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  1. Article: Clubhouse Model of Psychiatric Rehabilitation in China to Promote Recovery of People With Schizophrenia: A Systematic Review and Meta-Analysis.

    Yan, Haohao / Ding, Yudan / Guo, Wenbin

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 730552

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-09-13
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.730552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metformin plus L-carnitine enhances brown/beige adipose tissue activity via Nrf2/HO-1 signaling to reduce lipid accumulation and inflammation in murine obesity.

    Liang, Guojin / Fang, Jie / Zhang, Pingping / Ding, Shuxia / Zhao, Yudan / Feng, Yueying

    Open medicine (Warsaw, Poland)

    2024  Volume 19, Issue 1, Page(s) 20240900

    Abstract: This study investigated how Metformin (Met) combined with L-carnitine (L-car) modulates brown adipose tissue (BAT) to affect obesity. High-fat-induced obese rats received daily oral gavage with Met and/or L-car, followed by serum biochemical analysis, ... ...

    Abstract This study investigated how Metformin (Met) combined with L-carnitine (L-car) modulates brown adipose tissue (BAT) to affect obesity. High-fat-induced obese rats received daily oral gavage with Met and/or L-car, followed by serum biochemical analysis, histopathological observation on adipose tissues, and immunochemistry test for the abdominal expression of BAT-specific uncoupling protein 1 (UCP1). Mouse-embryonic-fibroblast cells were induced into adipocytes, during which Met plus L-car was added with/without saturated fatty acid (SFA). The role of nuclear factor erythroid 2-related factor 2 (Nrf2) in adipocyte browning was investigated by gene silencing. Mitochondria biogenesis in adipocytes was inspected by Mitotracker staining. Nrf2/heme oxygenase-1 (HO-1)/BAT-related genes/proinflammatory marker expressions in adipose tissues and/or adipocytes were analyzed by Western blot, qRT-PCR, and/or immunofluorescence test. Met or L-car improved metabolic disorders, reduced adipocyte vacuolization and swelling, upregulated levels of BAT-related genes including UCP1 and downregulated proinflammatory marker expressions, and activated the Nrf2/HO-1 pathway in adipose tissues of obese rats. Met and L-car functioned more strongly than alone. In adipocytes, Met plus L-car upregulated BAT-related gene levels and protected against SFA-caused inflammation promotion and mitochondria degeneration, which yet was attenuated by Nrf2 silencing. Met plus L-car enhances BAT activity and white adipose tissue browning via the Nrf2/HO-1 pathway to reduce lipid accumulation and inflammation in obese rats.
    Language English
    Publishing date 2024-02-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2024-0900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of molecular chaperone CCT/TRiC in translation elongation: A literature review.

    Que, Yueyue / Qiu, Yudan / Ding, Zheyu / Zhang, Shanshan / Wei, Rong / Xia, Jianing / Lin, Yingying

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e29029

    Abstract: Protein synthesis from mRNA is an energy-intensive and strictly controlled biological process. Translation elongation is a well-coordinated and multifactorial step in translation that ensures the accurate and efficient addition of amino acids to a ... ...

    Abstract Protein synthesis from mRNA is an energy-intensive and strictly controlled biological process. Translation elongation is a well-coordinated and multifactorial step in translation that ensures the accurate and efficient addition of amino acids to a growing nascent-peptide chain encoded in the sequence of messenger RNA (mRNA). Which undergoes dynamic regulation due to cellular state and environmental determinants. An expanding body of research points to translational elongation as a crucial process that controls the translation of an mRNA through multiple feedback mechanisms. Molecular chaperones are key players in protein homeostasis to keep the balance between protein synthesis, folding, assembly, and degradation. Chaperonin-containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC) is an essential eukaryotic molecular chaperone that plays an essential role in assisting cellular protein folding and suppressing protein aggregation. In this review, we give an overview of the factors that influence translation elongation, focusing on different functions of molecular chaperones in translation elongation, including how they affect translation rates and post-translational modifications. We also provide an understanding of the mechanisms by which the molecular chaperone CCT plays multiple roles in the elongation phase of eukaryotic protein synthesis.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiological, Radiographical, and Laboratorial Characteristics of Chinese Asymptomatic Cases With COVID-19: A Systematic Review and Meta-Analysis.

    Yan, Haohao / Ding, Yudan / Guo, Wenbin

    Frontiers in public health

    2022  Volume 10, Page(s) 808471

    Abstract: The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, ... ...

    Abstract The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, 2022 for relevant articles. Data synthesis, subgroup analysis, and sensitivity analysis were performed on the included studies.
    Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD 42021261130.
    MeSH term(s) Antibodies, Viral ; Asymptomatic Infections/epidemiology ; COVID-19/epidemiology ; Humans ; Immunoglobulin G ; Immunoglobulin M ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.808471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical Characteristics of Children With COVID-19: A Meta-Analysis.

    Ding, Yudan / Yan, Haohao / Guo, Wenbin

    Frontiers in pediatrics

    2020  Volume 8, Page(s) 431

    Abstract: Background: ...

    Abstract Background:
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2020.00431
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  6. Article ; Online: Epidemiological, Radiographical, and Laboratorial Characteristics of Chinese Asymptomatic Cases With COVID-19

    Haohao Yan / Yudan Ding / Wenbin Guo

    Frontiers in Public Health, Vol

    A Systematic Review and Meta-Analysis

    2022  Volume 10

    Abstract: The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, ... ...

    Abstract The comprehensive understanding of the characteristics of asymptomatic cases are helpful for the identification and management of patients with asymptomatic COVID-19 infection. Four electronic databases were searched from December 1, 2019 to February 8, 2022 for relevant articles. Data synthesis, subgroup analysis, and sensitivity analysis were performed on the included studies. I2 and Q tests were applied to evaluate heterogeneity across studies. The risk of publication bias was assessed and visualized using a funnel plot. A total of 45 studies consisting of 2,655 patients with no symptoms at the screening point were included. Pooled results showed that in China, 65% of initial no-symptoms COVID-19 patients did not present any COVID-19-related symptom during follow-up or by end of disease course (asymptomatic infections). High proportions of initial no-symptoms COVID-19 patients (76%) and patients with asymptomatic infection (55%) had abnormal CT features at the screening point. High proportion of patients with asymptomatic infection had been detected Ig G+ (72%) and/or Ig M+ (57%) at the screening point. The chest CT scan and SARS-CoV-2-specific antibody testing could serve as effective supplementary methods to identify asymptomatic cases in the early stage of SARS-CoV-2 infection. However, the chest CT scan and the SARS-CoV-2-specific IgM and IgG testing should not replace reverse transcription–polymerase chain reaction (RT-PCR) for screening in asymptomatic patients. The combination of repeated RT-PCR, chest CT scans, and the SARS-CoV-2-specific IgM and IgG testing should be performed for those highly suspected SARS-CoV-2 infections.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD 42021261130.
    Keywords COVID-19 ; SARS-CoV-2 ; asymptomatic infection ; presymptomatic infection ; CT ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Mental Health of Pregnant and Postpartum Women During the Coronavirus Disease 2019 Pandemic: A Systematic Review and Meta-Analysis.

    Yan, Haohao / Ding, Yudan / Guo, Wenbin

    Frontiers in psychology

    2020  Volume 11, Page(s) 617001

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-11-25
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2020.617001
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  8. Article ; Online: Similar imaging changes and their relations to genetic profiles in bipolar disorder across different clinical stages.

    Zhang, Leyi / Ding, Yudan / Li, Tingting / Li, Huabing / Liu, Feng / Li, Ping / Zhao, Jingping / Lv, Dongsheng / Lang, Bing / Guo, Wenbin

    Psychiatry research

    2024  Volume 335, Page(s) 115868

    Abstract: Bipolar disorder (BD) across different clinical stages may present shared and distinct changes in brain activity. We aimed to reveal the neuroimaging homogeneity and heterogeneity of BD and its relationship with clinical variables and genetic variations. ...

    Abstract Bipolar disorder (BD) across different clinical stages may present shared and distinct changes in brain activity. We aimed to reveal the neuroimaging homogeneity and heterogeneity of BD and its relationship with clinical variables and genetic variations. In present study, we conducted fractional amplitude of low-frequency fluctuations (fALFF), functional connectivity (FC) and genetic neuroimaging association analyses with 32 depressed, 26 manic, 35 euthymic BD patients and 87 healthy controls (HCs). Significant differences were found in the bilateral pre/subgenual anterior cingulate cortex (ACC) across the four groups, and all bipolar patients exhibited decreased fALFF values in the ACC when compared to HCs. Furthermore, positive associations were significantly observed between fALFF values in the pre/subgenual ACC and participants' cognitive functioning. No significant changes were found in ACC-based FC. We identified fALFF-alteration-related genes in BD, with enrichment in biological progress including synaptic and ion transmission. Taken together, abnormal activity in ACC is a characteristic change associated with BD, regardless of specific mood stages, serving as a potential neuroimaging feature in BD patients. Our genetic neuroimaging association analysis highlights possible heterogeneity in biological processes that could be responsible for different clinical stages in BD.
    MeSH term(s) Humans ; Bipolar Disorder/diagnostic imaging ; Bipolar Disorder/genetics ; Genetic Profile ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Gyrus Cinguli/diagnostic imaging ; Brain/diagnostic imaging
    Language English
    Publishing date 2024-03-27
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115868
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1541: Show issues Location:
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  9. Article ; Online: Highly efficient anion exchange membrane water electrolyzers via chromium-doped amorphous electrocatalysts.

    Li, Sicheng / Liu, Tong / Zhang, Wei / Wang, Mingzhen / Zhang, Huijuan / Qin, Chunlan / Zhang, Lingling / Chen, Yudan / Jiang, Shuaiwei / Liu, Dong / Liu, Xiaokang / Wang, Huijuan / Luo, Qiquan / Ding, Tao / Yao, Tao

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3416

    Abstract: In-depth comprehension and modulation of the electronic structure of the active metal sites is crucial to enhance their intrinsic activity of electrocatalytic oxygen evolution reaction (OER) toward anion exchange membrane water electrolyzers (AEMWEs). ... ...

    Abstract In-depth comprehension and modulation of the electronic structure of the active metal sites is crucial to enhance their intrinsic activity of electrocatalytic oxygen evolution reaction (OER) toward anion exchange membrane water electrolyzers (AEMWEs). Here, we elaborate a series of amorphous metal oxide catalysts (FeCrO
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47736-0
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  10. Article ; Online: Whether full-length IL-38 acts as a promoter or inhibitor in activating rheumatoid arthritis fibroblast-like synoviocytes depends on IL-1β.

    Ding, Yudan / Shao, Ju / Liu, Cai / Li, Zhengtong / Zhang, Yuping / Jie, Ligang / Zhu, Xiaotong / Liang, Bibo / Yu, Qinghong / Wu, Jing

    International journal of rheumatic diseases

    2024  Volume 27, Issue 1, Page(s) e15020

    Abstract: Aim: IL-38 is a recently discovered inflammatory factor that belongs to the IL-1 family and has full-length and truncated forms. Clinical findings demonstrated that serum IL-38 levels in people with infectious and autoimmune diseases are significantly ... ...

    Abstract Aim: IL-38 is a recently discovered inflammatory factor that belongs to the IL-1 family and has full-length and truncated forms. Clinical findings demonstrated that serum IL-38 levels in people with infectious and autoimmune diseases are significantly different from those in healthy people, but the form remains unclear. We are keenly interested in learning more about the regulatory role of full-length IL-38 in rheumatoid arthritis (RA), a classic autoimmune disease.
    Methods: RA-fibroblast-like synoviocytes (RA-FLS) were isolated from six RA patients and stimulated with full-length IL-38 to observe IL-6 and IL-8 secretion. Then, the migration and invasion functions of FLS were assessed. Next, the protein expressions of the MAPK, NF-κB, and JAK pathways were evaluated. In addition, we examined the effect of full-length IL-38 on FLS functions in the presence of IL-1β. The function of FLS affected by full-length IL-38 was also examined after blocking IL-1 and IL-36 receptors.
    Results: The functions of FLS were activated after the cells were stimulated with full-length IL-38. IL-6 and IL-8 levels increased with an increase in the full-length IL-38 concentration, and full-length IL-38 induced the acceleration of FLS migration and invasion functions. In addition, the levels of proteins in the MAPK signaling pathway increased after stimulation with full-length IL-38 and depended on its concentration. However, when the FLS were stimulated by IL-38 and IL-1β simultaneously, all experiments generated opposite results. Full-length IL-38 inhibited FLS function in the presence of IL-1β. IL-1R and IL-36R blockers terminated all effects of full-length IL-38 on RA-FLS.
    Conclusion: Full-length IL-38 activates FLS functions and acts as a promoter in RA, whereas it inhibits FLS functions and acts as an inhibitor of RA in the presence of IL-1β. The function of full-length IL-38 can be blocked by IL-1Ra and IL-36Ra.
    MeSH term(s) Humans ; Synoviocytes/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Cells, Cultured ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Fibroblasts/metabolism ; Interleukin-1 ; Synovial Membrane ; Interleukins/pharmacology
    Chemical Substances Interleukin-6 ; Interleukin-8 ; Interleukin-1 ; IL-38 protein, human ; Interleukins
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
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