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  1. Article ; Online: Dolutegravir dosing with rifampicin.

    Cattaneo, Dario / Gervasoni, Cristina

    The lancet. HIV

    2023  Volume 10, Issue 10, Page(s) e635–e636

    Language English
    Publishing date 2023-09-14
    Publishing country Netherlands
    Document type Letter
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00229-1
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  2. Article: No effects of nirmatrelvir/ritonavir on darunavir plasma trough concentrations: a case report.

    Cattaneo, Dario / Pagano, Simone / Lazzarin, Samuel / Calvagna, Nunziata / Gervasoni, Cristina

    European journal of hospital pharmacy : science and practice

    2024  

    Abstract: COVID-19 may be associated with worst outcomes in people living with HIV compared with HIV-negative patients. Nirmatrelvir/ritonavir can be safely co-administered with all the HIV antiretroviral drugs, without considering dose adjustment. However, no ... ...

    Abstract COVID-19 may be associated with worst outcomes in people living with HIV compared with HIV-negative patients. Nirmatrelvir/ritonavir can be safely co-administered with all the HIV antiretroviral drugs, without considering dose adjustment. However, no studies have formally investigated the effect of a double booster (ritonavir plus cobicistat) regimen on darunavir concentrations. We presented a case describing the lack of effects of adding nirmatrelvir/ritonavir on darunavir plasma trough concentrations in a patient with HIV already on treatment with a booster-based antiretroviral regimen. We believe this could be a reassuring message for physicians, allowing them to prevent unnecessary denial of COVID-19 treatment or inappropriate discontinuation of co-medications in patients with HIV.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2023-004015
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  3. Article ; Online: Management of enzyme de-induction in a woman with HIV on methadone maintenance switched from nevirapine- to bictegravir-based antiretroviral regimen.

    Cattaneo, Dario / Giacomelli, Andrea / Casalini, Giacomo / Ridolfo, Anna Lisa / Gervasoni, Cristina

    European journal of clinical pharmacology

    2024  

    Language English
    Publishing date 2024-03-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-024-03681-x
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    Zs.A 672: Show issues Location:
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  4. Article ; Online: Hematological toxicities associated with linezolid therapy in adults: key findings and clinical considerations.

    Cattaneo, Dario / Marriott, Deborah Je / Gervasoni, Cristina

    Expert review of clinical pharmacology

    2023  Volume 16, Issue 3, Page(s) 219–230

    Abstract: Introduction: Linezolid can cause serious adverse effects including thrombocytopenia and anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment.: Areas covered: We review ... ...

    Abstract Introduction: Linezolid can cause serious adverse effects including thrombocytopenia and anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult patients requiring prolonged drug treatment.
    Areas covered: We review the available evidence on the likelihood of hematological toxicity in adult patients treated with linezolid, with a focus on the main risk factors and strategies to prevent this adverse event. A MEDLINE PubMed search for articles published from January 2000 to May 2022 was completed matching the terms linezolid, hematology, hematological toxicity, anemia, and thrombocytopenia. Moreover, additional studies were identified from the reference lists of retrieved articles.
    Expert opinion: Thrombocytopenia is the major concern with administration of linezolid for Gram-positive infections, whereas anemia is more common in patients with tuberculosis. The important clinical risk factors for the development of linezolid-related thrombocytopenia are aging, renal dysfunction, low baseline platelet count, duration of treatment, and linezolid plasma trough concentrations >8 mg/L. Patients receiving linezolid for extended periods of time or patient populations with increased risk of altered drug pharmacokinetics would benefit from therapeutic drug monitoring or from the availability of toxico-dynamic predictive models to optimize linezolid dosing.
    MeSH term(s) Humans ; Adult ; Linezolid ; Anti-Bacterial Agents ; Thrombocytopenia ; Drug-Related Side Effects and Adverse Reactions ; Anemia
    Chemical Substances Linezolid (ISQ9I6J12J) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Review ; Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2181160
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  5. Article ; Online: Switching to deltoid intramuscular injections maintains therapeutic trough concentrations of rilpivirine and cabotegravir in people with HIV.

    Cossu, Maria Vittoria / D'Avolio, Antonio / Gervasoni, Cristina / Giacomelli, Andrea / Cattaneo, Dario / Moschese, Davide

    Antimicrobial agents and chemotherapy

    2024  Volume 68, Issue 5, Page(s) e0017524

    MeSH term(s) Humans ; Rilpivirine/therapeutic use ; Rilpivirine/pharmacokinetics ; Rilpivirine/administration & dosage ; Injections, Intramuscular ; HIV Infections/drug therapy ; Pyridones/pharmacokinetics ; Pyridones/administration & dosage ; Pyridones/therapeutic use ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/therapeutic use ; Anti-HIV Agents/administration & dosage ; Male ; Female ; Middle Aged ; Adult ; Diketopiperazines
    Chemical Substances Rilpivirine (FI96A8X663) ; Pyridones ; cabotegravir (HMH0132Z1Q) ; Anti-HIV Agents ; Diketopiperazines
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00175-24
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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  6. Article ; Online: Drug Shortages Highlight the Need for Expanded Treatment Options for Syphilis.

    Lazzarin, Samuel / Giacomelli, Andrea / Moschese, Davide / Antinori, Spinello / Gervasoni, Cristina

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 9, Page(s) 1356

    MeSH term(s) Humans ; Pregnancy ; Female ; Syphilis/drug therapy ; Syphilis, Congenital ; Pregnancy Complications, Infectious/drug therapy
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad396
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  7. Article ; Online: Potential association between chia seeds use and low atazanavir trough concentrations in an HIV-infected patient.

    Cattaneo, Dario / Pagano, Simone / Beltrami, Martina / Micheli, Valeria / Gervasoni, Cristina

    European journal of clinical pharmacology

    2023  Volume 79, Issue 8, Page(s) 1145–1146

    MeSH term(s) Humans ; Atazanavir Sulfate/therapeutic use ; HIV Protease Inhibitors/adverse effects ; Pyridines ; HIV Infections/drug therapy ; Ritonavir/therapeutic use
    Chemical Substances Atazanavir Sulfate (4MT4VIE29P) ; Salvia hispanica seed extract ; HIV Protease Inhibitors ; Pyridines ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2023-06-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-023-03524-1
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    Zs.A 672: Show issues Location:
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  8. Article ; Online: Comment on: Doravirine plus lamivudine two-drug regimen as maintenance antiretroviral therapy in people living with HIV: a French observational study.

    Giacomelli, Andrea / Cossu, Maria Vittoria / Moschese, Davide / Gervasoni, Cristina

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 12, Page(s) 3009–3010

    MeSH term(s) Humans ; Lamivudine/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; HIV Infections/drug therapy ; Pyridones/therapeutic use
    Chemical Substances Lamivudine (2T8Q726O95) ; doravirine (913P6LK81M) ; Anti-Retroviral Agents ; Pyridones
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad318
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  9. Article ; Online: Different effects of the companion antiretroviral drugs on dolutegravir trough concentrations.

    Cattaneo, Dario / Pagano, Simone / Colombo, Martina Laura / Giacomelli, Andrea / Gori, Andrea / Gervasoni, Cristina

    AIDS (London, England)

    2024  Volume 38, Issue 6, Page(s) 847–851

    Abstract: Background: Dolutegravir is widely used in different dual and triple antiretroviral regimens. Here, we sought to investigate the effect of the companion antiretroviral drug(s) on dolutegravir plasma trough concentrations in persons with HIV, with a ... ...

    Abstract Background: Dolutegravir is widely used in different dual and triple antiretroviral regimens. Here, we sought to investigate the effect of the companion antiretroviral drug(s) on dolutegravir plasma trough concentrations in persons with HIV, with a focus on dual regimens.
    Methods: Dolutegravir concentrations collected from October 2015 to March 2023 ( n  = 900) were stratified according to the main antiretroviral classes (NRTIs, NNRTIs, protease inhibitors) and according to single drugs. Dolutegravir concentrations measured in persons with HIV concomitantly treated with lamivudine were considered as the reference group.
    Results: Dolutegravir trough concentrations were significantly higher in persons with HIV given protease inhibitors compared with the reference [1886 (1036-2940) versus 1575 (1026-2226) ng/ml; P  = 0.004]. The highest dolutegravir concentrations were measured in persons with HIV concomitantly treated with unboosted atazanavir [2908 (2130-4135) ng/ml]. Conversely, co-administration of darunavir/ritonavir resulted in significantly lower dolutegravir exposure [909 (496-1397) ng/ml; P  = 0.002 versus reference]. Among NNRTIs, the higher dolutegravir concentrations were measured in presence of rilpivirine [2252 (1489-2686); P  < 0.001 versus reference].
    Conclusion: Dolutegravir trough concentrations are differently affected by individual antiretroviral drugs, with some drug combinations (i.e. dolutegravir/darunavir/cobicistat, or dolutegravir/rilpivirine) providing significantly higher than expected dolutegravir exposure. Such combinations might be advantageous when there are concerns about dolutegravir plasma exposure or resistance.
    MeSH term(s) Humans ; Darunavir/therapeutic use ; Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; Pharmaceutical Preparations ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Oxazines/therapeutic use ; Pyridones/therapeutic use ; Rilpivirine/therapeutic use ; HIV Protease Inhibitors/therapeutic use ; Piperazines
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Darunavir (YO603Y8113) ; Anti-HIV Agents ; Pharmaceutical Preparations ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Pyridones ; Rilpivirine (FI96A8X663) ; HIV Protease Inhibitors ; Piperazines
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003843
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    Zs.A 2228: Show issues Location:
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  10. Article ; Online: Fostemsavir to overcome drug-drug interactions in heavily treatment-experienced people with HIV and cancer.

    Giacomelli, Andrea / Cattaneo, Dario / Pozza, Giacomo / Moschese, Davide / Cossu, Maria Vittoria / Dalu, Davide / Gervasoni, Cristina

    The Journal of antimicrobial chemotherapy

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae121
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    Zs.MO 124: Show issues

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