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Article ; Online: Clindamycin: An Unusual Cause of Acute Kidney Injury.

Subedi, Pratima / Chowdhury, Ayesha / Tanovic, Kristina / Dumic, Igor

2019 Volume 20, Page(s) 248–251

Abstract: BACKGROUND Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, ... ...

Abstract	BACKGROUND Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, the most commonly implicated agents are aminoglycosides, cephalosporins, trimethoprim-sulfamethoxazole, acyclovir, and amphotericin. Despite its widespread use, clindamycin has been rarely associated with AKI. CASE REPORT A 52-year-old male patient with type II insulin dependent diabetes mellitus without diabetic nephropathy was treated with clindamycin for chronic osteomyelitis. Five days following initiation of therapy, he developed nausea, poor appetite, decrease in urine output, and profound generalized weakness. His symptoms were initially attributed to gastrointestinal side effects of clindamycin and he was advised to take it with food and to hydrate himself vigorously. Despite this change, his symptoms progressed and he developed hematuria and AKI which prompted hospital admission. Extensive workup for AKI that included evaluation for pre-renal, intrinsic renal, and post-renal etiologies failed to point to other etiologies apart from clindamycin-induced AKI. Following cessation of medication and temporary renal replacement therapy (RRT), his renal function returned to baseline. CONCLUSIONS We present a case of clindamycin-induced AKI that was diagnosed after a delay due to uremia symptoms being mistakenly attributed to gastrointestinal side effects of clindamycin. Although rare, clindamycin can be a cause of AKI and clinician should be aware of this association in order to recognize and treat it in timely manner.
MeSH term(s)	Acute Kidney Injury/etiology ; Anti-Bacterial Agents/adverse effects ; Clindamycin/adverse effects ; Humans ; Male ; Middle Aged ; Osteomyelitis/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Clindamycin (3U02EL437C)
Language	English
Publishing date	2019-02-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.913779
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae

Jun Huang / David Rowe / Pratima Subedi / Wei Zhang / Tyler Suelter / Barbara Valent / David E. Cook

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 18

Abstract: In this work, Huang and colleagues describe variation in DNA repair outcomes due to distinct repair mechanisms following CRISPR targeting of different loci in the plant pathogenic fungus Magnaporthe oryzae. ...

Abstract	In this work, Huang and colleagues describe variation in DNA repair outcomes due to distinct repair mechanisms following CRISPR targeting of different loci in the plant pathogenic fungus Magnaporthe oryzae.
Keywords	Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae.

Huang, Jun / Rowe, David / Subedi, Pratima / Zhang, Wei / Suelter, Tyler / Valent, Barbara / Cook, David E

Nature communications

2022 Volume 13, Issue 1, Page(s) 7168

Abstract: CRISPR-Cas mediated genome engineering has revolutionized functional genomics. However, understanding of DNA repair following Cas-mediated DNA cleavage remains incomplete. Using Cas12a ribonucleoprotein genome editing in the fungal pathogen, Magnaporthe ... ...

Abstract	CRISPR-Cas mediated genome engineering has revolutionized functional genomics. However, understanding of DNA repair following Cas-mediated DNA cleavage remains incomplete. Using Cas12a ribonucleoprotein genome editing in the fungal pathogen, Magnaporthe oryzae, we detail non-canonical DNA repair outcomes from hundreds of transformants. Sanger and nanopore sequencing analysis reveals significant variation in DNA repair profiles, ranging from small INDELs to kilobase size deletions and insertions. Furthermore, we find the frequency of DNA repair outcomes varies between loci. The results are not specific to the Cas-nuclease or selection procedure. Through Ku80 deletion analysis, a key protein required for canonical non-homologous end joining, we demonstrate activity of an alternative end joining mechanism that creates larger DNA deletions, and uses longer microhomology compared to C-NHEJ. Together, our results suggest preferential DNA repair pathway activity in the genome that can create different mutation profiles following repair, which could create biased genome variation and impact genome engineering and genome evolution.
MeSH term(s)	CRISPR-Cas Systems/genetics ; DNA Breaks, Double-Stranded ; Mutation ; DNA/genetics
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-34736-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Current Utility of Plant Growth-Promoting Rhizobacteria as Biological Control Agents towards Plant-Parasitic Nematodes

Subedi, Pratima / Gattoni, Kaitlin / Liu, Wenshan / Lawrence, Kathy S / Park, Sang-Wook

Plants. 2020 Sept. 09, v. 9, no. 9

2020

Abstract: Plant-parasitic nematodes (PPN) are among the most economically and ecologically damaging pests, causing severe losses of crop production worldwide. Chemical-based nematicides have been widely used, but these may have adverse effects on human health and ... ...

Abstract	Plant-parasitic nematodes (PPN) are among the most economically and ecologically damaging pests, causing severe losses of crop production worldwide. Chemical-based nematicides have been widely used, but these may have adverse effects on human health and the environment. Hence, biological control agents (BCAs) have become an alternative option for controlling PPN, since they are environmentally friendly and cost effective. Lately, a major effort has been made to evaluate the potential of a commercial grade strain of plant growth-promoting rhizobacteria (PGPR) as BCAs, because emerging evidence has shown that PGPR can reduce PPN in infested plants through direct and/or indirect antagonistic mechanisms. Direct antagonism occurs by predation, release of antinematicidal metabolites and semiochemicals, competition for nutrients, and niche exclusion. However, the results of direct antagonism may be inconsistent due to unknown endogenous and exogenous factors that may prevent PGPR from colonizing plant’s roots. On the other hand, indirect antagonism may occur from the induced systemic resistance (ISR) that primes whole plants to better fight against various biotic and abiotic constraints, actuating faster and/or stronger defense responses (adaption), enhancing their promise as BCAs. Hence, this review will briefly revisit (i) two modes of PGPR in managing PPN, and (ii) the current working models and many benefits of ISR, in the aim of reassessing current progresses and future directions for isolating more effective BCAs and/or developing better PPN management strategy.
Keywords	adverse effects ; antagonism ; biological control agents ; cost effectiveness ; crop production ; metabolites ; models ; nematicides ; nutrients ; plant growth-promoting rhizobacteria ; plant parasitic nematodes ; predation ; roots ; semiochemicals ; systemic acquired resistance
Language	English
Dates of publication	2020-0909
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants9091167
Database	NAL-Catalogue (AGRICOLA)

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Article: Current Utility of Plant Growth-Promoting Rhizobacteria as Biological Control Agents towards Plant-Parasitic Nematodes.

Subedi, Pratima / Gattoni, Kaitlin / Liu, Wenshan / Lawrence, Kathy S / Park, Sang-Wook

Plants (Basel, Switzerland)

2020 Volume 9, Issue 9

Abstract	Plant-parasitic nematodes (PPN) are among the most economically and ecologically damaging pests, causing severe losses of crop production worldwide. Chemical-based nematicides have been widely used, but these may have adverse effects on human health and the environment. Hence, biological control agents (BCAs) have become an alternative option for controlling PPN, since they are environmentally friendly and cost effective. Lately, a major effort has been made to evaluate the potential of a commercial grade strain of plant growth-promoting rhizobacteria (PGPR) as BCAs, because emerging evidence has shown that PGPR can reduce PPN in infested plants through direct and/or indirect antagonistic mechanisms. Direct antagonism occurs by predation, release of antinematicidal metabolites and semiochemicals, competition for nutrients, and niche exclusion. However, the results of direct antagonism may be inconsistent due to unknown endogenous and exogenous factors that may prevent PGPR from colonizing plant's roots. On the other hand, indirect antagonism may occur from the induced systemic resistance (ISR) that primes whole plants to better fight against various biotic and abiotic constraints, actuating faster and/or stronger defense responses (adaption), enhancing their promise as BCAs. Hence, this review will briefly revisit (i) two modes of PGPR in managing PPN, and (ii) the current working models and many benefits of ISR, in the aim of reassessing current progresses and future directions for isolating more effective BCAs and/or developing better PPN management strategy.
Language	English
Publishing date	2020-09-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants9091167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lesson from COVID-19: restructuring the current health system and policies in Nepal

Subedi, Madhusudan Subedi Prativa

Applied Science and Technology Annals

Abstract: Although COVID-19 pandemic has created a state of alarm worldwide, the downfall in health and economy is rather paramount in low income countries Nepal, due to its inadequate health resources and poor health system, is more vulnerable to the plight But ... ...

Abstract	Although COVID-19 pandemic has created a state of alarm worldwide, the downfall in health and economy is rather paramount in low income countries Nepal, due to its inadequate health resources and poor health system, is more vulnerable to the plight But on a positive note, the weaknesses that have been exposed can be taken as lessons to learn With the policies committed to achieving health as the fundamental right of people as per the constitution, capacity building, intersectoral coordination, preventive, promotive and curative facilities, and appropriate strategies and preparedness plan, Nepal can combat the pandemic and develop a resilient and well-functioning health system in future Now is a moment of historic opportunity Public health program must be strengthened as soon as possible by ensuring that at least minimum requirement are in place at the province and municipality levels and media partnership should be created to prevent societal fear Furthermore, this is an opportunity to implement the power devolution in federal republic of Nepal
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #926193
Database	COVID19

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Article ; Online: Lesson from COVID-19

Subedi, Madhusudan / Subedi, Prativa

Applied Science and Technology Annals; Vol 1 No; 183-186 ; 2717-5014

restructuring the current health system and policies in Nepal

2020 Volume 1, Issue : COVID-19 Special Issue

Abstract: Although COVID-19 pandemic has created a state of alarm worldwide, the downfall in health and economy is rather paramount in low income countries. Nepal, due to its inadequate health resources and poor health system, is more vulnerable to the plight. But ...

Abstract	Although COVID-19 pandemic has created a state of alarm worldwide, the downfall in health and economy is rather paramount in low income countries. Nepal, due to its inadequate health resources and poor health system, is more vulnerable to the plight. But on a positive note, the weaknesses that have been exposed can be taken as lessons to learn. With the policies committed to achieving health as the fundamental right of people as per the constitution, capacity building, intersectoral coordination, preventive, promotive and curative facilities, and appropriate strategies and preparedness plan, Nepal can combat the pandemic and develop a resilient and well-functioning health system in future. Now is a moment of historic opportunity. Public health program must be strengthened as soon as possible by ensuring that at least minimum requirement are in place at the province and municipality levels and media partnership should be created to prevent societal fear. Furthermore, this is an opportunity to implement the power devolution in federal republic of Nepal
Keywords	covid19
Subject code	300
Language	English
Publishing date	2020-06-30
Publisher	Research Centre for Applied Science and Technology (RECAST), Tribhuvan University, Kathmandu, Nepal
Publishing country	np
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Emergency Caesarean Section in a COVID-19 Infected Mother in a Primary Health Care Centre.

Kc, Anil / Subedi, Prativa / Dahal, Sujata / Poudel, Ujjawal

JNMA; journal of the Nepal Medical Association

2022 Volume 60, Issue 249, Page(s) 494–496

Abstract: People from rural areas of Nepal struggle to have access to adequate medical care on time. Most of the tertiary centres are overburdened by patients, while the peripheral health facilities have been unable to function efficiently due to a lack of ... ...

Abstract	People from rural areas of Nepal struggle to have access to adequate medical care on time. Most of the tertiary centres are overburdened by patients, while the peripheral health facilities have been unable to function efficiently due to a lack of infrastructures and skilled manpower needed to run hospitals smoothly. We present a case of a 21-year-old primigravida at 41 weeks and 3 days of gestation with mild COVID-19 symptoms who underwent a Caesarean section for non-progression of labour and foetal distress at a primary health care centre in Nepal; however, both maternal and foetal outcomes were favourable. Therefore, upgrading the quality of care in peripheral health facilities can help in the achievement of accessibility, equity, and quality in health care service in Nepal. Keywords: caesarean section; COVID-19; health equity; Nepal; primary health care.
MeSH term(s)	Adult ; COVID-19 ; Cesarean Section ; Female ; Health Facilities ; Humans ; Labor, Obstetric ; Mothers ; Pregnancy ; Primary Health Care ; Young Adult
Language	English
Publishing date	2022-05-05
Publishing country	Nepal
Document type	Case Reports ; Journal Article
ZDB-ID	2209910-4
ISSN	1815-672X ; 0028-2715
ISSN (online)	1815-672X
ISSN	0028-2715
DOI	10.31729/jnma.7450
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association of urinary albumin-to-creatinine ratio with lipid abnormalities and glycemic control in patients with type 2 diabetes mellitus.

Khadka, Sitaram / Yadav, Gopal K / Subedi, Prativa / Amgain, Kapil / Sharma, Arun / Joshi, Rinku

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 9, Page(s) 4329–4333

Abstract: Introduction: While proteinuria aggravates dyslipidemia in diabetic patients, dyslipidemia further worsens proteinuria via inflammatory cytokines-mediated glomerular damage. Urinary albumin creatinine ratio (ACR) is an easy and reliable method of ... ...

Abstract	Introduction: While proteinuria aggravates dyslipidemia in diabetic patients, dyslipidemia further worsens proteinuria via inflammatory cytokines-mediated glomerular damage. Urinary albumin creatinine ratio (ACR) is an easy and reliable method of detecting proteinuria. This study aims to determine the association of ACR with lipid abnormalities and glycemic control in the Nepalese population. Methods: This was a cross-sectional study conducted among 201 diabetes patients visiting the outpatient department of internal medicine. Based on ACR values, patients were categorized as nonalbuminuric (less than 300 μg/mg) or albuminuric (more than 300 μg/mg). An unpaired Results: Albuminuric patients had higher mean cholesterol (192.8±53.5 vs. 184.2± 37.6; Conclusions: Urine ACR of more than 30 mg/gram was associated with higher triglyceride and low-density lipoprotein levels and lower high-density lipoprotein levels. The HbA1c level strongly correlates with the development of albuminuria.
Language	English
Publishing date	2023-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antibiotic Prophylaxis in Patients On Extracorporeal Membrane Oxygenation: A Systematic Review.

Sah, Ranjit / Shah, Sangam / Subedi, Prativa / Kashyap, Ashutosh / Kc, Anil / Wosti, Deepa / Sanghavi, Devang / Bhattacharyya, Anirban / Guru, Pramod / Chaudhary, Sanjay

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2024

Abstract: Despite the frequent use of prophylactic antibiotics in hospitals for extracorporeal membrane oxygenation (ECMO) patients, the Extracorporeal Life Support Organization (ELSO) Infectious Disease Task Force does not recommend routine antibiotic prophylaxis ...

Abstract	Despite the frequent use of prophylactic antibiotics in hospitals for extracorporeal membrane oxygenation (ECMO) patients, the Extracorporeal Life Support Organization (ELSO) Infectious Disease Task Force does not recommend routine antibiotic prophylaxis due to a lack of compelling evidence. We assessed the effectiveness of prophylactic antibiotics in ECMO patients. We conducted a comprehensive search of multiple databases from their inception up to September 6, 2023, on various databases using keywords like "antibiotics," "prophylaxis," "extracorporeal membrane oxygenation," and "ECMO." Newcastle-Ottawa Scale (NOS) was used to assess the quality of the included research. We collected data using Microsoft Excel version 2016, mean and standard deviations were calculated for continuous data, while frequencies and percentages were calculated for binomial data. A total of three studies was included in the review with a total of 8,954 participants, of which 4,483 (50.06%) received antibiotic prophylaxis, and 1,131 (25.22%) were female. The administration of antibiotics prophylactically was associated with reduction in rate of mortality, the risk of infections, and complications like acute kidney injury and diarrhea. Although there have been some benefits on antibiotic prophylaxis, prospective research, and possibly the creation of tailored, ECMO-specific bundles will be needed to identify efficient ways to prevent ECMO infection.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000002192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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