LIVIVO - Search results -

Search results

Result 1 - 10 of total 26

Search options

Article: Chronology of the Youfang site and its implications for the emergence of microblade technology in North China

Nian, Xiaomei / Fei Xie / Huijie Mei / Liping Zhou / Xing Gao

Quaternary international. 2014 Oct. 09, v. 347

2014

Abstract: The Youfang Paleolithic site, located in the eastern Nihewan Basin, Hebei Province, China, was ... The results suggest that human occupation at the Youfang site ranged from ca. 26 ka to 29 ka. Indeed ...

Abstract	The Youfang Paleolithic site, located in the eastern Nihewan Basin, Hebei Province, China, was discovered in 1984. However, the microblade assemblages which were excavated from the site lacked reliable chronological data. In this study, an optical dating technique was applied to nine samples from Late Pleistocene eolian sequences at the site. The ages of three samples from artifact-bearing deposits were in the range of ca. 26–29 ka with depths between 2.1 m and 2.9 m obtained with medium-grained quartz, corresponding to Marine Isotope Stage 3 (MIS3). These displayed evidence of a longer-term climate trend, in which the climate became gradually warmer and more humid. The sample from the upper culture layer was dated to 26.4 ± 2.1 ka. Five samples taken from the lower culture layer yielded ages between ca. 28 ka and 43 ka. The results suggest that human occupation at the Youfang site ranged from ca. 26 ka to 29 ka. Indeed, the Nihewan Basin yields the oldest microblade site in northern high latitudes (40° N), and offers a unique opportunity to study the emergence and characteristics of microblade technologies in northeast Asia. Nevertheless, extensive archeological field surveys and excavations are still needed to understand further the developmental process of microblade technologies in the region.
Keywords	basins ; climate ; humans ; latitude ; paleoclimatology ; quartz ; surveys ; China
Language	English
Dates of publication	2014-1009
Size	p. 113-121.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1040-6182
DOI	10.1016/j.quaint.2014.05.053
Database	NAL-Catalogue (AGRICOLA)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Clinical Features and Treatment Protocol in Eleven Chinese Children with Mild COVID-19.

Gao, Youfang / Zhang, Dongfeng / Sui, Sumin / Xu, Renying

Indian journal of pediatrics

2020 Volume 87, Issue 9, Page(s) 748

Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-020-03352-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 826: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Development and validation of a disulfidptosis and disulfide metabolism-related risk index for predicting prognosis in lung adenocarcinoma.

Zhong, Leqi / Chang, Wuguang / Luo, Bin / Gao, Wuyou / He, Huanhuan / Fang, Mouxiang / Li, Hongmu / Wen, Zhesheng / Chen, Youfang

Cancer cell international

2024 Volume 24, Issue 1, Page(s) 2

Abstract: Background: Disulfidptosis is a recently proposed novel cell death mode in which cells with high SLC7A11 expression induce disulfide stress and cell death in response to glucose deficiency. The purpose of the research was to explore the function of ... ...

Abstract	Background: Disulfidptosis is a recently proposed novel cell death mode in which cells with high SLC7A11 expression induce disulfide stress and cell death in response to glucose deficiency. The purpose of the research was to explore the function of disufidptosis and disulfide metabolism in the progression of lung adenocarcinoma (LUAD). Methods: The RNA-seq data from TCGA were divided into high/low expression group on the base of the median expression of SLC7A11, and the characteristic of differentially expressed disulfide metabolism-related genes. Least absolute shrinkage and selection operator (LASSO) algorithm was conducted the disulfidptosis and disulfide metabolism risk index. The tumor mutation burden (TMB), mechanism, pathways, tumor microenvironment (TME), and immunotherapy response were assessed between different risk groups. The role of TXNRD1 in LUAD was investigated by cytological experiments. Results: We established the risk index containing 5 genes. There are significant differences between different risk groups in terms of prognosis, TMB and tumor microenvironment. Additionally, the low-risk group demonstrated a higher rate of response immunotherapy in the prediction of immunotherapy response. Experimental validation suggested that the knockdown of TXNRD1 suppressed cell proliferation, migration, and invasion of LUAD. Conclusion: Our research highlights the enormous potential of disulfidptosis and disulfide metabolism risk index in predicting the prognosis of LUAD. And TXNRD1 has great clinical translational ability.
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-03204-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer.

Li, Hongmu / Wu, Chun / Chang, Wuguang / Zhong, Leqi / Gao, Wuyou / Zeng, Mingyue / Wen, Zhesheng / Mai, Shijuan / Chen, Youfang

Frontiers in bioscience (Landmark edition)

2023 Volume 28, Issue 10, Page(s) 243

Abstract: Purpose: Current evidence suggests that phosphoserine aminotransferase 1 (: Methods: The expression profile of : Results: Analysis of transcriptional expression profiles using TCGA data revealed overexpression of : Conclusions: ... ...

Abstract	Purpose: Current evidence suggests that phosphoserine aminotransferase 1 ( Methods: The expression profile of Results: Analysis of transcriptional expression profiles using TCGA data revealed overexpression of Conclusions: PSAT1
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line ; Cell Proliferation/genetics ; Immunotherapy ; Lung Neoplasms/genetics ; Tumor Microenvironment/genetics
Chemical Substances	PSAT1 protein, human (EC 2.6.1.52)
Language	English
Publishing date	2023-11-02
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2810243
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Retinopathy as a predictive indicator for significant hepatic fibrosis according to T2DM status: A cross-sectional study based on the national health and nutrition examination survey data.

Li, Jinze / Xiang, Yi / Han, Jiahao / Gao, Youfang / Wang, Ruiying / Dong, Zihe / Chen, Huihui / Gao, Ruixia / Liu, Chuan / Teng, Gao-Jun / Qi, Xiaolong

Annals of hepatology

2024 Volume 29, Issue 4, Page(s) 101478

Abstract: Introduction and objectives: Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with a range of complications, with retinopathy being particularly common. Recent studies have shed light on a potential connection between ... ...

Abstract	Introduction and objectives: Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with a range of complications, with retinopathy being particularly common. Recent studies have shed light on a potential connection between diabetic retinopathy (DR) and hepatic fibrosis, indicating a possible shared pathophysiological foundation in T2DM. This study investigates the correlation between retinopathy and hepatic fibrosis among individuals with T2DM, as well as evaluates the diagnostic value of DR for significant hepatic fibrosis. Materials and methods: Our cross-sectional analysis incorporated 5413 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. The Fibrosis-4 score (FIB-4) classified hepatic fibrosis into different grades (F0-F4), with significant hepatic fibrosis marked as F2 or higher. Retinopathy severity was determined using retinal imaging and categorized into four levels. The analysis of variance or Chi-square tests facilitated group comparisons. Additionally, the receiver operating characteristic (ROC) analysis appraised the predictive accuracy of retinopathy for significant hepatic fibrosis in the T2DM population. Results: Among 5413 participants, the mean age was 59.56 ± 12.41, with 50.2% male. And 20.6% were diagnosed with T2DM. Hepatic fibrosis grading was positively associated with retinopathy severity (OR [odds ratio]: 1.521, 95%CI [confidence interval]: 1.152-2.008, P = 0.003) across the entire population. The association was amplified in the T2DM population according to Pearson's analysis results. The ROC curve demonstrated retinopathy's diagnostic capacity for significant hepatic fibrosis in the T2DM population (AUC [area under curve] = 0.72, 95%CI: 0.651-0.793, P < 0.001). Conclusions: Retinopathy could serve as an independent predictor of significant hepatic fibrosis in T2DM population. Ophthalmologists are advised to closely monitor T2DM patients with retinopathy.
Language	English
Publishing date	2024-02-12
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2024.101478
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6221: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inhibiting miR-182-3p Alleviates Gestational Diabetes Mellitus by Improving Insulin Resistance in Skeletal Muscle

Jinghong Rao / Youfang Chen / Jingying Huang / Ruoying Wu / Zhenzhu Dong / Yuling Gao / Xuan Chen

Balkan Medical Journal, Vol 39, Iss 2, Pp 121-

2022 Volume 129

Abstract: Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182- 3p participates in a variety of physiological processes such as cell proliferation, apoptosis, differentiation, and ... ...

Abstract	Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182- 3p participates in a variety of physiological processes such as cell proliferation, apoptosis, differentiation, and migration5, but its role in GDM is largely unknown. Aims: To investigate the relationship between miRNA-182-3p and GDM and explore a potential therapeutic strategy for GDM. Study Design: Animal experimentation Methods: To evaluate the effect of miRNA182-3p in GDM, mice were separated as negative control (NC), miRNA-182-3p mimic or miRNA-182-3p inhibitor, and miRNAs were administered intraperitoneally. Additionally, miRNA-182-3p mimic or miRNA-182-3p inhibitor was transfected into C2C12 cells to evaluate glucose metabolism and insulin-related pathways. Results: The miR-182-3p mimic accelerated GDM, which was effectively reversed by the inhibitor in GDM mice (P = 0.005, miR- 182-3p inhibitor vs. mimic). Insulin receptor 1 (INSR1) was predicted to be the direct target gene of miR-182-3p using online tools. In addition, the miR-182-3p mimic inhibited INSR1 expression and insulin-related pathways in vivo and in vitro, which were all reversed by the miRNA82-3p inhibitor. Furthermore, the miR-182-3p mimic impaired glucose uptake and consumption by inhibiting translocation of glucose transporter type 4 (GLUT4) toward the C2C12 cell membrane (P = 0.007 vs. control), while the inhibitor accelerated these processes (P = 0.032 vs. control; P = 0.005, miRNA-182-3p inhibitor vs. mimic). Conclusion: Inhibiting miR-182-3p effectively alleviated the development of GDM through INSR1, suggesting a potential therapeutic strategy for GDM.
Keywords	Medicine ; R
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Galenos Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transcriptomic Profiling of Meat Quality Traits of Skeletal Muscles of the Chinese Indigenous Huai Pig and Duroc Pig.

Li, Xiaojin / Lu, Liangyue / Tong, Xinwei / Li, Ruidong / Jin, Erhui / Ren, Man / Gao, Yafei / Gu, Youfang / Li, Shenghe

Genes

2023 Volume 14, Issue 8

Abstract: The Huai pig is a well-known indigenous pig breed in China. The main advantages of Huai pigs over Western commercial pig breeds include a high intramuscular fat (IMF) content and good meat quality. There are significant differences in the meat quality ... ...

Abstract	The Huai pig is a well-known indigenous pig breed in China. The main advantages of Huai pigs over Western commercial pig breeds include a high intramuscular fat (IMF) content and good meat quality. There are significant differences in the meat quality traits of the same muscle part or different muscle parts of the same variety. To investigate the potential genetic mechanism underlying the meat quality differences in different pig breeds or muscle groups, longissimus dorsi (LD), psoas major (PM), and biceps femoris (BF) muscle tissues were collected from two pig breeds (Huai and Duroc). There were significant differences in meat quality traits and amino acid content. We assessed the muscle transcriptomic profiles using high-throughput RNA sequencing. The IMF content in the LD, PM, and BF muscles of Huai pigs was significantly higher than that in Duroc pigs (
MeSH term(s)	Animals ; Amino Acids/analysis ; Amino Acids/biosynthesis ; Amino Acids/genetics ; China ; Food Quality ; Meat/standards ; Muscle Fibers, Skeletal/chemistry ; Muscle Fibers, Skeletal/metabolism ; Paraspinal Muscles/chemistry ; Paraspinal Muscles/metabolism ; Swine/genetics ; Transcriptome/genetics
Chemical Substances	Amino Acids
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14081548
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Clinical Features and Treatment Protocol in Eleven Chinese Children with Mild COVID-19

Gao, Youfang / Zhang, Dongfeng / Sui, Sumin / Xu, Renying

Indian J Pediatr

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #505762
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Inhibiting miR-182-3p Alleviates Gestational Diabetes Mellitus by Improving Insulin Resistance in Skeletal Muscle.

Rao, Jinghong / Chen, Youfang / Huang, Jingying / Wu, Ruoying / Dong, Zhenzhu / Gao, Yuling / Chen, Xuan

Balkan medical journal

2022 Volume 39, Issue 2, Page(s) 121–129

Abstract: Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182-3p participates in a variety of physiological processes such as cell proliferation, apoptosis, differentiation, and ... ...

Abstract	Background: Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases occurring during pregnancy. MiR-182-3p participates in a variety of physiological processes such as cell proliferation, apoptosis, differentiation, and migration5, but its role in GDM is largely unknown. Aims: To investigate the relationship between miRNA-182-3p and GDM and explore a potential therapeutic strategy for GDM. Study design: Animal experimentation. Methods: To evaluate the effect of miRNA182-3p in GDM, mice were separated as negative control (NC), miRNA-182-3p mimic or miRNA-182-3p inhibitor, and miRNAs were administered intraperitoneally. Additionally, miRNA-182-3p mimic or miRNA-182-3p inhibitor was transfected into C2C12 cells to evaluate glucose metabolism and insulin-related pathways. Results: The miR-182-3p mimic accelerated GDM, which was effectively reversed by the inhibitor in GDM mice ( Conclusion: Inhibiting miR-182-3p effectively alleviated the development of GDM through INSR1, suggesting a potential therapeutic strategy for GDM.
MeSH term(s)	Animals ; Diabetes, Gestational/genetics ; Diabetes, Gestational/metabolism ; Female ; Humans ; Insulin/metabolism ; Insulin/therapeutic use ; Insulin Resistance/genetics ; Mice ; MicroRNAs/genetics ; Muscle, Skeletal/metabolism ; Pregnancy
Chemical Substances	Insulin ; MicroRNAs ; Mirn182 microRNA, human ; Mirn182 microRNA, mouse
Language	English
Publishing date	2022-02-25
Publishing country	Turkey
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2021.2021-8-140
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Immune‐viral dynamics modeling for SARS‐CoV‐2 drug development

Youfang Cao / Wei Gao / Luzelena Caro / Julie A. Stone

Clinical and Translational Science, Vol 14, Iss 6, Pp 2348-

2021 Volume 2359

Abstract: Abstract Coronavirus disease 2019 (COVID‐19) global pandemic is caused by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral infection, which can lead to pneumonia, lung injury, and death in susceptible populations. Understanding viral ... ...

Abstract	Abstract Coronavirus disease 2019 (COVID‐19) global pandemic is caused by severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral infection, which can lead to pneumonia, lung injury, and death in susceptible populations. Understanding viral dynamics of SARS‐CoV‐2 is critical for development of effective treatments. An Immune‐Viral Dynamics Model (IVDM) is developed to describe SARS‐CoV‐2 viral dynamics and COVID‐19 disease progression. A dataset of 60 individual patients with COVID‐19 with clinical viral load (VL) and reported disease severity were assembled from literature. Viral infection and replication mechanisms of SARS‐CoV‐2, viral‐induced cell death, and time‐dependent immune response are incorporated in the model to describe the dynamics of viruses and immune response. Disease severity are tested as a covariate to model parameters. The IVDM was fitted to the data and parameters were estimated using the nonlinear mixed‐effect model. The model can adequately describe individual viral dynamics profiles, with disease severity identified as a covariate on infected cell death rate. The modeling suggested that it takes about 32.6 days to reach 50% of maximum cell‐based immunity. Simulations based on virtual populations suggested a typical mild case reaches VL limit of detection (LOD) by 13 days with no treatment, a moderate case by 17 days, and a severe case by 41 days. Simulations were used to explore hypothetical treatments with different initiation time, disease severity, and drug effects to demonstrate the usefulness of such modeling in informing decisions. Overall, the IVDM modeling and simulation platform enables simulations for viral dynamics and treatment efficacy and can be used to aid in clinical pharmacokinetic/pharmacodynamic (PK/PD) and dose‐efficacy response analysis for COVID‐19 drug development.
Keywords	Therapeutics. Pharmacology ; RM1-950 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED