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Article ; Online: Investigations of an organic-inorganic nanotheranostic hybrid for pancreatic cancer therapy using cancer-in-a-dish and

David, Karolyn Infanta / Ravikumar, T S / Sethuraman, Swaminathan / Krishnan, Uma Maheswari

2022 Volume 18, Issue 1

Abstract: The incidence of highly aggressive pancreatic cancer is increasing across the globe and is projected to increase to 18.6% by 2050. The mortality rate for this form of cancer is very high and the 5 y relative survival rate is only about 9%-10%. The 3D ... ...

Abstract	The incidence of highly aggressive pancreatic cancer is increasing across the globe and is projected to increase to 18.6% by 2050. The mortality rate for this form of cancer is very high and the 5 y relative survival rate is only about 9%-10%. The 3D pancreatic cancer microenvironment exerts a major influence on the poor survival rate. A key factor is the prevention of the penetration of the chemotherapeutic drugs in the three-dimensional (3D) microenvironment leading to the development of chemoresistance which is a major contributor to the survival rates. Hence,
MeSH term(s)	Humans ; Theranostic Nanomedicine ; Spheroids, Cellular/pathology ; Cell Line, Tumor ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Antineoplastic Agents/pharmacology ; Tumor Microenvironment ; Pancreatic Neoplasms
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ac9cb2
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Article: Comparison of Furlow's Double Opposing Z-plasty and Straight-Line Intravelar Veloplasty as Methods of Cleft Palate Repair.

Mahajan, Ravikumar / Tambotra, Ankush / Ghildiyal, Harish / Singh, Mahipal / Thussu, Thakur / Bhamre, Abhishek / Srinivasan, Krishnan

Cureus

2024 Volume 16, Issue 1, Page(s) e52897

Abstract: Background One of the common craniofacial abnormalities is cleft lip and palate. Various surgical procedures have been employed to repair the cleft. However, immediate post-operative complications and formation of palatal fistula post surgery are common ... ...

Abstract	Background One of the common craniofacial abnormalities is cleft lip and palate. Various surgical procedures have been employed to repair the cleft. However, immediate post-operative complications and formation of palatal fistula post surgery are common in surgical procedures. The study aims to compare the fistula rate, soft palate lengthening, and immediate complications of cleft palate repair of Furlow's Z-plasty and straight-line intravelar veloplasty techniques. Method Fifty Patients with isolated or unilateral cleft palate and lip with age between 9-18 months were randomly divided into two groups. One group underwent Furlow's Z-plasty while the other underwent straight-line intravelar veloplasty procedures. Post surgery, after discharge, the patients were followed up at 2 weeks, 1 month, and 3 months intervals. Immediate post-operative complications and fistula formation rate were compared along with other parameters like fistula width, duration of the procedure, intra-operative soft palate length, etc. Results Straight-line procedures took less time as compared to Furlow's Z-plasty. Bleeding (N=2, 8%) and dehiscence (N=1, 4%) of the wound were the immediate post-operative complications found in the straight-line group. Bleeding was also present in the Furlow's group (N=1, 4%). At 1-month follow-up, in the straight-line group (N=3, 12%) patients had fistula while (N=2, 8%) had minimal nasal regurgitation of liquids when compared to the Furlow's group. At 3-month follow-up, patients in the straight-line procedure group (three out of N=25, 12%) exhibited fistula, whereas in the Furlow's group, fistula occurrence was observed in one out of N=25 participants (4%). Intra-operative soft palate lengthening was 6.44 ± 0.768 mm and 1.64 ± 0.952 mm in the Furlow and straight-line groups, respectively. Conclusion Furlow's Z-plasty was observed to be the better surgical procedure for cleft repair as it had low immediate post-operative complications, and fistula development and had higher intra-operative soft palate lengthening.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52897
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Article ; Online: Development and evaluation of a multi-functional organic-inorganic nanotheranostic hybrid for pancreatic cancer therapy.

David, Karolyn Infanta / Ravikumar, T S / Sethuraman, Swaminathan / Krishnan, Uma Maheswari

Biomedical materials (Bristol, England)

2021 Volume 16, Issue 5

Abstract: Pancreatic cancer is a highly invasive disease with low survival rates. The high death rates associated with pancreatic cancer are due to multiple factors including late stage diagnosis, multi-drug resistance, invasive nature and restricted access of the ...

Abstract	Pancreatic cancer is a highly invasive disease with low survival rates. The high death rates associated with pancreatic cancer are due to multiple factors including late stage diagnosis, multi-drug resistance, invasive nature and restricted access of the therapeutic moiety to the cancer cells due to the stroma. Smart multifunctional nanocarriers that deliver the therapeutic agent in to the cancer tissue as well as enable imaging of the tissue represent an emerging paradigm in cancer therapy. Accurate and reliable detection of cancerous lesions in pancreas is essential for designing appropriate therapeutic strategy to annihilate the highly aggressive pancreatic cancer. A combination of imaging modalities can enhance the reliability of cancer detection. In this context, we report here a hybrid iron oxide-gold nanoparticle with dual contrast enhancing ability for both magnetic resonance imaging (MRI) and micro-computed tomography (micro-CT) that is co-encapsulated with the nucleotide analogue gemcitabine in a chitosan matrix. The theranostic system displayed enhanced cytotoxicity against PanC-1 pancreatic cancer cells when compared to normal cells over 48 h due to differences in cell internalization. The iron oxide-gold hybrid enabled visualization of the theranostic nanoparticle by MRI as well as micro-CT. Further, the magnetocaloric effect of the iron oxide enabled faster release of the chemotherapeutic agent as well as augmented the cytotoxicity by inducing hyperthermia. This system holds promise for further exploration as an integrated diagnostic and therapeutic platform for pancreatic cancer.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Chitosan/chemistry ; Contrast Media/chemistry ; Contrast Media/pharmacokinetics ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/chemistry ; Deoxycytidine/pharmacology ; Gold/chemistry ; Humans ; Magnetic Resonance Imaging ; Magnetite Nanoparticles/chemistry ; Pancreas/metabolism ; Pancreatic Neoplasms/metabolism ; Theranostic Nanomedicine/methods
Chemical Substances	Antineoplastic Agents ; Contrast Media ; Magnetite Nanoparticles ; Deoxycytidine (0W860991D6) ; Gold (7440-57-5) ; Chitosan (9012-76-4) ; gemcitabine (B76N6SBZ8R)
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ac177c
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Article ; Online: Malignant Transformation of Hypertrophic Lichen Planus in a Young Pregnant Woman: A Case Report.

Ravikumar, Bharathi / Kumudhini, S / Krishnan, S

The international journal of lower extremity wounds

2019 Volume 19, Issue 4, Page(s) 388–390

Abstract: In this article, we report a case of hypertrophic lichen planus transforming into cutaneous squamous cell carcinoma in a 24-year-old Indian woman at 34 weeks of gestational age. We hypothesize that immunologic alterations during pregnancy could transform ...

Abstract	In this article, we report a case of hypertrophic lichen planus transforming into cutaneous squamous cell carcinoma in a 24-year-old Indian woman at 34 weeks of gestational age. We hypothesize that immunologic alterations during pregnancy could transform a long-standing hypertrophic lichen planus into cutaneous neoplasm.
Language	English
Publishing date	2019-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171119-7
ISSN	1552-6941 ; 1534-7346
ISSN (online)	1552-6941
ISSN	1534-7346
DOI	10.1177/1534734619881584
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Article ; Online: The importance of rapid assessment tools in evaluating mental health in emergency departments among patients with chronic diseases.

Vallath, Aditya Lal / Sivasubramanian, Barath Prashanth / Ravikumar, Diviya Bharathi / Lalendran, Akshita / Krishnan, Suhasini / Samanta, Sudeshna / Banerjee, Snigda / Das, Tania / Kundu, Ritwick / Richharia, Vyom / More, Ravisha / Khithani, Mishika / Nazimudeen, Sahana / Gunturu, Sasidhar / Dasgupta, Indraneel

Frontiers in public health

2024 Volume 12, Page(s) 1258749

Abstract: Background: Rapid screening tools such as the WHO well-being Index (WWBI), Six-item screener (SIS), and the CLOX-1 test can be used to assess overall mental health and cognition, respectively. We sought to evaluate mental health with cognition in ... ...

Abstract	Background: Rapid screening tools such as the WHO well-being Index (WWBI), Six-item screener (SIS), and the CLOX-1 test can be used to assess overall mental health and cognition, respectively. We sought to evaluate mental health with cognition in individuals with chronic diseases and stable vital signs presenting to the Emergency Department (ED). Methods: An observational study in the ED with 279 participants was conducted. Results: Chronic diseases were more prevalent among 51-70 years (43.4%) and diabetes was most common (58.8%). Fever (22.6%) and GI bleeding (32.6%) presentation were high. Participants with low WWBI had low SIS compared to the ones with higher scores (83.3% vs. 17.7%, Conclusion: In the ED, the evaluation of mental health even among cognitive impaired is feasible and crucial.
MeSH term(s)	Humans ; Chronic Disease ; Cognition Disorders/diagnosis ; Cognitive Dysfunction ; Emergency Service, Hospital ; Mental Health ; Middle Aged ; Aged
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1258749
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Article ; Online: Apoptolysis: a less understood concept in the pathogenesis of Pemphigus Vulgaris.

Ramani, Pratibha / Ravikumar, Renu / Pandiar, Deepak / Monica, K / Krishnan, Reshma Poothakulath / Ramasubramanian, Abilasha / Sukumaran, Gheena

Apoptosis : an international journal on programmed cell death

2022 Volume 27, Issue 5-6, Page(s) 322–328

Abstract: Pemphigus Vulgaris (PV) is a severe autoimmune disease characterized by supra-basal blisters in the skin and mucous membranes of a wide range of mammals, including humans. It not only affects the skin but also has severe oral manifestations. It has been ... ...

Abstract	Pemphigus Vulgaris (PV) is a severe autoimmune disease characterized by supra-basal blisters in the skin and mucous membranes of a wide range of mammals, including humans. It not only affects the skin but also has severe oral manifestations. It has been stated that auto-antibodies are produced, for unknown reasons, which are directed against desmogleins present on the epithelium and thus leads to acantholysis and intraepithelial blistering. But the exact mechanism is still not completely understood. Here we would like to shed light on a new pathologic mechanism i.e., apoptolysis, which emphasizes that apoptotic enzymes contribute to acantholysis development both in terms of molecular events and chronologic sequence. A possible role of apoptolysis has been discussed in purview of PV.
MeSH term(s)	Acantholysis/etiology ; Acantholysis/pathology ; Animals ; Apoptosis ; Humans ; Mammals ; Pemphigus/etiology ; Pemphigus/pathology ; Skin
Language	English
Publishing date	2022-04-20
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1452360-7
ISSN	1573-675X ; 1360-8185
ISSN (online)	1573-675X
ISSN	1360-8185
DOI	10.1007/s10495-022-01726-z
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Article ; Online: Role of halogen-halogen contacts in the crystal structures of three new solvates of the drug oxyclozanide.

Sridhar, Balasubramanian / Ravikumar, Krishnan

Acta crystallographica. Section C, Structural chemistry

2017 Volume 73, Issue Pt 12, Page(s) 1056–1063

Abstract: Halogen-halogen contacts are electrostatic in nature and exhibit directionality similar to hydrogen bonds. Oxyclozanide [systematic name: 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide] is a drug used for the treatment of ... ...

Abstract	Halogen-halogen contacts are electrostatic in nature and exhibit directionality similar to hydrogen bonds. Oxyclozanide [systematic name: 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide] is a drug used for the treatment of fascioliasis in domestic animals. The molecule carries five chlorine substituents and represents an ideal candidate for the study of halogen bonds in the crystal. Three new crystalline solvates of oxyclozanide, namely, oxyclozanide benzene hemisolvate, C
Language	English
Publishing date	2017-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2025703-X
ISSN	2053-2296 ; 1600-5759 ; 0108-2701
ISSN (online)	2053-2296 ; 1600-5759
ISSN	0108-2701
DOI	10.1107/S2053229617015923
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Article ; Online: Insights into the molecular basis of hypergravity-induced root growth phenotype in bread wheat (Triticum aestivum L.).

Sathasivam, Malarvizhi / Swamy, Basavalingayya K / Krishnan, Kushagra / Sharma, Rita / Nayak, Spurthi N / Uppar, D S / Hosamani, Ravikumar

Genomics

2022 Volume 114, Issue 2, Page(s) 110307

Abstract: Hypergravity is a condition where the force of gravity exceeds that on the surface of the Earth and can be simulated by centrifugation. Previously, a significant increase in root growth phenotype was observed when wheat seeds were exposed to hypergravity ...

Abstract	Hypergravity is a condition where the force of gravity exceeds that on the surface of the Earth and can be simulated by centrifugation. Previously, a significant increase in root growth phenotype was observed when wheat seeds were exposed to hypergravity (10 g for 12 h). In the present study, we investigated the molecular basis of this change through root transcriptome. The data revealed a total of 3765 up-regulated and 2102 down-regulated transcripts in response to hypergravity. GO enrichment analysis revealed hormonal responses, cell division, and cell-wall-related terms were significantly enriched in hypergravity. The increased isoform level expression of transcripts involved in auxin biosynthesis, transport, and signaling was observed. Further, enhanced expression of cell division transcripts and down-regulation of cell number regulator genes suggests rapid cell division. Overexpression of cellulose and hemicellulose biosynthesis transcripts suggests demand for cell-wall constituents. Collectively, this study identified candidate genes associated with hypergravity-induced enhanced root growth.
MeSH term(s)	Bread ; Cell Wall/genetics ; Cell Wall/metabolism ; Gene Expression Regulation, Plant ; Hypergravity ; Phenotype ; Triticum/metabolism
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2022.110307
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Article: Insights into the molecular basis of hypergravity-induced root growth phenotype in bread wheat (Triticum aestivum L.)

Sathasivam, Malarvizhi / Swamy, Basavalingayya K. / Krishnan, Kushagra / Sharma, Rita / Nayak, Spurthi N. / Uppar, D.S. / Hosamani, Ravikumar

Genomics. 2022 Mar., v. 114, no. 2

2022

Abstract	Hypergravity is a condition where the force of gravity exceeds that on the surface of the Earth and can be simulated by centrifugation. Previously, a significant increase in root growth phenotype was observed when wheat seeds were exposed to hypergravity (10 g for 12 h). In the present study, we investigated the molecular basis of this change through root transcriptome. The data revealed a total of 3765 up-regulated and 2102 down-regulated transcripts in response to hypergravity. GO enrichment analysis revealed hormonal responses, cell division, and cell-wall-related terms were significantly enriched in hypergravity. The increased isoform level expression of transcripts involved in auxin biosynthesis, transport, and signaling was observed. Further, enhanced expression of cell division transcripts and down-regulation of cell number regulator genes suggests rapid cell division. Overexpression of cellulose and hemicellulose biosynthesis transcripts suggests demand for cell-wall constituents. Collectively, this study identified candidate genes associated with hypergravity-induced enhanced root growth.
Keywords	Triticum aestivum ; auxins ; biosynthesis ; cell division ; cellulose ; centrifugation ; genomics ; gravity ; hemicellulose ; phenotype ; root growth ; transcriptome ; wheat
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2022.110307
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: DNA Targeting Long-Chain Alkoxy Appended Tin(IV) Porphyrin Scaffolds: Photophysical and Antimicrobial PDT Investigations.

Ravikumar, Murugan / Raghav, Darpan / Rathinasamy, Krishnan / Kathiravan, Arunkumar / Mothi, Ebrahim M

ACS applied bio materials

2018 Volume 1, Issue 5, Page(s) 1705–1716

Abstract: Tin(IV) porphyrin scaffolds having long-chain ( ... ...

Abstract	Tin(IV) porphyrin scaffolds having long-chain (C
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.8b00507
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