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  1. Book ; Thesis: Interactions of Klebsiella pneumoniae with host cells and their contribution to pathogenesis

    Sahly, Hany

    (Schriften des Instituts für Medizinische Mikrobiologie und Virologie der Christian-Albrechts-Universität zu Kiel ; 6)

    2003  

    Author's details Hany Sahly
    Series title Schriften des Instituts für Medizinische Mikrobiologie und Virologie der Christian-Albrechts-Universität zu Kiel ; 6
    Collection
    Keywords Friedländer-Bakterium ; Wirtszelle ; Wechselwirkung ; Pathogenese
    Subject Wechselwirkungen ; Interaktion ; Klebsiella pneumoniae ; Friedländer-Bazillus
    Language German
    Size XII, 115 S. : graph. Darst., 21 cm, 192 gr.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tel Aviv, Univ., Diss., 2002
    HBZ-ID HT014768998
    ISBN 3-8322-1656-1 ; 978-3-8322-1656-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 3759 order for loan Magazin

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  2. Book ; Thesis: Seroepidemiologische und zellbiologische Untersuchungen zur Rolle von Klebsiella-Serotypen in der HLA-B27-assoziierten Spondylitis ankylosans (Morbus Bechterew)

    Sahly, Hany

    (Schriften des Instituts für Medizinische Mikrobiologie und Virologie der Christian-Albrechts-Universität zu Kiel ; 5)

    2003  

    Author's details Hany Sahly
    Series title Schriften des Instituts für Medizinische Mikrobiologie und Virologie der Christian-Albrechts-Universität zu Kiel ; 5
    Collection
    Keywords Bechterew-Krankheit ; Pathogenese ; HLA-System ; Klebsiella ; Granulozyt ; Phagozytose ; Cytologie
    Subject Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle ; Human leucocyte antigen-system ; Histokompatibilitäts-Antigen-System ; Transplantations-Antigen-System ; Humanes Leukozyten-Antigen-System ; Phagocytose ; Granulocyt ; Granulocyten ; Granulozyten ; Ankylosierende Spondylitis ; Spondylarthritis ankylopoetica ; Spondylitis ankylopoetica ; Spondylitis ankylosans ; Morbus Bechterew ; Bechterew-Strümpell-Marie-Krankheit
    Language German
    Size 156 S. : Ill., graph. Darst., 21 cmm, 240 gr.
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Habil.-Schr., 2000
    HBZ-ID HT014776074
    ISBN 3-8322-1655-3 ; 978-3-8322-1655-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 3832 order for loan Magazin

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  3. Book ; Thesis: Vergleichende Untersuchungen über Hämagglutinine bei Klebsiella species verschiedener Herkunft

    Sahly, Hany

    1990  

    Author's details vorgelegt von Hany Sahly
    Keywords Klebsiella ; Hemagglutinins / analysis
    Size [2], 28 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1990
    HBZ-ID HT003932687
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Impact of Chain Length on Release Behavior of Modified Polyethylene Glycol Intercalated-Montmorillonite Nanocomposite.

    Al-Sahly, Mosaed / El-Hamshary, Hany / Al-Deyab, Salem S

    Journal of nanoscience and nanotechnology

    2020  Volume 20, Issue 9, Page(s) 5546–5554

    Abstract: A new drug delivery nanocomposite system was prepared from sodium montmorillonite ( ... ...

    Abstract A new drug delivery nanocomposite system was prepared from sodium montmorillonite (Na
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4899
    ISSN (online) 1533-4899
    DOI 10.1166/jnn.2020.17860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhancing the Antifungal Activity of Griseofulvin by Incorporation a Green Biopolymer-Based Nanocomposite.

    Shehabeldine, Amr / El-Hamshary, Hany / Hasanin, Mohamed / El-Faham, Ayman / Al-Sahly, Mosaed

    Polymers

    2021  Volume 13, Issue 4

    Abstract: Fungal biofilms have caused several medical problems, resulting in significant morbidity and mortality as well as poor response to antifungal drugs. The current study was designed to evaluate the enhancement of antifungal and anti-biofilm activity of ... ...

    Abstract Fungal biofilms have caused several medical problems, resulting in significant morbidity and mortality as well as poor response to antifungal drugs. The current study was designed to evaluate the enhancement of antifungal and anti-biofilm activity of Griseofulvin-loaded green nanocomposite-based biopolymers (Ge-Nco) of glycogen and gelatin against different strains of pathogenic
    Language English
    Publishing date 2021-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13040542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches.

    Sahly, Nora Naif / Banaganapalli, Babajan / Sahly, Ahmed N / Aligiraigri, Ali H / Nasser, Khalidah K / Shinawi, Thoraia / Mohammed, Arif / Alamri, Abdulhakeem S / Bondagji, Nabeel / Elango, Ramu / Shaik, Noor Ahmad

    Systems biology in reproductive medicine

    2021  Volume 67, Issue 3, Page(s) 209–220

    Abstract: Uterine smooth muscular neoplastic growths like benign leiomyomas (UL) and metastatic leiomyosarcomas (ULMS) share similar clinical symptoms, radiological and histological appearances making their clinical distinction a difficult task. Therefore, the ... ...

    Abstract Uterine smooth muscular neoplastic growths like benign leiomyomas (UL) and metastatic leiomyosarcomas (ULMS) share similar clinical symptoms, radiological and histological appearances making their clinical distinction a difficult task. Therefore, the objective of this study is to identify key genes and pathways involved in transformation of UL to ULMS through molecular differential analysis. Global gene expression profiles of 25 ULMS, 25 UL, and 29 myometrium (Myo) tissues generated on Affymetrix U133A 2.0 human genome microarrays were analyzed by deploying robust statistical, molecular interaction network, and pathway enrichment methods. The comparison of expression signals across Myo vs UL, Myo vs ULMS, and UL vs ULMS groups identified 249, 1037, and 716 significantly expressed genes, respectively (p ≤ 0.05). The analysis of 249 DEGs from Myo vs UL confirms multistage dysregulation of various key pathways in extracellular matrix, collagen, cell contact inhibition, and cytokine receptors transform normal myometrial cells to benign leiomyomas (p value ≤ 0.01). The 716 DEGs between UL vs ULMS were found to affect cell cycle, cell division related Rho GTPases and PI3K signaling pathways triggering uncontrolled growth and metastasis of tumor cells (p value ≤ 0.01). Integration of gene networking data, with additional parameters like estimation of mutation burden of tumors and cancer driver gene identification, has led to the finding of 4 hubs (JUN, VCAN, TOP2A, and COL1A1) and 8 bottleneck genes (PIK3R1, MYH11, KDR, ESR1, WT1, CCND1, EZH2, and CDKN2A), which showed a clear distinction in their distribution pattern among leiomyomas and leiomyosarcomas. This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.
    MeSH term(s) Female ; Gene Regulatory Networks ; Humans ; Leiomyoma/genetics ; Leiomyosarcoma/genetics ; Phosphatidylinositol 3-Kinases ; Uterine Neoplasms/genetics
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2417234-0
    ISSN 1939-6376 ; 1939-6368
    ISSN (online) 1939-6376
    ISSN 1939-6368
    DOI 10.1080/19396368.2021.1876179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1377: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Impact of the SARS-CoV-2 pandemic on health-care workers.

    Harrison, Darren / Muradali, Komal / El Sahly, Hana / Bozkurt, Biykem / Jneid, Hani

    Hospital practice (1995)

    2020  Volume 48, Issue 4, Page(s) 161–164

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Health Personnel/statistics & numerical data ; Humans ; Occupational Health/statistics & numerical data ; Pandemics ; Personal Protective Equipment/statistics & numerical data ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.1080/21548331.2020.1771010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 890: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Stochastic interventional approach to assessing immune correlates of protection: Application to the COVE messenger RNA-1273 vaccine trial.

    Hejazi, Nima S / Shen, Xiaoying / Carpp, Lindsay N / Benkeser, David / Follmann, Dean / Janes, Holly E / Baden, Lindsey R / El Sahly, Hana M / Deng, Weiping / Zhou, Honghong / Leav, Brett / Montefiori, David C / Gilbert, Peter B

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 137, Page(s) 28–39

    Abstract: Background: Stochastic interventional vaccine efficacy (SVE) analysis is a new approach to correlate of protection (CoP) analysis of a phase III trial that estimates how vaccine efficacy (VE) would change under hypothetical shifts of an immune marker.!## ...

    Abstract Background: Stochastic interventional vaccine efficacy (SVE) analysis is a new approach to correlate of protection (CoP) analysis of a phase III trial that estimates how vaccine efficacy (VE) would change under hypothetical shifts of an immune marker.
    Methods: We applied nonparametric SVE methodology to the COVE trial of messenger RNA-1273 vs placebo to evaluate post-dose 2 pseudovirus neutralizing antibody (nAb) titer against the D614G strain as a CoP against COVID-19. Secondly, we evaluated the ability of these results to predict VE against variants based on shifts of geometric mean titers to variants vs D614G. Prediction accuracy was evaluated by 13 validation studies, including 12 test-negative designs.
    Results: SVE analysis of COVE supported post-dose 2 D614G titer as a CoP: estimated VE ranged from 66.9% (95% confidence interval: 36.2, 82.8%) to 99.3% (99.1, 99.4%) at 10-fold decreased or increased titer shifts, respectively. The SVE estimates only weakly predicted variant-specific VE estimates (concordance correlation coefficient 0.062 for post 2-dose VE).
    Conclusion: SVE analysis of COVE supports nAb titer as a CoP for messenger RNA vaccines. Predicting variant-specific VE proved difficult due to many limitations. Greater anti-Omicron titers may be needed for high-level protection against Omicron vs anti-D614G titers needed for high-level protection against pre-Omicron COVID-19.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; RNA, Messenger/genetics ; Vaccines
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; RNA, Messenger ; Vaccines
    Language English
    Publishing date 2023-10-25
    Publishing country Canada
    Document type Clinical Trial, Phase III ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Epilepsy surgery outcomes in patients with GATOR1 gene complex variants: Report of new cases and review of literature.

    Sahly, Ahmed N / Whitney, Robyn / Costain, Gregory / Chau, Vann / Otsubo, Hiroshi / Ochi, Ayako / Donner, Elizabeth J / Cunningham, Jessie / Jones, Kevin C / Widjaja, Elysa / Ibrahim, George M / Jain, Puneet

    Seizure

    2023  Volume 107, Page(s) 13–20

    Abstract: Aim: To report seizure outcomes in children with GATOR1 gene complex disorders who underwent epilepsy surgery and perform a systematic literature search to study the available evidence.: Methods: The records of children with pathogenic/likely ... ...

    Abstract Aim: To report seizure outcomes in children with GATOR1 gene complex disorders who underwent epilepsy surgery and perform a systematic literature search to study the available evidence.
    Methods: The records of children with pathogenic/likely pathogenic variants in GATOR1 gene complex who underwent epilepsy surgery were reviewed. Clinical, radiological, neurophysiological, and histological data were extracted/summarized. The systematic review included all case series/reports and observational studies reporting on children or adults with genetic (germline or somatic) variants in the GATOR1 complex genes (DEPDC5, NPRL2, NPRL3) with focal epilepsy with/without focal cortical dysplasia who underwent epilepsy surgery; seizure outcomes were analyzed.
    Results: Eight children with pathogenic/likely pathogenic variants in GATOR1 complex genes were included. All had drug-resistant epilepsy. Six children had significant neurodevelopmental delay. Epilepsy surgery was performed in all; clinical seizure freedom was noted in 4 children (50%). Systematic literature search identified 17 eligible articles; additional 30 cases with patient-level data were studied. Lesional MRI brain was seen in 80% cases. The pooled rate of seizure freedom following surgery was 60%; FCD IIa was the most encountered pathology.
    Interpretation: Epilepsy surgery may be effective in some children with GATOR1 complex gene variants. Seizure outcomes may be compromised by extensive epileptogenic zones.
    MeSH term(s) Child ; Adult ; Humans ; Epilepsy/genetics ; Epilepsy/surgery ; Epilepsies, Partial/genetics ; Seizures/genetics ; Drug Resistant Epilepsy/genetics ; Drug Resistant Epilepsy/surgery ; GTPase-Activating Proteins/genetics ; Retrospective Studies
    Chemical Substances GTPase-Activating Proteins ; NPRL3 protein, human
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: MF59™ as a vaccine adjuvant: a review of safety and immunogenicity.

    El Sahly, Hana

    Expert review of vaccines

    2010  Volume 9, Issue 10, Page(s) 1135–1141

    Abstract: Approximately 70 years passed between the licensing of alum salts as vaccine adjuvants and that of MF59™ MF59, an oil-in-water emulsion, is currently licensed for use in the elderly as an adjuvant in seasonal influenza vaccines. Its mechanism of action ... ...

    Abstract Approximately 70 years passed between the licensing of alum salts as vaccine adjuvants and that of MF59™ MF59, an oil-in-water emulsion, is currently licensed for use in the elderly as an adjuvant in seasonal influenza vaccines. Its mechanism of action is not fully understood, but enhancement of the interaction between the antigen and the dendritic cell seems to be involved. When used with seasonal influenza vaccines, an increase occurs in the hemagglutination inhibition antibody titers against some, but not all, seasonal vaccine influenza strains. The adjuvant effect is more pronounced when MF59 is combined with novel influenza antigens such as H9 and H5. The use of the adjuvant is associated with an increase in the frequency of local and systemic early post-vaccine adverse events (3-7 days), but no increase in adverse events was observed thereafter. Currently, MF59 is under evaluation as an adjuvant with other antigens such as pandemic influenza antigens and cytomegalovirus antigens.
    MeSH term(s) Adjuvants, Immunologic/adverse effects ; Aged ; Antibodies, Viral/blood ; Child ; Child, Preschool ; Clinical Trials as Topic ; Female ; Hemagglutination Inhibition Tests ; Humans ; Infant ; Influenza A virus/immunology ; Influenza B virus/immunology ; Influenza Vaccines/adverse effects ; Influenza Vaccines/immunology ; Influenza Vaccines/therapeutic use ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Polysorbates/adverse effects ; Squalene/adverse effects ; Squalene/immunology
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Influenza Vaccines ; MF59 oil emulsion ; Polysorbates ; Squalene (7QWM220FJH)
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1586/erv.10.111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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