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  1. Article ; Online: Supervalence Bonding in Bi-icosahedral Cores of [M

    Ito, Emi / Ito, Shun / Takano, Shinjiro / Nakamura, Toshikazu / Tsukuda, Tatsuya

    JACS Au

    2022  Volume 2, Issue 11, Page(s) 2627–2634

    Abstract: ... ...

    Abstract Au
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.2c00519
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  2. Article ; Online: Photoluminescence of Doped Superatoms M@Au

    Takano, Shinjiro / Hirai, Haru / Nakashima, Takuya / Iwasa, Takeshi / Taketsugu, Tetsuya / Tsukuda, Tatsuya

    Journal of the American Chemical Society

    2021  Volume 143, Issue 28, Page(s) 10560–10564

    Abstract: A series of doped gold superatoms M@Au ...

    Abstract A series of doped gold superatoms M@Au
    Language English
    Publishing date 2021-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c05019
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  3. Article ; Online: Doping-Mediated Energy-Level Engineering of M@Au

    Hirai, Haru / Takano, Shinjiro / Nakashima, Takuya / Iwasa, Takeshi / Taketsugu, Tetsuya / Tsukuda, Tatsuya

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 36, Page(s) e202207290

    Abstract: We synthesized a series of ... ...

    Abstract We synthesized a series of MAu
    Language English
    Publishing date 2022-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202207290
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  4. Article ; Online: Synthesis of Trimetallic (HPd@M

    Hirai, Haru / Takano, Shinjiro / Tsukuda, Tatsuya

    ACS omega

    2019  Volume 4, Issue 4, Page(s) 7070–7075

    Abstract: We have recently reported that hydride ( ... ...

    Abstract We have recently reported that hydride (H
    Language English
    Publishing date 2019-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b00575
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  5. Article ; Online: Characterization of M Cells in Tear Duct-Associated Lymphoid Tissue of Mice: A Potential Role in Immunosurveillance on the Ocular Surface.

    Oya, Yuki / Kimura, Shunsuke / Nakamura, Yutaka / Ishihara, Narumi / Takano, Shunsuke / Morita, Ryo / Endo, Mayumi / Hase, Koji

    Frontiers in immunology

    2021  Volume 12, Page(s) 779709

    Abstract: ... associated lymphoid tissue is covered by a monolayer of epithelium containing microfold (M) cells ... Therefore, antigen uptake and the presence of M cells in TALT are not fully understood. The present study found ... that a small population of FAE cells in the TALT expressed intestinal M-cell markers, namely Sox8, Tnfaip2, GP2 ...

    Abstract The ocular mucosal tissues are exposed to potentially harmful foreign antigens in the air and tear fluid. The tear duct-associated lymphoid tissue (TALT) may contribute to immune surveillance in the eye region. Follicle-associated epithelium (FAE) of TALTs is classified as stratified squamous epithelium and consists of squamous epithelial cells arranged in layers on the basement membrane. In contrast, most mucosa-associated lymphoid tissue is covered by a monolayer of epithelium containing microfold (M) cells. Therefore, antigen uptake and the presence of M cells in TALT are not fully understood. The present study found that a small population of FAE cells in the TALT expressed intestinal M-cell markers, namely Sox8, Tnfaip2, GP2, and OPG. This cell population was identified as functional M cells because of their uptake capacity of luminal nanoparticles. In addition, RANKL, which is essential for M-cell differentiation, was expressed by stroma-like cells at the subepithelial region and its receptor RANK by the FAE in the TALT. The administration of RANKL markedly increased the number of Sox8
    MeSH term(s) Animals ; Epithelial Cells/immunology ; Immunologic Surveillance/immunology ; Lymphoid Tissue/immunology ; Mice ; Nasolacrimal Duct/immunology
    Language English
    Publishing date 2021-11-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.779709
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  6. Article ; Online: R/X exchange reactions in cis-[M(R)

    Itazaki, Masumi / Tsuchida, Noriko / Shigesato, Yuka / Takano, Keiko / Nakazawa, Hiroshi

    Dalton transactions (Cambridge, England : 2003)

    2016  Volume 45, Issue 48, Page(s) 19216–19220

    Abstract: R/X exchange reactions in cis-[M(R) ...

    Abstract R/X exchange reactions in cis-[M(R)
    Language English
    Publishing date 2016-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c6dt02314b
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  7. Article ; Online: Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization.

    Takano, Ikuko / Takeshita, Nobuo / Yoshida, Michiko / Seki, Daisuke / Oyanagi, Toshihito / Kimura, Seiji / Jiang, Wei / Sasaki, Kiyo / Sogi, Chisumi / Kawatsu, Masayoshi / Takano-Yamamoto, Teruko

    Journal of cellular physiology

    2020  Volume 236, Issue 4, Page(s) 2906–2919

    Abstract: Tenascin-like molecule major (Ten-m)/odd Oz (Odz), a type II transmembrane molecule, is well known ... to modulate neural development. We have reported that Ten-m/Odz3 is expressed in cartilaginous tissues and ... of Ten-m/Odz3 during chondrogenesis, focusing on RhoA and the actin cytoskeleton. Ten-m/Odz3 was ...

    Abstract Tenascin-like molecule major (Ten-m)/odd Oz (Odz), a type II transmembrane molecule, is well known to modulate neural development. We have reported that Ten-m/Odz3 is expressed in cartilaginous tissues and cells. Actin cytoskeleton and its regulator ras homolog gene family member A (RhoA) are closely associated with chondrogenesis. The present study aimed to evaluate the function and molecular mechanism of Ten-m/Odz3 during chondrogenesis, focusing on RhoA and the actin cytoskeleton. Ten-m/Odz3 was expressed in precartilaginous condensing mesenchyme in mouse limb buds. Ten-m/Odz3 knockdown in ATDC5 induced actin cytoskeleton reorganization and change of cell shape through modulation of RhoA activity and FGF2 expression. Ten-m/Odz3 knockdown suppressed ATDC5 migration and expression of genes associated with chondrogenesis, such as Sox9 and type II collagen, via RhoA. On the other hand, Ten-m/Odz3 knockdown inhibited proliferation of ATDC5 in a RhoA-independent manner. These findings suggest that Ten-m/Odz3 plays an important role in early chondrogenesis regulating RhoA-mediated actin reorganization.
    MeSH term(s) Actin Cytoskeleton/drug effects ; Actin Cytoskeleton/metabolism ; Actins/metabolism ; Animals ; Cell Differentiation/genetics ; Cell Line ; Cell Movement/genetics ; Cell Proliferation ; Cell Shape ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Chondrogenesis/genetics ; Fibroblast Growth Factor 2/metabolism ; Gene Expression Regulation ; Humans ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; rhoA GTP-Binding Protein/metabolism ; Mice
    Chemical Substances Actins ; Membrane Proteins ; Nerve Tissue Proteins ; TENM3 protein, human ; Tenm3 protein, mouse ; Fibroblast Growth Factor 2 (103107-01-3) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30058
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
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  8. Article ; Online: Randomized phase III trial comparing pegylated liposomal doxorubicin (PLD) at 50 mg/m² versus 40 mg/m² in patients with platinum-refractory and -resistant ovarian carcinoma: the JGOG 3018 Trial.

    Motohashi, Takashi / Yabuno, Akira / Michimae, Hiroshi / Ohishi, Tetsuro / Nonaka, Miwa / Takano, Masashi / Nishio, Shin / Fujiwara, Hiroyuki / Fujiwara, Keiichi / Kondo, Eiji / Sugiyama, Toru / Tabata, Tsutomu

    Journal of gynecologic oncology

    2020  Volume 32, Issue 1, Page(s) e9

    Abstract: Objective: The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks ... While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking ... for patients with platinum-resistant ovarian carcinoma between an experimental arm (40 mg/m² PLD) and ...

    Abstract Objective: The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking.
    Methods: This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with platinum-resistant ovarian carcinoma between an experimental arm (40 mg/m² PLD) and a standard arm (50 mg/m² PLD) until 10 courses, disease progression or unacceptable toxicity. Eligible patients had received ≤2 prior lines. Stratification was by performance status and PFS of prior chemotherapy (<3 months versus ≥3 months). The primary endpoint was PFS and secondary endpoints were overall survival (OS), toxicity profile, clinical response and tolerability. The total number of patients was 470.
    Results: The trial was prematurely closed due to slow recruitment, with 272 patients randomized to the experimental arm (n=137) and standard arm (n=135). Final analysis was performed with 234 deaths and 269 events for PFS. In the experimental arm vs. standard arm, median PFS was 4.0 months vs. 4.0 months (hazard ratio [HR]=1.065; 95% confidence interval [CI]=0.830-1.366) and median OS was 14.0 months vs. 14.0 months (HR=1.078; 95% CI=0.831-1.397). Hematologic toxicity and oral cavity mucositis (≥grade 2) were more frequent in the standard arm than in the experimental arm, but no difference was seen in ≥grade 2 hand-foot skin reaction.
    Conclusion: Non-inferiority of 2 PLD dosing schedule was not confirmed because the trial was closed prematurely. However, recommendation of dose reduction of PLD should be based both on efficacy and safety.
    Trial registration: UMIN Clinical Trials Registry Identifier: UMIN000003130.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Ovarian Epithelial/drug therapy ; Disease-Free Survival ; Doxorubicin/adverse effects ; Doxorubicin/analogs & derivatives ; Female ; Humans ; Ovarian Neoplasms/drug therapy ; Platinum/therapeutic use ; Polyethylene Glycols/adverse effects
    Chemical Substances liposomal doxorubicin ; Polyethylene Glycols (3WJQ0SDW1A) ; Platinum (49DFR088MY) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2020-11-10
    Publishing country Korea (South)
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2478405-9
    ISSN 2005-0399 ; 2005-0380
    ISSN (online) 2005-0399
    ISSN 2005-0380
    DOI 10.3802/jgo.2021.32.e9
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    Zs.A 6484: Show issues Location:
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  9. Article ; Online: Controlled Dimerization and Bonding Scheme of Icosahedral M@Au

    Ito, Emi / Takano, Shinjiro / Nakamura, Toshikazu / Tsukuda, Tatsuya

    Angewandte Chemie (International ed. in English)

    2020  Volume 60, Issue 2, Page(s) 645–649

    Abstract: Targeted syntheses of MM' ... ...

    Abstract Targeted syntheses of MM'Au
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202010342
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  10. Article: Photoluminescence of Doped Superatoms M@Au₁₂ (M = Ru, Rh, Ir) Homoleptically Capped by (Ph₂)PCH₂P(Ph₂): Efficient Room-Temperature Phosphorescence from Ru@Au₁₂

    Takano, Shinjiro / Hirai, Haru / Nakashima, Takuya / Iwasa, Takeshi / Taketsugu, Tetsuya / Tsukuda, Tatsuya

    Journal of the American Chemical Society. 2021 July 07, v. 143, no. 28

    2021  

    Abstract: A series of doped gold superatoms M@Au₁₂ (M = Ru, Rh, Ir) was synthesized by capping ... with the bidentate ligand (Ph₂)PCH₂P(Ph₂). A single-crystal X-ray diffraction analysis showed that all the M@Au₁₂ ...

    Abstract A series of doped gold superatoms M@Au₁₂ (M = Ru, Rh, Ir) was synthesized by capping with the bidentate ligand (Ph₂)PCH₂P(Ph₂). A single-crystal X-ray diffraction analysis showed that all the M@Au₁₂ superatoms had icosahedral motifs with a significantly higher symmetry than that of the pure Au₁₃ counterpart due to different coordination geometries. The Ru@Au₁₂ superatom exhibited a room-temperature phosphorescence with the highest quantum yield of 0.37 in deaerated dichloromethane. Density functional theory calculations suggested that the efficient phosphorescence is ascribed to a rapid intersystem crossing due to the similarity between the singlet and triplet excited states in terms of structure and energy.
    Keywords X-ray diffraction ; ambient temperature ; density functional theory ; energy ; gold ; ligands ; methylene chloride ; phosphorescence ; photoluminescence
    Language English
    Dates of publication 2021-0707
    Size p. 10560-10564.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c05019
    Database NAL-Catalogue (AGRICOLA)

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