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  1. Article ; Online: Why block a small hole? The adverse effects of nasogastric tubes.

    Sporik, R

    Archives of disease in childhood

    1994  Volume 71, Issue 5, Page(s) 393–394

    MeSH term(s) Bronchiolitis, Viral/therapy ; Humans ; Infant ; Infant, Newborn ; Intubation, Gastrointestinal/adverse effects ; Mouth Breathing/physiopathology ; Nasal Obstruction/etiology ; Respiratory Insufficiency/etiology
    Language English
    Publishing date 1994-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/adc.71.5.393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Early childhood wheezing.

    Sporik, R

    Current opinion in pediatrics

    1994  Volume 6, Issue 6, Page(s) 650–655

    Abstract: This review touches on what is being learned about wheezing in infants, how it differs from wheezing in later childhood, and what has been relearned about its natural history. Wheeze is a common symptom with a number of different causal mechanisms and ... ...

    Abstract This review touches on what is being learned about wheezing in infants, how it differs from wheezing in later childhood, and what has been relearned about its natural history. Wheeze is a common symptom with a number of different causal mechanisms and has a better prognosis in infants than in older children. The current ability to measure the lung function of infants has clearly shown the harmful effects of exposure to tobacco smoke. These effects begin in utero and continue during infancy and childhood. Improved viral isolation techniques have confirmed the important role of infections with respiratory syncytial virus, rhinovirus, and adenovirus in wheezing episodes. In later childhood, allergen sensitization and allergen exposure become of increasing importance.
    MeSH term(s) Child ; Humans ; Infant ; Respiratory Sounds
    Language English
    Publishing date 1994-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/00008480-199412000-00007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Asthma management guidelines.

    Sporik, R

    BMJ (Clinical research ed.)

    1993  Volume 306, Issue 6885, Page(s) 1132

    MeSH term(s) Allergens/adverse effects ; Animals ; Asthma/prevention & control ; Cats ; Humans ; Mites
    Chemical Substances Allergens
    Language English
    Publishing date 1993-04-24
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.306.6885.1132-a
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  4. Article: Clinical Immunology Review Series: An approach to the patient with allergy in childhood

    Sporik, R / Henderson, J / Hourihane, J. O'B

    Clinical and experimental immunology. 2009 Mar., v. 155, no. 3

    2009  

    Abstract: Allergic conditions are common, with asthma being the most common chronic illness in childhood in most developed countries. Some 80% of asthmatic children are sensitized to aeroallergens, usually indoor animal dander and house dust mite. Some 80% of ... ...

    Abstract Allergic conditions are common, with asthma being the most common chronic illness in childhood in most developed countries. Some 80% of asthmatic children are sensitized to aeroallergens, usually indoor animal dander and house dust mite. Some 80% of asthmatics also have rhinitis. Rhinitis and eczema receive less medical attention than asthma, but they can cause long-term morbidity and have substantial direct and indirect economic costs. Food allergy and anaphylaxis are increasingly recognised and are usually easily diagnosed and managed. Clinicians can use in vivo and in vitro measurements of allergen-specific immunoglobulin E to better time reintroduction of implicated foods. Specific parenteral and sublingual immunotherapy is widely practiced internationally but is uncommon in the UK. It may alter the natural history of aeroallergen reactive diseases in the upper and lower airways. Specific oral tolerance induction represents the current cutting edge in clinical allergy research. It remands resource intensive at present and cannot be adopted into routine clinical practice at this time.
    Keywords hypersensitivity ; children ; foods
    Language English
    Dates of publication 2009-03
    Size p. 378-386.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/j.1365-2249.2008.03852.x
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Clinical Immunology Review Series: An approach to the patient with allergy in childhood.

    Sporik, R / Henderson, J / Hourihane, J O'B

    Clinical and experimental immunology

    2008  Volume 155, Issue 3, Page(s) 378–386

    Abstract: Allergic conditions are common, with asthma being the most common chronic illness in childhood in most developed countries. Some 80% of asthmatic children are sensitized to aeroallergens, usually indoor animal dander and house dust mite. Some 80% of ... ...

    Abstract Allergic conditions are common, with asthma being the most common chronic illness in childhood in most developed countries. Some 80% of asthmatic children are sensitized to aeroallergens, usually indoor animal dander and house dust mite. Some 80% of asthmatics also have rhinitis. Rhinitis and eczema receive less medical attention than asthma, but they can cause longterm morbidity and have substantial direct and indirect economic costs. Food allergy and anaphylaxis are increasingly recognised and are usually easily diagnosed and managed.Clinicians can use in vivo and in vitro measurements of allergen-specific immunoglobulin E to better time reintroduction of implicated foods. Specific parenteral and sublingual immunotherapy is widely practiced internationally but is uncommon in the UK. It may alter the natural history of aeroallergen reactive diseases in the upper and lower airways. Specific oral tolerance induction represents the current cutting edge in clinical allergy research. It remands resource intensive at present and cannot be adopted into routine clinical practice at this time.
    MeSH term(s) Allergens ; Anaphylaxis ; Anti-Allergic Agents/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/immunology ; Child ; Desensitization, Immunologic ; Eczema/diagnosis ; Eczema/drug therapy ; Food Hypersensitivity/diagnosis ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/drug therapy ; Hypersensitivity/immunology ; Immunoglobulin E/blood ; Insect Bites and Stings/immunology
    Chemical Substances Allergens ; Anti-Allergic Agents ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2008-01-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/j.1365-2249.2008.03852.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Topical triclosan treatment of atopic dermatitis.

    Sporik, R / Kemp, A S

    The Journal of allergy and clinical immunology

    1997  Volume 99, Issue 6 Pt 1, Page(s) 861

    MeSH term(s) Administration, Cutaneous ; Anti-Infective Agents, Local/therapeutic use ; Child ; Child, Preschool ; Dermatitis, Atopic/drug therapy ; Humans ; Infant ; Triclosan/therapeutic use
    Chemical Substances Anti-Infective Agents, Local ; Triclosan (4NM5039Y5X)
    Language English
    Publishing date 1997-06
    Publishing country United States
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1085-8725 ; 1097-6825 ; 0091-6749
    ISSN (online) 1085-8725 ; 1097-6825
    ISSN 0091-6749
    DOI 10.1016/s0091-6749(97)80029-2
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  7. Article: Allergy to peanut, nuts, and sesame seed in Australian children.

    Sporik, R / Hill, D

    BMJ (Clinical research ed.)

    1996  Volume 313, Issue 7070, Page(s) 1477–1478

    MeSH term(s) Adolescent ; Arachis/adverse effects ; Child ; Child, Preschool ; Food Hypersensitivity/epidemiology ; Humans ; Infant ; Infant, Newborn ; Nuts/adverse effects ; Seeds ; Victoria/epidemiology
    Language English
    Publishing date 1996-12-07
    Publishing country England
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.313.7070.1477c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Allergen exposure and the development of asthma.

    Sporik, R / Platts-Mills, T A

    Thorax

    2001  Volume 56 Suppl 2, Page(s) ii58–63

    MeSH term(s) Allergens/administration & dosage ; Allergens/adverse effects ; Animals ; Asthma/epidemiology ; Asthma/etiology ; Asthma/immunology ; Cats ; Child ; Follow-Up Studies ; Humans ; Infant, Newborn ; Prevalence
    Chemical Substances Allergens
    Language English
    Publishing date 2001-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
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  9. Article: Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children.

    Sporik, R / Hill, D J / Hosking, C S

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2000  Volume 30, Issue 11, Page(s) 1540–1546

    Abstract: Background: The specificity of allergen skin prick testing to diagnose clinically relevant food allergy is controversial.: Objectives: To determine the specificity of the allergen weal diameter to correctly identify children who react on formal open ... ...

    Abstract Background: The specificity of allergen skin prick testing to diagnose clinically relevant food allergy is controversial.
    Objectives: To determine the specificity of the allergen weal diameter to correctly identify children who react on formal open food challenges.
    Methods: Over a 9-year period children referred to a tertiary allergy clinic for the evaluation of suspected food allergy were prospectively studied. Allergen skin prick testing to cow milk, egg white and peanut extracts (Dome-Hollister-Stier, Spokane, WA, USA) was undertaken using a lancet technique. All children underwent open food challenges to the relevant food(s) in a hospital clinic. Challenges were classified as positive, if objective signs were seen; negative, if the child could tolerate normal quantities of the food, daily, for one week; or inconclusive if none of the former criteria were met.
    Results: Five hundred and fifty-five challenges were undertaken in 467 children: 339 challenges to cow milk, 121 to egg, and 95 to peanut. Fifty-five percentage of challenges were positive, 37% negative, and 8% inconclusive. For each food it was possible to identify a skin weal diameter at, and above, which negative reactions did not occur: cow milk, 8 mm; egg, 7 mm; peanut, 8 mm. In contrast, positive reactions could occur with a skin wheal diameter of 0 mm.
    Conclusions: In this high risk referral population it was possible to define skin weal diameters to egg, milk and peanut above which open oral food challenges were positive (100% specificity). By utilizing these measurements the need for formal food challenges can be reduced.
    MeSH term(s) Animals ; Arachis/adverse effects ; Child, Preschool ; Eggs/adverse effects ; Female ; Food Hypersensitivity/diagnosis ; Humans ; Male ; Milk Hypersensitivity/diagnosis ; Prospective Studies ; Sensitivity and Specificity ; Skin Tests
    Language English
    Publishing date 2000-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1046/j.1365-2222.2000.00928.x
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  10. Article: Exposure to house dust mite allergen of children admitted to hospital with asthma.

    Sporik, R / Platts-Mills, T A / Cogswell, J J

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2000  Volume 23, Issue 9, Page(s) 740–746

    Abstract: Eighty-two children admitted to hospital with exacerbations of asthma were studied to determine how many were exposed to house dust mites at the time of admission and displayed immediate hypersensitivity to house dust mites. The concentration of house ... ...

    Abstract Eighty-two children admitted to hospital with exacerbations of asthma were studied to determine how many were exposed to house dust mites at the time of admission and displayed immediate hypersensitivity to house dust mites. The concentration of house dust mite allergen (Der p I) was measured in dust obtained from the child's mattress, bedroom floor and living room floor. Sixty-two (75%) children admitted had been exposed to > 10 microg Der p I/g. Sixty-seven (82%) children were sensitive to house dust mite (RAST > or = 1 +, or weal > or = 3 mm): 49 (60%) children were both exposed and sensitive. In contrast in a control group of 44 children, 31 (70%) (n.s.) were exposed to > 10 microg Der p I/g, 10 (23%) (P<0.001) were sensitive to house dust mite, and 7 (16%) (P<0.001) were both exposed and sensitive. Seventy-three homes were revisited 6 months after the child's initial admission. During the preceding month 14 children had been readmitted, 12 were fully investigated; of these 10 were both sensitive to house dust mite and still exposed to > 10 microg Der p I/g. In contrast, of the remaining 62 children who were not readmitted, only 19 were both sensitive and still exposed to > 10 microg Der p I/g (P<0.001). In conclusion, the majority of children admitted to hospital with exacerbations of asthma were exposed to house dust mite allergen and were house dust mite sensitive. Further the results suggest that continued exposure to higher concentrations of mite allergen may be associated with the risk of readmission.
    MeSH term(s) Adolescent ; Animals ; Antigens, Dermatophagoides ; Asthma/epidemiology ; Asthma/etiology ; Asthma/immunology ; Bedding and Linens ; Cats ; Child ; Child, Preschool ; Cohort Studies ; Dust/adverse effects ; Dust/analysis ; England/epidemiology ; Environmental Exposure ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Glycoproteins/adverse effects ; Glycoproteins/analysis ; Glycoproteins/immunology ; Hospitalization ; Hospitals, General ; Housing ; Humans ; Infant ; Male ; Mites/immunology ; Radioallergosorbent Test ; Recurrence ; Risk ; Seasons
    Chemical Substances Antigens, Dermatophagoides ; Dust ; Glycoproteins
    Language English
    Publishing date 2000-04-01
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/j.1365-2222.1993.tb00361.x
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