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  1. Book: Cancer Neuroscience

    Scheff, Nicole N. / Amit, Moran

    2023  

    Author's details Dr. Amit is dedicated to key areas of cancer research that will develop therapeutic approaches to improve patients' survival, treatment responses, and quality of life. During his residency training, Dr. Amit became interested in the biology of cancer. After completing his residency, he undertook further training in Head and Neck Surgical Oncology at The University of Texas MD Anderson Cancer Center, where he completed a clinical fellowship as a head and neck surgical oncologist and a postdoctoral fellowship with a focus on the neurobiology of cancer. Dr. Amit has an active research laboratory focusing on cancer-related neurogenesis and axonogenesis and on the role of neuro-immunology in cancer. One exciting finding of Dr. Amit's lab involved describing a mechanism by which head and neck tumors can reprogram adrenergic signaling in neurons and the effect of targeting the peripheral nervous system on cancer initiation and progression. This will serve as a basisfor combining treatment
    Keywords cancer therapeutics ; Neurobiology ; tumor microenvironment ; Neuronal plasticity ; cns ; PNS ; Neuroimmunology ; Oncology ; perineural invasion ; Tumor models ; Tumor microenvironment ; CNS ; neuroimmunology
    Language English
    Size 216 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_22
    Format 160 x 241 x 18
    ISBN 9783031324284 ; 3031324285
    Database PDA

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  2. Article ; Online: Cancer Neuroscience: Evidence for a New Hallmark of Cancer.

    Amit, Moran

    Advanced biology

    2022  Volume 6, Issue 9, Page(s) e2200192

    MeSH term(s) Humans ; Neoplasms/therapy ; Neurosciences
    Language English
    Publishing date 2022-09-18
    Publishing country Germany
    Document type Editorial
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202200192
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  3. Article: Role of ultrasound and MRI in the evaluation of postoperative rotator cuff.

    Sahu, Amit Kumar / Moran, Erin Kathleen / Gandikota, Girish

    Journal of ultrasonography

    2023  Volume 23, Issue 95, Page(s) e188–e201

    Abstract: Rotator cuff tears are common shoulder injuries in patients above 40 years of age, causing pain, disability, and reduced quality of life. Most recurrent rotator cuff tears happen within three months. Surgical repair is often necessary in patients with ... ...

    Abstract Rotator cuff tears are common shoulder injuries in patients above 40 years of age, causing pain, disability, and reduced quality of life. Most recurrent rotator cuff tears happen within three months. Surgical repair is often necessary in patients with large or symptomatic tears to restore shoulder function and relieve symptoms. However, 25% of patients experience pain and dysfunction even after successful surgery. Imaging plays an essential role in evaluating patients with postoperative rotator cuff pain. The ultrasound and magnetic resonance imaging are the most commonly used imaging modalities for evaluating rotator cuff. The ultrasound is sometimes the preferred first-line imaging modality, given its easy availability, lower cost, ability to perform dynamic tendon evaluation, and reduced post-surgical artifacts compared to magnetic resonance imaging. It may also be superior in terms of earlier diagnosis of smaller re-tears. Magnetic resonance imaging is better for assessing the extent of larger tears and for detecting other complications of rotator cuff surgery, such as hardware failure and infection. However, postoperative imaging of the rotator cuff can be challenging due to the presence of hardware and variable appearance of the repaired tendon, which can be confused with a re-tear. This review aims to provide an overview of the current practice and findings of postoperative imaging of the rotator cuff using magnetic resonance imaging and ultrasound. We discuss the advantages and limitations of each modality and the normal and abnormal imaging appearance of repaired rotator cuff tendon.
    Language English
    Publishing date 2023-11-23
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2843824-3
    ISSN 2084-8404
    ISSN 2084-8404
    DOI 10.15557/jou.2023.0028
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  4. Article ; Online: Eliminating waste with waste: transforming spent coffee grounds into microrobots for water treatment.

    Singh, Amit Kumar / Basireddy, Tarini / Moran, Jeffrey L

    Nanoscale

    2023  Volume 15, Issue 43, Page(s) 17494–17507

    Abstract: Water pollutants such as oil spills, industrial dyes, and microplastics threaten public health and aquatic ecosystems. There are considerable challenges in removing water contaminants using traditional methods. Several studies have been conducted in ... ...

    Abstract Water pollutants such as oil spills, industrial dyes, and microplastics threaten public health and aquatic ecosystems. There are considerable challenges in removing water contaminants using traditional methods. Several studies have been conducted in recent years to develop effective water purification materials. Despite this, the mass production of most materials is extremely challenging because they involve multiple intricate steps and sophisticated equipment. Herein, we report the facile synthesis of spent coffee ground (SCG)-derived magnetic microrobots, which we dub "CoffeeBots", to remove oil, organic dyes, and microplastic pollution from contaminated seawater. In order to meet eco-friendly, high-yield and low-cost requirements, iron oxide nanoparticles (IONPs) were deposited on biodegradable SCGs using green chemistry. The IONPs on CoffeeBots facilitate magnetic navigation and recycling, microswarm assembly, and ease of retrieval after water remediation tasks. CoffeeBots' intrinsic surface hydrophobicity enables efficient on-the-fly capture and removal of oil droplets and microplastics from contaminated water with remote magnetic guidance. CoffeeBots were also functionalized with ascorbic acid (AA@CoffeeBots) to remove methylene blue (MB) dye contaminants from polluted seawater. SCGs and AA act as bioadsorbent and reducing agent, respectively, for MB dye removal whereas magnetic propulsion enhances mixing and accelerates MB decolorization. These CoffeeBots can be recycled numerous times for removing oil spills, organic dyes, and microplastics from the seawater. CoffeeBots hold considerable potential as sustainable, recyclable, and low-cost remediation agents for water treatment in the near future.
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03592a
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  5. Article ; Online: The Boring Schwann Cells: Tumor Me-TAST-asis along Nerves.

    Amit, Moran / Maitra, Anirban

    Cancer discovery

    2022  Volume 12, Issue 10, Page(s) 2240–2243

    Abstract: Perineural spread is an ominous feature of cancer. Here, Deborde and colleagues describe for the first time the biophysical coupling driving this route of tumor spread and the role of Schwann cell activation in the mobilization of cancer cells within and ...

    Abstract Perineural spread is an ominous feature of cancer. Here, Deborde and colleagues describe for the first time the biophysical coupling driving this route of tumor spread and the role of Schwann cell activation in the mobilization of cancer cells within and along the tumor-associated nerves. See related article by Deborde et al., p. 2454 (8).
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Schwann Cells/metabolism ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-0829
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
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  6. Article ; Online: Neuro-immune interactions and immuno-oncology.

    Khanmammadova, Narmina / Islam, Shajedul / Sharma, Padmanee / Amit, Moran

    Trends in cancer

    2023  Volume 9, Issue 8, Page(s) 636–649

    Abstract: The nervous system is an important component of the tumor microenvironment (TME), driving tumorigenesis and tumor progression. Neuronal cues (e.g., neurotransmitters and neuropeptides) in the TME cause phenotypic changes in immune cells, such as ... ...

    Abstract The nervous system is an important component of the tumor microenvironment (TME), driving tumorigenesis and tumor progression. Neuronal cues (e.g., neurotransmitters and neuropeptides) in the TME cause phenotypic changes in immune cells, such as increased exhaustion and inhibition of effector cells, which promote immune evasion and cancer progression. Two types of immune regulation by tumor-associated nerves are discussed in this review: regulation via neuronal stimuli (i.e., by neural transmission) and checkpoint-mediated neuronal immune regulation. The latter occurs via the expression of immune checkpoints on the membranes of intratumoral nerves and glial cells. Here, we summarize novel findings regarding the neuroimmune circuits in the tumor milieu, while emphasizing the potential targets of new and affordable anticancer therapeutic approaches.
    MeSH term(s) Humans ; Neuroimmunomodulation ; Immunotherapy ; Neoplasms/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.05.002
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  7. Article ; Online: Targeting the Nerve-Cancer Circuit.

    Ye, Yi / Xie, Tongxin / Amit, Moran

    Cancer research

    2023  Volume 83, Issue 15, Page(s) 2445–2447

    Abstract: The tumor microenvironment is innervated by sensory, sympathetic, and parasympathetic nerves that actively stimulate cancer growth and dissemination. The cross-talk among the peripheral nerves, cancer cells, and stromal cells is mediated by a diverse set ...

    Abstract The tumor microenvironment is innervated by sensory, sympathetic, and parasympathetic nerves that actively stimulate cancer growth and dissemination. The cross-talk among the peripheral nerves, cancer cells, and stromal cells is mediated by a diverse set of bioactive ligands and their corresponding receptors. Dissecting the specific neuronal subtypes and molecular signals that drive cancer-nerve interaction holds the hope of developing targeted therapies for cancer. A recent study by Restaino and colleagues demonstrated that regardless of tumor type, origin, or anatomic location, tumors are densely innervated, predominantly by transient receptor potential cation channel subfamily V member 1 positive (TRPV1+) sensory fibers. The intratumoral fibers likely have functional connectivity and contribute to increased electrical activity in the tumor bed. Importantly, the neuropeptide substance P produced by intratumoral fibers stimulates its neurokinin 1 receptor (NK1R) expressed on tumor cells to drive tumor proliferation and migration. The findings raised the intriguing possibility of a generalizable molecular pathway that mediates cancer-nerve interaction that can be targeted to inhibit tumor growth and metastasis across different tumor types.
    MeSH term(s) Humans ; Neurons/metabolism ; Receptors, Neurokinin-1/metabolism ; Neuropeptides/metabolism ; Substance P/metabolism ; Neoplasms/metabolism
    Chemical Substances Receptors, Neurokinin-1 ; Neuropeptides ; Substance P (33507-63-0)
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-1754
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  8. Article ; Online: Psilocybin-assisted psychotherapy for cancer-related anxiety and depression.

    Yaniv, Dan / Ramondetta, Lois Michelle / Cohen, Lorenzo / Amit, Moran

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 8, Page(s) 1327–1328

    MeSH term(s) Humans ; Psilocybin/therapeutic use ; Depression/etiology ; Depression/therapy ; Anxiety/etiology ; Anxiety/therapy ; Psychotherapy ; Neoplasms/complications ; Neoplasms/therapy
    Chemical Substances Psilocybin (2RV7212BP0)
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004659
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Book ; Online: Multiclass Boosting

    Brukhim, Nataly / Daniely, Amit / Mansour, Yishay / Moran, Shay

    Simple and Intuitive Weak Learning Criteria

    2023  

    Abstract: We study a generalization of boosting to the multiclass setting. We introduce a weak learning condition for multiclass classification that captures the original notion of weak learnability as being "slightly better than random guessing". We give a simple ...

    Abstract We study a generalization of boosting to the multiclass setting. We introduce a weak learning condition for multiclass classification that captures the original notion of weak learnability as being "slightly better than random guessing". We give a simple and efficient boosting algorithm, that does not require realizability assumptions and its sample and oracle complexity bounds are independent of the number of classes. In addition, we utilize our new boosting technique in several theoretical applications within the context of List PAC Learning. First, we establish an equivalence to weak PAC learning. Furthermore, we present a new result on boosting for list learners, as well as provide a novel proof for the characterization of multiclass PAC learning and List PAC learning. Notably, our technique gives rise to a simplified analysis, and also implies an improved error bound for large list sizes, compared to previous results.
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-07-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Head and neck cancer exosomes drive microRNA-mediated reprogramming of local neurons.

    Hunt, Patrick J / Amit, Moran

    Extracellular vesicles and circulating nucleic acids

    2020  Volume 1, Page(s) 57–62

    Abstract: ... Recently, Amit ...

    Abstract Solid tumors are complex collections of cells surrounded by benign tissues that influence and are influenced by the tumor. These surrounding cells include vasculature, immune cells, neurons, and other cell types, and are collectively known as the tumor microenvironment. Tumors manipulate their microenvironment for the benefit of the tumor. Autonomic neurons innervate and drive malignant growth in a variety of solid tumors. However, the mechanisms underlying neuron-tumor relationships are not well understood. Recently, Amit
    Language English
    Publishing date 2020-12-30
    Document type Journal Article
    DOI 10.20517/evcna.2020.04
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