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  1. Article: Pelvis reconstruction by proximal femur upshifting and total hip arthroplasty after radical resection of an adolescent patient pelvic Ewing's sarcoma, a case report, and literature review.

    Mahran, Mohamed A / Khalifa, Ahmed A / El-Sayed, Amr

    International journal of surgery case reports

    2023  Volume 106, Page(s) 108146

    Abstract: Introduction and importance: Pelvis reconstruction after tumor resection poses a challenge, especially in younger patients where preserving the patient's function and mobility is paramount.: Case presentation: A 16 years old female presented in March ...

    Abstract Introduction and importance: Pelvis reconstruction after tumor resection poses a challenge, especially in younger patients where preserving the patient's function and mobility is paramount.
    Case presentation: A 16 years old female presented in March 2019 with vague right iliac area pain, diagnosed as pelvic Ewing's sarcoma after imaging studies (MRI and MSCT scan) and obtaining an incisional biopsy. After initial chemotherapy cycles, the tumor decreased in size, and surgical intervention in two stages was performed. The first stage was in October 2019 and consisted of pelvic resection type I and II according to Enneking and Dunham classification, proximal femur upshifting to compensate for the pelvic bone defect, and a cement spacer to fill the space of the resected proximal femur. The second stage was performed after two months and consisted of implanting a total hip arthroplasty using Megaprostheses and a cementless dual mobility acetabular cup. No local recurrence or distant metastases were detected during follow-ups. At the final follow up after 36 months, the patient showed acceptable functional outcomes (HHS score 83, and MSTS score 23 (76.7 %) points), and the radiographs showed proper implant positioning and stability.
    Clinical discussion: Treating pelvic Ewing's sarcoma requires a multidisciplinary team. After surgical resection, the pelvic reconstruction options include using allografts or autografts, femur upshifting, and hemipelvis prostheses, which should be chosen considering patients and tumor characteristics as well as surgical team efficiency.
    Conclusion: Reconstructing the pelvic defect after bone tumor resection by proximal femoral upshifting is a valid biological option with acceptable outcomes.
    Language English
    Publishing date 2023-04-12
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2023.108146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epigenetics and the role of nutraceuticals in health and disease.

    El-Sayed, Amr / Aleya, Lotfi / Kamel, Mohamed

    Environmental science and pollution research international

    2023  Volume 30, Issue 11, Page(s) 28480–28505

    Abstract: In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding ... ...

    Abstract In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding understanding of epigenetic mechanisms, as well as widespread acceptance of their hypothesized role in disease induction, facilitated the development of a number of novel diagnostic markers and therapeutic concepts. Epigenetic aberrations are reversible in nature, which enables the treatment of serious incurable diseases. Therefore, the interest in epigenetic modulatory effects has increased over the last decade, so about 60,000 publications discussing the expression of epigenetics could be detected in the PubMed database. Out of these, 58,442 were published alone in the last 10 years, including 17,672 reviews (69 historical articles), 314 clinical trials, 202 case reports, 197 meta-analyses, 156 letters to the editor, 108 randomized controlled trials, 87 observation studies, 40 book chapters, 22 published lectures, and 2 clinical trial protocols. The remaining publications are either miscellaneous or a mixture of the previously mentioned items. According to the species and gender, the publications included 44,589 human studies (17,106 females, 14,509 males, and the gender is not mentioned in the remaining papers) and 30,253 animal studies. In the present work, the role of epigenetic modulations in health and disease and the influencing factors in epigenetics are discussed.
    MeSH term(s) Male ; Animals ; Female ; Humans ; Epigenesis, Genetic ; Genomics ; Dietary Supplements
    Language English
    Publishing date 2023-01-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-25236-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetics and the role of nutraceuticals in health and disease

    El-Sayed, Amr / Aleya, Lotfi / Kamel, Mohamed

    Environ Sci Pollut Res. 2023 Mar., v. 30, no. 11 p.28480-28505

    2023  

    Abstract: In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding ... ...

    Abstract In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding understanding of epigenetic mechanisms, as well as widespread acceptance of their hypothesized role in disease induction, facilitated the development of a number of novel diagnostic markers and therapeutic concepts. Epigenetic aberrations are reversible in nature, which enables the treatment of serious incurable diseases. Therefore, the interest in epigenetic modulatory effects has increased over the last decade, so about 60,000 publications discussing the expression of epigenetics could be detected in the PubMed database. Out of these, 58,442 were published alone in the last 10 years, including 17,672 reviews (69 historical articles), 314 clinical trials, 202 case reports, 197 meta-analyses, 156 letters to the editor, 108 randomized controlled trials, 87 observation studies, 40 book chapters, 22 published lectures, and 2 clinical trial protocols. The remaining publications are either miscellaneous or a mixture of the previously mentioned items. According to the species and gender, the publications included 44,589 human studies (17,106 females, 14,509 males, and the gender is not mentioned in the remaining papers) and 30,253 animal studies. In the present work, the role of epigenetic modulations in health and disease and the influencing factors in epigenetics are discussed.
    Keywords biomarkers ; clinical trials ; databases ; dietary supplements ; epigenetics ; gender ; genome ; humans ; meta-analysis ; therapeutics
    Language English
    Dates of publication 2023-03
    Size p. 28480-28505.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    Note Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-25236-w
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Antiproliferative Activity of Some Newly Synthesized Substituted Pyridine Candidates Using 4-(Aaryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as Synthon.

    El-Sayed, Amira A / Elsayed, Elsayed A / Amr, Abd El-Galil E

    ACS omega

    2021  Volume 6, Issue 10, Page(s) 7147–7156

    Abstract: Herein, we used nicotinonitrile ... ...

    Abstract Herein, we used nicotinonitrile derivatives
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c00202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bovine mastitis prevention and control in the post-antibiotic era.

    El-Sayed, Amr / Kamel, Mohamed

    Tropical animal health and production

    2021  Volume 53, Issue 2, Page(s) 236

    Abstract: Mastitis is the most important disease in the dairy industry. Antibiotics are considered to be the first choice in the treatment of the disease. However, the problem of antibiotic residue and antimicrobial resistance, in addition to the impact of ... ...

    Abstract Mastitis is the most important disease in the dairy industry. Antibiotics are considered to be the first choice in the treatment of the disease. However, the problem of antibiotic residue and antimicrobial resistance, in addition to the impact of antibiotic abuse on public health, leads to many restrictions on uncontrolled antibiotic therapy in the dairy sector worldwide. Researchers have investigated novel therapeutic approaches to replace the use of antibiotics in mastitis control. These efforts, supported by the revolutionary development of nanotechnology, stem cell assays, molecular biological tools, and genomics, enabled the development of new approaches for mastitis-treatment and control. The present review discusses recent concepts to control mastitis such as breeding of mastitis-resistant dairy cows, the development of novel diagnostic and therapeutic tools, the application of communication technology as an educational and epidemiological tool, application of modern mastitis vaccines, cow drying protocols, teat disinfection, housing, and nutrition. These include the application of nanotechnology, stem cell technology, photodynamic and laser therapy or the use of traditional herbal medical plants, nutraceuticals, antibacterial peptides, bacteriocins, antibodies therapy, bacteriophages, phage lysins, and probiotics as alternatives to antibiotics.
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Bacteriocins ; Cattle ; Dairying ; Female ; Mammary Glands, Animal ; Mastitis, Bovine/drug therapy ; Mastitis, Bovine/prevention & control ; Milk ; Staphylococcal Infections/veterinary
    Chemical Substances Anti-Bacterial Agents ; Bacteriocins
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603363-5
    ISSN 1573-7438 ; 0049-4747
    ISSN (online) 1573-7438
    ISSN 0049-4747
    DOI 10.1007/s11250-021-02680-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Coronaviruses in humans and animals: the role of bats in viral evolution.

    El-Sayed, Amr / Kamel, Mohamed

    Environmental science and pollution research international

    2021  Volume 28, Issue 16, Page(s) 19589–19600

    Abstract: Bats act as a natural reservoir for many viruses, including coronaviruses, and have played a crucial epidemiological role in the emergence of many viral diseases. Coronaviruses have been known for 60 years. They are usually responsible for the induction ... ...

    Abstract Bats act as a natural reservoir for many viruses, including coronaviruses, and have played a crucial epidemiological role in the emergence of many viral diseases. Coronaviruses have been known for 60 years. They are usually responsible for the induction of mild respiratory signs in humans. However, since 2002, the bat-borne virus started to induce fatal epidemics according to WHO reports. In this year, the first serious human coronavirus epidemic (severe acute respiratory syndrome; SARS) occurred (China, 8098 cases, 774 deaths [9.5% of the cases] in 17 countries). The case fatality was higher in elderly patients above 60 years and reached 50% of the cases. SARS epidemic was followed 10 years later by the emergence of the middle east respiratory syndrome (MERS) in Saudi Arabia (in 2012, 2260 cases, 803 deaths [35.5% of the cases] in 27 countries). Finally, in December 2019, a new epidemic in Wuhan, China, (corona virus disease 2019, COVID-19) emerged and could spread to 217 countries infecting more than 86,255,226 cases and killing 1,863,973 people by the end of 2020. There are many reasons why bats are ideal reservoir hosts for viral diseases such as the tolerance of their immune system to the invading viruses for several months. They can actively shed the viruses, although they develop no clinical signs (will be discussed in details later in the review). Bats were directly or indirectly involved in the three previous coronavirus epidemics. The indirect transmission takes place via intermediate hosts including civet cats for SARS and dromedary camels in the case of MERS. Although bats are believed to be the source of COVID-19 pandemic, direct pieces of evidence are still lacking. Therefore, coronaviruses' role in epidemics induction and the epidemiological role of bats are discussed. The current work also presents different evidence (phylogenetic data, animal experiments, bats artificial infection studies, and computerized models of SARS-CoV2 evolution) that underline the involvement of bats in the epidemiology of the pandemic.
    MeSH term(s) Aged ; Animals ; COVID-19 ; China/epidemiology ; Chiroptera ; Humans ; Pandemics ; Phylogeny ; RNA, Viral ; SARS-CoV-2 ; Saudi Arabia
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-03-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-12553-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Climatic changes and their role in emergence and re-emergence of diseases.

    El-Sayed, Amr / Kamel, Mohamed

    Environmental science and pollution research international

    2020  Volume 27, Issue 18, Page(s) 22336–22352

    Abstract: Global warming and the associated climate changes are predictable. They are enhanced by burning of fossil fuels and the emission of huge amounts of ... ...

    Abstract Global warming and the associated climate changes are predictable. They are enhanced by burning of fossil fuels and the emission of huge amounts of CO
    MeSH term(s) Animals ; Climate Change ; Disease Vectors ; Ecosystem ; Europe ; Humans ; North America
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-020-08896-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Future threat from the past.

    El-Sayed, Amr / Kamel, Mohamed

    Environmental science and pollution research international

    2020  Volume 28, Issue 2, Page(s) 1287–1291

    Abstract: Global warming is one of the major challenges facing humanity. The increase in the Earth's temperature and thawing of ancient ice release viable viruses, bacteria, fungi, and other microorganisms which were trapped for thousands and millions of years. ... ...

    Abstract Global warming is one of the major challenges facing humanity. The increase in the Earth's temperature and thawing of ancient ice release viable viruses, bacteria, fungi, and other microorganisms which were trapped for thousands and millions of years. Such microorganisms may belong to novel microbial species, unknown genotypes of present pathogens, already eradicated pathogens, or even known pathogens that gained extremely robust characteristics due to their subjection to long-term stress. These worries drew more attention following the death of a child by ancient anthrax spores in Siberian in 2016 and the reconstruction of smallpox and Spanish flu genomes from ancient frozen biological samples. The present review illustrates some examples of recently recovered pathogens after being buried for millions of years, including some identified viable ancient viruses, bacteria and even other forms of life. While some pathogens could be revived, genomes of other ancient pathogens which could not be revived were re-constructed. The present study aims to highlight and alarm the hidden aspect of global warming on the international public health, which represents future threats from the past for humanity.
    MeSH term(s) Bacteria/genetics ; Child ; Fungi ; Global Warming ; Humans ; Influenza Pandemic, 1918-1919 ; Viruses/genetics
    Keywords covid19
    Language English
    Publishing date 2020-10-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-020-11234-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prognostic value of arterial lactate index in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: a prospective cohort study.

    Abdel-Salam, Ahmed / El-Sayed, Amr / Abdel-Haseeb, Ahmed / Ibrahim, Mostafa

    Future cardiology

    2023  Volume 19, Issue 16, Page(s) 767–777

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/surgery ; Prognosis ; Prospective Studies ; Lactic Acid ; Percutaneous Coronary Intervention/methods ; Treatment Outcome
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274267-0
    ISSN 1744-8298 ; 1479-6678
    ISSN (online) 1744-8298
    ISSN 1479-6678
    DOI 10.2217/fca-2023-0065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma

    Bjad K. Almutairy / El-Sayed Khafagy / Amr Selim Abu Lila

    Gels, Vol 9, Iss 12, p

    2023  Volume 952

    Abstract: The objective of the current study was to fabricate a thermosensitive in situ gelling system for the ocular delivery of carvedilol-loaded spanlastics (CRV-SPLs). In situ gel formulations were prepared using poloxamer analogs by a cold method and was ... ...

    Abstract The objective of the current study was to fabricate a thermosensitive in situ gelling system for the ocular delivery of carvedilol-loaded spanlastics (CRV-SPLs). In situ gel formulations were prepared using poloxamer analogs by a cold method and was further laden with carvedilol-loaded spanlastics to boost the precorneal retention of the drug. The gelation capacity, rheological characteristics, muco-adhesion force and in vitro release of various in situ gel formulations (CS-ISGs) were studied. The optimized formula (F2) obtained at 22% w / v poloxamer 407 and 5% w / v poloxamer 188 was found to have good gelation capacity at body temperature with acceptable muco-adhesion properties, appropriate viscosity at 25 °C that would ease its ocular application, and relatively higher viscosity at 37 °C that promoted prolonged ocular residence of the formulation post eye instillation and displayed a sustained in vitro drug release pattern. Ex vivo transcorneal penetration studies through excised rabbit cornea revealed that F2 elicited a remarkable ( p ˂ 0.05) improvement in CRV apparent permeation coefficient (P app = 6.39 × 10 −6 cm/s) compared to plain carvedilol-loaded in situ gel (CRV-ISG; P app = 2.67 × 10 −6 cm/s). Most importantly, in normal rabbits, the optimized formula (F2) resulted in a sustained intraocular pressure reduction and a significant enhancement in the ocular bioavailability of carvedilol, as manifested by a 2-fold increase in the AUC 0–6h of CRV in the aqueous humor, compared to plain CRV-ISG formulation. To sum up, the developed thermosensitive in situ gelling system might represent a plausible carrier for ophthalmic drug delivery for better management of glaucoma.
    Keywords carvedilol ; glaucoma ; in situ gel ; poloxamer ; spanlastics ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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