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Article ; Online: Rapid and Reliable

Huh, Ji Young / Song, Yong Ju / Park, Geon

Annals of clinical and laboratory science

2024 Volume 54, Issue 1, Page(s) 101–105

Abstract: Objective: Carbonic anhydrase inhibitors (CAIs) are intraocular pressure-reducing medications used in ophthalmology. Human leukocyte antigen-: Methods: Duplex allele-specific polymerase chain reaction (PCR) with an internal control was performed for ! ...

Abstract	Objective: Carbonic anhydrase inhibitors (CAIs) are intraocular pressure-reducing medications used in ophthalmology. Human leukocyte antigen- Methods: Duplex allele-specific polymerase chain reaction (PCR) with an internal control was performed for Results: In total, 50 Conclusion: Duplex allele-specific PCR is a rapid, reliable, and economical assay for screening the
MeSH term(s)	Humans ; Alleles ; Carbonic Anhydrase Inhibitors/adverse effects ; Genotype ; HLA-B Antigens/genetics
Chemical Substances	Carbonic Anhydrase Inhibitors ; HLA-B Antigens ; HLA-B59 antigen
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Article: Structural Colors on Al Surface via Capped Cu-Si

Rahman, M A / Kim, Dongkyu / Arora, Deepshikha / Huh, Joo-Youl / Byun, Ji Young

Micromachines

2023 Volume 14, Issue 2

Abstract: Tunable structural colors have a multitude of applications in the beautification of mobile devices, in the decoration of artwork, and in the creation of color filters. In this paper, we describe a Metal-Insulator-Metal (MIM) design that can be used to ... ...

Abstract	Tunable structural colors have a multitude of applications in the beautification of mobile devices, in the decoration of artwork, and in the creation of color filters. In this paper, we describe a Metal-Insulator-Metal (MIM) design that can be used to systematically tune structural colors by altering the thickness of the top metal and intermediate insulator. Cu and Si
Language	English
Publishing date	2023-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14020471
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Article: Conventional reversal of rocuronium-induced neuromuscular blockade by sugammadex in Korean children: pharmacokinetics, efficacy, and safety analyses.

Ji, Sang-Hwan / Huh, Ki Young / Oh, Jaeseong / Jeong, Hee-Jeong / Jang, Young-Eun / Kim, Eun-Hee / Lee, Ji-Hyun / Kim, Jin-Tae / Kim, Hee-Soo

Frontiers in pharmacology

2023 Volume 14, Page(s) 1127932

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1127932
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Article ; Online: Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis.

Huh, Ji-Won / Roh, Tae-Young

BMC microbiology

2020 Volume 20, Issue 1, Page(s) 208

Abstract: Background: The essential roles of gut microbiome have been emphasized in modulating human health and disease. Fusobacterium nucleatum (F. nucleatum), an obligate Gram-negative microorganism residing in oral cavity, gastrointestinal tract and elsewhere, ...

Abstract	Background: The essential roles of gut microbiome have been emphasized in modulating human health and disease. Fusobacterium nucleatum (F. nucleatum), an obligate Gram-negative microorganism residing in oral cavity, gastrointestinal tract and elsewhere, has been recently considered as a potential oncobacterium associated with human cancers. However, the consequence of its enrichment was not extensively explored in terms of microbial homeostasis and stability at the early stage of disease development. Result: Our analysis on longitudinal metagenomic data generated by the Integrative Human Microbiome Project (iHMP) showed that F. nucleatum was frequently found in inflammatory bowel diseases (IBD) subjects with reduced microbial diversity. Using non-parametric logarithmic linear discriminant analysis (LDA) effect size (LEfSe) algorithm, 12 IBD- and 14 non-IBD-specific bacterial species were identified in the fecal metagenome and the IBD-specific ones were over-represented in the F. nucleatum-experienced subjects during long-term surveillance. In addition, F. nucleatum experience severely abrogated intra-personal stability of microbiome in IBD patients and induced highly variable gut microbiome between subjects. From the longitudinal comparison between microbial distributions prior and posterior to F. nucleatum detection, 41 species could be proposed as indicative "classifiers" for dysbiotic gut state. By multiple logistic regression models established on these classifiers, the high probability of experiencing F. nucleatum was significantly correlated with decreased alpha-diversity and increased number of biomarker species for IBD and colorectal cancer (CRC). Finally, microbial clustering confirmed that biomarker species for IBD and non-IBD conditions as well as CRC signature markers were well distinguishable and could be utilized for explaining gut symbiosis and dysbiosis. Conclusion: F. nucleatum opportunistically appeared under early dysbiotic condition in gut, and discriminative classifier species associated with F. nucleatum were successfully applied to predict microbial alterations in both IBD and non-IBD conditions. Our prediction model and microbial classifier biomarkers for estimating gut dysbiosis should provide a novel aspect of microbial homeostasis/dynamics and useful information on non-invasive biomarker screening.
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2180
ISSN (online)	1471-2180
DOI	10.1186/s12866-020-01887-4
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Article ; Online: Comparison of anticholinergic burden with chronic polypharmacy on functional decline and mortality in Korean older people: a retrospective nationwide cohort study.

Huh, Youn / Kim, Ye-Jee / Choi, Jung-Yeon / Lee, Ji Eun / Jung, Hee-Won / Shin, Cheol Min / Won, Chang Won / Son, Ki Young

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 90

Abstract: Background: We aimed to evaluate the association of anticholinergic burden and chronic polypharmacy with the incidence of functional decline and all-cause mortality, and to determine the difference between anticholinergic burden and chronic polypharmacy ...

Abstract	Background: We aimed to evaluate the association of anticholinergic burden and chronic polypharmacy with the incidence of functional decline and all-cause mortality, and to determine the difference between anticholinergic burden and chronic polypharmacy among Korean older people. Methods: This nationwide cohort study included 42,132 older people aged ≥ 65 years who underwent Korean National Health Insurance Service health examinations from 2007 to 2008. Odds ratios (ORs) and 95% confidence intervals (CIs) for abnormal Timed Up and Go (TUG) test results were assessed using multivariate logistic regression analyses. Hazard ratios (HRs) and 95% CIs for all-cause mortality until the end of 2015 were estimated using multivariable Cox proportional hazards regression analysis. Results: Of the participants, 37.19% had abnormal TUG test results, and 7.66% of those died during the 5.7-year mean follow-up. The abnormal TUG test results OR increased by 27% among individuals with Korean Anticholinergic Burden Scale (KABS) scores ≥ 3 (OR 1.27, 95% CI 1.02-1.58) compared to those with KABS scores of 0. The HRs for all-cause mortality increased for individuals with higher KABS scores (P for trend < 0.001) or chronic polypharmacy (P for trend < 0.001) compared to those for individuals without these conditions. The combination of a higher KABS or chronic polypharmacy and abnormal TUG test results increased the risk of all-cause mortality (All P for trend < 0.001). Conclusion: Anticholinergic drug burden shows a better association with functional decline than chronic polypharmacy, and the use of medications and functional decline may be important risk factors for all-cause mortality among older people.
MeSH term(s)	Aged ; Humans ; Cholinergic Antagonists/adverse effects ; Cohort Studies ; Polypharmacy ; Republic of Korea ; Retrospective Studies ; Mortality
Chemical Substances	Cholinergic Antagonists
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04692-0
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Article ; Online: Health-Related Unmet Needs of Community-Dwelling Older Adults: A Nationwide Representative Descriptive Study in Korea.

Huh, Youn / Son, Ki Young / Lee, Ji Eun / Kim, Kwang-Il / Cho, Belong / Won, Chang Won

Annals of geriatric medicine and research

2023 Volume 27, Issue 1, Page(s) 66–72

Abstract: Background: South Korea has no official geriatric specialties or subspecialties. Moreover, studies on the unmet needs related to geriatric health problems in older Korean adults are scarce. Therefore, we investigated the unmet needs regarding geriatric ... ...

Abstract	Background: South Korea has no official geriatric specialties or subspecialties. Moreover, studies on the unmet needs related to geriatric health problems in older Korean adults are scarce. Therefore, we investigated the unmet needs regarding geriatric health problems among older Korean adults. Methods: This cross-sectional study included 411 Korean adults aged ≥70 years. We constructed a questionnaire for a field survey that comprised 21 items to understand the geriatric challenges related to the participants' physicians and the necessity for geriatric physicians to resolve participants' health problems. We used unweighted numbers (weighted percentages) or mean±standard deviation to describe the characteristics of the study participants for categorical and continuous variables, respectively. Results: This study included a total of 411 men and women. The mean age was 77.6±5.9 years. Among the participants, 88.6% had one or more chronic diseases (mean number of chronic diseases, 2.0±1.3). Of the participants, 32.8% said that their physicians did not spend enough time addressing their problems and only 24.3% felt that their physicians understood geriatric problems well. Of these, 76.2% (n=313) said that geriatricians were required to fulfill their unmet healthcare needs. Conclusions: The participants reported the need for help from a geriatrician, although most of the participants consulted regular physicians about their health problems. The study results support that geriatricians are needed to improve health services for older adults.
Language	English
Publishing date	2023-03-17
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3035056-6
ISSN	2508-4909 ; 2508-4798
ISSN (online)	2508-4909
ISSN	2508-4798
DOI	10.4235/agmr.23.0028
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Article ; Online: Prevalence Ratio of Primary Angle-Closure and Primary Open-Angle Glaucoma in Asian Population: A Meta-Analysis and Multiple Meta-Regression Analysis.

Lee, Jaekyoung / Park, Ji Sun / Jeong, Yoon / Shin, Young In / Huh, Min Gu / Jeoung, Jin Wook / Park, Ki Ho / Kim, Young Kook

Korean journal of ophthalmology : KJO

2023 Volume 38, Issue 1, Page(s) 42–50

Abstract: Purpose: To investigate the prevalence ratio of primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) in the Asian population.: Methods: Systematic searches of PubMed, Embase, and Cochrane databases for population-based studies ...

Abstract	Purpose: To investigate the prevalence ratio of primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) in the Asian population. Methods: Systematic searches of PubMed, Embase, and Cochrane databases for population-based studies in Asia published until August 5, 2022. We conducted a meta-analysis for PACG to POAG prevalence ratio using inverse variance-weighted random-effects meta-analyses so as to combine the study-specific measures of association. Between-study outcome variation (i.e., heterogeneity) was quantified with the I2 statistic. The multiple meta-regression analyses were performed in order to further account for the reasons for heterogeneity. Results: Twenty studies, with a total study population of 52,522 individuals, had been conducted in 13 countries. The pooled PACG to POAG prevalence ratio was 2.204 (95% confidence interval, 1.617-3.004) with high heterogeneity (p < 0.001). In multiple meta-regression model, prevalence of POAG is the most important predictor for heterogeneity (model importance, 0.954), followed continent (0.508), and publication year (0.222). For every additional elevation of POAG prevalence (i.e., increase of 1.0%), the PACG to POAG prevalence ratio is expected to rise by 0.471. Conclusions: We estimated the pooled PACG to POAG prevalence ratio in the Asian population. The POAG prevalence is the most important factor to determine the PACG to POAG prevalence ratio.
MeSH term(s)	Humans ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/epidemiology ; Glaucoma, Angle-Closure/diagnosis ; Glaucoma, Angle-Closure/epidemiology ; Prevalence ; Regression Analysis ; Intraocular Pressure
Language	English
Publishing date	2023-12-15
Publishing country	Korea (South)
Document type	Meta-Analysis ; Journal Article
ZDB-ID	639346-9
ISSN	2092-9382 ; 1011-8942
ISSN (online)	2092-9382
ISSN	1011-8942
DOI	10.3341/kjo.2023.0057
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Article ; Online: Comparison of Newly Proposed LDL-Cholesterol Estimation Equations.

Jeong, Yong Whi / Koo, Jun Hyuk / Huh, Ji Hye / Kim, Young-Jin / Jeong, Hoyeon / Kim, Eun Young / Kang, Dae Ryong

Journal of Korean medical science

2023 Volume 38, Issue 19, Page(s) e145

Abstract: Background: Low-density lipoprotein cholesterol is an important marker highly associated with cardiovascular disease. Since the direct measurement of it is inefficient in terms of cost and time, it is common to estimate through the Friedewald equation ... ...

Abstract	Background: Low-density lipoprotein cholesterol is an important marker highly associated with cardiovascular disease. Since the direct measurement of it is inefficient in terms of cost and time, it is common to estimate through the Friedewald equation developed about 50 years ago. However, various limitations exist since the Friedewald equation was not designed for Koreans. This study proposes a new low-density lipoprotein cholesterol estimation equation for South Koreans using nationally approved statistical data. Methods: This study used data from the Korean National Health and Nutrition Examination Survey from 2009 to 2019. The 18,837 subjects were used to develop the equation for estimating low-density lipoprotein cholesterol. The subjects included individuals with low-density lipoprotein cholesterol levels directly measured among those with high-density lipoprotein cholesterol, triglycerides, and total cholesterol measured. We compared twelve equations developed in the previous studies and the newly proposed equation (model 1) developed in this study with the actual low-density lipoprotein cholesterol value in various ways. Results: The low-density lipoprotein cholesterol value estimated using the estimation formula and the actual low-density lipoprotein cholesterol value were compared using the root mean squared error. When the triglyceride level was less than 400 mg/dL, the root mean squared of the model 1 was 7.96, the lowest compared to other equations, and the model 2 was 7.82. The degree of misclassification was checked according to the NECP ATP III 6 categories. As a result, the misclassification rate of the model 1 was the lowest at 18.9%, and Weighted Kappa was the highest at 0.919 (0.003), which means it significantly reduced the underestimation rate shown in other existing estimation equations. Root mean square error was also compared according to the change in triglycerides level. As the triglycerides level increased, the root mean square error showed an increasing trend in all equations, but it was confirmed that the model 1 was the lowest compared to other equations. Conclusion: The newly proposed low-density lipoprotein cholesterol estimation equation showed significantly improved performance compared to the 12 existing estimation equations. The use of representative samples and external verification is required for more sophisticated estimates in the future.
MeSH term(s)	Humans ; Cholesterol, LDL ; Nutrition Surveys ; Triglycerides ; Cholesterol, HDL ; Cardiovascular Diseases
Chemical Substances	Cholesterol, LDL ; Triglycerides ; Cholesterol, HDL
Language	English
Publishing date	2023-05-15
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e145
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Article ; Online: Physiological benefits of lung recruitment in the semi-lateral position after laparoscopic surgery: a randomized controlled study.

Oh, Eun Jung / Lee, Eun Ji / Heo, Burn-Young / Huh, Jin / Min, Jeong-Jin

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3909

Abstract: We evaluated the physiological benefits of performing lung recruitment maneuver (LRM) in the semi-lateral position compared in the supine position. Seventy-nine patients undergoing laparoscopic prostatectomy were randomly assigned to either the supine or ...

Abstract	We evaluated the physiological benefits of performing lung recruitment maneuver (LRM) in the semi-lateral position compared in the supine position. Seventy-nine patients undergoing laparoscopic prostatectomy were randomly assigned to either the supine or semi-lateral group according to body position during the LRM. At the end of surgery, LRM (35 cmH
MeSH term(s)	Humans ; Laparoscopy ; Lung/surgery ; Male ; Positive-Pressure Respiration/methods ; Respiration, Artificial ; Respiratory Physiological Phenomena
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-04841-8
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Article ; Online: Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma.

Kim, Kyung Bin / Ahn, Ji Hyun / Kwon, Soon Wook / Lee, Su Ji / Lee, Yury / Park, Seo Young / Kim, Ahrong / Choi, Kyung Un / Lee, Chang Hun / Huh, Gi Yeong

Pathology oncology research : POR

2023 Volume 29, Page(s) 1611216

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Disease-Free Survival ; Treatment Outcome ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/pathology ; Prognosis ; Bile Ducts, Intrahepatic/pathology ; Retrospective Studies
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1375979-6
ISSN	1532-2807 ; 1219-4956
ISSN (online)	1532-2807
ISSN	1219-4956
DOI	10.3389/pore.2023.1611216
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