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  1. Book: The behavioral consequences of stroke

    Schweizer, Tom A. / Macdonald, Robert Loch

    reinforcement learning, causal inference, and personalized medicine

    2014  

    Author's details Tom A. Schweizer ; R. Loch Macdonald eds
    Language English
    Size XVIII, 349 S. : Ill., graph. Darst., Kt.
    Publisher Springer
    Publishing place New York, NY u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017904037
    ISBN 978-1-4614-7671-9 ; 1-4614-7671-2 ; 9781461476726 ; 1461476720
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Erratum. Effects of decompressive craniectomy on functional outcomes and death in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

    Macdonald, R Loch

    Journal of neurosurgery

    2022  Volume 138, Issue 2, Page(s) 574

    MeSH term(s) Humans ; Subarachnoid Hemorrhage/surgery ; Decompressive Craniectomy ; Treatment Outcome ; Intracranial Hypertension/surgery
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Published Erratum
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2022.9.JNS161383a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Age and outcome after aneurysmal subarachnoid haemorrhage.

    Macdonald, R Loch

    Journal of neurology, neurosurgery, and psychiatry

    2021  Volume 92, Issue 11, Page(s) 1143

    MeSH term(s) Humans ; Intracranial Aneurysm/complications ; Subarachnoid Hemorrhage
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2021-326920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Cerebral vasospasm

    Macdonald, Robert Loch

    advances in research and treatment

    2005  

    Event/congress International Conference on Cerebral Vasospasm (8, 2003, ChicagoIll.)
    Author's details [Eighth International Conference on Cerebral Vasospasm ... in Chicago from July 9 to 12, 2003]. R. Loch Macdonald
    Keywords Vasospasm, Intracranial ; Subarachnoid Hemorrhage / complications ; Schädel-Hirn-Trauma ; Nervenverletzung ; Wirbelsäulenverletzung
    Subject Schädel-Hirn-Verletzung ; Schädelhirntrauma ; Schädeltrauma ; Schädelverletzung ; Hirntrauma ; Gehirntrauma ; Hirnverletzung ; Gehirnverletzung ; Wirbelsäule
    Language English
    Size XXX, 333 S. : zahlr. Ill., graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014222524
    ISBN 3-13-130781-1 ; 1-58890-283-8 ; 978-3-13-130781-1 ; 978-1-58890-283-2
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Pharmacological Prevention of Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage.

    Caylor, Meghan M / Macdonald, R Loch

    Neurocritical care

    2023  Volume 40, Issue 1, Page(s) 159–169

    Abstract: Background: Causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH) include early brain injury and delayed neurologic deterioration, which may result from delayed cerebral ischemia (DCI). Complex pathophysiological ... ...

    Abstract Background: Causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH) include early brain injury and delayed neurologic deterioration, which may result from delayed cerebral ischemia (DCI). Complex pathophysiological mechanisms underlie DCI, which often includes angiographic vasospasm (aVSP) of cerebral arteries.
    Methods: Despite the study of many pharmacological therapies for the prevention of DCI in aSAH, nimodipine-a dihydropyridine calcium channel blocker-remains the only drug recommended universally in this patient population. A common theme in the research of preventative therapies is the use of promising drugs that have been shown to reduce the occurrence of aVSP but ultimately did not improve functional outcomes in large, randomized studies. An example of this is the endothelin antagonist clazosentan, although this agent was recently approved in Japan.
    Results: The use of the only approved drug, nimodipine, is limited in practice by hypotension. The administration of nimodipine and its counterpart nicardipine by alternative routes, such as intrathecally or formulated as prolonged release implants, continues to be a rational area of study. Additional agents approved in other parts of the world include fasudil and tirilazad.
    Conclusions: We provide a brief overview of agents currently being studied for prevention of aVSP and DCI after aSAH. Future studies may need to identify subpopulations of patients who can benefit from these drugs and perhaps redefine acceptable outcomes to demonstrate impact.
    MeSH term(s) Humans ; Brain Ischemia/drug therapy ; Brain Ischemia/etiology ; Brain Ischemia/prevention & control ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Cerebral Infarction/complications ; Nimodipine/pharmacology ; Nimodipine/therapeutic use ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/prevention & control
    Chemical Substances Calcium Channel Blockers ; Nimodipine (57WA9QZ5WH)
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01847-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Commentary: Low-Dose Intravenous Heparin Infusion After Aneurysmal Subarachnoid Hemorrhage Is Associated With Decreased Risk of Delayed Neurological Deficit and Cerebral Infarction.

    Macdonald, R Loch

    Neurosurgery

    2020  Volume 88, Issue 3, Page(s) E234–E235

    MeSH term(s) Cerebral Infarction/drug therapy ; Cerebral Infarction/etiology ; Heparin/adverse effects ; Humans ; Infusions, Intravenous ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/drug therapy ; Vasospasm, Intracranial
    Chemical Substances Heparin (9005-49-6)
    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyaa476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Neurosurgical operative atlas / <vas>

    Macdonald, Robert Loch / Badie, Behnam / Wolfla, Christopher E. / Goodrich, James T.

    [CME credit available]

    2009  

    Institution American Association of Neurological Surgeons
    Author's details American Association of Neurological Surgeons
    Collection Neurosurgical operative atlas
    Keywords Vascualr Diseases / surgery ; Neurosurgical Procedures / methods ; Vascular Surgical Procedures / methods
    Language English
    Size XXIII, 280 S. : zahlr. Ill.
    Publisher Thieme ; AANS
    Publishing place New York u.a. ; Rolling Meadows, Ill
    Publishing country United States
    Document type Book
    HBZ-ID HT015683752
    ISBN 978-1-604-06034-8 ; 1-604-06034-4
    Database Catalogue ZB MED Medicine, Health

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  8. Book: Cerebral vasospasm

    Macdonald, Robert Loch / Weir, Bryce

    2001  

    Author's details R. Loch Macdonald ; Bryce Weir
    Language English
    Size XVI, 518 S. : Ill., graph. Darst.
    Publisher Academic Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012971733
    ISBN 0-12-464161-X ; 978-0-12-464161-7
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Letter to the Editor. Limited data?

    Macdonald, R Loch

    Journal of neurosurgery

    2018  Volume 130, Issue 2, Page(s) 670–671

    MeSH term(s) Glomus Jugulare Tumor ; Humans ; Neoplasms ; Radiosurgery
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type Journal Article ; Letter ; Comment
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2018.9.JNS182618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Introduction. Antithrombotic medication in neurosurgery: management and controversies of a growing clinical dilemma.

    Soleman, Jehuda / Macdonald, R Loch / Seiffge, David / Greuter, Ladina

    Neurosurgical focus

    2023  Volume 55, Issue 4, Page(s) E1

    MeSH term(s) Humans ; Fibrinolytic Agents/therapeutic use ; Neurosurgery ; Anticoagulants/therapeutic use ; Platelet Aggregation Inhibitors/therapeutic use ; Neurosurgical Procedures
    Chemical Substances Fibrinolytic Agents ; Anticoagulants ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2023.8.FOCUS23535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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