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Article ; Online: High-quality genome assembly of Huazhan and Tianfeng, the parents of an elite rice hybrid Tian-you-hua-zhan.

Zhang, Hui / Wang, Yuexing / Deng, Ce / Zhao, Sheng / Zhang, Peng / Feng, Jie / Huang, Wei / Kang, Shujing / Qian, Qian / Xiong, Guosheng / Chang, Yuxiao

Science China. Life sciences

2021 Volume 65, Issue 2, Page(s) 398–411

Abstract: ... wide variations and research on functional genomics and breeding. Tian-you-hua-zhan has been a leading ...

Abstract	High-quality rice reference genomes have accelerated the comprehensive identification of genome-wide variations and research on functional genomics and breeding. Tian-you-hua-zhan has been a leading hybrid in China over the past decade. Here, de novo genome assembly strategy optimization for the rice indica lines Huazhan (HZ) and Tianfeng (TF), including sequencing platforms, assembly pipelines and sequence depth, was carried out. The PacBio and Nanopore platforms for long-read sequencing were utilized, with the Canu, wtdbg2, SMARTdenovo, Flye, Canu-wtdbg2, Canu-SMARTdenovo and Canu-Flye assemblers. The combination of PacBio and Canu was optimal, considering the contig N50 length, contig number, assembled genome size and polishing process. The assembled contigs were scaffolded with Hi-C data, resulting in two "golden quality" rice reference genomes, and evaluated using the scaffold N50, BUSCO, and LTR assembly index. Furthermore, 42,625 and 41,815 non-transposable element genes were annotated for HZ and TF, respectively. Based on our assembly of HZ and TF, as well as Zhenshan97, Minghui63, Shuhui498 and 9311, comprehensive variations were identified using Nipponbare as a reference. The de novo assembly strategy for rice we optimized and the "golden quality" rice genomes we produced for HZ and TF will benefit rice genomics and breeding research, especially with respect to uncovering the genomic basis of the elite traits of HZ and TF.
MeSH term(s)	Chromosome Mapping ; Genes, Plant ; Genome Size ; Genome, Plant/genetics ; Genomic Structural Variation ; Genomics ; High-Throughput Nucleotide Sequencing ; Molecular Sequence Annotation ; Nanopore Sequencing ; Oryza/genetics ; Plant Breeding ; Sequence Analysis, DNA
Language	English
Publishing date	2021-06-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-020-1940-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson's disease: study protocol for a randomised controlled trial.

Zhang, Linlin / Liu, Xihua / Xi, Xiaoming / Chen, Yuxiao / Wang, Qing / Qu, Xinjie / Cao, Haihao / Wang, Limin / Sun, Wenyu / Chen, Guoming / Liu, Huifen / Jiang, Xiaoyu / Su, Hang / Jiang, Jiahui / Bi, Hongyan

BMJ open

2022 Volume 12, Issue 7, Page(s) e059625

Abstract: ... the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD ... The intervention group received conventional medicine plus Zhan Zhuang Qigong exercises five times a week at 30 min ... each time, over an 8-week period. The long-term effects of Zhan Zhuang Qigong on PD was investigated after ...

Abstract	Introduction: Currently, the first choice for the clinical treatment of static tremor in Parkinson's disease (PD) is drug therapy, however side effects are common. In recent years, the effects of physical therapy on PD has become a serious research focus. Studies have indicated that aerobic and resistance exercises alleviate PD movement disorders and improve aerobic capacity, but the effects of Qigong on PD static tremor and aerobic capacity remain unknown. Methods and analysis: OBJECTIVE: To observe the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD, we established a rigorous randomised, parallel-controlled, assignment hidden, evaluator-blinded protocol. Methods: Seventy-two patients with PD, at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, were recruited and randomly divided into a control (n=36) and experimental group (n=36). The intervention group received conventional medicine plus Zhan Zhuang Qigong exercises five times a week at 30 min each time, over an 8-week period. The long-term effects of Zhan Zhuang Qigong on PD was investigated after the intervention. Phyphox APP, CRST, CPET, UPDRS(II, III) were used to evaluate tremor, aerobic capacity, and motor function in groups. Discussion: We are investigating the effects of Zhan Zhuang Qigong on upper limb static tremor and aerobic capacity in patients with PD. If positive are identified, they will add a new research direction and evidence for the clinical exploration of exercise therapy for PD. Ethics and dissemination: This study was approved by the Ethics Committee of Shandong University of Traditional Chinese Medicine (Approval Number: 2021-025-KY). The Committee will be informed of any changes to the trial protocol, such as intervention intensity, outcome indicators and data collection. Study results will be presented as a paper at an international conference or in a journal. Trial registration number: ChiCTR2100053529.
MeSH term(s)	Exercise ; Humans ; Parkinson Disease ; Qigong/methods ; Quality of Life ; Randomized Controlled Trials as Topic ; Tremor/therapy ; Upper Extremity
Language	English
Publishing date	2022-07-12
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-059625
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Article ; Online: Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke.

Zhao, Jing / Lv, Chao / Wu, Qiuling / Zeng, Huawu / Guo, Xin / Yang, Jian / Tian, Saisai / Zhang, Weidong

Pharmacological research

2019 Volume 147, Page(s) 104365

Abstract: ... by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-Xi-Xin ...

Abstract	Herbs are typically prescribed in traditional Chinese medicine (TCM) to treat complex diseases. The multicomponent nature of herbal drug ingredients makes it difficult to readily understand their mode of action. To decipher their molecular mechanisms, here we proposed a novel computational systems pharmacology based approach, which consisted of transcriptome profiling, data collection, statistical analysis, network algorithm, bioinformatics analysis and pharmacological validation. The network algorithm called signed random walk with restart (SRWR) was used to simulate the propagation of drugs' effects on networks. This algorithm could identify proteins either positively or negatively regulated (activated or inhibited) by drugs on human signaling networks. To establish proof of principle, the herbal product Deng-Zhan-Xi-Xin injection (DZXXI), which exhibits pharmacological effects in ischemic stroke but its mechanism was unclear, was analyzed. Eighty-three targets were predicted with high confidence for DZXXI's active compounds in plasma, and 87 differentially expressed genes (DEGs) were identified in MCF7 cells treated with DZXXI. These target genes were further found to be associated with pathways involved in neuronal apoptosis in ischemic stroke, such as NF-κB signaling, TNF signaling, and PI3K-Akt signaling. Intersection analysis between DZXXI's putative targets with ischemic stroke-associated genes identified two important targets (PTGS1, PTGS2) corresponding to four DZXXI compounds, which were further validated using in silico and in vitro/vivo models. The most inhibited genes identified by the SRWR algorithm were significantly enriched with ischemic stroke-associated disease genes, antiplatelet associated pathways, and their encoded proteins were enriched in brain, vascular endothelium and platelets. The CMAP analysis based on DEGs suggested that DZXXI could function as both an anti-inflammatory and anti-platelet agent. Taken together, the computational analysis suggested that DZXXI exhibited anti-platelet and neuroprotective effects in the treatment of ischemic stroke. These deductions were preliminarily confirmed by subsequent in vitro/vivo studies. This approach provides a systems perspective to study the relevance between herbal drugs and disease processes, and can reveal possible pharmacological effects of multiple ingredients within herbal product.
MeSH term(s)	Animals ; Computational Biology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Gene Expression Profiling ; Humans ; Infarction, Middle Cerebral Artery/drug therapy ; MCF-7 Cells ; Male ; Mice ; Molecular Docking Simulation ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Aggregation Inhibitors/therapeutic use ; RAW 264.7 Cells ; Rabbits ; Rats, Sprague-Dawley ; Transcriptome/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Neuroprotective Agents ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2019-07-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2019.104365
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Book: Zhan zheng, she hui yu yi liao

Zhang, Ling

kang zhan shi qi Sichuan gong gong wei sheng jian she yan jiu

2015

Author's details	Zhang Ling zhu
MeSH term(s)	Public Health Administration/history ; World War II ; History, 20th Century
Keywords	China
Language	Chinese
Size	2, 231 pages :, illustrations, map ;, 24 cm
Edition	Di 1 ban.
Document type	Book
ISBN	9787516161944 ; 7516161942
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Rapid characterization and identification of the chemical constituents and rat metabolites of Deng-Zhan-Xi-Xin injection using ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Guo, Xin / Lin, Shan / Yang, Peiming / Ye, Ji / Du, Jiang / Mu, Xuemei / Mi, Nan / Qi, Xiaopo / Lei, Huibo / Zhang, Weidong / Tian, Xinhui

Journal of separation science

2018 Volume 41, Issue 18, Page(s) 3569–3582

Abstract: Deng-Zhan-Xi-Xin injection is a well-known traditional Chinese medicine prescription ... the chemical constituents and metabolites of Deng-Zhan-Xi-Xin injection using ultra high performance ... phenolic acids were identified or tentatively characterized, and five compounds were first reported in Deng-Zhan ...

Abstract	Deng-Zhan-Xi-Xin injection is a well-known traditional Chinese medicine prescription for the treatment of cardiovascular and cerebral vessel diseases. However, there have been few reports on its chemical constituents and metabolic pathway, which has blocked its further quality control and studies on its pharmacology and mechanism of action. In this study, an integrative method was established to rapidly explore the chemical constituents and metabolites of Deng-Zhan-Xi-Xin injection using ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and the UNIFI™ software combined with multiple data processing approaches. As a result, a total of 40 compounds, including 9 flavonoids and 31 phenolic acids were identified or tentatively characterized, and five compounds were first reported in Deng-Zhan-Xi-Xin injection. Under the same analysis conditions, 70 compounds have been detected in rats, including 25 prototypes and 45 metabolites. This was the first systematic research study on the metabolic profiling of Deng-Zhan-Xi-Xin injection. This study provides valuable chemical information for the quality control and research on pharmacology and mechanism of action of Deng-Zhan-Xi-Xin injection. Moreover, it provides a valuable strategy for analyzing the chemical components and metabolites of other traditional Chinese medicine prescriptions.
MeSH term(s)	Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/metabolism ; Erigeron/chemistry ; Male ; Mass Spectrometry ; Medicine, Chinese Traditional ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2018-08-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201800470
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Rapid characterization and identification of the chemical constituents and rat metabolites of Deng‐Zhan‐Xi‐Xin injection using ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Guo, Xin / Huibo Lei / Ji Ye / Jiang Du / Nan Mi / Peiming Yang / Shan Lin / Weidong Zhang / Xiaopo Qi / Xinhui Tian / Xuemei Mu

Journal of separation science. 2018 Sept., v. 41, no. 18

2018

Abstract: Deng‐Zhan‐Xi‐Xin injection is a well‐known traditional Chinese medicine prescription ... the chemical constituents and metabolites of Deng‐Zhan‐Xi‐Xin injection using ultra high performance ... phenolic acids were identified or tentatively characterized, and five compounds were first reported in Deng‐Zhan ...

Abstract	Deng‐Zhan‐Xi‐Xin injection is a well‐known traditional Chinese medicine prescription for the treatment of cardiovascular and cerebral vessel diseases. However, there have been few reports on its chemical constituents and metabolic pathway, which has blocked its further quality control and studies on its pharmacology and mechanism of action. In this study, an integrative method was established to rapidly explore the chemical constituents and metabolites of Deng‐Zhan‐Xi‐Xin injection using ultra high performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry and the UNIFITM software combined with multiple data processing approaches. As a result, a total of 40 compounds, including 9 flavonoids and 31 phenolic acids were identified or tentatively characterized, and five compounds were first reported in Deng‐Zhan‐Xi‐Xin injection. Under the same analysis conditions, 70 compounds have been detected in rats, including 25 prototypes and 45 metabolites. This was the first systematic research study on the metabolic profiling of Deng‐Zhan‐Xi‐Xin injection. This study provides valuable chemical information for the quality control and research on pharmacology and mechanism of action of Deng‐Zhan‐Xi‐Xin injection. Moreover, it provides a valuable strategy for analyzing the chemical components and metabolites of other traditional Chinese medicine prescriptions.
Keywords	biochemical pathways ; chemical composition ; computer software ; flavonoids ; information processing ; mechanism of action ; metabolites ; metabolomics ; Oriental traditional medicine ; pharmacology ; phenolic acids ; prototypes ; quality control ; rats ; tandem mass spectrometry ; ultra-performance liquid chromatography
Language	English
Dates of publication	2018-09
Size	p. 3569-3582.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201800470
Database	NAL-Catalogue (AGRICOLA)

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Book: Chang yong Zhong yao du xing yan jiu jin zhan ji ying yong

Zhang, Geng

2013

Author's details	zhu bian Zhang Geng, Ma Wei, Xu Hongfeng
MeSH term(s)	Drugs, Chinese Herbal/toxicity ; Plants, Medicinal/toxicity ; Drugs, Chinese Herbal/therapeutic use
Language	Chinese
Size	4, 798 pages.
Edition	Di 1 ban.
Document type	Book
ISBN	9787535262264 ; 7535262260
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Zhongguo nong ye fa zhan wen ti bao gao

Lin, Shanlang / Zhang, Guo

wen ti, xian zhuang, tiao zhan, dui ce = China agriculture development issue report

(21 shi ji Zhongguo fa zhan wen ti bao gao = 21st China development issue report)

2003

Title variant	China agriculture development issue report
Author's details	Lin Shanlang, Zhang Guo bian zhu
Series title	21 shi ji Zhongguo fa zhan wen ti bao gao = 21st China development issue report
Keywords	Agriculture/Economic aspects ; Agriculture and state
Language	Chinese
Size	2, 4, 7, 481 p. :, ill. ;, 24 cm.
Edition	Di 1 ban.
Publisher	Zhongguo fa zhan chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	780087544X ; 9787800875441
Database	NAL-Catalogue (AGRICOLA)

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Book: Zhan guo ce quan yi

Wang, Yandong / Sun, Shulan / Zhang, Qingchang

1994

Abstract: Ben shu yi qing dai huang pi lie du wei jian shu zhai de " zhan guo ce " wei di ben, zun xun " zhan ...

Title translation	Zhan guo ce
Author's details	Wang yan dong, sun shu lan [bian] yi; zhang qing chang shen ding
Abstract	Ben shu yi qing dai huang pi lie du wei jian shu zhai de " zhan guo ce " wei di ben, zun xun " zhan guo ce jian zhu " de xiao kan, zhu shi lai fan yi, bu fu yuan wen
Keywords	China
Language	Chinese
Size	6, [1], 20, 429 S, 21 cm
Edition	Di 1 ban
Publisher	Nan kai da xue chu ban she
Publishing place	Tian jin
Document type	Book
ISBN	7310006291 ; 9787310006298
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online: Inclusion Metallurgy

Zhang, Yanling / Cheng, Guoguang / Zhan, Zhonghua / Zhan, Zhonghua

2023

Keywords	Technology: general issues ; History of engineering & technology ; MnS ; inclusion ; cerium ; sulfur ; fracture ; Cr5 ; back-up roller ; forged ingot ; large-size inclusions ; SiO2-MnO-Al2O3 ; contact angle ; aluminum deoxidation ; magnetic particle inspection ; defects ; nonmetallic inclusion ; cleanliness ; Ti-bearing IF steel ; reoxidation ; long producing process ; U75V heavy rail steel ; Cerium treatment ; gleeble ; MgO saturation ; industrial trial ; non-metallic inclusions ; thermodynamic calculation ; nonmetallic inclusions ; MgO-Al2O3 ; CaO-MgO-Al2O3 ; thermodynamic ; kinetic ; electroslag remelting ; evolution ; CAFE ; equiaxed crystal ratio ; macrosegregation ; numerical simulation ; continuous casting ; process optimization ; rare earth Ce ; inclusions ; modification ; non-oriented silicon steel ; rare earth oxysulfides ; rare earth La-Ce ; magnetic property ; n/a
Language	English
Size	1 electronic resource (178 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	English
HBZ-ID	HT030381440
ISBN	9783036584478 ; 3036584471
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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