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  1. Article ; Online: Unraveling the Mysteries of PAX8 in Reproductive Tract Cancers.

    Chaves-Moreira, Daniele / Morin, Patrice J / Drapkin, Ronny

    Cancer research

    2020  Volume 81, Issue 4, Page(s) 806–810

    Abstract: Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or ...

    Abstract Paired Box 8 (PAX8) is a lineage-specific transcription factor that has essential roles during embryogenesis and tumorigenesis. The importance of PAX8 in the development of the reproductive system is highlighted by abnormalities observed upon the loss or mutation of this PAX family member. In cancer, PAX8 expression is deregulated in a key set of neoplasms, including those arising from the Müllerian ducts. The roles of PAX8 in oncogenesis are diverse and include epigenetic remodeling, stimulation of proliferation, inhibition of apoptosis, and regulation of angiogenesis. PAX8 can interact with different protein partners during cancer progression and may exhibit significant function-altering alternative splicing. Moreover, expression of PAX8 in cancer can also serve as a biomarker for diagnostic and prognostic purposes. In this review, we focus on the roles of PAX8 in cancers of the reproductive system. Understanding the diverse mechanisms of action of PAX8 in development and oncogenesis may identify new vulnerabilities in malignancies that currently lack effective therapies.
    MeSH term(s) Animals ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Female ; Genital Neoplasms, Female/diagnosis ; Genital Neoplasms, Female/genetics ; Genital Neoplasms, Female/pathology ; Genital Neoplasms, Female/therapy ; Genital Neoplasms, Male/diagnosis ; Genital Neoplasms, Male/genetics ; Genital Neoplasms, Male/pathology ; Genital Neoplasms, Male/therapy ; Humans ; Male ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; PAX8 Transcription Factor/physiology ; Prognosis
    Chemical Substances Biomarkers, Tumor ; PAX8 Transcription Factor ; PAX8 protein, human
    Language English
    Publishing date 2020-12-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-20-3173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genetically-defined ovarian cancer mouse models.

    Morin, Patrice J / Weeraratna, Ashani T

    The Journal of pathology

    2015  Volume 238, Issue 2, Page(s) 180–184

    Abstract: Epithelial ovarian cancer (EOC), the deadliest of gynaecological cancers, is a disease that remains difficult to detect early and treat efficiently. A significant challenge for researchers in the field is that the aetiology of EOC and the molecular ... ...

    Abstract Epithelial ovarian cancer (EOC), the deadliest of gynaecological cancers, is a disease that remains difficult to detect early and treat efficiently. A significant challenge for researchers in the field is that the aetiology of EOC and the molecular pathways important for its development are poorly understood. Moreover, precursor lesions have not been readily identifiable, making the mechanisms of EOC progression difficult to delineate. In order to address these issues, several genetically-defined ovarian mouse models have been generated in the past 15 years. However, because of the recent suggestion that most EOCs may not originate from the ovarian surface 'epithelium', but from other tissues of the female genital tract, some models may need to be re-evaluated within this new paradigm. In this review, we examine several genetically-defined EOC models and discuss how the new paradigm may explain some of the features of these models. A better understanding of the strengths and limitations of the current EOC mouse models will undoubtedly allow us to utilize these tools to better understand the biology of the disease and develop new approaches for EOC prevention, detection, and treatment.
    MeSH term(s) Adenoviridae ; Animals ; Carcinoma in Situ/genetics ; Carcinoma in Situ/pathology ; Carcinoma, Ovarian Epithelial ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Disease Models, Animal ; Epithelial Cells/pathology ; Fallopian Tube Neoplasms/genetics ; Female ; Genes, p53/genetics ; Glycoproteins/genetics ; Humans ; Mice ; Mice, Transgenic ; Mutation/genetics ; Neoplasms, Glandular and Epithelial/genetics ; Neoplasms, Glandular and Epithelial/pathology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; PTEN Phosphohydrolase/genetics ; Proto-Oncogene Proteins p21(ras)/genetics ; Retinoblastoma Protein/genetics
    Chemical Substances Glycoproteins ; Ovgp1 protein, mouse ; Retinoblastoma Protein ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pten protein, mouse (EC 3.1.3.67) ; Kras2 protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2015-10-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.4663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Learning about ovarian tumorigenesis by watching Cables.

    Morin, Patrice J

    Cancer biology & therapy

    2008  Volume 7, Issue 2, Page(s) 189–190

    MeSH term(s) Apoptosis ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cyclins/genetics ; Cyclins/metabolism ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; Loss of Heterozygosity ; Ovarian Neoplasms/classification ; Ovarian Neoplasms/etiology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Promoter Regions, Genetic ; Tumor Suppressor Proteins
    Chemical Substances CABLES1 protein, human ; Carrier Proteins ; Cyclins ; Phosphoproteins ; Tumor Suppressor Proteins
    Language English
    Publishing date 2008-02-12
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.4161/cbt.7.2.5743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: β-Catenin Mutations: Insights into the APC Pathway and the Power of Genetics.

    Morin, Patrice J / Kinzler, Kenneth W / Sparks, Andrew B

    Cancer research

    2016  Volume 76, Issue 19, Page(s) 5587–5589

    MeSH term(s) Adenomatous Polyposis Coli Protein/genetics ; Adenomatous Polyposis Coli Protein/metabolism ; Genes, APC ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism
    Chemical Substances APC protein, human ; Adenomatous Polyposis Coli Protein ; CTNNB1 protein, human ; beta Catenin
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-2387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Claudin proteins in ovarian cancer.

    Morin, Patrice J

    Disease markers

    2007  Volume 23, Issue 5-6, Page(s) 453–457

    Abstract: Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for ... ...

    Abstract Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for detection and prognosis, as well as ideal targets for therapy using the Clostridium perfringens enterotoxin.
    MeSH term(s) Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Membrane Proteins/analysis ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/drug therapy ; Prognosis ; Tight Junctions/genetics ; Tight Junctions/metabolism
    Chemical Substances Biomarkers, Tumor ; Membrane Proteins
    Language English
    Publishing date 2007-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2007/674058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  6. Article: Claudin proteins in human cancer: promising new targets for diagnosis and therapy.

    Morin, Patrice J

    Cancer research

    2005  Volume 65, Issue 21, Page(s) 9603–9606

    Abstract: The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the ... ...

    Abstract The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.
    MeSH term(s) Claudin-3 ; Claudin-4 ; Humans ; Membrane Proteins/biosynthesis ; Membrane Proteins/chemistry ; Membrane Proteins/metabolism ; Neoplasms/diagnosis ; Neoplasms/metabolism ; Neoplasms/therapy ; Tight Junctions/metabolism
    Chemical Substances CLDN3 protein, human ; CLDN4 protein, human ; Claudin-3 ; Claudin-4 ; Membrane Proteins
    Language English
    Publishing date 2005-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-05-2782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17.

    Chaves-Moreira, Daniele / Mitchell, Marilyn A / Arruza, Cristina / Rawat, Priyanka / Sidoli, Simone / Nameki, Robbin / Reddy, Jessica / Corona, Rosario I / Afeyan, Lena K / Klein, Isaac A / Ma, Sisi / Winterhoff, Boris / Konecny, Gottfried E / Garcia, Benjamin A / Brady, Donita C / Lawrenson, Kate / Morin, Patrice J / Drapkin, Ronny

    Science signaling

    2022  Volume 15, Issue 728, Page(s) eabm2496

    Abstract: PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of ... ...

    Abstract PAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs. Nearly all ovarian carcinomas express PAX8, and its knockdown results in apoptosis of ovarian cancer cells. To explore the role of PAX8 in these tissues, we purified the PAX8 protein complex from nonmalignant fallopian tube cells and high-grade serous ovarian carcinoma cell lines. We found that PAX8 was a member of a large chromatin remodeling complex and preferentially interacted with SOX17, another developmental transcription factor. Depleting either PAX8 or SOX17 from cancer cells altered the expression of factors involved in angiogenesis and functionally disrupted tubule and capillary formation in cell culture and mouse models. PAX8 and SOX17 in ovarian cancer cells promoted the secretion of angiogenic factors by suppressing the expression of
    MeSH term(s) Animals ; Fallopian Tubes/metabolism ; Fallopian Tubes/pathology ; Female ; HMGB Proteins/genetics ; HMGB Proteins/metabolism ; Humans ; Mice ; Neoplasm Grading ; Ovarian Neoplasms/metabolism ; PAX8 Transcription Factor/genetics ; PAX8 Transcription Factor/metabolism ; SOXF Transcription Factors/genetics ; SOXF Transcription Factors/metabolism ; Transcription Factors/metabolism
    Chemical Substances HMGB Proteins ; PAX8 Transcription Factor ; PAX8 protein, human ; SOX17 protein, human ; SOXF Transcription Factors ; Sox17 protein, mouse ; Transcription Factors
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abm2496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Claudin Proteins in Ovarian Cancer

    Patrice J. Morin

    Disease Markers, Vol 23, Iss 5-6, Pp 453-

    2007  Volume 457

    Abstract: Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for ... ...

    Abstract Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for detection and prognosis, as well as ideal targets for therapy using the Clostridium perfringens enterotoxin.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2007-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Drug resistance and the microenvironment: nature and nurture.

    Morin, Patrice J

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

    2003  Volume 6, Issue 4, Page(s) 169–172

    Abstract: Drug resistance remains a major obstacle to the successful use of chemotherapeutic drugs for cancer therapy. It is well documented that cancer cells can adapt to the presence of chemotherapeutic agents through mutations or expression changes of key genes ...

    Abstract Drug resistance remains a major obstacle to the successful use of chemotherapeutic drugs for cancer therapy. It is well documented that cancer cells can adapt to the presence of chemotherapeutic agents through mutations or expression changes of key genes that control drug metabolism or response to damage. In addition, it is becoming increasingly apparent that the tumor microenvironment can have an important impact on the success of chemotherapy. Indeed, cell-cell and cell-matrix interactions can influence the cancer cells sensitivity to apoptosis and affect drug resistance. A model is proposed in which the tumor cells may actively reorganize their environment to maximize their survival in the presence of anticancer agents.
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/physiology ; Cell Adhesion/drug effects ; Cell Adhesion/physiology ; Drug Resistance, Neoplasm/physiology ; Extracellular Matrix/drug effects ; Extracellular Matrix/physiology ; Humans ; Models, Biological
    Language English
    Publishing date 2003-08-25
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 1474513-6
    ISSN 1532-2084 ; 1368-7646
    ISSN (online) 1532-2084
    ISSN 1368-7646
    DOI 10.1016/s1368-7646(03)00059-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5099: Show issues Location:
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  10. Article: Renal cell carcinoma: taking care of business.

    Morin, Patrice J

    Cancer biology & therapy

    2002  Volume 1, Issue 5, Page(s) 537–538

    MeSH term(s) Base Pair Mismatch ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; DNA Repair ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Microsatellite Repeats ; Mutation/genetics ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism
    Chemical Substances Neoplasm Proteins
    Language English
    Publishing date 2002-12-20
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2146305-0
    ISSN 1538-4047
    ISSN 1538-4047
    DOI 10.4161/cbt.1.5.172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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