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Article ; Online: DNA-PKcs Phosphorylates Cofilin2 to Induce Endothelial Dysfunction and Microcirculatory Disorder in Endotoxemic Cardiomyopathy.

Du, Yingzhen / Zhu, Pingjun / Li, Yukun / Yu, Jiachi / Xia, Tian / Chang, Xing / Zhu, Hang / Li, Ruibing / He, Qingyong

Research (Washington, D.C.)

2024 Volume 7, Page(s) 331

Abstract: The presence of endotoxemia is strongly linked to the development of endothelial dysfunction and disruption of myocardial microvascular reactivity. These factors play a crucial role in the progression of endotoxemic cardiomyopathy. Sepsis-related ... ...

Abstract	The presence of endotoxemia is strongly linked to the development of endothelial dysfunction and disruption of myocardial microvascular reactivity. These factors play a crucial role in the progression of endotoxemic cardiomyopathy. Sepsis-related multiorgan damage involves the participation of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). However, whether DNA-PKcs contributes to endothelial dysfunction and myocardial microvascular dysfunction during endotoxemia remains unclear. Hence, we conducted experiments in mice subjected to lipopolysaccharide (LPS)-induced endotoxemic cardiomyopathy, as well as assays in primary mouse cardiac microvascular endothelial cells. Results showed that endothelial-cell-specific
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/research.0331
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Article ; Online: Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling.

Liu, Libao / Huang, Shuai / Du, Yingzhen / Zhou, Hao / Zhang, Kai / He, Jinyuan

International journal of biological sciences

2023 Volume 19, Issue 11, Page(s) 3428–3440

Abstract: Large tumor suppressor kinase 2 ( ...

Abstract	Large tumor suppressor kinase 2 (
MeSH term(s)	Animals ; Mice ; Apoptosis/genetics ; DNA, Mitochondrial/metabolism ; Hypoxia/metabolism ; Inflammation/metabolism ; Mitochondrial Dynamics/genetics ; Myocardial Infarction/metabolism ; Myocytes, Cardiac/metabolism
Chemical Substances	DNA, Mitochondrial ; LATS2 protein, mouse (EC 2.7.11.1) ; Sting1 protein, mouse ; Rela protein, mouse
Language	English
Publishing date	2023-07-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.84426
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Article ; Online: Investigation of the shared gene signatures and molecular mechanisms between obstructive sleep apnea syndrome and asthma.

Que, Yifan / Meng, Hao / Ding, Yongkai / Fan, Jiao / Du, Yingzhen / Xu, Guogang

Gene

2023 Volume 896, Page(s) 148029

Abstract: Background: Obstructive sleep apnea syndrome (OSAS) is highly related with asthma from the epidemiology to pathogenesis, while the underlying mechanism is still unclear. Herein, we aimed to reveal the shared gene signatures and molecular mechanisms ... ...

Abstract	Background: Obstructive sleep apnea syndrome (OSAS) is highly related with asthma from the epidemiology to pathogenesis, while the underlying mechanism is still unclear. Herein, we aimed to reveal the shared gene signatures and molecular mechanisms underlying the coexistence of OSAS and asthma and verified relating pathway in mouse models. We downloaded GSE75097 of OSAS and GSE165934 of asthma from GEO database and performed differential expression analysis and functional enrichment analysis to screen differentially expressed genes (DEGs) and potential pathogenic pathway. PPI network was constructed with the STRING database. Hub genes were identified with cytoHubba and immune infiltration analysis was performed with cibersort for further verification. Potential drugs were screened with Comparative Toxicogenomics Database and miRNA-gene network was constructed. Besides, to test the pulmonary function and inflammatory cytokine, mouse models with OSAS and asthma were constructed, followed by validating the involvement of NOD1/NOD2-RIPK2-NF-κB-MCPIP-1 pathway in associated diseases. Results: In total, 104 DEGs were identified, in which PLAUR, RIPK2, PELI1, ZC3H12A, and TNFAIP8 are the hub genes, while NOD-like receptor signaling pathway and apoptosis signaling pathway were the potential influential pathways. Increased γδT cells and neutrophils were detected in asthma patients through immune infiltration analysis. Significant difference was detected among genders in OSAS, and acetaminophen is a potential drug in the comorbidity by screening the drugs in the Comparative Toxicogenomics Database. Mice with OSAS and asthma presented with worse pulmonary function and higher levels of inflammatory cytokines. The relative proteins, including NOD1, NOD2, RIPK2, NF-κB, and MCPIP-1, were up-regulated in mice with the OSAS and asthma. Conclusions: This research firstly elucidates NOD1/NOD2-RIPK2-NF-κB-MCPIP-1 pathway as the shared pathway in the development of OSAS and asthma through bioinformatics and experimental methods. There is an interactive deterioration model between OSAS and asthma. This study may provide some potential biomarkers in the future research of the underlying pathogenesis and treatment of comorbidity of OSAS and asthma.
MeSH term(s)	Humans ; Male ; Female ; Animals ; Mice ; NF-kappa B ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/genetics ; Biomarkers ; MicroRNAs ; Gene Regulatory Networks ; Asthma/genetics ; Computational Biology/methods
Chemical Substances	NF-kappa B ; Biomarkers ; MicroRNAs
Language	English
Publishing date	2023-11-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.148029
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Article: Receptor-Interacting Protein Kinase 3 Suppresses Mitophagy Activation

Zhu, Pingjun / Chen, Yangxiaocao / Wang, Junyan / Lin, Geng / Wang, Runsheng / Que, Yifan / Zhou, Jin / Xu, Guogang / Luo, Jiang / Du, Yingzhen

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 856041

Abstract: Mitophagy, known as the main mechanism of mitochondrial quality control, determines the pathophysiology of septic cardiomyopathy, although the precise regulatory mechanisms remain elusive. Data from the present study suggested that receptor-interacting ... ...

Abstract	Mitophagy, known as the main mechanism of mitochondrial quality control, determines the pathophysiology of septic cardiomyopathy, although the precise regulatory mechanisms remain elusive. Data from the present study suggested that receptor-interacting protein kinase 3 (RIPK3) expression could be enhanced in response to lipopolysaccharide (LPS) challenge. Upregulated RIPK3 expression was accompanied by severe cardiac injury and cardiac dysfunction. Further examination revealed that elevated RIPK3 expression subsequently inhibited the Yes-associated protein (YAP) pathway, which was accompanied by reduced transcription factor EB (TFEB) expression. Inhibition of TFEB would reduce mitophagy, which ultimately induced cardiomyocyte death under LPS challenge. In contrast, loss of RIPK3 induced the YAP/TFEB/mitophagy pathway alleviated the sensitivity of cardiomyocytes to LPS-induced cytotoxicity. Collectively, the RIPK3/YAP/TFEB axis was confirmed to be responsible for the pathogenesis of septic cardiomyopathy by inhibiting mitophagy. These findings have potential significance for the progression of new approaches to the treatment of septic cardiomyopathy.
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.856041
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Article ; Online: Reply to Tsolaki and Zakynthinos: Are Patients with COVID-19 Dying of or with Cardiac Injury?

Du, Yingzhen / Wang, Xi / Chang, Christopher / Zhu, Pingjun / Tu, Lei / Hu, Qinyong / Jin, Yang / Xu, Guogang

American journal of respiratory and critical care medicine

2020 Volume 202, Issue 2, Page(s) 301–303

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202004-1156LE
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Article ; Online: Features of transbronchial lung cryobiopsy-diagnosed fibrotic hypersensitivity pneumonitis.

Zhan, Xi / Du, Yingzhen / Luo, Jiang / Que, Yifan / Hu, Chao / Xu, Lili / Wang, Zhen / Wu, Yanbing / Jin, Mulan / Zheng, Chunming / Gao, Yanhong / Chang, Christopher / Li, Hongxia / Tong, Zhaohui / Xu, Guogang

The clinical respiratory journal

2022

Abstract: Background: Hypersensitivity pneumonitis (HP) is a common type among all the interstitial lung diseases, and transbronchial lung cryobiopsy is an alternative diagnostic technique for interstitial lung diseases. In this study, we describe the clinical ... ...

Abstract	Background: Hypersensitivity pneumonitis (HP) is a common type among all the interstitial lung diseases, and transbronchial lung cryobiopsy is an alternative diagnostic technique for interstitial lung diseases. In this study, we describe the clinical and pathological features of fibrotic hypersensitivity pneumonitis diagnosed with transbronchial lung cryobiopsy (TBLC). Methods: A total of 46 diffused parenchyma lung disease (DPLD) patients received TBLC were included in this study. Medical records including medical history spirometry examinations, 6-min walk test (6MWT) results, high resolution computed tomographic (HRCT) scans, BAL, and histopathology were collected. Results of HRCT and histopathology were compared and classified, especially. Results: Sixteen patients were diagnosed with fibrotic HP, the mean age of whom was 56.3 ± 12.1 years, and 62.5% of them were male. Three of the 16 patients had been misdiagnosed as tuberculosis and received antituberculosis medications, five patients had been diagnosed as unclassifiable pulmonary fibrosis, and five patients had been diagnosed as idiopathic pulmonary fibrosis (IPF). Thirteen (81.3%) patients had a normal lymphocyte count in BAL. The pathological features of usual interstitial pneumonia (UIP) were detected in 11 (68.8%) of the cases, poor defined granulomatous was detected in nine (56.3%) of the cases, and bronchiolocentric fibrosis was detected in two (12.5%) of the 16 cases. Conclusions: Fibrotic hypersensitivity pneumonitis should be included in differential diagnosis of pulmonary fibrosis. Pathological characteristics of fibrotic hypersensitivity pneumonitis could be demonstrated from cryobiopsy lung tissue. TBLC is recommended as an alternative diagnostic technique, which may improve the specificity of hypersensitivity pneumonia detection, and UIP is the most frequent pathological finding.
Language	English
Publishing date	2022-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13561
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Article ; Online: Comparison of in vitro synergistic effect between clarithromycin or azithromycin in combination with amikacin against Mycobacterium intracellulare.

Zhang, Zhijian / Lu, Jie / Du, Yingzhen / Xie, Fei / Wang, Yufeng / Sun, Baojun / Pang, Yu

Journal of global antimicrobial resistance

2019 Volume 18, Page(s) 183–186

Abstract: Objectives: This study compared the in vitro synergistic effect between clarithromycin or azithromycin in combination with amikacin against Mycobacterium intracellulare.: Methods: In vitro antimicrobial susceptibility of M. intracellulare isolates ... ...

Abstract	Objectives: This study compared the in vitro synergistic effect between clarithromycin or azithromycin in combination with amikacin against Mycobacterium intracellulare. Methods: In vitro antimicrobial susceptibility of M. intracellulare isolates was determined by the broth microdilution method in cation-adjusted Mueller-Hinton broth. The fractional inhibitory concentration index (FICI) was also calculated to assess synergy between the antimicrobial agents. Results: A total of 32 respiratory M. intracellulare isolates were included in the study. Clarithromycin was the most potent agent against M. intracellulare, with MIC Conclusion: These data demonstrated that clarithromycin displayed more potent in vitro activity against M. intracellulare isolates than azithromycin. In addition, the antagonistic effect between azithromycin and amikacin was more frequent in M. intracellular isolates than that between clarithromycin and amikacin.
MeSH term(s)	Amikacin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Clarithromycin/pharmacology ; Drug Combinations ; Drug Synergism ; Microbial Sensitivity Tests ; Mycobacterium avium Complex/drug effects ; Mycobacterium avium Complex/isolation & purification
Chemical Substances	Anti-Bacterial Agents ; Drug Combinations ; Azithromycin (83905-01-5) ; Amikacin (84319SGC3C) ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2019-04-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7165
ISSN (online)	2213-7173
ISSN	2213-7165
DOI	10.1016/j.jgar.2019.03.017
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Article: Reply to Tsolaki and Zakynthinos: Are Patients with COVID-19 Dying of or with Cardiac Injury?

Du, Yingzhen / Wang, Xi / Chang, Christopher / Zhu, Pingjun / Tu, Lei / Hu, Qinyong / Jin, Yang / Xu, Guogang

American Journal of Respiratory and Critical Care Medicine

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #657287
Database	COVID19

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Article ; Online: A DE1 BINDING FACTOR 1-GLABRA2 module regulates rhamnogalacturonan I biosynthesis in Arabidopsis seed coat mucilage.

Xu, Yan / Wang, Yiping / Du, Jinge / Pei, Shengqiang / Guo, Shuaiqiang / Hao, Ruili / Wang, Dian / Zhou, Gongke / Li, Shengjun / O'Neill, Malcolm / Hu, Ruibo / Kong, Yingzhen

The Plant cell

2022 Volume 34, Issue 4, Page(s) 1396–1414

Abstract: The mucilage surrounding hydrated Arabidopsis thaliana seeds is a specialized extracellular matrix composed mainly of the pectic polysaccharide rhamnogalacturonan I (RG-I). Although, several genes responsible for RG-I biosynthesis have been identified, ... ...

Abstract	The mucilage surrounding hydrated Arabidopsis thaliana seeds is a specialized extracellular matrix composed mainly of the pectic polysaccharide rhamnogalacturonan I (RG-I). Although, several genes responsible for RG-I biosynthesis have been identified, the transcriptional regulatory mechanisms controlling RG-I production remain largely unknown. Here we report that the trihelix transcription factor DE1 BINDING FACTOR 1 (DF1) is a key regulator of mucilage RG-I biosynthesis. RG-I biosynthesis is significantly reduced in loss-of-function mutants of DF1. DF1 physically interacts with GLABRA2 (GL2) and both proteins transcriptionally regulate the expression of the RG-I biosynthesis genes MUCILAGE MODIFIED 4 (MUM4) and GALACTURONOSYLTRANSFERASE-LIKE5 (GATL5). Through chromatin immunoprecipitation-quantitative PCR and transcriptional activation assays, we uncover a cooperative mechanism of the DF1-GL2 module in activating MUM4 and GATL5 expression, in which DF1 binds to the promoters of MUM4 and GATL5 through interacting with GL2 and facilitates the transcriptional activity of GL2. The expression of DF1 and GL2 is directly regulated by TRANSPARENT TESTA GLABRA2 (TTG2) and, in turn, DF1 directly represses the expression of TTG2. Taken together, our data reveal that the transcriptional regulation of mucilage RG-I biosynthesis involves a regulatory module, comprising DF1, GL2, and TTG2.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Pectins ; Plant Mucilage/metabolism ; Polysaccharides/metabolism ; Seeds/genetics ; Seeds/metabolism
Chemical Substances	Arabidopsis Proteins ; Plant Mucilage ; Polysaccharides ; rhamnogalacturonan I ; Pectins (89NA02M4RX)
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	623171-8
ISSN	1532-298X ; 1040-4651
ISSN (online)	1532-298X
ISSN	1040-4651
DOI	10.1093/plcell/koac011
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Article ; Online: RIPK3 Induces Cardiomyocyte Necroptosis via Inhibition of AMPK-Parkin-Mitophagy in Cardiac Remodelling after Myocardial Infarction.

Zhu, Pingjun / Wan, Kun / Yin, Ming / Hu, Peng / Que, Yifan / Zhou, Xin / Zhang, Lei / Li, Tianzhi / Du, Yingzhen / Xu, Guogang / Fang, Xiangqun

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 6635955

Abstract: Receptor-interacting protein 3- (RIPK3-) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In the present study, we showed that ... ...

Abstract	Receptor-interacting protein 3- (RIPK3-) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In the present study, we showed that RIPK3 expression was upregulated in myocardial tissue after MI in a mouse model by coronary artery ligation, as well as in the cardiomyocytes following hypoxic injury
MeSH term(s)	AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Animals ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitophagy/physiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Necroptosis/physiology ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Ubiquitin-Protein Ligases/antagonists & inhibitors ; Ubiquitin-Protein Ligases/metabolism ; Ventricular Remodeling/physiology
Chemical Substances	Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Ripk3 protein, mouse (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2021-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/6635955
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