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Article ; Online: Synergistic effect of kanamycin and amikacin with setomimycin on biofilm formation inhibition of Listeria monocytogenes.

Wang, Wei / Liu, Jun-Sheng / Zhou, Jin-Wei / Jia, Ai-Qun

2023 Volume 185, Page(s) 106447

Abstract: Listeria monocytogenes, a foodborne pathogen that causes listeriosis with high fatality rate, exhibits multidrug resistance (MDR) known to be progressively increasing. Alternative antibacterial strategies are in high demand for treating this well-known ... ...

Abstract	Listeria monocytogenes, a foodborne pathogen that causes listeriosis with high fatality rate, exhibits multidrug resistance (MDR) known to be progressively increasing. Alternative antibacterial strategies are in high demand for treating this well-known pathogen. Anti-biofilm and anti-virulence strategies are being explored as novel approaches to treat bacterial infections. In this study, one rare antibacterial named setomimycin was isolated from Streptomyces cyaneochromogenes, which showed potent antibacterial activity against L. monocytogenes. Next, the inhibition of biofilm formation and listeriolysin O (LLO) production against L. monocytogenes were investigated at sub-minimal inhibitory concentrations (sub-MICs) of setomimycin alone or combined with kanamycin and amikacin. Crystal violet staining confirmed that setomimycin combining with kanamycin or amikacin could dramatically reduce biofilm formation against L. monocytogenes at sub-MICs, which was further evaluated by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). In the meantime, sub-MICs of setomimycin could significantly suppress the secretion of LLO. Furthermore, the transcription of genes associated with biofilms and main virulence factors, such as LLO, flagellum, and metalloprotease, were suppressed by setomimycin at sub-MICs. Hence, the study provided a deep insight into setomimycin as an alternative antibacterial agent against L. monocytogenes.
MeSH term(s)	Humans ; Listeria monocytogenes ; Amikacin/pharmacology ; Kanamycin/pharmacology ; Listeriosis/microbiology ; Biofilms ; Anti-Bacterial Agents/pharmacology ; Hemolysin Proteins/genetics
Chemical Substances	Amikacin (84319SGC3C) ; setomimycin (69431-87-4) ; Kanamycin (59-01-8) ; Anti-Bacterial Agents ; Hemolysin Proteins
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106447
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Article: Quorum Sensing Inhibition and Metabolic Intervention of 4-Hydroxycinnamic Acid Against

Zhou, Jin-Wei / Ji, Peng-Cheng / Jiang, Huan / Tan, Xiao-Juan / Jia, Ai-Qun

Frontiers in microbiology

2022 Volume 13, Page(s) 830632

Abstract: The natural product 4-hydroxycinnamic acid (HA) was firstly isolated from the metabolites ... ...

Abstract	The natural product 4-hydroxycinnamic acid (HA) was firstly isolated from the metabolites of
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.830632
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Article ; Online: Cellular strategies to induce immune tolerance after liver transplantation: Clinical perspectives.

Zhou, Ai-Wei / Jin, Jing / Liu, Yuan

World journal of gastroenterology

2024 Volume 30, Issue 13, Page(s) 1791–1800

Abstract: Liver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. ... ...

Abstract	Liver transplantation (LT) has become the most efficient treatment for pediatric and adult end-stage liver disease and the survival time after transplantation is becoming longer due to the development of surgical techniques and perioperative management. However, long-term side-effects of immunosuppressants, like infection, metabolic disorders and malignant tumor are gaining more attention. Immune tolerance is the status in which LT recipients no longer need to take any immunosuppressants, but the liver function and intrahepatic histology maintain normal. The approaches to achieve immune tolerance after transplantation include spontaneous, operational and induced tolerance. The first two means require no specific intervention but withdrawing immunosuppressant gradually during follow-up. No clinical factors or biomarkers so far could accurately predict who are suitable for immunosuppressant withdraw after transplantation. With the understanding to the underlying mechanisms of immune tolerance, many strategies have been developed to induce tolerance in LT recipients. Cellular strategy is one of the most promising methods for immune tolerance induction, including chimerism induced by hematopoietic stem cells and adoptive transfer of regulatory immune cells. The safety and efficacy of various cell products have been evaluated by prospective preclinical and clinical trials, while obstacles still exist before translating into clinical practice. Here, we will summarize the latest perspectives and concerns on the clinical application of cellular strategies in LT recipients.
MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Immunosuppressive Agents/therapeutic use ; Immunosuppressive Agents/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Immune Tolerance/immunology ; End Stage Liver Disease/surgery ; End Stage Liver Disease/immunology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Transplantation Tolerance/immunology ; Adoptive Transfer/methods ; Graft Survival/immunology ; Graft Survival/drug effects ; Animals ; Treatment Outcome ; T-Lymphocytes, Regulatory/immunology ; Liver/immunology ; Liver/pathology ; Liver/surgery
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Review ; Journal Article ; Editorial
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i13.1791
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Article ; Online: In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences

Su-Qing Yang / Liu-Xia Zhang / You-Jin Ge / Jin-Wei Zhang / Jian-Xin Hu / Cheng-Ying Shen / Ai-Ping Lu / Ting-Jun Hou / Dong-Sheng Cao

Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico approaches have been proposed to expedite time- and resource-consuming experiments for target ... ...

Abstract	Abstract Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico approaches have been proposed to expedite time- and resource-consuming experiments for target detection. Herein, we developed several chemogenomic models for target prediction based on multi-scale information of chemical structures and protein sequences. By combining the information of a compound with multiple protein targets together and putting these compound-target pairs into a well-established model, the scores to indicate whether there are interactions between compounds and targets can be derived, and thus a target prediction task can be completed by sorting the outputted scores. To improve the prediction performance, we constructed several chemogenomic models using multi-scale information of chemical structures and protein sequences, and the ensemble model with the best performance was used as our final model. The model was validated by various strategies and external datasets and the promising target prediction capability of the model, i.e., the fraction of known targets identified in the top-k (1 to 10) list of the potential target candidates suggested by the model, was confirmed. Compared with multiple state-of-art target prediction methods, our model showed equivalent or better predictive ability in terms of the top-k predictions. It is expected that our method can be utilized as a powerful computational tool to narrow down the potential targets for experimental testing. Graphical Abstract
Keywords	Target prediction ; Chemogenomic ; XGBoost ; Ensemble model ; Information technology ; T58.5-58.64 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inhibitory effect of norharmane on

Luo, Huai-Zhi / Zhou, Jin-Wei / Sun, Bing / Jiang, Huan / Tang, Shi / Jia, Ai-Qun

Biofouling

2021 Volume 37, Issue 2, Page(s) 145–160

Abstract: ... Serratia ... ...

Abstract	Serratia marcescens
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biofilms ; Carbolines/pharmacology ; Quorum Sensing ; Serratia marcescens/genetics ; Spectroscopy, Fourier Transform Infrared ; Virulence Factors/genetics
Chemical Substances	Anti-Bacterial Agents ; Carbolines ; Virulence Factors ; norharman (94HMA1I78O)
Language	English
Publishing date	2021-03-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1029-2454
ISSN (online)	1029-2454
DOI	10.1080/08927014.2021.1874942
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Virulence and biofilm inhibition of 3-methoxycinnamic acid against Agrobacterium tumefaciens.

Pan, Deng / Wang, Xing-Yun / Zhou, Jin-Wei / Yang, Liang / Khan, Abbas / Wei, Dong-Qing / Li, Jun-Jian / Jia, Ai-Qun

Journal of applied microbiology

2022 Volume 133, Issue 5, Page(s) 3161–3175

Abstract: Aims: In the current study the anti-virulence and anti-biofilm activities of the cinnamic acid derivative, 3-methoxycinnamic acid, was investigated against Agrobacterium tumefaciens.: Methods and results: Based on the disc diffusion test and β- ... ...

Abstract	Aims: In the current study the anti-virulence and anti-biofilm activities of the cinnamic acid derivative, 3-methoxycinnamic acid, was investigated against Agrobacterium tumefaciens. Methods and results: Based on the disc diffusion test and β-galactosidase activity assay, 3-methoxycinnamic acid was shown to interfere with the quorum sensing (QS) system of A. tumefaciens. Crystal violet staining assay, phenol-sulfuric acid method, Bradford protein assay and confocal laser scanning microscopy (CLSM) revealed that the biofilm formation of A. tumefaciens was inhibited after the treatment of 3-methoxycinnamic acid. Employing high-performance liquid chromatography (HPLC) analysis of culture supernatant revealed that the production of 3-oxo-octanoylhomoserine lactone (3-oxo-C8-HSL) decreased concentration-dependently after treatment with 3-methoxycinnamic acid. Swimming and chemotaxis assays also indicated that 3-methoxycinnamic acid had a good effect on reducing the motility and chemotaxis of A. tumefaciens. In addition, the RT-qPCR, molecular docking and simulations further demonstrated that 3-methoxycinnamic acid could competitively inhibit the binding of 3-oxo-C8-HSL to TraR and down-regulate virulence-related genes. Conclusions: 3-Methoxycinnamic acid is proved to have good anti-virulence and anti-biofilm activities against A. tumefaciens. Significance and impact of the study: This is the first study that investigates the anti-virulence and anti-biofilm activities of 3-methoxycinnamic acid against A. tumefaciens. With its potential QS-related virulence and biofilm inhibitory activities, 3-methoxycinnamic acid is expected to be developed as a potent pesticide or adjuvant for the prevention and treatment of crown gall caused by A. tumefaciens.
MeSH term(s)	Agrobacterium tumefaciens/metabolism ; Molecular Docking Simulation ; Gentian Violet/metabolism ; Gentian Violet/pharmacology ; Quorum Sensing ; Biofilms ; 4-Butyrolactone ; Phenols/pharmacology ; Pesticides/pharmacology ; beta-Galactosidase/metabolism
Chemical Substances	N-(3-oxododecanoyl)homoserine lactone ; Gentian Violet (J4Z741D6O5) ; 4-Butyrolactone (OL659KIY4X) ; Phenols ; Pesticides ; beta-Galactosidase (EC 3.2.1.23)
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15774
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Article: In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences.

Yang, Su-Qing / Zhang, Liu-Xia / Ge, You-Jin / Zhang, Jin-Wei / Hu, Jian-Xin / Shen, Cheng-Ying / Lu, Ai-Ping / Hou, Ting-Jun / Cao, Dong-Sheng

Journal of cheminformatics

2023 Volume 15, Issue 1, Page(s) 48

Abstract: Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico approaches have been proposed to expedite time- and resource-consuming experiments for target detection. ... ...

Abstract	Identification and validation of bioactive small-molecule targets is a significant challenge in drug discovery. In recent years, various in-silico approaches have been proposed to expedite time- and resource-consuming experiments for target detection. Herein, we developed several chemogenomic models for target prediction based on multi-scale information of chemical structures and protein sequences. By combining the information of a compound with multiple protein targets together and putting these compound-target pairs into a well-established model, the scores to indicate whether there are interactions between compounds and targets can be derived, and thus a target prediction task can be completed by sorting the outputted scores. To improve the prediction performance, we constructed several chemogenomic models using multi-scale information of chemical structures and protein sequences, and the ensemble model with the best performance was used as our final model. The model was validated by various strategies and external datasets and the promising target prediction capability of the model, i.e., the fraction of known targets identified in the top-k (1 to 10) list of the potential target candidates suggested by the model, was confirmed. Compared with multiple state-of-art target prediction methods, our model showed equivalent or better predictive ability in terms of the top-k predictions. It is expected that our method can be utilized as a powerful computational tool to narrow down the potential targets for experimental testing.
Language	English
Publishing date	2023-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2486539-4
ISSN	1758-2946
ISSN	1758-2946
DOI	10.1186/s13321-023-00720-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Folic acid-tagged titanium dioxide nanoparticles for enhanced anticancer effect in osteosarcoma cells.

Ai, Jin-Wei / Liu, Bin / Liu, Wei-Dong

Materials science & engineering. C, Materials for biological applications

2017 Volume 76, Page(s) 1181–1187

Abstract: In this study, folic acid surface modified-Titanium dioxide nanoparticles (FA-TiNP) were prepared as a suitable alternative to conventional chemotherapeutic agents to treat human osteosarcoma. The particle size of TiNP increased marked after polymer ... ...

Abstract	In this study, folic acid surface modified-Titanium dioxide nanoparticles (FA-TiNP) were prepared as a suitable alternative to conventional chemotherapeutic agents to treat human osteosarcoma. The particle size of TiNP increased marked after polymer assembly on the nanoparticles (NP) surface with a spherical morphology. FA-TiNP exhibited a superior anticancer effect in osteosarcoma cancer cells compared to that of bare TiNP. The reason might due to the specific interaction of FA with the folate receptor which is overexpressed in the cancer cells. Especially, FA-TiNP treated cells exhibited chromatin condensation, cell shrinkage and membrane blebbing. FA-TiNP showed significantly higher cancer cell apoptosis with nearly 38% of cells in apoptosis chamber (early and late) compared to only ~16% for TiNP. The higher proportion of Annexin V positive cells for FA-TiNP treated group was mainly attributed to the higher intracellular uptake of the TiO2. Importantly, FA-TiNP increased the sub-G0 population to ~25% indicating its superior anticancer effect. The results clearly indicated that FA-TiNP induced greater reactive oxygen species (ROS) generation that resulted in higher sub-G0 cell population with higher cell apoptosis. FA-TiNP showed a remarkably higher expression of cytochrome C (Cyt C) with a marked increase in the expression of cleaved caspase-3 and PARP. Overall, results suggest that surface modification of TiNP with a specific targeting moiety could enhance the chances of having successful therapies for cancer diseases.
Language	English
Publishing date	2017-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2017.03.027
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Article ; Online: Virulence and biofilm inhibition of 3‐methoxycinnamic acid against Agrobacterium tumefaciens

Pan, Deng / Wang, Xing‐Yun / Zhou, Jin‐Wei / Yang, Liang / K̲h̲ān, ʻAbbās / Wei, Dong‐Qing / Li, Jun‐Jian / Jia, Ai‐Qun

Journal of Applied Microbiology. 2022 Nov., v. 133, no. 5 p.3161-3175

2022

Abstract: AIMS: In the current study the anti‐virulence and anti‐biofilm activities of the cinnamic acid derivative, 3‐methoxycinnamic acid, was investigated against Agrobacterium tumefaciens. METHODS AND RESULTS: Based on the disc diffusion test and β‐ ... ...

Abstract	AIMS: In the current study the anti‐virulence and anti‐biofilm activities of the cinnamic acid derivative, 3‐methoxycinnamic acid, was investigated against Agrobacterium tumefaciens. METHODS AND RESULTS: Based on the disc diffusion test and β‐galactosidase activity assay, 3‐methoxycinnamic acid was shown to interfere with the quorum sensing (QS) system of A. tumefaciens. Crystal violet staining assay, phenol‐sulfuric acid method, Bradford protein assay and confocal laser scanning microscopy (CLSM) revealed that the biofilm formation of A. tumefaciens was inhibited after the treatment of 3‐methoxycinnamic acid. Employing high‐performance liquid chromatography (HPLC) analysis of culture supernatant revealed that the production of 3‐oxo‐octanoylhomoserine lactone (3‐oxo‐C8‐HSL) decreased concentration‐dependently after treatment with 3‐methoxycinnamic acid. Swimming and chemotaxis assays also indicated that 3‐methoxycinnamic acid had a good effect on reducing the motility and chemotaxis of A. tumefaciens. In addition, the RT‐qPCR, molecular docking and simulations further demonstrated that 3‐methoxycinnamic acid could competitively inhibit the binding of 3‐oxo‐C8‐HSL to TraR and down‐regulate virulence‐related genes. CONCLUSIONS: 3‐Methoxycinnamic acid is proved to have good anti‐virulence and anti‐biofilm activities against A. tumefaciens. SIGNIFICANCE AND IMPACT OF THE STUDY: This is the first study that investigates the anti‐virulence and anti‐biofilm activities of 3‐methoxycinnamic acid against A. tumefaciens. With its potential QS‐related virulence and biofilm inhibitory activities, 3‐methoxycinnamic acid is expected to be developed as a potent pesticide or adjuvant for the prevention and treatment of crown gall caused by A. tumefaciens.
Keywords	Agrobacterium radiobacter ; adjuvants ; biofilm ; chemotaxis ; cinnamic acid ; crown galls ; gentian violet ; high performance liquid chromatography ; microbiology ; microscopy ; pesticides ; virulence
Language	English
Dates of publication	2022-11
Size	p. 3161-3175.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15774
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway.

Liu, Ju / Wei, Ai-Hong / Liu, Ting-Ting / Ji, Xin-Hao / Zhang, Ying / Yan, Fei / Chen, Mei-Xiang / Hu, Jin-Bo / Zhou, Shao-Yu / Shi, Jing-Shan / Jin, Hai / Jin, Feng

The FEBS journal

2024

Abstract: It was reported that the Wnt/β-catenin pathway is involved in the regulation of aerobic glycolysis and that brain glycolytic dysfunction results in the development of Alzheimer's disease (AD). Icariin (ICA), an active component extracted from Epimedii ... ...

Abstract	It was reported that the Wnt/β-catenin pathway is involved in the regulation of aerobic glycolysis and that brain glycolytic dysfunction results in the development of Alzheimer's disease (AD). Icariin (ICA), an active component extracted from Epimedii Folium, has been reported to produce neuroprotective effects in multiple models of AD, but its underlying mechanism remains to be fully described. We aimed to investigate the protective effects of ICA on animal and cell models of AD and confirm whether the Wnt/β-catenin pathway has functions in the neuroprotective function of ICA. The 3 × Tg-AD mice were treated with ICA. HT22 cells, the Aβ
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2173655-8
ISSN	1742-4658 ; 1742-464X
ISSN (online)	1742-4658
ISSN	1742-464X
DOI	10.1111/febs.17099
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