Article ; Online: Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats.
PloS one
2014 Volume 9, Issue 2, Page(s) e87623
Abstract: Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var ...
| Abstract | Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in traditional Oriental medicine as a vitalizing medicine or as the prescription for patients with age-associated disorders such as amnesia and stroke. However, the potential protective value of KOK for the treatment of polycystic ovarian syndrome (PCOS) is largely unknown. We investigated whether pre-administration (daily from 2 hours before PCOS induction) and post-administration (daily after induction of PCOS) of KOK (0.5, 1.0, and 2.0 g/kg/day, p.o.) could have a protective effect in a dehydroepiandrosterone (DHEA, s.c.)-induced PCOS rat model. Pre-administration of KOK significantly decreased the elevated body weight and ovary weight, elevated size and number of follicular cysts, elevated level of serum glucose, and estradiol after DHEA injection. KOK reduced the elevated percentage of CD8 (+) T lymphocytes in lymph nodes, the elevated mRNA expression of CD11b and CD3 in ovaries, and infiltration of macrophages in ovarian tissue with PCOS. KOK diminished the increased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), chemokines (IL-8, MCP-1), and iNOS in the ovaries, and increased the reduced mRNA expression of growth factors (EGF, TGF-β) by DHEA injection. Post-administration of KOK also improved the DHEA-induced PCOS-like symptoms, generally similar to those evident from pre-administration of KOK. KOK may effectively prevent and improve DHEA-induced PCOS via anti-inflammatory action, indicating its preventive and therapeutic potential for suppressing PCOS. |
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| MeSH term(s) | Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; Dehydroepiandrosterone ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/toxicity ; Estradiol/blood ; Estrous Cycle/drug effects ; Fasting/blood ; Female ; Inflammation Mediators/metabolism ; Insulin/blood ; Lymph Nodes/drug effects ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Medicine, East Asian Traditional ; Organ Size/drug effects ; Ovary/drug effects ; Ovary/pathology ; Phytotherapy ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/pathology ; Polycystic Ovary Syndrome/prevention & control ; Progesterone/blood ; Rats ; Rats, Sprague-Dawley ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism |
| Chemical Substances | Blood Glucose ; Drugs, Chinese Herbal ; Inflammation Mediators ; Insulin ; Plant Extracts ; kyung-ok-ko ; Dehydroepiandrosterone (459AG36T1B) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) |
| Language | English |
| Publishing date | 2014-02-10 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0087623 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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