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  1. Article ; Online: Manipulating hepcidin in polycythemia vera.

    Girelli, Domenico / Busti, Fabiana

    Blood

    2023  Volume 141, Issue 26, Page(s) 3132–3134

    MeSH term(s) Humans ; Hepcidins ; Polycythemia Vera ; Homeostasis ; Iron
    Chemical Substances Hepcidins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023020509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  2. Article ; Online: Deironing the spleen with luspatercept.

    Girelli, Domenico / Marchi, Giacomo

    Blood

    2023  Volume 142, Issue 22, Page(s) 1856–1858

    MeSH term(s) Spleen ; Liver ; Activin Receptors, Type II ; Immunoglobulin Fc Fragments/therapeutic use
    Chemical Substances luspatercept (AQK7UBA1LS) ; Activin Receptors, Type II (EC 2.7.11.30) ; Immunoglobulin Fc Fragments
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Anemia in patients receiving anticancer treatments: focus on novel therapeutic approaches.

    Bozzini, Claudia / Busti, Fabiana / Marchi, Giacomo / Vianello, Alice / Cerchione, Claudio / Martinelli, Giovanni / Girelli, Domenico

    Frontiers in oncology

    2024  Volume 14, Page(s) 1380358

    Abstract: Anemia is common in cancer patients and impacts on quality of life and prognosis. It is typically multifactorial, often involving different pathophysiological mechanisms, making treatment a difficult task. In patients undergoing active anticancer ... ...

    Abstract Anemia is common in cancer patients and impacts on quality of life and prognosis. It is typically multifactorial, often involving different pathophysiological mechanisms, making treatment a difficult task. In patients undergoing active anticancer treatments like chemotherapy, decreased red blood cell (RBC) production due to myelosuppression generally predominates, but absolute or functional iron deficiency frequently coexists. Current treatments for chemotherapy-related anemia include blood transfusions, erythropoiesis-stimulating agents, and iron supplementation. Each option has limitations, and there is an urgent need for novel approaches. After decades of relative immobilism, several promising anti-anemic drugs are now entering the clinical scenario. Emerging novel classes of anti-anemic drugs recently introduced or in development for other types of anemia include activin receptor ligand traps, hypoxia-inducible factor-prolyl hydroxylase inhibitors, and hepcidin antagonists. Here, we discuss their possible role in the treatment of anemia observed in patients receiving anticancer therapies.
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1380358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: ERFE regulation in sickle cell disease: complex but promising.

    Girelli, Domenico / Busti, Fabiana

    British journal of haematology

    2020  Volume 189, Issue 6, Page(s) 1012–1013

    MeSH term(s) Anemia, Sickle Cell ; Erythropoiesis ; Hepcidins ; Homeostasis ; Humans ; Iron
    Chemical Substances Hepcidins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Replacing the suppressed hormone: toward a better treatment for iron overload in β-thalassemia major?

    Girelli, Domenico / Busti, Fabiana

    Haematologica

    2020  Volume 105, Issue 7, Page(s) 1752–1754

    MeSH term(s) Animals ; Erythropoiesis ; Hormones ; Iron Overload/drug therapy ; Iron Overload/etiology ; Mice ; Splenomegaly ; beta-Thalassemia/complications ; beta-Thalassemia/therapy
    Chemical Substances Hormones
    Language English
    Publishing date 2020-06-29
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2020.253393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of Neutrophil Extracellular Traps in Covid-19: Only an hypothesis or a potential new field of research?

    Mozzini, Chiara / Girelli, Domenico

    Thrombosis research

    2020  Volume 191, Page(s) 26–27

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Cytokine Release Syndrome/etiology ; Extracellular Traps/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Models, Immunological ; Oxidative Stress ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Thrombophilia/etiology ; Thrombophilia/immunology
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.04.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 863: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: The changing landscape of iron deficiency.

    Camaschella, Clara / Girelli, Domenico

    Molecular aspects of medicine

    2020  Volume 75, Page(s) 100861

    Abstract: Iron deficiency (ID) with or without anemia is common worldwide. ID is a broad definition encompassing decreased total body iron (absolute deficiency) as well as reduced iron supply to erythropoietic and/or other organs with preserved stores (functional ... ...

    Abstract Iron deficiency (ID) with or without anemia is common worldwide. ID is a broad definition encompassing decreased total body iron (absolute deficiency) as well as reduced iron supply to erythropoietic and/or other organs with preserved stores (functional iron deficiency, FID), as it occurs in inflammation. Increased iron needs unbalanced by iron supply, low iron intake, reduced absorption and chronic blood loss, often in combination, are the main causes of absolute ID, easily diagnosed by low ferritin levels. In all these cases hepcidin synthesis is repressed, while in FID is augmented by inflammatory cytokines, causing iron sequestration in stores. Because of increased ferritin levels diagnosis of ID in the latter condition may be tricky: global clinical evaluation, accepted threshold of iron tests together with response to iron treatment may be of help. Search and removal of the responsible cause(s) is as important as diagnosing ID or FID. The response to oral iron treatment is suboptimal when hepcidin levels are high. Future research is needed to establish/validate markers for improved diagnosis of complex cases and to test the therapeutic value of drugs under development aimed at interfering with the altered iron trafficking.
    MeSH term(s) Anemia, Iron-Deficiency ; Biomarkers ; Humans ; Inflammation ; Iron
    Chemical Substances Biomarkers ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2020.100861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anemia and adverse outcomes in the elderly: a detrimental inflammatory loop?

    Girelli, Domenico / Busti, Fabiana

    Haematologica

    2019  Volume 104, Issue 3, Page(s) 417–419

    MeSH term(s) Aged ; Anemia ; Cohort Studies ; Humans ; Quality of Life
    Language English
    Publishing date 2019-02-28
    Publishing country Italy
    Document type Editorial ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2018.208066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sucrosomial

    Gómez-Ramírez, Susana / Brilli, Elisa / Tarantino, Germano / Girelli, Domenico / Muñoz, Manuel

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 6

    Abstract: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly prevalent worldwide. Oral iron salts, especially ferrous sulfate, are commonly used for the treatment of iron deficiency (ID). However, its use is associated with gastrointestinal side ... ...

    Abstract Iron deficiency (ID) and iron deficiency anemia (IDA) are highly prevalent worldwide. Oral iron salts, especially ferrous sulfate, are commonly used for the treatment of iron deficiency (ID). However, its use is associated with gastrointestinal side effects, thus compromising treatment compliance. Intravenous iron administration is a more costly and logistically complex alternative and is not risk-free, as infusion and hypersensitivity reactions may occur. Sucrosomial
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16060847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Iron metabolism in infections: Focus on COVID-19.

    Girelli, Domenico / Marchi, Giacomo / Busti, Fabiana / Vianello, Alice

    Seminars in hematology

    2021  Volume 58, Issue 3, Page(s) 182–187

    Abstract: Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living organisms. During infections, a battle for iron takes place between the human host and the invading pathogens. The liver peptide hepcidin, which is ... ...

    Abstract Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living organisms. During infections, a battle for iron takes place between the human host and the invading pathogens. The liver peptide hepcidin, which is phylogenetically and structurally linked to defensins (antimicrobial peptides of the innate immunity), plays a pivotal role by subtracting iron to pathogens through its sequestration into host cells, mainly macrophages. While this phenomenon is well studied in certain bacterial infections, much less is known regarding viral infections. Iron metabolism also has implications on the functionality of cells of the immune system. Once primed by the contact with antigen presenting cells, lymphocytes need iron to sustain the metabolic burst required for mounting an effective cellular and humoral response. The COVID-19 pandemic has boosted an amount of clinical and translational research over the possible influences of nutrients on SARS-CoV-2 infection, in terms of either susceptibility or clinical course. Here we review the intersections between iron metabolism and COVID-19, belonging to the wider domain of the so-called "nutritional immunity". A better understanding of such connections has potential broad implications, either from a mechanistic standpoint, or for the development of more effective strategies for managing COVID-19 and possible future pandemics.
    MeSH term(s) COVID-19/immunology ; COVID-19/metabolism ; Humans ; Immunity, Innate ; Iron/metabolism ; Lymphocytes ; Pandemics
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2021.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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