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Article ; Online: SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation.

Pan, Zhen-Guo / An, Xu-Sheng

Biochemical and biophysical research communications

2018 Volume 498, Issue 3, Page(s) 416–423

Abstract: SARM1 (Sterile alpha and armadillo motif-containing protein 1) is the recently identified TIR domain-containing cytosolic protein, which is involved in toll-like receptors (TLRs) signaling transduction. In the present study, the role of SARM1 in high fat ...

Abstract	SARM1 (Sterile alpha and armadillo motif-containing protein 1) is the recently identified TIR domain-containing cytosolic protein, which is involved in toll-like receptors (TLRs) signaling transduction. In the present study, the role of SARM1 in high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) progression was explored. We found that SARM1 was expressed highly in fatty liver. And SARM1-knockout (KO) reduced steatohepatitis and metabolic disorders induced by HFD. SARM1-deletion decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in HFD-fed mice. Additionally, inflammatory response caused by HFD was alleviated by SARM1-deletion through inactivating TLR4/7/9 and nuclear factor kappa B (NF-κB) pathways. Of note, SARM1-deletion also reduced the expressions of inflammation-associated molecules in hypothalamus of HFD-fed mice. Furthermore, HFD administration led to oxidative stress in liver of mice, while being decreased in SARM1-KO mice. Moreover, SARM1-ablation improved lipid dyslipidemia by suppressing the mRNA levels of genes, linked to glycolysis, lipogenesis and transcriptional regulation. Insulin resistance was also attenuated by SARM1-deficiency through enhancing the activation of liver Akt/glycogen synthase kinase-3β (GSK3β) and insulin receptor substrate-1 (IRS1)/FOXO1 pathways in HFD-fed mice. Also, SARM1-knockout improved neuropeptide Y (NPY), Pro-Opiomelanocortins (POMC), Agouti-related Protein (AGRP) and Cocaine-and-Amphetamine Responsive Transcript 1 (CART1) expressions in hypothalamus of mice after HFD administration. In vitro, we found that the reduction of inflammatory response, oxidative stress and dyslipidemia induced by SARM1-knockout in primary hepatocytes after fructose stimulation was largely attributed to its suppression to TLR4/7/9. Together, the findings demonstrated that SARM1 might be an effective target for developing effective therapeutic strategies against NAFLD.
MeSH term(s)	Animals ; Armadillo Domain Proteins/genetics ; Armadillo Domain Proteins/metabolism ; Cells, Cultured ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Diet, High-Fat/adverse effects ; Gene Deletion ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Inflammation/etiology ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Insulin Resistance ; Lipid Metabolism ; Liver/metabolism ; Liver/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Oxidative Stress
Chemical Substances	Armadillo Domain Proteins ; Cytoskeletal Proteins ; SARM1 protein, human
Language	English
Publishing date	2018--06
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.02.115
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Article: Evolutionary and phylogenetic analyses of 11

Wan, Tian / Qiao, Bai-Xue / Zhou, Jing / Shao, Ke-Sen / Pan, Liu-Yi / An, Feng / He, Xu-Sheng / Liu, Tao / Li, Ping-Ke / Cai, Yu-Liang

Frontiers in plant science

2023 Volume 14, Page(s) 1070600

Abstract: ... The ... ...

Abstract	The subgenus
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1070600
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Article ; Online: CALCRL knockdown suppresses cancer stemness and chemoresistance in acute myeloid leukemia with FLT3-ITD and DNM3TA-R882 double mutations.

Tang, Shanhao / Zhu, Huiling / Sheng, Lixia / Mu, Qitian / Wang, Yi / Xu, Kaihong / Zhou, Miao / Xu, Zhijuan / Wu, An / Ouyang, Guifang

Drug development research

2024 Volume 85, Issue 1, Page(s) e22137

Abstract: Acute myeloid leukemia (AML) patients with FLT3 internal tandem duplication (FLT3-ITD) and DNA methyltransferase 3A (DNMT3A) R882 double mutations had a worse prognosis compared with AML with FLT3-ITD or DNMT3A R882 single mutation. This study was ... ...

Abstract	Acute myeloid leukemia (AML) patients with FLT3 internal tandem duplication (FLT3-ITD) and DNA methyltransferase 3A (DNMT3A) R882 double mutations had a worse prognosis compared with AML with FLT3-ITD or DNMT3A R882 single mutation. This study was designed to explore the specific role of Calcitonin Receptor Like (CALCRL) in AML with FLT3-ITD and DNMT3A R882 double mutations. MOLM13 cells were transduced with CRISPR knockout sgRNA constructs to establish the FTL3-ITD and DNMT3A-R882 double-mutated AML cell model. Quantitative real-time PCR and Western blot assay were carried out to examine corresponding gene and protein expression. Methylation of CALCRL promoter was measured by methylation-specific PCR (MSP). Cell viability, colony formation, flow cytometry, and sphere formation assays were conducted to determine cell proliferation, apoptosis, and stemness. MOLM13 cells were exposed to stepwise increasing concentrations of cytarabine (Ara-C) to generate MOLM13/Ara-C cells. An in vivo AML animal model was established, and the tumor volume and weight were recorded. TUNEL assay was adopted to examine cell apoptosis in tumor tissues. DNMT3A-R882 mutation upregulated the expression of CALCRL while downregulated the DNA methylation level of CALCRL in MOLM13 cells. CALCRL knockdown greatly inhibited cell proliferation, promoted apoptosis and repressed cell stemness, accompanied with the downregulated Oct4, SOX2, and Nanog in DNMT3A-R882-mutated MOLM13 cells and MOLM13/Ara-C cells. Furthermore, CALCRL knockdown restricted tumor growth and the chemoresistance of AML in vivo, as well as inducing cell apoptosis in tumor tissues. Together, these data reveal that CALCRL is a vital regulator of leukemia cell survival and resistance to chemotherapy, suggesting CALCRL as a promising therapeutic target for the treatment of FTL3-ITD and DNMT3A-R882 double-mutated AML.
MeSH term(s)	Animals ; Humans ; Receptors, Calcitonin ; Drug Resistance, Neoplasm/genetics ; RNA, Guide, CRISPR-Cas Systems ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Cytarabine ; fms-Like Tyrosine Kinase 3/genetics ; Calcitonin Receptor-Like Protein
Chemical Substances	Receptors, Calcitonin ; RNA, Guide, CRISPR-Cas Systems ; Cytarabine (04079A1RDZ) ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1) ; CALCRL protein, human ; Calcitonin Receptor-Like Protein
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22137
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Zs.B 2542: Show issues

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Article ; Online: Changes in the Biology and Susceptibility of Weevil (

Xu, Jin / Tang, An / Liu, Jun-Yan / Yao, Chang-Long / Liu, Ke-Ping / Huang, Xiao-Sheng / Shi, Pei-Qiong

Toxics

2024 Volume 12, Issue 4

Abstract: The sweet potato ... ...

Abstract	The sweet potato weevil
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12040304
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Article ; Online: 16S rRNA gene sequencing and machine learning reveal correlation between drug abuse and human host gut microbiota.

Liu, Yunting / Zhang, Pei / Sheng, Hongmei / Xu, Ding / Li, Daixi / An, Lizhe

Addiction biology

2023 Volume 28, Issue 10, Page(s) e13311

Abstract: Over the past few years, there has been increasing evidence highlighting the strong connection between gut microbiota and overall well-being of the host. This has led to a renewed emphasis on studying and addressing substance use disorder from the ... ...

Abstract	Over the past few years, there has been increasing evidence highlighting the strong connection between gut microbiota and overall well-being of the host. This has led to a renewed emphasis on studying and addressing substance use disorder from the perspective of brain-gut axis. Previous studies have suggested that alcohol, food, and cigarette addictions are strongly linked to gut microbiota and faecal microbiota transplantation or the use of probiotics achieved significant efficacy. Unfortunately, little is known about the relationship between drug abuse and gut microbiota. This paper aims to reveal the potential correlation between gut microbiota and drug abuse and to develop an accurate identification model for drug-related faeces samples by machine learning. Faecal samples were collected from 476 participants from three regions in China (Shanghai, Yunnan, and Shandong). Their gut microbiota information was obtained using 16S rRNA gene sequencing, and a substance use disorder identification model was developed by machine learning. Analysis revealed a lower diversity and a more homogeneous gut microbiota community structure among participants with substance use disorder. Bacteroides, Prevotella_9, Faecalibacterium, and Blautia were identified as important biomarkers associated with substance use disorder. The function prediction analysis revealed that the citrate and reductive citrate cycles were significantly upregulated in the substance use disorder group, while the shikimate pathway was downregulated. In addition, the machine learning model could distinguish faecal samples between substance users and nonsubstance users with an AUC = 0.9, indicating its potential use in predicting and screening individuals with substance use disorder within the community in the future.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; Genes, rRNA ; China ; Substance-Related Disorders ; Citrates
Chemical Substances	RNA, Ribosomal, 16S ; shikimate ; Citrates
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.13311
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Zs.A 4586: Show issues

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Article: Epidemiology and Risk Factors of Community-Associated Bloodstream Infections in Zhejiang Province, China, 2017-2020.

An, Rongcheng / Ou, Yingwei / Pang, Lingxiao / Yuan, Yongsheng / Li, Qian / Xu, Hao / Sheng, Bin

Infection and drug resistance

2023 Volume 16, Page(s) 1579–1590

Abstract: Purpose: Community-associated bloodstream infection (CA-BSI) is increasing in many community settings. However, the clinical significance and epidemiology of CA-BSI present in hospital admissions in China are not well established. In this work, we ... ...

Abstract	Purpose: Community-associated bloodstream infection (CA-BSI) is increasing in many community settings. However, the clinical significance and epidemiology of CA-BSI present in hospital admissions in China are not well established. In this work, we identified the risk factors in outpatients presenting with CA-BSI, and investigate the role of procalcitonin (PCT) and hypersensitive C-reactive protein (CRP) in diagnosing different types of the pathogen in patients with acute CA-BSI. Methods: A retrospective study enrolling 219 outpatients with CA-BSI from The Zhejiang People's Hospital from January 2017 to December 2020 was performed. Susceptibility of the isolates obtained from these patients was examined. Subjecting receiver operating characteristic curves (ROC) were constructed to analyze the specificity and sensitivity of PCT, CRP, and WBC in determining infections caused by different bacterial genera. Risk factors for CA-BSI in the emergency setting were analyzed using essential information and simple identification of other pathogenic bacterial species through rapidly tested biomarkers. Results: A total of 219 patients were included in the selection criteria, of which 103 were infected with Gram-positive bacteria (G+) and 116 with Gram-negative bacteria (G-). The PCT was significantly higher in the GN-BSI group than in the GP-BSI group, while no significant difference was observed between the two groups for CRP. Subjecting ROC curves were constructed to analyze WBC, CRP, and PCT, and the area under the curve (AUC) of the PCT in this model was 0.6661, with sensitivity = 0.798 and specificity = 0.489. Conclusion: The PCT between the GP-BSI group and the GN-BSI group was significantly different. By combining the knowledge of clinicians and the clinical signs of patients, PCT should be utilized as a supplementary approach to initially determine pathogens and direct medication in the early stages of clinical practice.
Language	English
Publishing date	2023-03-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S400108
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Article: Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection.

Shi, Sai / Xie, Lei / Ma, Sen / Xu, Binghong / An, Hailong / Ye, Sheng / Wang, Yaxin

Frontiers in pharmacology

2023 Volume 14, Page(s) 1118584

Abstract: Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other ... ...

Abstract	Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by enterovirus (EV) infection. EV71 is one of the major pathogens causing hand, foot, and mouth disease and is more likely to cause exacerbation and death than other enteroviruses. Although a monovalent vaccine for EV71 has been developed, there are no clinically available anti-EV71 specific drugs. Here, we performed virtual screening and biological experiments based on the traditional Chinese medicine monomer library. We identified a traditional Chinese medicine monomer, Salvianolic acid A (SA), a polyphenolic compound isolated from
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1118584
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Article ; Online: Monomer Emission Mechanism Research of Tetraphenylethene Derivative with Supramolecular Self-Assembly in Polymer Microspheres.

An, Zhihang / Liu, Renping / Liu, Jiaping / Du, Jiaying / Chen, Si / Wang, Xu / Sheng, Zhongyi / Liu, Heyang

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 34, Page(s) 12153–12158

Abstract: The monomer emission property of the tetraphenylethene (TPE) derivative is rarely reported, and its photoluminescence (PL) mechanism related to supramolecular self-assembly needs further in-depth research. Two long alkyl chain modified derivatives, the ... ...

Abstract	The monomer emission property of the tetraphenylethene (TPE) derivative is rarely reported, and its photoluminescence (PL) mechanism related to supramolecular self-assembly needs further in-depth research. Two long alkyl chain modified derivatives, the TPE derivative (TPE-C
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c01455
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Article ; Online: Systematic Review of Machine Learning Applied to the Secondary Prevention of Ischemic Stroke.

Chen, Meng / Qian, Dongbao / Wang, Yixuan / An, Junyan / Meng, Ke / Xu, Shuai / Liu, Sheng / Sun, Meiyan / Li, Miao / Pang, Chunying

Journal of medical systems

2024 Volume 48, Issue 1, Page(s) 8

Abstract: Ischemic stroke is a serious disease posing significant threats to human health and life, with the highest absolute and relative risks of a poor prognosis following the first occurrence, and more than 90% of strokes are attributable to modifiable risk ... ...

Abstract	Ischemic stroke is a serious disease posing significant threats to human health and life, with the highest absolute and relative risks of a poor prognosis following the first occurrence, and more than 90% of strokes are attributable to modifiable risk factors. Currently, machine learning (ML) is widely used for the prediction of ischemic stroke outcomes. By identifying risk factors, predicting the risk of poor prognosis and thus developing personalized treatment plans, it effectively reduces the probability of poor prognosis, leading to more effective secondary prevention. This review includes 41 studies since 2018 that used ML algorithms to build prognostic prediction models for ischemic stroke, transient ischemic attack (TIA), and acute ischemic stroke (AIS). We analyzed in detail the risk factors used in these studies, the sources and processing methods of the required data, the model building and validation, and their application in different prediction time windows. The results indicate that among the included studies, the top five risk factors in terms of frequency were cardiovascular diseases, age, sex, national institutes of health stroke scale (NIHSS) score, and diabetes. Furthermore, 64% of the studies used single-center data, 65% of studies using imbalanced data did not perform data balancing, 88% of the studies did not utilize external validation datasets for model validation, and 72% of the studies did not provide explanations for their models. Addressing these issues is crucial for enhancing the credibility and effectiveness of the research, consequently improving the development and implementation of secondary prevention measures.
MeSH term(s)	United States ; Humans ; Ischemic Stroke ; Secondary Prevention ; Stroke/prevention & control ; Risk Factors ; Machine Learning
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	423488-1
ISSN	1573-689X ; 0148-5598
ISSN (online)	1573-689X
ISSN	0148-5598
DOI	10.1007/s10916-023-02020-4
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Zs.A 1426: Show issues

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Article ; Online: The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction.

An, Ying / Xu, Bu-Tuo / Wan, Sheng-Rong / Ma, Xiu-Mei / Long, Yang / Xu, Yong / Jiang, Zong-Zhe

Cardiovascular diabetology

2023 Volume 22, Issue 1, Page(s) 237

Abstract: Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which leads to microangiopathy and macroangiopathy and ultimately increases the mortality of diabetic patients. Endothelial dysfunction, which has been recognized as a ... ...

Abstract	Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which leads to microangiopathy and macroangiopathy and ultimately increases the mortality of diabetic patients. Endothelial dysfunction, which has been recognized as a key factor in the pathogenesis of diabetic microangiopathy and macroangiopathy, is characterized by a reduction in NO bioavailability. Oxidative stress, which is the main pathogenic factor in diabetes, is one of the major triggers of endothelial dysfunction through the reduction in NO. In this review, we summarize the four sources of ROS in the diabetic vasculature and the underlying molecular mechanisms by which the pathogenic factors hyperglycaemia, hyperlipidaemia, adipokines and insulin resistance induce oxidative stress in endothelial cells in the context of diabetes. In addition, we discuss oxidative stress-targeted interventions, including hypoglycaemic drugs, antioxidants and lifestyle interventions, and their effects on diabetes-induced endothelial dysfunction. In summary, our review provides comprehensive insight into the roles of oxidative stress in diabetes-induced endothelial dysfunction.
MeSH term(s)	Humans ; Endothelial Cells ; Vascular Diseases ; Diabetes Mellitus/diagnosis ; Hyperglycemia ; Oxidative Stress
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-023-01965-7
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