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Article ; Online: Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity.

Firl, Christina E M / Halushka, Marc / Fraser, Nicola / Masson, Mala / Cuneo, Bettina F / Saxena, Amit / Clancy, Robert / Buyon, Jill

Frontiers in immunology

2023 Volume 14, Page(s) 1114808

Abstract: Background: Fibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies.: Objectives! ...

Abstract	Background: Fibrosis and dystrophic calcification disrupting conduction tissue architecture are histopathological lesions characterizing cardiac manifestations of neonatal lupus (cardiac-NL) associated with maternal anti-SSA/Ro antibodies. Objectives: Increased appreciation of heterogeneity in fibroblasts encourages re-examination of existing models with the consideration of multiple fibroblast subtypes (and their unique functional differences) in mind. This study addressed fibroblast heterogeneity by examining expression of α-Smooth Muscle Actin (myofibroblasts) and of S100 Calcium-Binding Protein A4 (S100A4). Methods: Using a previously established model of rheumatic scarring/fibrosis Results: S100A4 immunostaining was observed in 4 cardiac-NL hearts with positional identity in the conduction system at regions of dystrophic calcification but not fibrotic zones, the latter containing only myofibroblasts. Conclusions: These findings position the S100A4
MeSH term(s)	Infant, Newborn ; Humans ; Heart Block/etiology ; Heart Block/pathology ; Heart ; Biomarkers ; Calcinosis ; Fibrosis ; Fibroblasts/metabolism ; S100 Calcium-Binding Protein A4/metabolism
Chemical Substances	Biomarkers ; S100A4 protein, human (142662-27-9) ; S100 Calcium-Binding Protein A4
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1114808
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Article ; Online: The quality and content of hyperthermic intraperitoneal chemotherapy information available to patients: An evaluation of North American hyperthermic intraperitoneal chemotherapy websites.

Remer, Sarah L / Connelly, Tara M / Clancy, Cillian / DeBernardo, Robert / Joyce, Daniel / Steele, Scott R / Valente, Michael A

Surgery

2023 Volume 174, Issue 1, Page(s) 30–35

Abstract: Background: Patients commonly use the internet to obtain medical information. Patients in our outpatient setting frequently have incomplete or even incorrect information about hyperthermic intraperitoneal chemotherapy that they have found on the ... ...

Abstract	Background: Patients commonly use the internet to obtain medical information. Patients in our outpatient setting frequently have incomplete or even incorrect information about hyperthermic intraperitoneal chemotherapy that they have found on the internet. We aimed to assess the quality and content of Web-based information on hyperthermic intraperitoneal chemotherapy using validated and novel scoring systems. Methods: The keywords "HIPEC" and "hyperthermic intraperitoneal chemotherapy" were entered into the most commonly used internet search engines (Google, Bing, and Yahoo). The first 10 websites from each search were analyzed. Website quality was assessed using the validated Journal of the American Medical Association benchmark criteria and DISCERN scoring systems. We created a novel hyperthermic intraperitoneal chemotherapy-specific score with surgeon experts in the field. Results: Eighteen unique websites were identified. The majority (78%) were from academic institutions. The mean total DISCERN score for all websites was 41.8 ± 8.4 (maximum possible points = 75). The mean Journal of the American Medical Association and hyperthermic intraperitoneal chemotherapy-specific scores were 1.72 ± 1.13 (maximum possible score = 4) and 11.5 ± 4.5 (maximum possible score = 31), respectively. The lowest Journal of the American Medical Association scores were in the category of authorship. In total, 78% of websites omitted author details; 83% and 78% included the temperature and duration of hyperthermic intraperitoneal chemotherapy, respectively. Only 39% of websites mentioned complications of hyperthermic intraperitoneal chemotherapy. Conclusion: Web-based information on hyperthermic intraperitoneal chemotherapy is of variable content and quality. None of the websites achieved maximum scores using any of the scoring tools. Less than half of the websites provided any information on possible complications of the procedure. These findings should be highlighted to patients using the internet to obtain information about hyperthermic intraperitoneal chemotherapy.
MeSH term(s)	Humans ; Search Engine ; Internet ; Outpatients ; North America ; Comprehension ; Consumer Health Information
Language	English
Publishing date	2023-05-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2023.03.025
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Article ; Online: ApoL1 and the Immune Response of Patients with Systemic Lupus Erythematosus.

Blazer, Ashira D / Clancy, Robert M

Current rheumatology reports

2017 Volume 19, Issue 3, Page(s) 13

Abstract: Purpose of review: Systemic lupus erythematosus (SLE) confers up to a 50-fold increased risk of cardiovascular disease (CVD), and African Americans with SLE experience accelerated damage accrual and doubled cardiovascular risk when compared to their ... ...

Abstract	Purpose of review: Systemic lupus erythematosus (SLE) confers up to a 50-fold increased risk of cardiovascular disease (CVD), and African Americans with SLE experience accelerated damage accrual and doubled cardiovascular risk when compared to their European American counterparts. Recent findings: Genome-wide association studies have identified a substantial signal at 22q13, now assigned to variation at apolipoprotein L1 (APOL1), which has associated with progressive nondiabetic nephropathy, cardiovascular disease, and many immune-associated renal diseases, including lupus nephritis. We contend that alterations in crucial APOL1 intracellular pathways may underpin associated disease states based on structure-functional differences between variant and ancestral forms. While ancestral APOL1 may be a key driver of autophagy, nonconserved primary structure changes result in a toxic gain of function with attenuation of autophagy and an unsupervised pore-forming feature. Thus, the divergent intracellular biological pathways of ancestral and variant APOL1 may explain a worsened prognosis as demonstrated in SLE.
MeSH term(s)	Apolipoprotein L1 ; Apolipoproteins/genetics ; Apolipoproteins/physiology ; Autophagy/genetics ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/immunology ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Lipoproteins, HDL/genetics ; Lipoproteins, HDL/physiology ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Lupus Nephritis/genetics ; Lupus Nephritis/immunology
Chemical Substances	APOL1 protein, human ; Apolipoprotein L1 ; Apolipoproteins ; Lipoproteins, HDL
Language	English
Publishing date	2017-03-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-017-0637-9
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Article ; Online: Reply.

Buyon, Jill / Izmirly, Peter / Masson, Mala / Carlucci, Philip / Izmirly, Caroline G / Clancy, Robert / Cuneo, Bettina

Arthritis & rheumatology (Hoboken, N.J.)

2024

Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Letter
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42806
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Article ; Online: Multidisciplinary coordinated care of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease).

Alkhalid, Yasmine / Darji, Zeena / Shenkar, Robert / Clancy, Marianne / Dyamenahalli, Umesh / Awad, Issam A

Vascular medicine (London, England)

2023 Volume 28, Issue 2, Page(s) 153–165

Abstract: Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, is a rare disorder with a case prevalence as high as one in 5000, causing arteriovenous malformations in multiple organ systems. HHT is familial with autosomal dominant ...

Abstract	Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, is a rare disorder with a case prevalence as high as one in 5000, causing arteriovenous malformations in multiple organ systems. HHT is familial with autosomal dominant inheritance, with genetic testing allowing confirmation of the diagnosis in asymptomatic kindreds. Common clinical manifestations are epistaxis and intestinal lesions causing anemia and requiring transfusions. Pulmonary vascular malformations predispose to ischemic stroke and brain abscess and may cause dyspnea and cardiac failure. Brain vascular malformations can cause hemorrhagic stroke and seizures. Rarely, liver arteriovenous malformations can cause hepatic failure. A form of HHT can cause juvenile polyposis syndrome and colon cancer. Specialists in multiple fields may be called to care for one or more aspects of HHT, but few are familiar with evidence-based guidelines for HHT management or see a sufficient number of patients to gain experience with the unique characteristics of the disease. Primary care physicians and specialists are often unaware of the important manifestations of HHT in multiple systems and the thresholds for their screening and appropriate management. To improve familiarity, experience, and coordinated multisystem care for patients with HHT, the Cure HHT Foundation, which advocates for patients and families with this disease, has accredited 29 centers in North America with designated specialists for the evaluation and care of patients with HHT. Team assembly and current screening and management protocols are described as a model for evidence-based, multidisciplinary care in this disease.
MeSH term(s)	Humans ; Telangiectasia, Hereditary Hemorrhagic/diagnosis ; Telangiectasia, Hereditary Hemorrhagic/genetics ; Telangiectasia, Hereditary Hemorrhagic/therapy ; Arteriovenous Malformations/diagnostic imaging ; Arteriovenous Malformations/therapy ; Lung ; Central Nervous System Vascular Malformations ; Prevalence
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231151731
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Article ; Online: Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens.

Chaudhary, Shahid / Ali, Zahir / Tehseen, Muhammad / Haney, Evan F / Pantoja-Angles, Aarón / Alshehri, Salwa / Wang, Tiannyu / Clancy, Gerard J / Ayach, Maya / Hauser, Charlotte / Hong, Pei-Ying / Hamdan, Samir M / Hancock, Robert E W / Mahfouz, Magdy

Nature communications

2023 Volume 14, Issue 1, Page(s) 1464

Abstract: Antimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and their short plasma half-life render their clinical translation a challenge. ... ...

Abstract	Antimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and their short plasma half-life render their clinical translation a challenge. To address these shortcomings, we report efficient production of bioactive amidated AMPs by transient expression of glycine-extended AMPs in Nicotiana benthamiana line expressing the mammalian enzyme peptidylglycine α-amidating mono-oxygenase (PAM). Cationic AMPs accumulate to substantial levels in PAM transgenic plants compare to nontransgenic N. benthamiana. Moreover, AMPs purified from plants exhibit robust killing activity against six highly virulent and antibiotic resistant ESKAPE pathogens, prevent their biofilm formation, analogous to their synthetic counterparts and synergize with antibiotics. We also perform a base case techno-economic analysis of our platform, demonstrating the potential economic advantages and scalability for industrial use. Taken together, our experimental data and techno-economic analysis demonstrate the potential use of plant chassis for large-scale production of clinical-grade AMPs.
MeSH term(s)	Animals ; Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/pharmacology ; Antimicrobial Cationic Peptides/biosynthesis ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Peptides/biosynthesis ; Mammals ; Plants ; Nicotiana/chemistry ; Nicotiana/genetics ; Drug Resistance, Bacterial/drug effects
Chemical Substances	Anti-Bacterial Agents ; Antimicrobial Cationic Peptides ; Antimicrobial Peptides
Language	English
Publishing date	2023-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-37003-z
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Article ; Online: The modifying influence of HLA class II DQB1∗06:02 on the

Clancy, Robert M / Guthridge, Carla J / Marion, Miranda C / Guthridge, Joel / Howard, Timothy D / Izmirly, Peter M / Masson, Mala / Buyon, Jill P / James, Judith A / Langefeld, Carl D

Genes & diseases

2022 Volume 10, Issue 4, Page(s) 1169–1171

Language	English
Publishing date	2022-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2022.11.006
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Article ; Online: Chronic Exposure to Polystyrene Microplastic Fragments Has No Effect on Honey Bee Survival, but Reduces Feeding Rate and Body Weight.

Al Naggar, Yahya / Sayes, Christie M / Collom, Clancy / Ayorinde, Taiwo / Qi, Suzhen / El-Seedi, Hesham R / Paxton, Robert J / Wang, Kai

Toxics

2023 Volume 11, Issue 2

Abstract: Microplastics (MPs), in the form of fragments and fibers, were recently found in honey samples collected in Ecuador as well as in honey bees collected from Denmark and China. However, little is known about how MPs impact bee health. To fill this ... ...

Abstract	Microplastics (MPs), in the form of fragments and fibers, were recently found in honey samples collected in Ecuador as well as in honey bees collected from Denmark and China. However, little is known about how MPs impact bee health. To fill this knowledge gap, we investigated the potential toxicity of irregularly shaped polystyrene (PS)-MP fragments on honey bee health. In the first experiment of its kind with honey bees, we chronically exposed bees with a well-established gut microbiome to small (27 ± 17 µm) or large (93 ± 25 µm) PS-MP fragments at varying concentrations (1, 10, 100 µg mL
Language	English
Publishing date	2023-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11020100
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Article: APOL1

Blazer, Ashira / Qian, Yingzhi / Schlegel, Martin Paul / Algasas, Huda / Buyon, Jill P / Cadwell, Ken / Cammer, Michael / Heffron, Sean P / Liang, Feng-Xia / Mehta-Lee, Shilpi / Niewold, Timothy / Rasmussen, Sara E / Clancy, Robert M

Frontiers in genetics

2022 Volume 13, Page(s) 769936

Abstract: Polymorphisms in the Apolipoprotein L1 ( ...

Abstract	Polymorphisms in the Apolipoprotein L1 (
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.769936
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Article ; Online: Transplantation of kidneys after normothermic perfusion: A single center experience.

Pearson, Robert / Geddes, Colin / Mark, Patrick / Clancy, Marc / Asher, John

Clinical transplantation

2021 Volume 35, Issue 10, Page(s) e14431

Abstract: Background: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability.: Methods: Data was obtained from a prospectively ... ...

Abstract	Background: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability. Methods: Data was obtained from a prospectively maintained database between December 2012 and September 2018. Primary endpoints were incidence of delayed graft function (DGF) and estimated glomerular filtration rate (eGFR). Results: Six-hundred and thirty-two decease donor kidneys were transplanted, 229 from DCD donors, 29 of which had NRP. The DGF rate was lower for NRP versus DCD (six of 29, 20.7% vs. 70 of 200, 35.0%) with reduced duration of DGF. Multivariate analysis demonstrated transplant type to be a statistically significant independent predictor of eGFR at 7 and 14 days. Early transplant function in NRP kidneys was comparable to DBD. There were no graft losses within 30 days in the NRP group. One-year graft loss rate was 3.4% for NRP and 6.0% for standard DCD. Conclusion: This data suggests NRP is safe, and reduces rates of DGF and improves early renal transplant function.
MeSH term(s)	Delayed Graft Function/etiology ; Graft Survival ; Humans ; Kidney ; Organ Preservation ; Perfusion ; Tissue Donors
Language	English
Publishing date	2021-08-03
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14431
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