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  1. Article ; Online: Reply.

    Kaushik, Shubhi / Derespina, Kim R / Medar, Shivanand S

    The Journal of pediatrics

    2020  Volume 226, Page(s) 315

    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.07.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Methylene Blue Use in Pediatrics

    Moss, Rachel / Derespina, Kim R. / Frye, Jessica / Kaushik, Shubhi

    Journal of Pediatric Intensive Care

    2023  

    Abstract: Catecholamine-resistant shock, also known as vasoplegia, is a challenging entity with a significant risk of mortality. We seek to provide further data on the safety and effectiveness of methylene blue (MB) for vasoplegic shock in the pediatric population. ...

    Abstract Catecholamine-resistant shock, also known as vasoplegia, is a challenging entity with a significant risk of mortality. We seek to provide further data on the safety and effectiveness of methylene blue (MB) for vasoplegic shock in the pediatric population. We conducted a retrospective observational study of pediatric patients admitted to the pediatric intensive care unit or pediatric cardiac intensive care unit at Mount Sinai Kravis Children's Hospital from 2011 to 2021 who received MB for refractory shock. A list of patients was obtained by performing a pharmaceutical query from 2011 to 2021 for “MB.” Chart review was performed to determine indication for use and to collect demographic and clinical data. There were 33 MB administrations: 18 administrations (16 unique patients) for vasoplegic shock, 11 for surgical dye, and 4 for methemoglobinemia. The median age was 5 years (interquartile range [IQR]: 0.08, 13). Ten patients required MB following congenital cardiac repair (62.5%); one administration for myocarditis, septic shock, postcardiac arrest, high output chylothorax, scoliosis repair, and one multisystem inflammatory syndrome in children. No patients experienced hemolytic anemia or serotonin syndrome following administration. The median dose of MB was 1 mg/kg. Vasoactive-inotrope score (VIS) improved in 4 out of 18 administrations at 1 hour. Mean arterial pressure (MAP) improved in 10 out of 18 administrations at 1 hour. Systolic blood pressure (SBP) improved in 8 out of 18 administrations at 1 hour. VIS, MAP, and SBP improved in 8 out of 18 administrations at 6 hours. MB may be safely considered as rescue therapy in catecholamine-resistant shock in pediatrics.
    Keywords vasoplegic shock ; methylene blue ; vasoplegia ; pediatrics
    Language English
    Publishing date 2023-01-05
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-4626 ; 2146-4618
    ISSN (online) 2146-4626
    ISSN 2146-4618
    DOI 10.1055/s-0042-1760297
    Database Thieme publisher's database

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  3. Article ; Online: Response to "Thiamin deficiency secondary to loop diuretics, an overlooked cause of multiorgan failure".

    Derespina, Kim R / Kaushik, Shubhi / Mahadeo, Kris / McCabe, Megan

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2021  Volume 36, Issue 5, Page(s) 1088–1089

    MeSH term(s) Heart Failure ; Humans ; Sodium Potassium Chloride Symporter Inhibitors ; Thiamine ; Thiamine Deficiency
    Chemical Substances Sodium Potassium Chloride Symporter Inhibitors ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Letter
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pediatric Shock: An Uncommon and Underrecognized Etiology.

    Derespina, Kim R / Kaushik, Shubhi / Medar, Shivanand S

    Journal of pediatric intensive care

    2020  Volume 9, Issue 3, Page(s) 210–212

    Abstract: Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a well-known disease entity. Kawasaki shock syndrome (KSS), on the other hand, is less well recognized and has been reported in small single-center international studies and case ... ...

    Abstract Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a well-known disease entity. Kawasaki shock syndrome (KSS), on the other hand, is less well recognized and has been reported in small single-center international studies and case reports. We report a case in the United States of an 11-year-old male with multiorgan failure and shock, presumed to be secondary to toxic shock but later diagnosed with KSS, an underrecognized entity in the US and review the literature. KSS should be considered in a critically ill child with unexplained shock.
    Language English
    Publishing date 2020-01-10
    Publishing country Germany
    Document type Case Reports
    ISSN 2146-4618
    ISSN 2146-4618
    DOI 10.1055/s-0039-1700964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply.

    Derespina, Kim R / Kaushik, Shubhi / Ushay, Henry M / Medar, Shivanand S

    The Journal of pediatrics

    2020  Volume 231, Page(s) 301–302

    MeSH term(s) Adolescent ; COVID-19 ; Child ; Critical Illness ; Humans ; New York City ; SARS-CoV-2
    Language English
    Publishing date 2020-11-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.11.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Lactic Acidosis Secondary to Thiamin Deficiency Following Autologous Stem Cell Transplantation

    Derespina, Kim R / Kaushik, Shubhi / Mahadeo, Kris / McCabe, Megan

    Nutrition in clinical practice. 2021 Apr., v. 36, no. 2

    2021  

    Abstract: A 22‐month‐old female with high‐risk neuroblastoma completed 5 cycles of chemotherapy then underwent high‐dose chemotherapy with autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she was unable to ... ...

    Abstract A 22‐month‐old female with high‐risk neuroblastoma completed 5 cycles of chemotherapy then underwent high‐dose chemotherapy with autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she was unable to tolerate nasogastric feeds because of grade IV mucositis and vomiting. On day +12, she developed worsening metabolic acidosis with above reportable levels of lactic acid. Given the patient's well clinical appearance and paucity of evidence of end‐organ dysfunction on physical examination and on laboratory studies, there was high suspicion that the patient's lactic acidosis did not result from tissue hypoxia and was, in fact, a type B lactic acidosis. Thiamin was empirically administered, with rapid improvement in lactic acidosis. Thiamin deficiency was later confirmed by laboratory studies drawn prior to thiamin administration.
    Keywords acidosis ; cell transplantation ; clinical examination ; drug therapy ; females ; hypoxia ; lactic acid ; parenteral feeding ; patients ; stem cells ; thiamin
    Language English
    Dates of publication 2021-04
    Size p. 414-418.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10560
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Lactic Acidosis Secondary to Thiamin Deficiency Following Autologous Stem Cell Transplantation.

    Derespina, Kim R / Kaushik, Shubhi / Mahadeo, Kris / McCabe, Megan

    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

    2020  Volume 36, Issue 2, Page(s) 414–418

    Abstract: A 22-month-old female with high-risk neuroblastoma completed 5 cycles of chemotherapy then underwent high-dose chemotherapy with autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she was unable to ... ...

    Abstract A 22-month-old female with high-risk neuroblastoma completed 5 cycles of chemotherapy then underwent high-dose chemotherapy with autologous stem cell rescue (ASCR). Parenteral nutrition was administered from day +2 following ASCR, as she was unable to tolerate nasogastric feeds because of grade IV mucositis and vomiting. On day +12, she developed worsening metabolic acidosis with above reportable levels of lactic acid. Given the patient's well clinical appearance and paucity of evidence of end-organ dysfunction on physical examination and on laboratory studies, there was high suspicion that the patient's lactic acidosis did not result from tissue hypoxia and was, in fact, a type B lactic acidosis. Thiamin was empirically administered, with rapid improvement in lactic acidosis. Thiamin deficiency was later confirmed by laboratory studies drawn prior to thiamin administration.
    MeSH term(s) Acidosis, Lactic/etiology ; Acidosis, Lactic/therapy ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Infant ; Thiamine ; Thiamine Deficiency/etiology ; Transplantation, Autologous
    Chemical Substances Thiamine (X66NSO3N35)
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645074-x
    ISSN 1941-2452 ; 0884-5336
    ISSN (online) 1941-2452
    ISSN 0884-5336
    DOI 10.1002/ncp.10560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply.

    Kaushik, Shubhi / Jhaveri, Simone / Derespina, Kim R / Medar, Shivanand S / Stern, Kenan / Aydin, Scott I

    The Journal of pediatrics

    2020  Volume 228, Page(s) 315–316

    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.09.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pediatric Shock: An Uncommon and Underrecognized Etiology

    Derespina, Kim R. / Kaushik, Shubhi / Medar, Shivanand S.

    Journal of Pediatric Intensive Care

    2020  Volume 09, Issue 03, Page(s) 210–212

    Abstract: Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a well-known disease entity. Kawasaki shock syndrome (KSS), on the other hand, is less well recognized and has been reported in small single-center international studies and case ... ...

    Abstract Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a well-known disease entity. Kawasaki shock syndrome (KSS), on the other hand, is less well recognized and has been reported in small single-center international studies and case reports. We report a case in the United States of an 11-year-old male with multiorgan failure and shock, presumed to be secondary to toxic shock but later diagnosed with KSS, an underrecognized entity in the US and review the literature. KSS should be considered in a critically ill child with unexplained shock.
    Keywords Kawasaki disease ; Kawasaki shock syndrome ; erythema
    Language English
    Publishing date 2020-01-10
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2146-4626 ; 2146-4618
    ISSN (online) 2146-4626
    ISSN 2146-4618
    DOI 10.1055/s-0039-1700964
    Database Thieme publisher's database

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