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  1. Book: Advanced epidemiologic methods for the study of rheumatic diseases

    Johnson, Sindhu R.

    (Rheumatic disease clinics of North America ; volume 44, number 2 (May 2018))

    2018  

    Author's details editor Sindhu R. Johnson
    Series title Rheumatic disease clinics of North America ; volume 44, number 2 (May 2018)
    Collection
    Language English
    Size xvi Seiten, Seite 178-370, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019740216
    ISBN 978-0-323-61050-6 ; 0-323-61050-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Innovations in systemic sclerosis.

    Johnson, Sindhu R

    Best practice & research. Clinical rheumatology

    2021  Volume 35, Issue 3, Page(s) 101708

    MeSH term(s) Humans ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/therapy
    Language English
    Publishing date 2021-09-03
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2021.101708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Approach to Systemic Sclerosis Patient Assessment: How Does Patient Subsetting Help?

    Johnson, Sindhu R / Foeldvari, Ivan

    Rheumatic diseases clinics of North America

    2023  Volume 49, Issue 2, Page(s) 193–210

    Abstract: Systemic sclerosis (SSc) is a heterogeneous disease comprising of a wide spectrum of ages of onset, sex-based differences, ethnic variations, disease manifestations, differential serologic profiles, and variable response to therapy resulting in reduced ... ...

    Abstract Systemic sclerosis (SSc) is a heterogeneous disease comprising of a wide spectrum of ages of onset, sex-based differences, ethnic variations, disease manifestations, differential serologic profiles, and variable response to therapy resulting in reduced health-related quality of life, disability, and survival. The ability to subset groups of patients with SSc can assist with refining the diagnosis, guide appropriate monitoring, inform aggressiveness of immunosuppression, and predict prognosis. The ability to subset patients with SSc has several important practical implications for patient care.
    MeSH term(s) Humans ; Quality of Life ; Scleroderma, Systemic/diagnosis ; Prognosis
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advanced Autoantibody Testing in Systemic Sclerosis

    Kholoud Almaabdi / Zareen Ahmad / Sindhu R. Johnson

    Diagnostics, Vol 13, Iss 851, p

    2023  Volume 851

    Abstract: Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have ... ...

    Abstract Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have been limited to antinuclear antibody (ANA), antitopoisomerase I (also known as anti-Scl-70) antibody, and anticentromere antibody testing. Many clinicians now have improved access to an expanded profile of autoantibody testing. In this narrative review article, we review the epidemiology, clinical associations, and prognostic value of advanced autoantibody testing in people with systemic sclerosis.
    Keywords systemic sclerosis ; scleroderma ; antibodies ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Advanced Autoantibody Testing in Systemic Sclerosis.

    Almaabdi, Kholoud / Ahmad, Zareen / Johnson, Sindhu R

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have ... ...

    Abstract Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have been limited to antinuclear antibody (ANA), antitopoisomerase I (also known as anti-Scl-70) antibody, and anticentromere antibody testing. Many clinicians now have improved access to an expanded profile of autoantibody testing. In this narrative review article, we review the epidemiology, clinical associations, and prognostic value of advanced autoantibody testing in people with systemic sclerosis.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Understanding the employment landscape in people with systemic sclerosis.

    Jazayeri, Hila / Gignac, Monique / Ahmad, Zareen / Johnson, Sindhu R

    The Journal of rheumatology

    2024  

    Abstract: Objective: Systemic sclerosis (SSc) can restrict employment participation. Our objectives were to comparatively evaluate health factors, work factors and workplace accommodations between those who are employed and those who recently gave up employment.!# ...

    Abstract Objective: Systemic sclerosis (SSc) can restrict employment participation. Our objectives were to comparatively evaluate health factors, work factors and workplace accommodations between those who are employed and those who recently gave up employment.
    Methods: A cross-sectional study was conducted of employed and recently working, but now unemployed individuals with SSc. Demographics, employment sectors, health factors, flare frequency, work context, and information about the need, availability and use of workplace supports were collected.
    Results: Participants were 140 individuals (108 (77.1%) women, 32 (22.9%) men) where 110 (78.6%) were employed and 30 (21.4%) unemployed. Participants worked in Education/Health/Sciences/Arts (n=51, 36.4%), Sales/Retail (n=23, 16.5%), Banking/Insurance/Business/Technology (n=22, 15.7%), Government (n=15, 10.7%), Construction/Utilities (n=10, 7.1%), and Manufacturing/Agriculture/Mining/ Logging (n=10, 7.1%). Employed participants had a lower mean age (48.4 versus 54.3 years), and higher level of education (77.3% with post-secondary education versus 22.7% without). Those who had no flares were most frequently employed (41.7%), compared to those who had 1-2 flares (35.2%) and ≥3 flares (23.1%). The availability of workplace accommodations differed significantly between the employed and unemployed: flexible hours (75.2% versus 41.4%, p=0.005), more rest periods (81.8% versus 46.7%, p=0.0001), special equipment (87.5% versus 50.0%, p=0.0001), and alternative work-schedule flexibility (70.2% versus 38.8%, p=0.003).
    Conclusion: Health factors alone do not differentiate those who are employed and those who gave up employment. This study lays the groundwork for where SSc-specific efforts in workplace policies/practices should be directed, especially workplace support.
    Language English
    Publishing date 2024-02-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-0975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Defining the key clinician skills and attributes for competency in managing patients with osteoporosis and fragility fractures.

    Jackson, Lesley E / Saag, Kenneth G / Johnson, Sindhu R / Danila, Maria I

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2024  

    Abstract: Osteoporosis and fragility fractures are managed by clinicians across many medical specialties. The key competencies of clinicians delivering bone health care have not been systematically established. We aimed to develop a decision rule to define the ... ...

    Abstract Osteoporosis and fragility fractures are managed by clinicians across many medical specialties. The key competencies of clinicians delivering bone health care have not been systematically established. We aimed to develop a decision rule to define the threshold of adequate skills and attributes associated with clinical competency in bone health for a clinician serving as a referral source for bone health care. Using a modified-Delphi method, we invited clinicians with expertise in treating osteoporosis and representatives of patient advocacy groups focused on bone health to create a list of desirable characteristics of a clinician with bone health competency. Characteristics were defined as "attributes" with "levels" within each attribute. Participants prioritized levels by perceived importance. To identify the cut points for defining adequate competency, participants next ranked 20 hypothetical clinicians defined by various levels of attributes from highest to lowest likelihood of having adequate bone health competency. Lastly, we conducted a discrete choice experiment (DCE) to generate a weighted score for each attribute/level. The threshold for competency was a priori determined as the total weighted score at which ≥70% of participants agreed a clinician had adequate bone health competency. Thirteen participants generated lists of desirable characteristics, and 30 participants ranked hypothetical scenarios and participated in the DCE. The modified-Delphi exercise generated 108 characteristics, which were reduced to 8 categories with 20 levels with associated points. The maximum possible score was 25 points. A summed threshold score of >12 points classified a clinician as having adequate bone health competency. We developed a numeric additive decision rule to define clinicians across multiple specialties as having adequate competency in managing bone health/osteoporosis. Our data provides a rigorously defined criteria for a clinician with competency in bone health and can be used to quantitate the skills of clinicians participating in bone health research and clinical care.
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1093/jbmr/zjae019
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  8. Article ; Online: Advanced Epidemiologic Methods for the Study of Rheumatic and Musculoskeletal Diseases.

    Johnson, Sindhu R

    Rheumatic diseases clinics of North America

    2018  Volume 44, Issue 2, Page(s) xv–xvi

    MeSH term(s) Biomedical Research ; Epidemiologic Methods ; Humans ; Musculoskeletal Diseases ; Rheumatic Diseases
    Language English
    Publishing date 2018-02-21
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2018.02.001
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  9. Article ; Online: Systemic Lupus Erythematosus Classification and Diagnosis.

    Aringer, Martin / Johnson, Sindhu R

    Rheumatic diseases clinics of North America

    2021  Volume 47, Issue 3, Page(s) 501–511

    Abstract: Since the European League Against Rheumatism/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus (SLE) were published, they were externally validated by groups worldwide. In particular, the new criteria worked ... ...

    Abstract Since the European League Against Rheumatism/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus (SLE) were published, they were externally validated by groups worldwide. In particular, the new criteria worked well also in East Asian and pediatric cohorts. Antinuclear antibodies (ANA) as an entry criterion were critically discussed, but the group of ANA-negative patients is small (<5%) worldwide. Specificity of the criteria is dependent on correct attribution only of those criteria that are not better explained by other causes. Although the classification criteria should not be used for diagnosis, many novel aspects inform diagnostic considerations.
    MeSH term(s) Antibodies, Antinuclear ; Child ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Rheumatic Diseases ; Rheumatology
    Chemical Substances Antibodies, Antinuclear
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2021.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Quality Measures in Systemic Sclerosis.

    Aboabat, Aos / Ahmad, Zareen / Steiman, Amanda / Johnson, Sindhu R

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Quality improvement is an emerging field, that applies principles of improvement science and utilizes measurement methods with the aim of improving patient care. Systemic sclerosis (SSc) is a systemic autoimmune rheumatic disease associated with ... ...

    Abstract Quality improvement is an emerging field, that applies principles of improvement science and utilizes measurement methods with the aim of improving patient care. Systemic sclerosis (SSc) is a systemic autoimmune rheumatic disease associated with increased healthcare burden, cost, morbidity, and mortality. Gaps in delivering care to patients with SSc have been consistently observed. In this article, we introduce the discipline of quality improvement and its use of quality measures. We summarize and comparatively evaluate three sets of quality measures that have been proposed to evaluate the quality of care of patients with SSc. Finally, we highlight the areas of unmet needs and indicate future directions for quality improvement and quality measures in SSc.
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13040579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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