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Article ; Online: Impact of Developmental Disability on Frequent School Absenteeism in US Children Aged 6 to 17 Years: National Survey of Children's Health, 2016 to 2017.

Stromberg, Mary Harbert / Rubtsova, Anna / Sales, Jessica / McGee, Robin

2022 Volume 92, Issue 7, Page(s) 681–691

MeSH term(s)	Absenteeism ; Child ; Child Health ; Developmental Disabilities/epidemiology ; Health Surveys ; Humans ; Schools
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	952835-0
ISSN	1746-1561 ; 0022-4391
ISSN (online)	1746-1561
ISSN	0022-4391
DOI	10.1111/josh.13168
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Article ; Online: Classifying a novel brain malformation.

Harbert, Mary J / Gleeson, Joseph G

Brain : a journal of neurology

2007 Volume 130, Issue Pt 9, Page(s) 2242–2244

MeSH term(s)	Brain Stem/abnormalities ; Brain Stem/pathology ; Child ; Humans ; Magnetic Resonance Imaging ; Nervous System Malformations/classification ; Syndrome
Language	English
Publishing date	2007-09
Publishing country	England
Document type	Comment ; Journal Article ; Review
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awm194
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Article: COVID-19 and Nurse-Sensitive Indicators: Using Performance Improvement Teams to Address Quality Indicators During a Pandemic

Stifter, Janet / Sermersheim, Emily / Ellsworth, Mary / Dowding, Erin / Day, Elizabeth / Silvestri, Karen / Margwarth, Jessica / Korkmaz, Kerem / Walkowiak, Nicole / Boudreau, Lisa / Hernandez, Laura / Harbert, Bryce / Ambutas, Shirley / Abraham, Aney / Shaw, Phil

J. nurs. care qual

Abstract: BACKGROUND: Nurse-sensitive quality indicators have historically been used as a metric of nursing care quality in health care organizations. PROBLEM: At our academic medical center, critically ill COVID-19 patients led to a dramatic change in the ... ...

Abstract	BACKGROUND: Nurse-sensitive quality indicators have historically been used as a metric of nursing care quality in health care organizations. PROBLEM: At our academic medical center, critically ill COVID-19 patients led to a dramatic change in the organizational standard of care resulting in an increase in nurse-sensitive health care-associated infections. APPROACH: Nursing performance improvement teams provided the structure for development of innovative strategies implemented in real time by our frontline clinicians to address the quality and safety issues found with these elevated health care-associated infections. OUTCOMES: A new COVID-19 CLABSI (central line-associated bloodstream infection) Tip Sheet and a Prone Positioning Kit for HAPI Prevention are strategies developed to address quality of care issues experienced with the COVID-19 patients. CONCLUSIONS: Deployment of these innovative practice strategies has led to a decline in health care-associated infections and instituted a new care standard for the COVID-19 patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #880848
Database	COVID19

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Article ; Online: COVID-19 and Nurse-Sensitive Indicators: Using Performance Improvement Teams to Address Quality Indicators During a Pandemic.

Journal of nursing care quality

2020 Volume 36, Issue 1, Page(s) 1–6

Abstract: Background: Nurse-sensitive quality indicators have historically been used as a metric of nursing care quality in health care organizations.: Problem: At our academic medical center, critically ill COVID-19 patients led to a dramatic change in the ... ...

Abstract	Background: Nurse-sensitive quality indicators have historically been used as a metric of nursing care quality in health care organizations. Problem: At our academic medical center, critically ill COVID-19 patients led to a dramatic change in the organizational standard of care resulting in an increase in nurse-sensitive health care-associated infections. Approach: Nursing performance improvement teams provided the structure for development of innovative strategies implemented in real time by our frontline clinicians to address the quality and safety issues found with these elevated health care-associated infections. Outcomes: A new COVID-19 CLABSI (central line-associated bloodstream infection) Tip Sheet and a Prone Positioning Kit for HAPI Prevention are strategies developed to address quality of care issues experienced with the COVID-19 patients. Conclusions: Deployment of these innovative practice strategies has led to a decline in health care-associated infections and instituted a new care standard for the COVID-19 patients.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/nursing ; Humans ; Nursing Staff, Hospital/standards ; Pandemics ; Quality Improvement/organization & administration ; Quality Improvement/standards ; Quality Indicators, Health Care/standards ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089089-0
ISSN	1550-5065 ; 1057-3631
ISSN (online)	1550-5065
ISSN	1057-3631
DOI	10.1097/NCQ.0000000000000523
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Article ; Online: Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.

Sharpe, Cynthia / Reiner, Gail E / Davis, Suzanne L / Nespeca, Mark / Gold, Jeffrey J / Rasmussen, Maynard / Kuperman, Rachel / Harbert, Mary Jo / Michelson, David / Joe, Priscilla / Wang, Sonya / Rismanchi, Neggy / Le, Ngoc Minh / Mower, Andrew / Kim, Jae / Battin, Malcolm R / Lane, Brian / Honold, Jose / Knodel, Ellen /

Arnell, Kathy / Bridge, Renee / Lee, Lilly / Ernstrom, Karin / Raman, Rema / Haas, Richard H

Pediatrics

2020 Volume 145, Issue 6

Abstract: Background and objectives: There are no US Food and Drug Administration-approved therapies for neonatal seizures. Phenobarbital and phenytoin frequently fail to control seizures. There are concerns about the safety of seizure medications in the ... ...

Abstract	Background and objectives: There are no US Food and Drug Administration-approved therapies for neonatal seizures. Phenobarbital and phenytoin frequently fail to control seizures. There are concerns about the safety of seizure medications in the developing brain. Levetiracetam has proven efficacy and an excellent safety profile in older patients; therefore, there is great interest in its use in neonates. However, randomized studies have not been performed. Our objectives were to study the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment of neonatal seizures. Methods: The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause. The primary outcome measure was complete seizure freedom for 24 hours, assessed by independent review of the EEGs by 2 neurophysiologists. Results: Eighty percent of patients (24 of 30) randomly assigned to phenobarbital remained seizure free for 24 hours, compared with 28% of patients (15 of 53) randomly assigned to levetiracetam ( Conclusions: In this phase IIb study, phenobarbital was more effective than levetiracetam for the treatment of neonatal seizures. Higher rates of adverse effects were seen with phenobarbital treatment. Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed.
MeSH term(s)	Anticonvulsants/therapeutic use ; Dose-Response Relationship, Drug ; Double-Blind Method ; Epilepsy, Benign Neonatal/diagnosis ; Epilepsy, Benign Neonatal/drug therapy ; Epilepsy, Benign Neonatal/physiopathology ; Female ; Humans ; Infant, Newborn ; Levetiracetam/therapeutic use ; Male ; Phenobarbital/therapeutic use ; Seizures/diagnosis ; Seizures/drug therapy ; Seizures/physiopathology
Chemical Substances	Anticonvulsants ; Levetiracetam (44YRR34555) ; Phenobarbital (YQE403BP4D)
Language	English
Publishing date	2020-05-08
Publishing country	United States
Document type	Clinical Trial, Phase II ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2019-3182
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Article ; Online: Perinatal risk factors and later social, thought, and attention problems after perinatal stroke.

Harbert, Mary J / Jett, Micaela / Appelbaum, Mark / Nass, Ruth / Trauner, Doris A

Stroke research and treatment

2012 Volume 2012, Page(s) 914546

Abstract: Objective. Survivors of perinatal stroke may be at risk for behavioral problems. Perinatal risk factors that might increase the likelihood of later behavior problems have not been identified. The goal of this study was to explore whether perinatal ... ...

Abstract	Objective. Survivors of perinatal stroke may be at risk for behavioral problems. Perinatal risk factors that might increase the likelihood of later behavior problems have not been identified. The goal of this study was to explore whether perinatal factors might contribute to behavior problems after perinatal stroke. Methods. 79 children with unilateral perinatal stroke were studied. Perinatal factors included gender, gestational age, neonatal seizures, instrumented delivery, fetal distress, acute birth problems, birth weight, and time of diagnosis. Subjects with evidence of hypoxic ischemic encephalopathy were excluded. Parents completed the Achenbach Child Behavior Checklist (CBCL) (Achenbach 1985). The CBCL yields T-scores in several symptom scales. We focused on Social, Thought, and Attention Problems scates. Results. Gestational age and the presence of uteroplacental insufficiency were associated with significant differences on the Thought Problems scale; Attention Problems scores approached significance for these variables. Fetal distress, neonatal seizures, or neonatal diagnosis was associated with 25-30% incidence of clinically significant T-scores on Social, Thought, and Attention Problems scales. Conclusions. Several perinatal factors were associated with a high incidence of social, thought, and behavior problems in children with perinatal stroke. These findings may be useful in anticipatory guidance to parents and physicians caring for these children.
Language	English
Publishing date	2012-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573724-7
ISSN	2042-0056 ; 2090-8105
ISSN (online)	2042-0056
ISSN	2090-8105
DOI	10.1155/2012/914546
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Article ; Online: Perinatal Risk Factors and Later Social, Thought, and Attention Problems after Perinatal Stroke

Mary J. Harbert / Micaela Jett / Mark Appelbaum / Ruth Nass / Doris A. Trauner

Stroke Research and Treatment , Vol

2012 Volume 2012

Keywords	Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extending the mutation spectrum for Galloway-Mowat syndrome to include homozygous missense mutations in the WDR73 gene.

Rosti, Rasim O / Dikoglu, Esra / Zaki, Maha S / Abdel-Salam, Ghada / Makhseed, Nawal / Sese, Jordan C / Musaev, Damir / Rosti, Basak / Harbert, Mary J / Jones, Marilyn C / Vaux, Keith K / Gleeson, Joseph G

American journal of medical genetics. Part A

2016 Volume 170A, Issue 4, Page(s) 992–998

Abstract: Galloway-Mowat syndrome is a rare autosomal-recessive disorder classically described as the combination of microcephaly and nephrotic syndrome. Recently, homozygous truncating mutations in WDR73 (WD repeat domain 73) were described in two of 31 unrelated ...

Abstract	Galloway-Mowat syndrome is a rare autosomal-recessive disorder classically described as the combination of microcephaly and nephrotic syndrome. Recently, homozygous truncating mutations in WDR73 (WD repeat domain 73) were described in two of 31 unrelated families with Galloway-Mowat syndrome which was followed by a report of two sibs in an Egyptian consanguineous family. In this report, seven affecteds from four families showing biallelic missense mutations in WDR73 were identified by exome sequencing and confirmed to follow a recessive model of inheritance. Three-dimensional modeling predicted conformational alterations as a result of the mutation, supporting pathogenicity. An additional 13 families with microcephaly and renal phenotype were negative for WDR73 mutations. Missense mutations in the WDR73 gene are reported for the first time in Galloway-Mowat syndrome. A detailed phenotypic comparison of all reported WDR73-linked Galloway-Mowat syndrome patients with WDR73 negative patients showed that WDR73 mutations are limited to those with classical Galloway-Mowat syndrome features, in addition to cerebellar atrophy, thin corpus callosum, brain stem hypoplasia, occasional coarse face, late-onset and mostly slow progressive nephrotic syndrome, and frequent epilepsy.
MeSH term(s)	Cohort Studies ; Exome ; Facies ; Female ; Genetic Association Studies ; Hernia, Hiatal/diagnosis ; Hernia, Hiatal/genetics ; High-Throughput Nucleotide Sequencing ; Homozygote ; Humans ; Male ; Microcephaly/diagnosis ; Microcephaly/genetics ; Models, Molecular ; Mutation, Missense ; Nephrosis/diagnosis ; Nephrosis/genetics ; Pedigree ; Phenotype ; Protein Conformation ; Proteins/chemistry ; Proteins/genetics
Chemical Substances	Proteins ; WDR73 protein, human
Language	English
Publishing date	2016-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1493479-6
ISSN	1552-4833 ; 1552-4825
ISSN (online)	1552-4833
ISSN	1552-4825
DOI	10.1002/ajmg.a.37533
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 and Nurse-Sensitive Indicators ; Using Performance Improvement Teams to Address Quality Indicators During a Pandemic

Journal of Nursing Care Quality

2020 Volume Publish Ahead of Print

Keywords	General Nursing ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	1089089-0
ISSN	1550-5065 ; 1057-3631
ISSN (online)	1550-5065
ISSN	1057-3631
DOI	10.1097/ncq.0000000000000523
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Randomized Clinical Trial of Umbilical Cord Milking vs Delayed Cord Clamping in Preterm Infants: Neurodevelopmental Outcomes at 22-26 Months of Corrected Age.

Katheria, Anup / Garey, Donna / Truong, Giang / Akshoomoff, Natacha / Steen, Jane / Maldonado, Mauricio / Poeltler, Debra / Harbert, Mary Jane / Vaucher, Yvonne E / Finer, Neil

The Journal of pediatrics

2017 Volume 194, Page(s) 76–80

Abstract: Objective: To compare the effect of umbilical cord milking vs delayed cord clamping (DCC) on neurodevelopmental and health outcomes in very preterm infants at 22-26 months of corrected age.: Study design: Neurodevelopmental outcomes at 2 years of age ...

Abstract	Objective: To compare the effect of umbilical cord milking vs delayed cord clamping (DCC) on neurodevelopmental and health outcomes in very preterm infants at 22-26 months of corrected age. Study design: Neurodevelopmental outcomes at 2 years of age were assessed using the Bayley Scales of Infant Development, third edition, and a standardized neurologic examination. Data regarding pulmonary morbidities, neurosensory impairments, and hospitalizations were obtained by parental interview. Intention-to-treat was used for primary analyses. Results: Of the 197 infants enrolled in the original study there were 15 deaths, 5 in the umbilical cord milking group and 10 in DCC group. Of the remaining infants, 135 (74%) were assessed at 22-26 months of corrected age. Demographics in umbilical cord milking (n = 70) and DCC (n = 65) groups were similar. Infants randomized to umbilical cord milking at birth had significantly higher cognitive and language composite scores, and were less likely to have a cognitive composite score of <85 (4% vs 15%; P = .04). Motor function was similar in both groups. There were no differences in the incidences of mild or moderate to severe neurodevelopmental impairment, hearing or visual impairments, pulmonary morbidities, or rehospitalizations between the 2 groups. Conclusions: Infants randomized to umbilical cord milking had higher language and cognitive scores compared with those randomized to DCC. There was no difference in rates of mild or moderate to severe neurodevelopmental impairment. Trial registration: clinicaltrials.gov: NCT01434732.
MeSH term(s)	Child Development/physiology ; Child, Preschool ; Cognition ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Male ; Motor Activity/physiology ; Time Factors ; Umbilical Cord/surgery
Language	English
Publishing date	2017-12-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2017.10.037
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