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Article: Measurement of Serum Immunoglobulins: A National Survey of Practice.

Beverland, A / Cronin, T / Khalib, K / Keogan, M

2022 Volume 115, Issue 1, Page(s) 523

Abstract: Aim To survey how serum immunoglobulins (IgG, IgA, IgM) are measured and reported across public hospitals in Ireland. Methods We developed a seven-point questionnaire to elicit the methodology, reporting and reference intervals of serum immunoglobulins. ... ...

Abstract	Aim To survey how serum immunoglobulins (IgG, IgA, IgM) are measured and reported across public hospitals in Ireland. Methods We developed a seven-point questionnaire to elicit the methodology, reporting and reference intervals of serum immunoglobulins. It was distributed electronically by email to sixteen laboratory managers of Irish public hospitals. Results A total of twelve questionnaires were completed. The test method was the same in each laboratory, whilst the analyser and source of the reference intervals varied. In some institutions, the reference interval differed within the adult age population and for sex. The IgG parameter contained the highest spread of results. The lower reference limit ranged 5.4-8.0 g/L, with a standard deviation of 0.81, and the upper reference limit ranged 14.9-18.2 g/L (SD 1.04). Conclusion Considerable variation exists in the reference intervals of serum immunoglobulins within different Irish public hospitals. This has important implications for users of the test, patients and referral patterns.
MeSH term(s)	Adult ; Age Factors ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Sex Factors
Chemical Substances	Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2022-01-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	193134-9
ISSN	0332-3102 ; 0021-129X
ISSN	0332-3102 ; 0021-129X
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Article ; Online: Clinical Immunology Review Series: an approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome.

Keogan, M T

Clinical and experimental immunology

2008 Volume 156, Issue 1, Page(s) 1–11

Abstract: Patients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema ... ...

Abstract	Patients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema multiforme, erosive lichen planus). Behçet's syndrome is a multi-system vasculitis of unknown aetiology for which there is no diagnostic test. Diagnosis is based on agreed clinical criteria that require recurrent oral ulcers and two of the following: recurrent genital ulcers, ocular inflammation, defined skin lesions and pathergy. The condition can present with a variety of symptoms, hence a high index of suspicion is necessary. The most common presentation is with recurrent mouth ulcers, often with genital ulcers; however, it may take some years before diagnostic criteria are met. All patients with idiopathic orogenital ulcers should be kept under review, with periodic focused assessment to detect evolution into Behçet's disease. There is often a delay of several years between patients fulfilling diagnostic criteria and a diagnosis being made, which may contribute to the morbidity of this condition. Despite considerable research effort, the aetiology and pathogenesis of this condition remains enigmatic.
MeSH term(s)	Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Diagnosis, Differential ; Female ; Genital Diseases, Female/diagnosis ; Genital Diseases, Male/diagnosis ; Humans ; Male ; Recurrence ; Stomatitis, Aphthous/diagnosis ; Ulcer/diagnosis
Language	English
Publishing date	2008-12-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/j.1365-2249.2008.03857.x
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Article ; Online: Braak's Unfinished Hypothesis: A Clinicopathological Case Report of α-Synuclein Peripheral Neuropathy Preceding Parkinsonism by 20 Years.

Donlon, Eoghan / Lynch, Rionagh / Murphy, Olwen C / Farrell, Michael / Noel, Jaques / Keogan, Mary / O'Connell, Martin / Lynch, Timothy

Movement disorders clinical practice

2021 Volume 8, Issue 7, Page(s) 1129–1133

Abstract: Background: α-synuclein aggregates in the form of Lewy bodies and Lewy neurites are the pathological hallmark of Parkinson disease (PD) and dementia with Lewy bodies (DLB). Autopsy studies suggest that α-synuclein aggregates appear in localized areas of ...

Abstract	Background: α-synuclein aggregates in the form of Lewy bodies and Lewy neurites are the pathological hallmark of Parkinson disease (PD) and dementia with Lewy bodies (DLB). Autopsy studies suggest that α-synuclein aggregates appear in localized areas of the central nervous system before spreading in a sequential pattern from the brainstem to the cerebral cortex, known as the Braak hypothesis. Increased prevalence of peripheral neuropathy in PD is recognized, with multiple hypothesized mechanisms including α-synuclein deposition. Method: We describe a patient who developed a peripheral sensory neuropathy at age 60, which progressed insidiously over the following decade. Results: During the patient's eighth decade, the patient developed a fluctuant cognitive disturbance with hallucinations before becoming overtly parkinsonian at age 78 years leading to a diagnosis of DLB. At this point, histology slides from a sural nerve biopsy taken at age 72 were re-evaluated and immunohistochemistry demonstrated α-synuclein deposition. Conclusion: This case provides important in vivo clinical correlation for the Braak hypothesis, extending its scope beyond idiopathic PD. A growing body of evidence supports the α-synuclein spreading hypothesis that posits the pathologic process begins in the peripheral nerves and spreads trans-synaptically to the CNS in an ascending pattern.
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Journal Article
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.13321
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Article: Clinical Immunology Review Series: An approach to the patient with recurrent orogenital ulceration, including Behçet's syndrome

Keogan, M.T

Clinical and experimental immunology. 2009 Apr., v. 156, no. 1

2009

Abstract	Patients presenting with recurrent orogenital ulcers may have complex aphthosis, Behçet's disease, secondary complex aphthosis (e.g. Reiter's syndrome, Crohn's disease, cyclical neutropenia) or non-aphthous disease (including bullous disorders, erythema multiforme, erosive lichen planus). Behçet's syndrome is a multi-system vasculitis of unknown aetiology for which there is no diagnostic test. Diagnosis is based on agreed clinical criteria that require recurrent oral ulcers and two of the following: recurrent genital ulcers, ocular inflammation, defined skin lesions and pathergy. The condition can present with a variety of symptoms, hence a high index of suspicion is necessary. The most common presentation is with recurrent mouth ulcers, often with genital ulcers; however, it may take some years before diagnostic criteria are met. All patients with idiopathic orogenital ulcers should be kept under review, with periodic focused assessment to detect evolution into Behçet's disease. There is often a delay of several years between patients fulfilling diagnostic criteria and a diagnosis being made, which may contribute to the morbidity of this condition. Despite considerable research effort, the aetiology and pathogenesis of this condition remains enigmatic.
Language	English
Dates of publication	2009-04
Size	p. 1-11.
Publisher	Blackwell Publishing Ltd
Publishing place	Oxford, UK
Document type	Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/j.1365-2249.2008.03857.x
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Article ; Online: Identification of the novel B*27:144 allele in an Irish Individual.

Kelleher, J / Mullany, P / Wallis-Jones, S / Turner, T / Keogan, M

HLA

2016 Volume 88, Issue 1-2, Page(s) 47–48

Abstract: The sequence of HLA-B*27:144 differs from HLA-B*27:05:02 by one nucleotide change at position 506. ...

Abstract	The sequence of HLA-B27:144 differs from HLA-B27:05:02 by one nucleotide change at position 506.
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.12846
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Article: Radiology of urinary diversions.

Keogan, M T

Current opinion in urology

2000 Volume 10, Issue 2, Page(s) 117–122

Abstract: Radiologic evaluation of urinary diversion has three objectives: to monitor upper tract distention, to detect new urothelial tumors and to detect metastasis. The type of imaging procedure and the frequency of imaging is dictated by the urologist ... ...

Abstract	Radiologic evaluation of urinary diversion has three objectives: to monitor upper tract distention, to detect new urothelial tumors and to detect metastasis. The type of imaging procedure and the frequency of imaging is dictated by the urologist preference. As many surgical procedures are available for noncontinent and continent diversion, interpretation of radiographic studies requires a detailed knowledge of the type of surgical procedure that has been performed.
MeSH term(s)	Cecum/surgery ; Contrast Media ; Humans ; Ileum/surgery ; Postoperative Complications/diagnostic imaging ; Radiology, Interventional ; Urinary Bladder/surgery ; Urinary Diversion/methods ; Urography
Chemical Substances	Contrast Media
Language	English
Publishing date	2000-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/00042307-200003000-00012
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Article ; Online: Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis.

Annals of the American Thoracic Society

2022 Volume 19, Issue 11, Page(s) 1818–1826

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Cystic Fibrosis ; Lung ; C-Reactive Protein/metabolism ; Anti-Bacterial Agents/therapeutic use ; Biomarkers ; Inflammation/drug therapy ; Phenotype ; Disease Progression
Chemical Substances	C-Reactive Protein (9007-41-4) ; Anti-Bacterial Agents ; Biomarkers
Language	English
Publishing date	2022-06-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202111-1266OC
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Article ; Online: The Study to Investigate COVID-19 Infection in People Living in Ireland (SCOPI): A seroprevalence study, June to July 2020.

Heavey, Laura / Garvey, Patricia / Colgan, Aoife M / Thornton, Lelia / Connell, Jeff / Roux, Thomas / Hunt, Meadhbh / O'Callaghan, Fiona / Culkin, Fiona / Keogan, Mary / O'Connor, Nuala / O'Sullivan, Margaret B / O'Sullivan, Siobhán / Tait, Michele / De Gascun, Cillian F / Igoe, Derval

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2021 Volume 26, Issue 48

Abstract: BackgroundRobust data on SARS-CoV-2 population seroprevalence supplement surveillance data in providing evidence for public health action.AimTo conduct a SARS-CoV-2 population-based seroprevalence survey in Ireland.MethodsUsing a cross-sectional study ... ...

Abstract	BackgroundRobust data on SARS-CoV-2 population seroprevalence supplement surveillance data in providing evidence for public health action.AimTo conduct a SARS-CoV-2 population-based seroprevalence survey in Ireland.MethodsUsing a cross-sectional study design, we selected population samples from individuals aged 12-69 years in counties Dublin and Sligo using the Health Service Executive Primary Care Reimbursement Service database as a sampling frame. Samples were selected with probability proportional to the general population age-sex distribution, and by simple random sampling within age-sex strata. Antibodies to SARS-CoV-2 were detected using the Abbott Architect SARS-CoV-2 IgG Assay and confirmed using the Wantai Assay. We estimated the population SARS-CoV-2 seroprevalence weighted for age, sex and geographic area.ResultsParticipation rates were 30% (913/3,043) and 44% (820/1,863) in Dublin and Sligo. Thirty-three specimens had detectable SARS-CoV-2 antibodies (1.9%). We estimated weighted seroprevalences of 3.12% (95% confidence interval (CI): 2.05-4.53) and 0.58% (95% CI: 0.18-1.38) for Dublin and Sligo, and 1.69% (95% CI: 1.13-2.41) nationally. This equates to an estimated 59,482 (95% CI: 39,772-85,176) people aged 12-69 years nationally having had infection with SARS-CoV-2, 3.0 (95% CI: 2.0-4.3) times higher than confirmed notifications. Ten participants reported a previous laboratory-confirmed SARS-CoV-2 -infection; eight of these were antibody-positive. Twenty-five antibody-positive participants had not reported previous laboratory-confirmed infection.ConclusionThe majority of people in Ireland are unlikely to have been infected with SARS-CoV-2 by June-July 2020. Non-pharmaceutical public health measures remained key pending widespread availability of vaccination, and effective treatments.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Cross-Sectional Studies ; Humans ; Ireland/epidemiology ; SARS-CoV-2 ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2021-12-03
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2021.26.48.2001741
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Article: Variation and correlation in the timing of breeding of North Atlantic seabirds across multiple scales

Keogan, Katharine / Daunt, Francis / Wanless, Sarah / Phillips, Richard A. / Alvarez, David / Anker‐Nilssen, Tycho / Barrett, Robert T. / Bech, Claus / Becker, Peter H. / Berglund, Per‐Arvid / Bouwhuis, Sandra / Burr, Zofia M. / Chastel, Olivier / Christensen‐Dalsgaard, Signe / Descamps, Sebastien / Diamond, Tony / Elliott, Kyle / Erikstad, Kjell‐Einar / Harris, Mike /

Hentati‐Sundberg, Jonas / Heubeck, Martin / Kress, Stephen W. / Langset, Magdalene / Lorentsen, Svein‐Håkon / Major, Heather L. / Mallory, Mark / Mellor, Mick / Miles, Will T. S. / Moe, Børge / Mostello, Carolyn / Newell, Mark / Nisbet, Ian / Reiertsen, Tone Kirstin / Rock, Jennifer / Shannon, Paula / Varpe, Øystein / Lewis, Sue / Phillimore, Albert B.

journal of animal ecology. 2022 Sept., v. 91, no. 9

2022

Abstract: Timing of breeding, an important driver of fitness in many populations, is widely studied in the context of global change, yet despite considerable efforts to identify environmental drivers of seabird nesting phenology, for most populations we lack ... ...

Abstract	Timing of breeding, an important driver of fitness in many populations, is widely studied in the context of global change, yet despite considerable efforts to identify environmental drivers of seabird nesting phenology, for most populations we lack evidence of strong drivers. Here we adopt an alternative approach, examining the degree to which different populations positively covary in their annual phenology to infer whether phenological responses to environmental drivers are likely to be (a) shared across species at a range of spatial scales, (b) shared across populations of a species or (c) idiosyncratic to populations. We combined 51 long‐term datasets on breeding phenology spanning 50 years from nine seabird species across 29 North Atlantic sites and examined the extent to which different populations share early versus late breeding seasons depending on a hierarchy of spatial scales comprising breeding site, small‐scale region, large‐scale region and the whole North Atlantic. In about a third of cases, we found laying dates of populations of different species sharing the same breeding site or small‐scale breeding region were positively correlated, which is consistent with the hypothesis that they share phenological responses to the same environmental conditions. In comparison, we found no evidence for positive phenological covariation among populations across species aggregated at larger spatial scales. In general, we found little evidence for positive phenological covariation between populations of a single species, and in many instances the inter‐year variation specific to a population was substantial, consistent with each population responding idiosyncratically to local environmental conditions. Black‐legged kittiwake Rissa tridactyla was the exception, with populations exhibiting positive covariation in laying dates that decayed with the distance between breeding sites, suggesting that populations may be responding to a similar driver. Our approach sheds light on the potential factors that may drive phenology in our study species, thus furthering our understanding of the scales at which different seabirds interact with interannual variation in their environment. We also identify additional systems and phenological questions to which our inferential approach could be applied.
Keywords	Rissa tridactyla ; animal ecology ; data collection ; global change ; phenology ; seabirds
Language	English
Dates of publication	2022-09
Size	p. 1797-1812.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	3024-7
ISSN	1365-2656 ; 0021-8790
ISSN (online)	1365-2656
ISSN	0021-8790
DOI	10.1111/1365-2656.13758
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Article: Technologic advances in abdominal MR imaging.

Keogan, M T / Edelman, R R

Radiology

2001 Volume 220, Issue 2, Page(s) 310–320

Abstract: Magnetic resonance (MR) imaging is finding an ever-growing role in the evaluation of a wide range of conditions in the abdomen. No longer confined to problem solving regarding abnormalities in solid organs, such as the liver and kidneys, MR imaging is ... ...

Abstract	Magnetic resonance (MR) imaging is finding an ever-growing role in the evaluation of a wide range of conditions in the abdomen. No longer confined to problem solving regarding abnormalities in solid organs, such as the liver and kidneys, MR imaging is increasingly being applied to the evaluation of the pancreatic and biliary ductal systems and even the bowel. Recent technical advances in hardware and software have allowed the acquisition of MR images that are largely free of artifact secondary to bowel peristalsis or respiratory motion; images providing excellent anatomic detail can now be obtained routinely. Faster sequences have reduced image acquisition time, thereby improving patient acceptance and allowing more efficient utilization of machine time. New three-dimensional sequences allow rapid image acquisition, reducing section misregistration and motion artifact while improving multiplanar reformations. The potential of MR imaging to provide functional and anatomic information is intriguing, and new techniques, including diffusion and perfusion imaging, are being evaluated. This review considers the advances in imaging hardware and pulse sequence design that underlie the increasing role of MR imaging in evaluation of the abdomen and discusses evolving clinical applications.
MeSH term(s)	Abdomen/anatomy & histology ; Cholangitis, Sclerosing/diagnosis ; Cholecystitis/diagnosis ; Humans ; Intestines/anatomy & histology ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods ; Pancreatitis/diagnosis
Language	English
Publishing date	2001-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiology.220.2.r01au22310
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