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  1. Article ; Online: Bronchiolitis Obliterans After Cefuroxime-Induced Stevens-Johnson Syndrome.

    Shabrawishi, Mohammed / Qanash, Sultan A

    The American journal of case reports

    2019  Volume 20, Page(s) 171–174

    Abstract: BACKGROUND Bronchiolitis obliterans is the term used to describe a clinical syndrome of irreversible airflow obstruction. Among the etiologies linked to this entity is the rarely reported association with Stevens-Johnson syndrome, which has had a poor ... ...

    Abstract BACKGROUND Bronchiolitis obliterans is the term used to describe a clinical syndrome of irreversible airflow obstruction. Among the etiologies linked to this entity is the rarely reported association with Stevens-Johnson syndrome, which has had a poor outcome in most of the previously published cases. The optimum management of bronchiolitis obliterans as a complication of Stevens-Johnson syndrome is not well defined. CASE REPORT A 41-year-old woman developed significant shortness of breath 3 months after recovering from Stevens-Johnson syndrome precipitated by a second-generation cephalosporin. She was found to have severe irreversible airway obstruction on physiology studies, and computed tomography scans of the inspiratory and expiratory phases of respiration showed air trapping that was more prominent on expiratory films. The patient was diagnosed with bronchiolitis obliterans, for which bronchodilators and long-term macrolide therapy were administered. Although she did not recover completely, her follow-up physiology studies showed that the bronchiolitis obliterans was stable. CONCLUSIONS Bronchiolitis obliterans secondary to Stevens-Johnson syndrome is a rare entity that is progressive and can lead to functional impairment. Identifying the disease at an early stage might stabilize or slow its progression. Herein, we describe a case of bronchiolitis obliterans as a complication of Stevens-Johnson syndrome and review the literature to raise awareness of this condition, highlight its course, and discuss the available treatments.
    MeSH term(s) Adult ; Anti-Bacterial Agents/adverse effects ; Bronchiolitis Obliterans/diagnostic imaging ; Bronchiolitis Obliterans/etiology ; Cefuroxime/adverse effects ; Female ; Humans ; Stevens-Johnson Syndrome/complications ; Stevens-Johnson Syndrome/etiology
    Chemical Substances Anti-Bacterial Agents ; Cefuroxime (O1R9FJ93ED)
    Language English
    Publishing date 2019-02-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.913723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diagnostic accuracy of different bronchoscopic specimens in sputum Xpert MBT/RIF- negative pulmonary TB patients.

    Badr, Omaima Ibrahim / Elrefaey, Wael Aly / Shabrawishi, Mohammed / Assaggaf, Hamza M / Minshawi, Faisal

    Multidisciplinary respiratory medicine

    2022  Volume 17, Issue 1, Page(s) 872

    Abstract: Background: Tuberculosis (TB) control remains a critical public health problem worldwide. Rapid diagnosis and proper treatment are beneficial for the effective control of tuberculosis transmission. Diagnostic challenges arise when a patient has a ... ...

    Abstract Background: Tuberculosis (TB) control remains a critical public health problem worldwide. Rapid diagnosis and proper treatment are beneficial for the effective control of tuberculosis transmission. Diagnostic challenges arise when a patient has a clinical and radiological suspicion of tuberculosis but cannot produce sputum, sputum acid-fast bacilli, or Xpert
    Methods: A retrospective study recruited 330 suspected pulmonary TB patients with negative sputum of Xpert MBT/RIF who underwent bronchoscopy between March 2018 and December 2021. The diagnostic yields of bronchoalveolar lavage fluid (acid-fast bacilli, Xpert MTB/RIF, and culture) and histopathologic examination (HPE) were calculated and compared to the final diagnosis and culture as a gold standard.
    Results: Out of 330 suspected pulmonary TB patients, 181 had a final diagnosis of TB, and 149 had non-TB. The sensitivity of BALF (culture, Xpert, acid-fast bacilli) and trans-bronchial lung biopsy (HPE) was 80.7%, 72.9%, 21.1%, and 87.1%, respectively. Multiple nodules were associated with significantly higher BALF Xpert MTB, bronchoalveolar lavage fluid culture, and trans-bronchial lung biopsy (HPE) positivity.
    Conclusions: Bronchoscopic specimens are essential for accurate and rapid diagnosis of sputum Xpert MBT/RIF negative patients with high clinical and radiological suspicion of tuberculosis.
    Language English
    Publishing date 2022-10-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2677839-7
    ISSN 2049-6958 ; 1828-695X
    ISSN (online) 2049-6958
    ISSN 1828-695X
    DOI 10.4081/mrm.2022.872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: New disease and old threats: A case series of COVID-19 and tuberculosis coinfection in Saudi Arabia.

    Shabrawishi, Mohammed / AlQarni, Abdullmoin / Ghazawi, Maher / Melibari, Baraa / Baljoon, Tebra / Alwafi, Hassan / Samannodi, Mohammed

    Clinical case reports

    2021  Volume 9, Issue 5, Page(s) e04233

    Abstract: COVID-19 and TB coinfection are not common and may occur more in TB endemic countries. However, patients with pre-COVID-19 chronic respiratory symptoms should be screened for TB as well. ...

    Abstract COVID-19 and TB coinfection are not common and may occur more in TB endemic countries. However, patients with pre-COVID-19 chronic respiratory symptoms should be screened for TB as well.
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.4233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Negative Nasopharyngeal SARS-CoV-2 PCR Conversion in Response to Different Therapeutic Interventions.

    Alwafi, Hassan / Shabrawishi, Mohammed H / Naser, Abdallah Y / Aldobyany, Ahmad M / Qanash, Sultan A / Touman, Abdelfattah A

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21442

    Abstract: Background The current management practices for patients with COVID-19 consist of infection prevention and supportive care. We aimed to explore the association between negative nasopharyngeal SARS-CoV-2 polymerase chain reaction (PCR) clearance and ... ...

    Abstract Background The current management practices for patients with COVID-19 consist of infection prevention and supportive care. We aimed to explore the association between negative nasopharyngeal SARS-CoV-2 polymerase chain reaction (PCR) clearance and different therapeutic interventions. Methods This study is a retrospective cohort study of 93 patients who were admitted to a tertiary hospital in Saudi Arabia with a PCR confirmed diagnosis of COVID-19. There were three intervention subgroups (group A) (n = 45), which included those who received chloroquine or hydroxychloroquine (HCQ) only (A1), those who received chloroquine or HCQ in combination with azithromycin (A2), and those who received chloroquine or HCQ in combination with antiviral drugs with or without azithromycin (A3), as well as one supportive care group (group B) (n = 48). The primary and secondary endpoints were achieving negative SARS-CoV-2 nasopharyngeal PCR samples within five and 12 days from the start of the intervention, respectively. Results A median time of three days (interquartile range (IQR): 2.00-6.50) is needed from the time of starting the intervention/supportive care to the first negative PCR sample. There was no statistically significant difference neither between the percentage of patients in the intervention group and the supportive care group who achieved the primary or secondary endpoint nor in the median time needed to achieve the first negative PCR sample (p > 0.05). Conclusion Prescribing antimalarial medications was not shown to shorten the disease course nor to accelerate the negative PCR conversion rate.
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: New disease and old threats

    Mohammed Shabrawishi / Abdullmoin AlQarni / Maher Ghazawi / Baraa Melibari / Tebra Baljoon / Hassan Alwafi / Mohammed Samannodi

    Clinical Case Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)

    A case series of COVID‐19 and tuberculosis coinfection in Saudi Arabia

    2021  

    Abstract: Abstract COVID‐19 and TB coinfection are not common and may occur more in TB endemic countries. However, patients with pre‐COVID‐19 chronic respiratory symptoms should be screened for TB as well. ...

    Abstract Abstract COVID‐19 and TB coinfection are not common and may occur more in TB endemic countries. However, patients with pre‐COVID‐19 chronic respiratory symptoms should be screened for TB as well.
    Keywords COVID‐19 ; Co‐infection ; Prognosis ; Tuberculosis ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Incidence and Outcomes of Pulmonary Embolism among Hospitalized COVID-19 Patients.

    Badr, Omaima Ibrahim / Alwafi, Hassan / Elrefaey, Wael Aly / Naser, Abdallah Y / Shabrawishi, Mohammed / Alsairafi, Zahra / Alsaleh, Fatemah M

    International journal of environmental research and public health

    2021  Volume 18, Issue 14

    Abstract: Objectives: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, ... ...

    Abstract Objectives: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, risk factors, and the impact on survival.
    Methods: A retrospective case-control study was conducted at Al-Noor Specialist Hospital in Saudi Arabia between 15 March 2020 and 15 June 2020. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and confirmed diagnosis of pulmonary embolism by Computed Tomography pulmonary angiogram (CTPA) formed the case group. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and without confirmed diagnose of pulmonary embolism formed the control group. Logistic regression analysis was used to identify predictors of pulmonary embolism and survival.
    Results: A total of 159 patients participated were included in the study, of which 51 were the cases (patients with pulmonary embolism) and 108 patients formed the control group (patients without pulmonary embolism). The incidence of PE among those hospitalized was around 32%. Smoking history, low level of oxygen saturation, and higher D-dimer values were important risk factors that were associated with a higher risk of developing PE (
    Conclusions: Pulmonary embolism is common among hospitalized patients with COVID-19. Preventive measures should be considered for hospitalized patients with smoking history, low level of oxygen saturation, high D-dimer values, and high respiratory rate.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; Case-Control Studies ; Computed Tomography Angiography ; Humans ; Incidence ; Pulmonary Embolism/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Saudi Arabia/epidemiology
    Language English
    Publishing date 2021-07-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18147645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Severe Primary Raynaud's Disease Treated with Rituximab.

    Shabrawishi, Mohammed / Albeity, Abdurahman / Almoallim, Hani

    Case reports in rheumatology

    2016  Volume 2016, Page(s) 2053804

    Abstract: Raynaud's phenomenon refers to reversible spasms of the peripheral arterioles that can be primary Raynaud's phenomenon (PRP) or secondary Raynaud's phenomenon (SRP) to underlying connective tissue disease, both of which are characterized by a triphasic ... ...

    Abstract Raynaud's phenomenon refers to reversible spasms of the peripheral arterioles that can be primary Raynaud's phenomenon (PRP) or secondary Raynaud's phenomenon (SRP) to underlying connective tissue disease, both of which are characterized by a triphasic color response triggered by cold exposure or stress. PRP is typically a benign disease, whereas SRP may progress into digital ulcers and/or gangrene. Here, we report a case of a 55-year-old female diagnosed with PRP 7 years ago. Treatment with first-line agents, including calcium channel blocker, aspirin, and phosphodiesterase inhibitor, did not control her symptoms, which progressed to digital ulceration and gangrene. There were no symptoms of underlying autoimmune disease or malignancy, and autoimmune, serology, and immunology test results were normal; a biopsy of her left little finger was negative for vasculitis. Development to critical digital ischemia necessitated treatment with intravenous iloprost and heparin infusion followed by angioplasty, which led to a partial improvement. Due to persistent symptoms, rituximab therapy was initiated and two cycles induced a complete resolution of symptoms.
    Language English
    Publishing date 2016-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2666708-3
    ISSN 2090-6897 ; 2090-6889
    ISSN (online) 2090-6897
    ISSN 2090-6889
    DOI 10.1155/2016/2053804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Incidence and Outcomes of Pulmonary embolism among hospitalized COVID-19 patients

    Badr, Omaima / Alwafi, Hassan / Elrefaey, Wael / Naser, Abdallah Y / Shabrawishi, Mohammed

    medRxiv

    Abstract: Background: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, ... ...

    Abstract Background: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, risk factors and the impact on survival. Method: A retrospective case-control study was conducted at Al-Noor Specialist Hospital in, Saudi Arabia between March 15, 2020, and June 15, 2020. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and confirmed diagnosis of pulmonary embolism by Computed Tomography pulmonary angiogram (CTPA) formed the case group. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and without confirmed diagnose of pulmonary embolism formed the control group. Logistic regression analysis was used to identify predictors of pulmonary embolism and its survival. Results: A total of 159 patients participated were included in the study, of which 51 were the cases (patients with pulmonary embolism) and 108 patients formed the control group (patients without pulmonary embolism). The incidence of PE among hospitalized was around 32%. Smoking history, low level of oxygen saturation and higher D-dimer values were important risk factors that were associated with a higher risk of developing PE (p< 0.05). Higher respiratory rate was associated with higher odds of death, and decrease the possibility of survival among hospitalised patients with PE. Conclusion: Pulmonary embolism is common among hospitalized patients with COVID-19. Preventive measures should be considered for hospitalized patients with smoking history, low level of oxygen saturation, high D-dimer values, and high respiratory rate.
    Keywords covid19
    Language English
    Publishing date 2021-02-19
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.16.21251676
    Database COVID19

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  9. Article: Psychological Effects on Health Science Students After Implementation of COVID-19 Quarantine and Distance Learning in Saudi Arabia.

    Qanash, Sultan / Al-Husayni, Faisal / Alemam, Shereen / Alqublan, Lina / Alwafi, Emad / Mufti, Hani N / Qanash, Husam / Shabrawishi, Mohammed / Ghabashi, Ala'a

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11767

    Abstract: Background The 2019 novel coronavirus disease (COVID-19) pandemic has impacted the globe dramatically. It has affected daily life noticeably and the teaching process is one of the significantly affected aspects as the learning approach has been shifted ... ...

    Abstract Background The 2019 novel coronavirus disease (COVID-19) pandemic has impacted the globe dramatically. It has affected daily life noticeably and the teaching process is one of the significantly affected aspects as the learning approach has been shifted to distance learning (DL). These new changes may affect student performance and emotional well-being. This study aimed to assess the psychological impact of the COVID-19 pandemic and distance learning on healthcare students. Method An online self-administered cross-sectional survey was distributed to healthcare students for the period between April 2020 to June 2020. The study included students from different universities in Saudi Arabia. Knowledge and perception of COVID-19 and the experience of distance learning during the pandemic period were assessed using a 5-point Likert scale. Psychological effect was evaluated using Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4). Results A total of 721 students completed the survey with the majority being females. Around 25% of students had experienced anxiety, while 35% had depression. Severe anxiety and depression were noted in over 6% of the participants. Younger age and female gender were more affected psychologically. Students with higher scores in PHQ-4 were strongly disagreeing that hand gloves and surgical masks may help in preventing COVID-19 transmission. Students with normal psychological assessment were more likely to favor DL, while students with moderate to severe anxiety and depression disagreed. Conclusion Healthcare students have alarmingly high levels of anxiety and depression during the COVID-19 pandemic. General knowledge of the pandemic is not associated with the psychological impact. DL is a convenient approach for students with normal PHQ-4 scores. Programs to help students overcome the psychological impact of COVID-19 are highly recommended.
    Language English
    Publishing date 2020-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Incidence and Outcomes of Pulmonary Embolism among Hospitalized COVID-19 Patients

    Omaima Ibrahim Badr / Hassan Alwafi / Wael Aly Elrefaey / Abdallah Y. Naser / Mohammed Shabrawishi / Zahra Alsairafi / Fatemah M. Alsaleh

    International Journal of Environmental Research and Public Health, Vol 18, Iss 7645, p

    2021  Volume 7645

    Abstract: Objectives: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, ... ...

    Abstract Objectives: Patients with COVID-19 may be at high risk for thrombotic complications due to excess inflammatory response and stasis of blood flow. This study aims to assess the incidence of pulmonary embolism among hospitalized patients with COVID-19, risk factors, and the impact on survival. Methods: A retrospective case-control study was conducted at Al-Noor Specialist Hospital in Saudi Arabia between 15 March 2020 and 15 June 2020. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and confirmed diagnosis of pulmonary embolism by Computed Tomography pulmonary angiogram (CTPA) formed the case group. Patients with confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) and without confirmed diagnose of pulmonary embolism formed the control group. Logistic regression analysis was used to identify predictors of pulmonary embolism and survival. Results: A total of 159 patients participated were included in the study, of which 51 were the cases (patients with pulmonary embolism) and 108 patients formed the control group (patients without pulmonary embolism). The incidence of PE among those hospitalized was around 32%. Smoking history, low level of oxygen saturation, and higher D-dimer values were important risk factors that were associated with a higher risk of developing PE ( p < 0.05). Higher respiratory rate was associated with higher odds of death, and decreased the possibility of survival among hospitalized patients with PE. Conclusions: Pulmonary embolism is common among hospitalized patients with COVID-19. Preventive measures should be considered for hospitalized patients with smoking history, low level of oxygen saturation, high D-dimer values, and high respiratory rate.
    Keywords COVID-19 ; hospitalized ; pulmonary embolism ; survival ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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