single-celled organisms transmitted by haematophagous (blood-feeding) invertebrates. They can cause debilitating diseases that impact wildlife, livestock, companion animals and humans. ... ...

    Abstract Vector-borne haemoprotozoans comprise a diverse group of eukaryote single-celled organisms transmitted by haematophagous (blood-feeding) invertebrates. They can cause debilitating diseases that impact wildlife, livestock, companion animals and humans. Recent research has shown that Australian wildlife host a diverse range of haemoprotozoan species; however, to date this work has primarily been confined to a few host species or isolated populations in rural habitats. There has been little investigation into the presence of these blood parasites in wildlife inhabiting urban and peri-urban areas. In this study, blood and tissue samples and ticks were collected from wildlife in New South Wales and Western Australia. Extracted DNA samples were screened with pan-specific molecular assays to determine the presence of haemoprotozoans using amplicon metabarcoding and Sanger sequencing approaches. In addition, light microscopy was performed on blood films. Eight haemoprotozoans were identified in the present study, which included species of
    Language English
    Publishing date 2021-09-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-114X
    ISSN (online) 2667-114X
    DOI 10.1016/j.crpvbd.2021.100052
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  9. Article ; Online: (

    Armstrong, Jessica L / Casey, Austen B / Saraf, Tanishka S / Mukherjee, Munmun / Booth, Raymond G / Canal, Clinton E

    ACS pharmacology & translational science

    2020  Volume 3, Issue 3, Page(s) 509–523

    Abstract: Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disabilities and a plethora of neuropsychiatric symptoms. FXS is the leading monogenic cause of autism spectrum disorder (ASD), which is defined clinically by ... ...

    Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disabilities and a plethora of neuropsychiatric symptoms. FXS is the leading monogenic cause of autism spectrum disorder (ASD), which is defined clinically by repetitive and/or restrictive patterns of behavior and social communication deficits. Epilepsy and anxiety are also common in FXS and ASD. Serotonergic neurons directly innervate and modulate the activity of neurobiological circuits altered in both disorders, providing a rationale for investigating serotonin receptors (5-HTRs) as targets for FXS and ASD drug discovery. Previously we unveiled an orally active aminotetralin, (
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.9b00101
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  10. Article ; Online: Identifying Causative Microorganisms in Left Ventricular Assist Device Infections as a Guide for Developing Bacteriophage Therapy.

    Kamat, Ishan / Lamba, Harveen / Hines-Munson, Casey / Hudson, Samuel / Liao, Kenneth / Muldrew, Kenneth L / Green, Sabrina / Terwilliger, Austen / Kaplan, Heidi B / Ramig, Robert F / Maresso, Anthony / Trautner, Barbara W

    The Journal of surgical research

    2021  Volume 271, Page(s) 73–81

    Abstract: Background: As more left ventricular-assist devices (LVADs) are implanted, multidrug-resistant LVAD infections are becoming increasingly common, partly due to bacterial biofilm production. To aid in developing bacteriophage therapy for LVAD infections, ... ...

    Abstract Background: As more left ventricular-assist devices (LVADs) are implanted, multidrug-resistant LVAD infections are becoming increasingly common, partly due to bacterial biofilm production. To aid in developing bacteriophage therapy for LVAD infections, we have identified the most common bacterial pathogens that cause LVAD driveline infections (DLIs) in our heart transplant referral center.
    Materials and methods: We studied a retrospective cohort of patients who received LVADs from November 2003 to August 2017 to identify the common causative organisms of LVAD infection. We also studied a prospective cohort of patients diagnosed with DLIs from October 2018 to May 2019 to collect bacterial strains from DLIs for developing bacteriophages to lyse causative pathogens. LVAD infections were classified as DLI, bacteremia, and pump/device infections in the retrospective cohort.
    Results: In the retrospective cohort of 582 patients, 186 (32.0%) developed an LVAD infection, with 372 microbial isolates identified. In the prospective cohort, 96 bacterial strains were isolated from 54 DLIs. The microorganisms causing DLIs were similar in the two cohorts; the most common isolate was Staphylococcus aureus. We identified 6 prospective S. aureus strains capable of biofilm formation. We developed 3 bacteriophages that were able to lyse 5 of 6 of the biofilm-forming S. aureus strains.
    Conclusions: Similar pathogens caused LVAD DLIs in our retrospective and prospective cohorts, indicating our bacterial strain bank will be representative of future DLIs. Our banked bacterial strains will be useful in developing phage cocktails that can lyse ≥80% of the bacteria causing LVAD infections at our institution.
    MeSH term(s) Heart Failure/complications ; Heart-Assist Devices/adverse effects ; Humans ; Phage Therapy/adverse effects ; Prospective Studies ; Prosthesis-Related Infections/etiology ; Prosthesis-Related Infections/therapy ; Retrospective Studies ; Staphylococcus aureus
    Language English
    Publishing date 2021-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2021.10.010
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