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  1. Article ; Online: Health-care systems' resource footprints and their access and quality in 49 regions between 1995 and 2015: an input-output analysis.

    Andrieu, Baptiste / Marrauld, Laurie / Vidal, Olivier / Egnell, Mathis / Boyer, Laurent / Fond, Guillaume

    The Lancet. Planetary health

    2023  Volume 7, Issue 9, Page(s) e747–e758

    Abstract: Background: Strategies to reduce the environmental impact of health care are often limited to greenhouse gas emissions. To broaden their scope, our aim was to determine the evolution of the resource footprints, dependency, and efficiency of health-care ... ...

    Abstract Background: Strategies to reduce the environmental impact of health care are often limited to greenhouse gas emissions. To broaden their scope, our aim was to determine the evolution of the resource footprints, dependency, and efficiency of health-care systems and to determine the relationship between this evolution and their Healthcare Access and Quality (HAQ) index.
    Methods: We carried out an input-output analysis of 49 health-care systems from 1995 to 2015. We harmonised the EXIOBASE v3.8.2 database-providing data for 49 world regions-to the World Health Organization Health Expenditures Database. We then performed a panel data analysis to understand the relationship between Healthcare Access and Quality index and energy footprint per capita of health-care systems. EXIOBASE3 does not provide measurement errors so it was not possible to propagate the uncertainties as can be done with other input-output databases.
    Findings: Health-care systems' footprint increased over the past two decades, reaching 7% of global non-metallic minerals footprint, 4% of global metal ores footprint, and 5% of global fossil fuels footprint in 2013. This increase was mostly due to China, rising from 7% of the non-metallic minerals footprint in 1995 to 45% in 2013. 80% of the health-care systems studied were dependent at more than 50% on fossil fuel imports. The energy footprint per capita was correlated exponentially with the HAQ index but some countries performed much better than others at a given energy footprint. Health-care systems have not become more efficient between 2002 and 2015.
    Interpretation: Health-care systems' resources footprint are exponentially linked to their HAQ. Both prevention and efficiency measures will be needed to change this relationship. If it is not enough, high-income countries will have to choose between further reducing the resource consumption of their health-care systems or shifting the efforts to other sectors, health being considered an incompressible need. We call for the creation of a HAQE (health-care access, quality, and efficiency) index that would add resource efficiency to access and quality when ranking health-care systems.
    Funding: The Shift Project.
    MeSH term(s) Health Expenditures ; China ; Fossil Fuels ; Greenhouse Gases ; Health Facilities
    Chemical Substances Fossil Fuels ; Greenhouse Gases
    Language English
    Publishing date 2023-07-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2542-5196
    ISSN (online) 2542-5196
    DOI 10.1016/S2542-5196(23)00169-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Early Life Microbiota Is Not a Major Factor Underlying the Susceptibility to Postweaning Diarrhea in Piglets.

    Beaumont, Martin / Lencina, Corinne / Bertide, Allan / Gallo, Lise / Barilly, Céline / Marrauld, Christelle / Cauquil, Laurent / Samson, Arnaud / Combes, Sylvie

    Microbiology spectrum

    2023  Volume 11, Issue 4, Page(s) e0069423

    Abstract: Postweaning diarrhea (PWD) in piglets impair welfare, induce economic losses and lead to overuse of antibiotics. The early life gut microbiota was proposed to contribute to the susceptibility to PWD. The objective of our study was to evaluate in a large ... ...

    Abstract Postweaning diarrhea (PWD) in piglets impair welfare, induce economic losses and lead to overuse of antibiotics. The early life gut microbiota was proposed to contribute to the susceptibility to PWD. The objective of our study was to evaluate in a large cohort of 116 piglets raised in 2 separate farms whether the gut microbiota composition and functions during the suckling period were associated with the later development of PWD. The fecal microbiota and metabolome were analyzed by 16S rRNA gene amplicon sequencing and nuclear magnetic based resonance at postnatal day 13 in male and female piglets. The later development of PWD was recorded for the same animals from weaning (day 21) to day 54. The gut microbiota structure and α-diversity during the suckling period were not associated with the later development of PWD. There was no significant difference in the relative abundances of bacterial taxa in suckling piglets that later developed PWD. The predicted functionality of the gut microbiota and the fecal metabolome signature during the suckling period were not linked to the later development of PWD. Trimethylamine was the bacterial metabolite which fecal concentration during the suckling period was the most strongly associated with the later development of PWD. However, experiments in piglet colon organoids showed that trimethylamine did not disrupt epithelial homeostasis and is thus not likely to predispose to PWD through this mechanism. In conclusion, our data suggest that the early life microbiota is not a major factor underlying the susceptibility to PWD in piglets.
    MeSH term(s) Animals ; Female ; Male ; Swine ; RNA, Ribosomal, 16S/genetics ; Microbiota ; Diarrhea/veterinary ; Diarrhea/microbiology ; Methylamines ; Bacteria/genetics
    Chemical Substances trimethylamine (LHH7G8O305) ; RNA, Ribosomal, 16S ; Methylamines
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00694-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Climate change and health

    Marrauld, L / Cucchi, M / Lainey, E / Depoux, A

    European Journal of Public Health

    time for action!

    2020  Volume 30, Issue Supplement_5

    Abstract: Abstract Issue For several weeks, prophylactic messages against the extension of Covid-19 have saturated the public space. To protect populations, efficient measures have been rapidly put to limit the movement of people and manufactured goods. These ... ...

    Abstract Abstract Issue For several weeks, prophylactic messages against the extension of Covid-19 have saturated the public space. To protect populations, efficient measures have been rapidly put to limit the movement of people and manufactured goods. These policies have reduced global greenhouse gas emissions as well as air pollution, especially in China. Problem If climate change were an epidemic, we would probably have already restored it. But it results directly from the thermo-industrial activities linked to the consumption society. For Friel (Lancet, 2020), the dramatic consequences of this disturbances have to be considered as an essential health issue. She advocates for 'climate change and health alliances'. Results Within such alliances, health professionals have the responsibility (1) to describe the morbidity inherent in our thermo-industrial societies (2) to alert populations, and (3) to work with allies to tackle climate change and protect human populations, starting with the most vulnerable. This type of alliance is underway in the battle against air pollution, as it has been for years for fighting smoking. Alliances are intended to extend to all population health issues, with a complete decompartmentalization of minds and practices at large scale. Lessons Health professionals have to be mindful not to cause any harm while practicing. The health system alone produces up to 8% of global greenhouse gas in developed countries (Pichler, 2019; HCWH, 2019). There is room for action. Since 2009, the British health care system (NHS) has adopted an efficient decarbonation policy, reducing global emission from 8 to 4%, but this outstanding initiative remains an exception worldwide. Key messages A review of public health strategies is necessary to meet the energy, environmental and health issues, both in terms of health risks due to climate change and of decarbonation of care activities. Health professionals have the responsibility to alert populations and to work with allies to tackle climate change and protect human populations.
    Keywords Public Health, Environmental and Occupational Health ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckaa166.144
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Plea for the Evaluation of the Carbon Footprint of New Mini-invasive Surgical Technologies in Urology.

    Misrai, Vincent / Taille, Alexandre de la / Zorn, Kevin C / Marrauld, Laurie / Pon, Dominique / Shariat, Shahrokh F / Rouprêt, Morgan

    European urology

    2020  Volume 78, Issue 3, Page(s) 474–476

    MeSH term(s) Carbon Footprint ; Humans ; Minimally Invasive Surgical Procedures ; Urologic Surgical Procedures/methods
    Language English
    Publishing date 2020-03-21
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: [No title information]

    Laviolle, Bruno / Degon, Pierre-Frédéric / Gillet-Giraud, Cécile / Thiveaud, Dominique / Lechat, Philippe / Boïko-Alaux, Vera / Fougerou, Claire / Jolly, Clara / Petit, Abir / Rémy-Jouet, Isabelle / Yven, Raphaël / Bouret, Laurence / Marrauld, Laurie / Vaslet, Marie-Pierre / Delay, Virginie / Gavory, Anne-Laure / Olle, Florence / Langevin, Julie / Forteau, Louise

    Therapie

    2023  Volume 79, Issue 1, Page(s) 47–60

    Title translation Comment prendre en compte la dimension éco-responsable des produits de santé tout au long de leur cycle de vie?
    Language French
    Publishing date 2023-11-03
    Publishing country France
    Document type Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2023.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How can the environmental sustainability of healthcare products be taken into account throughout their life cycle?

    Laviolle, Bruno / Degon, Pierre-Frédéric / Gillet-Giraud, Cécile / Thiveaud, Dominique / Lechat, Philippe / Boïko-Alaux, Vera / Fougerou, Claire / Jolly, Clara / Petit, Abir / Rémy-Jouet, Isabelle / Yven, Raphaël / Bouret, Laurence / Marrauld, Laurie / Vaslet, Marie-Pierre / Delay, Virginie / Gavory, Anne-Laure / Olle, Florence / Langevin, Julie / Forteau, Louise

    Therapie

    2023  Volume 79, Issue 1, Page(s) 61–74

    Abstract: Healthcare product procurement accounts for around 50% of the French healthcare system's greenhouse gas emissions. This lesson learned from the publication of the Shift Project's work in November 2021 has been a catalyst within the healthcare system, ... ...

    Abstract Healthcare product procurement accounts for around 50% of the French healthcare system's greenhouse gas emissions. This lesson learned from the publication of the Shift Project's work in November 2021 has been a catalyst within the healthcare system, accelerating the consideration and implementation of actions aimed at reducing the environmental impact of the healthcare system, before, during and after care. In addition to their carbon footprint, healthcare products have a wide range of environmental impacts, including on water, air and soil, throughout their entire life cycle. We have chosen to divide this life cycle into four main stages: from research and development to production, distribution and market access, use and finally end-of-life management. Analysis of the regulatory framework at each stage and of existing initiatives described in the literature or by those in the field have structured and fuelled our thinking. We found that existing regulations focus exclusively on the health risk, with little or no consideration of the environmental risk, which is in itself a health risk. Furthermore, the implementation of certain structuring actions during the first 3 stages of the life cycle would make it possible to simplify or even eliminate the major problem of waste management associated with the end-of-life of healthcare products. With this in mind, we have produced 9 recommendations to ensure that the environmental impact of healthcare products is better taken into account throughout their life cycle.
    MeSH term(s) Humans ; Animals ; Greenhouse Effect ; Carbon Footprint ; Delivery of Health Care ; Life Cycle Stages ; Death
    Language English
    Publishing date 2023-12-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
    DOI 10.1016/j.therap.2023.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Soil Photosynthetic Microbial Communities Mediate Aggregate Stability: Influence of Cropping Systems and Herbicide Use in an Agricultural Soil.

    Crouzet, Olivier / Consentino, Laurent / Pétraud, Jean-Pierre / Marrauld, Christelle / Aguer, Jean-Pierre / Bureau, Sylvie / Le Bourvellec, Carine / Touloumet, Line / Bérard, Annette

    Frontiers in microbiology

    2019  Volume 10, Page(s) 1319

    Abstract: Edaphic cyanobacteria and algae have been extensively studied in dryland soils because they play key roles in the formation of biological soil crusts and the stabilization of soil surfaces. Yet, in temperate agricultural crop soils, little is understood ... ...

    Abstract Edaphic cyanobacteria and algae have been extensively studied in dryland soils because they play key roles in the formation of biological soil crusts and the stabilization of soil surfaces. Yet, in temperate agricultural crop soils, little is understood about the functional significance of indigenous photosynthetic microbial communities for various soil processes. This study investigated how indigenous soil algae and cyanobacteria affected topsoil aggregate stability in cereal cropping systems. Topsoil aggregates from conventional and organic cropping systems were incubated in microcosms under dark or photoperiodic conditions with or without a treatment with an herbicide (isoproturon). Physicochemical parameters (bound exopolysaccharides, organic carbon) and microbial parameters (esterase activity, chlorophyll
    Originality/significance: Edaphic algal and cyanobacterial communities are known to form photosynthetic microbial crusts in arid soils, where they drive key ecosystem functions. Although less well characterized, such communities are also transiently abundant in temperate and mesic cropped soils. This microcosm study investigated the communities' functional significance in topsoil aggregate formation and stabilization in two temperate cropping systems. Overall, our results showed that the development of indigenous microalgal communities under our experimental conditions drove higher structural stability in topsoil aggregates in temperate cropland soils. Also, herbicide use affected photosynthetic microbial communities and consequently impaired soil aggregation.
    Language English
    Publishing date 2019-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.01319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Digital health at the age of the Anthropocene.

    Chevance, Guillaume / Hekler, Eric B / Efoui-Hess, Maxime / Godino, Job / Golaszewski, Natalie / Gualtieri, Lisa / Krause, Andrew / Marrauld, Laurie / Nebeker, Camille / Perski, Olga / Simons, David / Taylor, Jennifer C / Bernard, Paquito

    The Lancet. Digital health

    2020  Volume 2, Issue 6, Page(s) e290–e291

    MeSH term(s) Delivery of Health Care ; Digital Technology/instrumentation ; Digital Technology/methods ; Ecosystem ; Environment ; Humans
    Language English
    Publishing date 2020-12-16
    Publishing country England
    Document type Letter
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(20)30130-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Optimisation of Direct Copper Determination in Human Breast Milk Without Digestion by Zeeman Graphite Furnace Atomic Absorption Spectrophotometry with Two Chemical Modifiers.

    Pineau, Alain / Fauconneau, Bernard / Marrauld, Annie / Lebeau, Alexandra / Hankard, Regis / Guillard, Olivier

    Biological trace element research

    2015  Volume 166, Issue 2, Page(s) 119–122

    Abstract: ... found to be 0.077 and 0.26 μmol/L, respectively. Within-run (n = 30) and between-run (n = 15) variations ... μmol/L. In conclusion, with minimal preparation and quick determination, the method proposed is ...

    Abstract Milk is an important food in the human diet, and copper (Cu) in human milk is indispensable to children's normal growth and development. It is consequently important that Cu deficiency, occurring in malnourished women or in malabsorption following bariatric surgery, be prevented. The objective of this work is to provide hospital-based paediatricians with a tool enabling rapid measurement of Cu in human breast milk through a technique that biology laboratories can easily apply. Using electrothermal atomic absorption spectrophotometry with Zeeman correction, we have optimized this method with two chemical modifiers and without digestion for analytical procedure. Detection limits and quantification limits for Cu in human milk were found to be 0.077 and 0.26 μmol/L, respectively. Within-run (n = 30) and between-run (n = 15) variations in a pool of human milk samples were 1.50 and 3.62%, respectively. Average recoveries ranged from 98.67 to 100.61%. The reliability of this method was also confirmed by analysing certified reference material (10%). In breast milk samples collected from 100 lactating mothers, Cu mean (±1 SD) was 7.09 ± 1.60 μmol/L. In conclusion, with minimal preparation and quick determination, the method proposed is suitable for measurement of Cu in human breast milk.
    MeSH term(s) Chemistry Techniques, Analytical ; Copper/analysis ; Humans ; Milk, Human/chemistry ; Spectrophotometry, Atomic
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-015-0249-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An analytical procedure for the determination of aluminum used in antiperspirants on human skin in Franz™ diffusion cell.

    Guillard, Olivier / Fauconneau, Bernard / Favreau, Frédéric / Marrauld, Annie / Pineau, Alain

    Toxicology mechanisms and methods

    2012  Volume 22, Issue 3, Page(s) 205–210

    Abstract: A local case report of hyperaluminemia (aluminum concentration: 3.88 µmol/L) in a woman using ... and quantification limits were set at ≤ 3 µg/L. Precision analysis as within-run (n = 12) and between ... run (n = 15-68 days) yield CV ≤ 6%. The high analytic sensitivity (2-3 µg/L) and low variability ...

    Abstract A local case report of hyperaluminemia (aluminum concentration: 3.88 µmol/L) in a woman using an aluminum-containing antiperspirant for 4 years raises the question of possible transdermal uptake of aluminum salt as a future public health problem. Prior to studying the transdermal uptake of three commercialized cosmetic formulas, an analytical assay of aluminum (Al) in chlorohydrate form (ACH) by Zeeman Electrothermal Atomic Absorption Spectrophotometer (ZEAAS) in a clean room was optimized and validated. This analysis was performed with different media on human skin using a Franz(™) diffusion cell. The detection and quantification limits were set at ≤ 3 µg/L. Precision analysis as within-run (n = 12) and between-run (n = 15-68 days) yield CV ≤ 6%. The high analytic sensitivity (2-3 µg/L) and low variability should allow an in vitro study of the transdermal uptake of ACH.
    MeSH term(s) Aluminum Compounds/analysis ; Antiperspirants/analysis ; Biological Assay/instrumentation ; Biological Assay/methods ; Biological Assay/standards ; Biopsy ; Calibration ; Diffusion Chambers, Culture ; Humans ; Limit of Detection ; Reproducibility of Results ; Skin/chemistry ; Spectrophotometry, Atomic
    Chemical Substances Aluminum Compounds ; Antiperspirants
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.3109/15376516.2011.610386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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