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  1. Book: Can cong

    Chen, Zhanqi / Jiang, Yasha / Jing, Li

    (Wan qing zhen xi qi kan hui bian : 晚清珍稀期刊汇编 ; / Jiang ya sha, jing li, chen zhan qi zhu bian ; 22)

    2009  

    Institution Quan guo tu shu guan wen xian suo wei fu zhi zhong xin (China)
    全国图书馆文献缩微复制中心 (China)
    Series title Wan qing zhen xi qi kan hui bian : 晚清珍稀期刊汇编
    / Jiang ya sha, jing li, chen zhan qi zhu bian ; 22
    Language Chinese
    Size 748 p
    Publisher Quan guo tu shu guan wen xian suo wei fu zhi zhong xin
    Publishing place Bei jing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.

    Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Chu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

    Pharmaceutical biology

    2022  Volume 60, Issue 1, Page(s) 1478–1490

    Abstract: Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss ...

    Abstract Context: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly.
    Objective: To explore the mechanism of YQCM decoction in the treatment of ARHL.
    Materials and methods: The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an
    Results: The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H
    Conclusions: Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
    MeSH term(s) Aged ; Caspase 3 ; Drugs, Chinese Herbal/therapeutic use ; Hearing Loss/drug therapy ; Humans ; Hydrogen Peroxide/toxicity ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Network Pharmacology ; Neurodegenerative Diseases/drug therapy
    Chemical Substances Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2022.2101671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Phoenix Dan Cong Tea: An Oolong Tea variety with promising antioxidant and

    Zhang, Xiaobin / Song, Zhenhuan / You, Yuanyuan / Li, Xiaoling / Chen, Tianfeng

    Food & nutrition research

    2018  Volume 62

    Abstract: Background: Phoenix Dan Cong tea is an Oolong tea produced in Chaozhou, China. Nowaday ... the experimental studies on the benefical effects of the Phoenix Dan Cong tea are rare.: Objective ... The objective of this study was to comprehensively evaluate the activity of Phoenix Dan Cong tea aqueous extract ...

    Abstract Background: Phoenix Dan Cong tea is an Oolong tea produced in Chaozhou, China. Nowaday, the experimental studies on the benefical effects of the Phoenix Dan Cong tea are rare.
    Objective: The objective of this study was to comprehensively evaluate the activity of Phoenix Dan Cong tea aqueous extract (PDCe).
    Methods: We used a series of evaluation methods in the present study to achieve an in-depth understanding and evaluation of the antioxidant and antitumor activity of PDCe.
    Results: High-performance liquid chromatography (HPLC) studies have indicated that PDCe is rich in catechins such as gallocatechin (GC), epigallocatechin (EGCG) and epicatechin gallate (ECG), with sparse amounts of theaflavins. We discovered that PDCe scavenges ABTS•+ and DPPH• free radicals in a dose-dependent manner. In addition, PDCe can significantly induce apoptosis of MDA-MB231 cells, mainly through the death-receptor-mediated extrinsic apoptotic pathway. Internalized PDCe can not only downregulate intracellular reactive oxygen species levels but also induce oxidative damage to mitochondria in MDA-MB231 cells.
    Conclusions: Phoenix Dan Cong tea may act as a substitute for natural antioxidants and as a promising anticancer agent due to its protective effect on human health.
    Language English
    Publishing date 2018-11-13
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2418338-6
    ISSN 1654-661X
    ISSN 1654-661X
    DOI 10.29219/fnr.v62.1500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson's Disease.

    Lin, Yao / Tang, Lanfang / Huang, Peizhen / Liu, Ting / Zhong, Jianan / Xu, Qian / Li, Xiyu / Lin, Youning / Xiao, Shaojian / Cai, Jing

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 1818307

    Abstract: This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound ...

    Abstract This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model of Parkinson's disease (PD). A total of 40 rats were subcutaneously injected with rotenone-sunflower oil emulsion into the back of the neck to establish a rat model of PD. These PD rats were randomly divided into low-, medium-, and high-dose groups (intragastric administration of 0.5, 1, and 2 g/kg CRSJ, respectively) and a model group (intragastric administration of the solvent; 10 rats per group). Furthermore, 10 rats each were attributed to the control and vehicle groups (both received intragastric administration of the CRSJ solvent, and the vehicle group were injected additionally with sunflower oil alone). A traction test was conducted two times, after the PD model establishment and after 14 days of CRSJ gavage. The numbers of tyrosine hydroxylase- (TH-) positive cells and the dopamine levels in the substantia nigra were assessed using immunohistochemistry and high-performance liquid chromatography, respectively. Western blotting detected the expression levels of
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/1818307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss

    Yang, Yi-Fang / Yan, Xi-Rui / Wu, Rui-Xin / Li, Ning / Zhu, Min / Dong, Yang / Fu, Shu-Ping / Shi, Jian-Rong / Liu, Qing

    Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1478-1490

    2022  

    Abstract: Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL ...

    Abstract Yi-Qi Cong-Ming (YQCM) decoction has been widely used to prevent age-related hearing loss (ARHL), the most prevalent neurodegenerative disease in the elderly. To explore the mechanism of YQCM decoction in the treatment of ARHL. The chemical constituents of YQCM were screened from the Traditional Chinese Medicine Systems Pharmacology Database. Potential targets of YQCM against ARHL were predicted by DrugBank, GeneCards, and OMIM database. Protein-protein network and enrichment analysis were used for exploring possible molecular mechanisms. Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 μM H₂O₂ for 3 h were applied. Cell viability and mitochondrial membrane potential (ΔΨM) were detected by CCK-8 and high-content analysis. γH2AX and cleaved caspase-3 were detected by Western blot. The main compounds have good affinities with hub targets, especially AKT1, PTGS2, and CASP3. GO and KEGG analysis showed that the main biological process and key targets were related to negative regulation of the apoptotic process. H₂O₂ treatment could reduce the cell viability by 68% and impaired ΔΨM, while 90 μg/mL YQCM pre-treatment could restore the cell viability by 97.45% and increase ΔΨM (2-fold higher). YQCM pre-treatment also reduced γH2AX and cleaved caspase-3 protein levels. Our study suggested that YQCM prevents ARHL by modulating the apoptosis process in auditory hair cells. Moreover, this study proved that bioinformatics analysis combined with molecular docking and cell model is a promising method to explore other possible pharmacological interventions of ARHL.
    Keywords Oriental traditional medicine ; Western blotting ; apoptosis ; bioinformatics ; caspase-3 ; cell viability ; databases ; elderly ; membrane potential ; mitochondrial membrane ; models ; neurodegenerative diseases ; pharmacology ; Molecular docking ; molecular dynamics simulation ; HEI-OC1 ; mitochondrial membrane potential ; AKT1
    Language English
    Dates of publication 2022-1231
    Size p. 1478-1490.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2022.2101671
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1300: Show issues Location:
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  6. Article: Erratum: Li, Z.; Zhang, W.; Wang, R.; Chen, F.; Jia, X.; Cong, P. Effects of Reactive MgO on the Reaction Process of Geopolymer.

    Li, Zhaoheng / Zhao, Kexin / Yang, Yongmin

    Materials (Basel, Switzerland)

    2019  Volume 12, Issue 9

    Abstract: Author Contributions: ...

    Abstract Author Contributions:
    Language English
    Publishing date 2019-04-29
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma12091388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson’s Disease

    Yao Lin / Lanfang Tang / Peizhen Huang / Ting Liu / Jianan Zhong / Qian Xu / Xiyu Li / Youning Lin / Shaojian Xiao / Jing Cai

    Evidence-Based Complementary and Alternative Medicine, Vol

    2020  Volume 2020

    Abstract: This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound ...

    Abstract This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model of Parkinson's disease (PD). A total of 40 rats were subcutaneously injected with rotenone-sunflower oil emulsion into the back of the neck to establish a rat model of PD. These PD rats were randomly divided into low-, medium-, and high-dose groups (intragastric administration of 0.5, 1, and 2 g/kg CRSJ, respectively) and a model group (intragastric administration of the solvent; 10 rats per group). Furthermore, 10 rats each were attributed to the control and vehicle groups (both received intragastric administration of the CRSJ solvent, and the vehicle group were injected additionally with sunflower oil alone). A traction test was conducted two times, after the PD model establishment and after 14 days of CRSJ gavage. The numbers of tyrosine hydroxylase- (TH-) positive cells and the dopamine levels in the substantia nigra were assessed using immunohistochemistry and high-performance liquid chromatography, respectively. Western blotting detected the expression levels of α-synuclein, endoplasmic reticulum stress pathways-related proteins, cerebral dopamine neurotrophic factor (CDNF), mesencephalic astrocyte-derived neurotrophic factor (MANF), and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway-related proteins. Compared with the model group, the number of TH-positive cells in the substantia nigra was increased in the CRSJ groups. The expression levels of α-synuclein and the endoplasmic reticulum stress pathways-associated proteins glucose regulatory protein 78, inositol-requiring enzyme 1, apoptosis signal-regulating kinase 1, phosphorylated c-Jun N-terminal kinase, and caspase-12 were reduced. However, CRSJ administration elevated the expression levels of the neurotrophic factors CDNF and MANF, as well as those of p-PI3K and p-AKT. The CRSJ compound can relieve endoplasmic reticulum stress in PD rats and exerts protective effects in this animal model. These effects may be ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Book: Cong DNA dao Zhong yi

    Li, Ling

    2012  

    Author's details Li Ling zhu
    MeSH term(s) Congenital Abnormalities ; Genetics, Medical/methods ; Medicine, Chinese Traditional/methods
    Language Chinese
    Size iv, 171 pages :, illustrations ;, 24 cm
    Edition Di 1 ban.
    Document type Book
    ISBN 9787030331236 ; 7030331230
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.

    Li, Zhiming / Lin, Huinuan / Gu, Long / Gao, Jingwen / Tzeng, Chi-Meng

    Frontiers in pharmacology

    2016  Volume 7, Page(s) 41

    Abstract: Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly ...

    Abstract Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly distributed in the arid lands and warm deserts of northwestern China. Within Traditional Chinese Medicine (TCM), Herba Cistanche is applied as a tonic and/or in a formula for chronic renal disease, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia, and senile constipation. The chemical constituents of Herba Cistanche mainly consist of volatile oils, non-volatile phenylethanoid glycosides (PhGs), iridoids, lignans, alditols, oligosaccharides, and polysaccharides. There have been an increasing number of studies focusing on its bio-activities, including antioxidation, neuroprotection, and antiaging. The objective of this review is to introduce this herb to the world. Its taxonomy, distribution, and corresponding biological functions and molecular mechanisms are addressed in this review.
    Language English
    Publishing date 2016-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2016.00041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Minguo shi qi she hui diao cha cong bian

    Li, Wenhai

    2014  

    Title variant Yi liao wei sheng yu she hui bao zhang juan
    Author's details zhu bian Li Wenhai ; fu zhu bian Xia Mingfang, Huang Xingtao
    MeSH term(s) Delivery of Health Care/history ; Social Security/history ; History, 20th Century
    Keywords China
    Language Chinese
    Size 2 volumes :, illustrations ;, 26 cm
    Edition Di 1 ban.
    Document type Book
    ISBN 9787533463984 ; 7533463986
    Database Catalogue of the US National Library of Medicine (NLM)

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