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Article: Maternal and Fetal Effects of Gestational Vitamin D Concentration.

Kwon, Ki-Wook / Lee, Young-Hyeon / Yeo, Min-Ho / Park, Sang-Hyun / Kim, Hye-Ran / Kim, Hye-Sook / Chang, Kyung-Soo

2023 Volume 11, Issue 16

Abstract: Most (90%) vitamin D synthesis occurs in the skin using sunlight (ultraviolet rays), and 10% is ... obtained through food. Vitamin D is an essential nutrient for skeletal growth and maintenance ... cell proliferation and differentiation, and immune function. This study investigated whether maternal serum vitamin D ...

Abstract	Most (90%) vitamin D synthesis occurs in the skin using sunlight (ultraviolet rays), and 10% is obtained through food. Vitamin D is an essential nutrient for skeletal growth and maintenance, cell proliferation and differentiation, and immune function. This study investigated whether maternal serum vitamin D concentrations induce maternofetal effects. Hematological analysis, serological changes, and precision fetal ultrasound findings were analyzed by maternal vitamin D concentration in gestational weeks 22-25 to ascertain direct effects on fetal growth. Bone density-vitamin D concentration correlation was analyzed. No hematologic or serological effect of maternal vitamin D concentration was detected; however, the sexually transmitted infection and cross-infection rates were inversely proportional to maternal vitamin D concentration. No significant correlation between vitamin D concentration and vertebral and femoral BMD was detected. For fetal growth, biparietal diameter, head circumference, abdominal circumference, femur length, and humerus length were analyzed. Humerus (
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11162325
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Article ; Online: Perception de l’annonce du diagnostic de cancer dans un cadre hospitalo-universitaire en Côte d’Ivoire. À propos de 120 patients suivis dans les services d’oncologie et d’onco-hématologie.

Touré, Petiori G Laurence / Kamara, Ismaël / Traoré, Samuel / Touré, Moctar / Adoubi, Innocent / Yéo-Ténéna, Jean-Marie

Bulletin du cancer

2022 Volume 109, Issue 6, Page(s) 679–684

Abstract: Background: The diagnostic of cancer is generally associated with a psychological shock. Body's defense mechanisms and drugs cannot resolve emotional distress and symptoms of cancer. A need for psychosocial management of the African patient is necessary. ...

Title translation	Perception of the cancer diagnosis announcement in a university hospital setting in Ivory Coast: About 120 patients followed in oncology and onco-hematology services.
Abstract	Background: The diagnostic of cancer is generally associated with a psychological shock. Body's defense mechanisms and drugs cannot resolve emotional distress and symptoms of cancer. A need for psychosocial management of the African patient is necessary. Objectif: Study of perception of the cancer diagnosis announcement by Ivory Coast patients suffering of cancer. Patients and methods: This is a bicenter retrospective and cross-sectional study which aims at describing data over a period of seven (7) months (November 2017 to May 2018). This study took place in the haematology and oncology departments respectively in CHU of Yopougon and Treichville. Patient recruitment was carried out exhaustively. The data was collected using a standardized questionnaire, developed in the french language, which was given individually under the direction of the oncopsychiatrist investigator. The investigation required the presence of an interpreter for patients who did not speak French. This study exhibits sociodemographic, clinical, therapeutical and medico-psychosocial data. So, 120 patients were included. Results: Breast's cancer was frequent (61%) and found at advanced stages (71%). Incurability and death's idea were 0.8% and 3.3%, respectively. Diagnostic announcement was good in 95% cases, but patients developed sadness (63.3%), denial (10%) and idea of suicide (3.4%). The psychosocial life of patients was affected by depressed state (35%). The therapeutical route was marked by medical treatment (42%), religious (41%), herbal treatment (9%). Altogether, 68.3% of patients had a social support, either given by friends (47.6%) or were financially supported (36.6 %) . Conclusion: This study was oriented towards formalization or integration of a psycho-oncological intervention during the management of a black patient group suffering from various cancers.
MeSH term(s)	Cote d'Ivoire ; Cross-Sectional Studies ; Hematology ; Hospitals ; Humans ; Neoplasms/diagnosis ; Neoplasms/psychology ; Neoplasms/therapy ; Perception ; Retrospective Studies ; Stress, Psychological/psychology
Language	French
Publishing date	2022-02-17
Publishing country	France
Document type	Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2021.08.014
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Article: Effects of Vitamin D Supplementation on Testosterone, Prostate, and Lower Urinary Tract Symptoms: A Prospective, Comparative Study.

Yeo, Jeong Kyun / Park, Sun Gu / Park, Min Gu

The world journal of men's health

2023 Volume 41, Issue 4, Page(s) 874–881

Abstract: Purpose: Several studies have associated the serum vitamin D level with total testosterone levels ... and the prostate volume. Herein, we investigated the effect of vitamin D supplementation ... years of age diagnosed with a vitamin D deficiency (25[OH]D <20 ng/mL) who received vitamin D ...

Abstract	Purpose: Several studies have associated the serum vitamin D level with total testosterone levels and the prostate volume. Herein, we investigated the effect of vitamin D supplementation on testosterone, prostate, and lower urinary tract symptoms (LUTS) in men. Materials and methods: Men over 40 years of age diagnosed with a vitamin D deficiency (25[OH]D <20 ng/mL) who received vitamin D supplementation for one year were included in the study and administered 25,000 IU of cholecalciferol every 2 weeks. Prostate ultrasound, uroflowmetry, postvoid residual urine volume measurement, and serological tests (serum testosterone levels, Results: A significant increase was observed in the vitamin D level following one year of vitamin D supplementation, with a significant decrease in the postvoid residual urine volume, total IPSS score and without a significant change in the prostate volume. Improved psychological subscale score of AMS questionnaire was observed with a statistical significance. Conclusions: Vitamin D supplementation suppressed the increase in the prostate volume and improved the LUTS. Although there is no direct effect on serum testosterone levels, vitamin D supplementation helped improve hypogonadal symptoms.
Language	English
Publishing date	2023-01-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2719786-4
ISSN	2287-4690 ; 2287-4208
ISSN (online)	2287-4690
ISSN	2287-4208
DOI	10.5534/wjmh.220180
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Article: Multicenter comparison of analytical interferences of 25-OH vitamin D immunoassay and mass spectrometry methods by endogenous interferents and cross-reactivity with 3-epi-25-OH-vitamin D

Lee, Joon Hee / Seo, Jong Do / Lee, Kyunghoon / Roh, Eun Youn / Yun, Yeo-Min / Lee, Yong-Wha / Cho, Sung-Eun / Song, Junghan

Practical laboratory medicine

2023 Volume 38, Page(s) e00347

Abstract: Background: Vitamin D (vit-D) deficiency is highly prevalent in the Korean population ... cross-reactive substances were compared between routine vit-D immunoassays and mass spectrometry (MS) methods ... 25-OH-D: Results: Significant interferences were observed in hemolytic (Roche), icteric (Beckman ...

Abstract	Background: Vitamin D (vit-D) deficiency is highly prevalent in the Korean population, highlighting the need for accurate measurements. In this study, the interferences by endogenous and cross-reactive substances were compared between routine vit-D immunoassays and mass spectrometry (MS) methods. Methods: Two MS methods and 4 immunoassays from different manufacturers (Abbott, Beckman Coulter, Roche, Siemens) were compared. Residual samples that were icteric, lipemic, hemolyzed, high in rheumatoid factor, from myeloma patients, or patients undergoing hemodialysis were collected. Also, 4 levels of National Institute of Standards and Technology (NIST) Standard Reference Material 972a, and 12 samples serially spiked with 3-epi-25-OH-D Results: Significant interferences were observed in hemolytic (Roche), icteric (Beckman and Siemens) and lipemic samples (all 4 immunoassays). Level 4 NIST material and 3-epi-25-OH-D Conclusion: Most observed interferences were consistent with manufacturers' claims, but overall improvement of immunoassay bias limits is required. Awareness of potential interference is important to increase the accuracy of vit-D measurements. Moreover, care is due when interpreting vit-D results of newborns, infants and less commonly, pregnant women, who are known to have physiologically high levels of the highly cross-reactive 3-epi-25-OH-D
Language	English
Publishing date	2023-12-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834973-8
ISSN	2352-5517
ISSN	2352-5517
DOI	10.1016/j.plabm.2023.e00347
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Article ; Online: Purpurin ameliorates D-galactose-induced aging phenotypes in mouse hippocampus by reducing inflammatory responses.

Kwon, Hyun Jung / Hahn, Kyu Ri / Nam, Sung Min / Yoon, Yeo Sung / Moon, Seung Myung / Hwang, In Koo / Kim, Dae Won

Neurochemistry international

2023 Volume 167, Page(s) 105552

Abstract: ... the effects of purpurin against D-galactose-induced aging phenotypes in mice. Exposure to 100 mM D-galactose ... dependent manner. Treatment with 6 mg/kg purpurin significantly improved D-galactose-induced memory ... significantly mitigated D-galactose-induced changes of microglial morphology in the mouse hippocampus and ...

Abstract	Purpurin, an anthraquinone, has potent anti-oxidant and anti-inflammatory effects in various types of brain damage. In a previous study, we showed that purpurin exerts neuroprotective effects against oxidative and ischemic damage by reducing pro-inflammatory cytokines. In the present study, we investigated the effects of purpurin against D-galactose-induced aging phenotypes in mice. Exposure to 100 mM D-galactose significantly decreased cell viability in HT22 cells, and purpurin treatment significantly ameliorated the reduction of cell viability, formation of reactive oxygen species, and lipid peroxidation in a concentration-dependent manner. Treatment with 6 mg/kg purpurin significantly improved D-galactose-induced memory impairment in the Morris water maze test in C57BL/6 mice and alleviated the reduction of proliferating cells and neuroblasts in the subgranular zone of the dentate gyrus. In addition, purpurin treatment significantly mitigated D-galactose-induced changes of microglial morphology in the mouse hippocampus and the release of pro-inflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α. In addition, purpurin treatment significantly ameliorated D-galactose-induced phosphorylation of c-Jun N-terminal kinase and cleavage of caspase-3 in HT22 cells. These results suggest that purpurin can delay aging by reducing the inflammatory cascade and phosphorylation of the c-Jun N-terminal in the hippocampus.
MeSH term(s)	Mice ; Animals ; Galactose/toxicity ; Mice, Inbred C57BL ; Aging/pathology ; Anthraquinones/pharmacology ; Hippocampus ; Cytokines ; Oxidative Stress
Chemical Substances	Galactose (X2RN3Q8DNE) ; purpurin anthraquinone (L1GT81LS6N) ; Anthraquinones ; Cytokines
Language	English
Publishing date	2023-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	283190-9
ISSN	1872-9754 ; 0197-0186
ISSN (online)	1872-9754
ISSN	0197-0186
DOI	10.1016/j.neuint.2023.105552
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Article ; Online: Predicting ablation zones with multislice volumetric 2-D magnetic resonance thermal imaging.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2021 Volume 38, Issue 1, Page(s) 907–915

Abstract: ... robotically-assisted (MRgRA) needle-based therapeutic ultrasound (NBTU) using multislice volumetric 2-D ... collateral tissue damage than current methods.: Objective: To correlate multislice volumetric 2-D MRTI ...

Abstract	Background: High-intensity focused ultrasound (HIFU) serves as a noninvasive stereotactic system for the ablation of brain metastases; however, treatments are limited to simple geometries and energy delivery is limited by the high acoustic attenuation of the calvarium. Minimally-invasive magnetic resonance-guided robotically-assisted (MRgRA) needle-based therapeutic ultrasound (NBTU) using multislice volumetric 2-D magnetic resonance thermal imaging (MRTI) overcomes these limitations and has potential to produce less collateral tissue damage than current methods. Objective: To correlate multislice volumetric 2-D MRTI volumes with histologically confirmed regions of tissue damage in MRgRA NBTU. Methods: Seven swine underwent a total of 8 frontal MRgRA NBTU lesions. MRTI ablation volumes were compared to histologic tissue damage on brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). Bland-Altman analyses and correlation trends were used to compare MRTI and TTC ablation volumes. Results: Data from the initial and third swine's ablations were excluded due to sub-optimal tissue staining. For the remaining ablations ( Conclusion: We used a volumetric MRTI technique to accurately track thermal changes during MRgRA NBTU in preparation for human trials. Improved volumetric coverage with MRTI enhanced our delivery of therapy and has far-reaching implications for focused ultrasound in the broader clinical setting.
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Brain/surgery ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; High-Intensity Focused Ultrasound Ablation ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Swine ; Ultrasonic Therapy
Language	English
Publishing date	2021-06-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.1080/02656736.2021.1936215
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Article ; Online: Multiplex LC-MS/MS for simultaneous determination of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D

Ko, Dae-Hyun / Jun, Sun-Hee / Nam, Youngwon / Song, Sang H / Han, Minje / Yun, Yeo-Min / Lee, Kyunghoon / Song, Junghan

The Journal of steroid biochemistry and molecular biology

2020 Volume 206, Page(s) 105796

Abstract: Bioavailable vitamin D and vitamin D metabolite ratio (VMR) have emerged as potential novel vitamin ... D markers. We developed a multiplex liquid chromatography-tandem mass spectrometry (LC-MS/MS) method ... to determine all elements necessary for the calculation of bioavailable vitamin D and VMR, including 25 ...

Abstract	Bioavailable vitamin D and vitamin D metabolite ratio (VMR) have emerged as potential novel vitamin D markers. We developed a multiplex liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to determine all elements necessary for the calculation of bioavailable vitamin D and VMR, including 25-hydroxyvitamin D [25-(OH)D] and 24,25-dihydroxyvitamin D
MeSH term(s)	24,25-Dihydroxyvitamin D 3/blood ; 24,25-Dihydroxyvitamin D 3/isolation & purification ; Biological Availability ; Calcifediol/pharmacology ; Chromatography, Liquid ; Humans ; Protein Isoforms/blood ; Protein Isoforms/isolation & purification ; Serum Albumin/isolation & purification ; Tandem Mass Spectrometry ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/genetics ; Vitamin D/isolation & purification ; Vitamin D/metabolism ; Vitamin D-Binding Protein/blood ; Vitamin D-Binding Protein/isolation & purification
Chemical Substances	Protein Isoforms ; Serum Albumin ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; 24,25-Dihydroxyvitamin D 3 (40013-87-4) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcifediol (P6YZ13C99Q)
Language	English
Publishing date	2020-11-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2020.105796
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Article ; Online: Structures and Biosynthetic Pathway of Pulvomycins B-D: 22-Membered Macrolides from an Estuarine

Moon, Kyuho / Cui, Jinsheng / Kim, Eunji / Riandi, Evan Setiawan / Park, So Hyun / Byun, Woong Sub / Kal, Youngju / Park, Jun Young / Hwang, Sunghoon / Shin, Daniel / Sun, Jeongyoon / Oh, Ki-Bong / Cha, Sangwon / Shin, Jongheon / Lee, Sang Kook / Yoon, Yeo Joon / Oh, Dong-Chan

Organic letters

2020 Volume 22, Issue 14, Page(s) 5358–5362

Abstract: Pulvomycins B-D ( ...

Abstract	Pulvomycins B-D (
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Macrolides/chemistry ; Macrolides/metabolism ; Macrolides/pharmacology ; Streptomyces/metabolism
Chemical Substances	Antineoplastic Agents ; Macrolides
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.0c01249
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Article ; Online: Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells.

Jeon, Hyunbum / Kim, Yeo Jin / Hwang, Su-Kyeong / Seo, Jinsoo / Mun, Ji Young

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: ... of lysosomes through restoration of cathepsin D in disease conditions. ...

Abstract	L-serine is a non-essential amino acid endogenously produced by astrocytes and is abundant in human diets. Beneficial roles of the metabolic products from L-serine in various conditions in the brain including neuronal development have been reported. Through several preclinical studies, L-serine treatment was also shown to offer beneficial therapeutic effects for brain damage such as ischemic stroke, amyotrophic lateral sclerosis, and Parkinson's disease. Despite evidence for the value of L-serine in the clinic, however, its beneficial effects on the propionic acid (PPA)-induced neuronal toxicity and underlying mechanisms of L-serine-mediated neuroprotection are unknown. In this study, we observed that PPA-induced acidic stress induces abnormal lipid accumulation and functional defects in lysosomes of hippocampal neurons. L-serine treatment was able to rescue the structure and function of lysosomes in PPA-treated hippocampal neuronal cells. We further identified that L-serine suppressed the formation of lipid droplets and abnormal lipid membrane accumulations inside the lysosomes in PPA-treated hippocampal neuronal cells. Taken together, these findings indicate that L-serine can be utilized as a neuroprotective agent for the functionality of lysosomes through restoration of cathepsin D in disease conditions.
MeSH term(s)	Cathepsin D/metabolism ; Humans ; Lysosomes/metabolism ; Neurons/metabolism ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacology ; Propionates/pharmacology ; Serine/metabolism ; Serine/pharmacology
Chemical Substances	Neuroprotective Agents ; Propionates ; Serine (452VLY9402) ; Cathepsin D (EC 3.4.23.5) ; propionic acid (JHU490RVYR)
Language	English
Publishing date	2022-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810613
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Article: Préparation du personnel de santé dune région sanitaire de Côte dIvoire face à la menace du virus Ebola.

Kouassi, Damus Paquin / Ekra, Kouadio Daniel / Angbo-Effi, Odile / Kouakou Ahoussou, Éric Martial / Bliabo, Guy Modeste / Yéo, Nawa Samuel / Coulibaly, Daouda / Dagnan, N Cho Simplice

Sante publique (Vandoeuvre-les-Nancy, France)

2016 Volume 28, Issue 1, Page(s) 113–122

Abstract: Introduction: Since the declaration of the Ebola virus disease outbreak in West Africa, the government of Ivory Coast has organized the training of medical staff in all health regions of the country. This study was conducted one month after this ... ...

Title translation	Preparation of healthcare workers against the threat of Ebola virus disease in Ivory Coast.
Abstract	Introduction: Since the declaration of the Ebola virus disease outbreak in West Africa, the government of Ivory Coast has organized the training of medical staff in all health regions of the country. This study was conducted one month after this training in order to assess the knowledge, attitudes and practices of health workers concerning Ebola virus disease in an Ivory Coast health region their preparation in relation to this disease. Methods: In May-June 2014, we conducted a descriptive cross-sectional study of 176 health workers from private and public health facilities in 5 health districts. Results: Among the respondents, 15.5% attended the training on Ebola disease organized by the Ministry of Health. They knew that the disease is transmitted from animals to humans by body fluids (85.6%), and from human to human by body fluids of a sick person or a cadavre (82.8%). 96% said they were at risk of contracting the disease. Discussion: In view of the persistent threat of the disease, ignorance of certain aspects of the disease could be a weakness in the prevention of nosocomial transmission of the disease. Knowledge of the disease should lead to adoption of prevention measures. However, routine use of protection equipment, including gloves, depends on its availability. Conclusion: The lack of infection prevention and control equipment could be a weak point in preparation of the response to an Ebola disease outbreak.
MeSH term(s)	Clinical Competence ; Cote d'Ivoire ; Cross-Sectional Studies ; Disease Transmission, Infectious/prevention & control ; Health Personnel/education ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/transmission ; Humans ; Inservice Training
Language	French
Publishing date	2016-01
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
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