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  1. Article ; Online: The Case for Inclusion of a Lipid Panel in the Standard Precatheterization Laboratory Blood Draw-Stating What Should Be Obvious.

    Ranard, Lauren S / Duffy, Eamon Y / Kirtane, Ajay J

    JAMA cardiology

    2023  Volume 8, Issue 7, Page(s) 629–630

    MeSH term(s) Humans ; Lipids/blood ; Diagnostic Tests, Routine ; Catheterization
    Chemical Substances Lipids
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.1287
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  2. Article ; Online: Weighing Transcatheter Aortic Valve Replacement vs Surgical Aortic Valve Replacement for Native Aortic Regurgitation.

    Ranard, Lauren S / Vahl, Torsten P / Thourani, Vinod H

    The Annals of thoracic surgery

    2023  Volume 115, Issue 4, Page(s) 877–878

    MeSH term(s) Humans ; Aortic Valve/surgery ; Transcatheter Aortic Valve Replacement ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/surgery ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation ; Treatment Outcome ; Aortic Valve Stenosis/surgery ; Prosthesis Design
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2023.02.001
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    Zs.A 252: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Transfemoral Transcatheter Mitral Valve Implantation With a Dedicated Device in a Rheumatic Mitral Stenosis Patient.

    Ranard, Lauren S / Grizzell, Brett E / Vahl, Torsten P / Granada, Juan F / Chehab, Bassem M

    JACC. Case reports

    2023  Volume 22, Page(s) 101986

    Abstract: A 65-year-old obese woman with rheumatic heart disease and restrictive lung disease presented with decompensated heart failure. Evaluation demonstrated severely thickened mitral valve leaflets, severe mitral stenosis, and moderate mitral regurgitation. ... ...

    Abstract A 65-year-old obese woman with rheumatic heart disease and restrictive lung disease presented with decompensated heart failure. Evaluation demonstrated severely thickened mitral valve leaflets, severe mitral stenosis, and moderate mitral regurgitation. She underwent successful transfemoral transseptal transcatheter mitral valve replacement with a dedicated valve resulting in improved functional status. (
    Language English
    Publishing date 2023-08-14
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.101986
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  4. Article ; Online: Transcatheter transseptal treatment of patients with severe mitral regurgitation using an atrial fixation mitral valve replacement technology.

    Ninios, Vlasis / Ninios, Ilias / Ranard, Lauren S / Vahl, Torsten P / Wróbel, Krzysztof

    Cardiovascular revascularization medicine : including molecular interventions

    2023  Volume 58, Page(s) 25–30

    Abstract: Background: Mitral regurgitation (MR) is the most common valvular heart disease worldwide with a 5-year mortality rate of 50 % with medical therapy alone. Several transcatheter mitral valve replacement (TMVR) devices are being investigated in clinical ... ...

    Abstract Background: Mitral regurgitation (MR) is the most common valvular heart disease worldwide with a 5-year mortality rate of 50 % with medical therapy alone. Several transcatheter mitral valve replacement (TMVR) devices are being investigated in clinical trials. Early evidence has demonstrated clinical benefits with a reduction in heart failure symptoms, low rates of residual MR, and reverse remodeling of the left ventricle (LV) over time. However, high anatomical screen failure rates limit its applicability. The primary reasons for the anatomical screen failure are risk of LV outflow tract obstruction, large mitral valve annulus size, and the presence of mitral annular calcification. Our clinical experiences using an atrial only fixation TMVR technology delivered via a transfemoral-transseptal approach is described.
    Methods: Three consecutive patients with severe functional MR underwent TMVR implantation using an atrial only fixation technology and a low-profile transseptal delivery system.
    Results: Technical success was achieved in 100 % of the patients with a clinically significant reduction in MR. Longer-term follow-up (up to 6-months) has demonstrated a sustained reduction in MR and significant improvement in quality of life for all patients.
    Conclusions: Longer-term outcomes in our patients showed persistent reduction in MR, sustained implant performance, and notable improvements in NYHA Class and quality of life. There were no major adverse events. Follow-up CT data showed no evidence of device-related thrombosis, with stable valve position and integrity. The atrial fixation TMVR technology may have benefits in preserving the dynamics of the native mitral valve annulus thereby reducing the overall risk of LVOT obstruction.
    Short abstract: We present a single-center experience of three consecutive patients with severe functional MR treated with the AltaValve using a low-profile transseptal delivery system. A clinically significant reduction in mitral regurgitation was achieved in all patients, and longer-term follow-up has demonstrated sustained clinical benefits.
    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology ; Heart Valve Prosthesis Implantation ; Quality of Life ; Cardiac Catheterization ; Treatment Outcome ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2023.07.006
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    Zs.A 5562: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Renal Artery Denervation for Hypertension.

    Ranard, Lauren S / Swaminathan, Rajesh V

    Current treatment options in cardiovascular medicine

    2019  Volume 21, Issue 2, Page(s) 7

    Abstract: Purpose of review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of ... ...

    Abstract Purpose of review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Current hypertensive pharmacotherapy has not fully targeted the SNS; therefore, the SNS has become a prominent research therapeutic target. This review summarizes the evidence and rationale behind renal denervation (RDN) therapy and the technology available.
    Recent findings: Prior to the SYMPLICITY HTN-3 clinical trial, trials found RDN to be an effective procedure to control resistant hypertension. The failure of SYMPLICITY HTN-3 to meet its primary efficacy endpoint sparked further studies to address potential shortcomings. The subsequent SPYRAL program trials demonstrated efficacy of RDN therapy in a controlled manner; however, they were not adequately powered. Ongoing research is examining new, innovative RDN technology as well as defining appropriate patients to target for treatment. The data currently available for RDN in HTN and other states of SNS activation suffer from potential biases and limitations, highlighting the need for continued exploration. Contemporary studies are more promising and hypothesis-generating. Future trials and continued device innovation will be crucial for understanding the clinical applications of RDN therapy.
    Language English
    Publishing date 2019-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057337-6
    ISSN 1534-3189 ; 1092-8464
    ISSN (online) 1534-3189
    ISSN 1092-8464
    DOI 10.1007/s11936-019-0715-6
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    Zs.A 5529: Show issues Location:
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  6. Article ; Online: COVID-19-Specific Strategies for the Treatment of ST-Segment Elevation Myocardial Infarction in China.

    Ranard, Lauren S / Parikh, Sahil A / Kirtane, Ajay J

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 11, Page(s) 1325–1327

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Humans ; Pandemics ; Percutaneous Coronary Intervention ; Pneumonia, Viral ; SARS-CoV-2 ; ST Elevation Myocardial Infarction
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.07.054
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  7. Article ; Online: An Unusual Cause of Shortness of Breath: Pulmonary Vein Stenosis After Surgical Mitral Valve Replacement.

    Guber, Kenneth / Ranard, Lauren S / Ng, Vivian / Hahn, Rebecca T / Sommer, Robert / Vahl, Torsten P

    JACC. Case reports

    2022  Volume 4, Issue 9, Page(s) 533–537

    Abstract: A 79-year-old man with prior bioprosthetic mitral valve replacement presented with progressive shortness of breath and was found to have right upper pulmonary vein stenosis and paravalvular leak diagnosed with the use of multimodal imaging. The patient ... ...

    Abstract A 79-year-old man with prior bioprosthetic mitral valve replacement presented with progressive shortness of breath and was found to have right upper pulmonary vein stenosis and paravalvular leak diagnosed with the use of multimodal imaging. The patient underwent balloon angioplasty, stenting of the pulmonary vein, and paravalvular leak closure with ultimate resolution of symptoms. (
    Language English
    Publishing date 2022-05-04
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.01.026
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  8. Article ; Online: Procedural performance and healing response of a novel lowprofile transseptal transcatheter mitral valve replacement system.

    Ranard, Lauren S / Cheng, Yanping / Yi, Genghua / Ordanes, Diane / McBride, Mitchell / Butziger, John / Forde, Sean / Righini, Giovanni / Denti, Paolo / Vahl, Torsten

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2024  Volume 20, Issue 4, Page(s) e261–e263

    MeSH term(s) Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation ; Heart Valve Prosthesis ; Cardiac Catheterization ; Treatment Outcome ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery
    Language English
    Publishing date 2024-02-19
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-23-00478
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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  9. Article ; Online: Cardiopulmonary Resuscitation During the COVID-19 Pandemic: A View From Trainees on the Front Line.

    DeFilippis, Ersilia M / Ranard, Lauren S / Berg, David D

    Circulation

    2020  Volume 141, Issue 23, Page(s) 1833–1835

    MeSH term(s) Advance Directives ; Aerosols ; Attitude of Health Personnel ; Body Fluids/virology ; COVID-19 ; Cardiology/education ; Cardiopulmonary Resuscitation/ethics ; Cardiopulmonary Resuscitation/methods ; Chest Wall Oscillation ; Coronavirus Infections/complications ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Coronavirus Infections/transmission ; Heart Arrest/etiology ; Heart Arrest/therapy ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Intubation, Intratracheal/adverse effects ; Occupational Diseases/prevention & control ; Occupational Diseases/psychology ; Occupational Exposure ; Pandemics/prevention & control ; Patients' Rooms ; Personnel, Hospital/psychology ; Pneumonia, Viral/complications ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Pneumonia, Viral/transmission ; Protective Devices/supply & distribution ; Resuscitation Orders ; Risk
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.047260
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    Ui IV Zs.60: Show issues Location:
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  10. Article ; Online: Coronary and cerebral thrombosis in a young patient after mild COVID-19 illness: a case report.

    Ranard, Lauren S / Engel, David J / Kirtane, Ajay J / Masoumi, Amirali

    European heart journal. Case reports

    2020  Volume 4, Issue 5, Page(s) 1–5

    Abstract: Background: COVID-19 has spread worldwide and has caused significant morbidity and mortality. Myocardial injury and thrombo-embolism are known complications for those with severe forms of disease. The incidence and risk factors for these complications ... ...

    Abstract Background: COVID-19 has spread worldwide and has caused significant morbidity and mortality. Myocardial injury and thrombo-embolism are known complications for those with severe forms of disease. The incidence and risk factors for these complications for those patients who are asymptomatic or with mild forms of COVID-19 is unknown.
    Case summary: In this report we describe the case of a 35-year-old man with no past cardiac history who presented with chest pain and a high-sensitivity troponin level of 386 ng/L in the context of an unspecified mild viral illness 1 month previously. Diagnostic evaluation revealed a new cardiomyopathy, left ventricular thrombus, and mid right coronary artery thrombosis. The coronary thrombosis was treated with thrombectomy. SARS-CoV-2 antibodies returned positive. He initially did well post-procedure; however, prior to discharge, he developed a second arterial thrombo-embolism event, a middle cerebral artery stroke. He was treated with thrombectomy and remains hospitalized.
    Discussion: Recognition that mild COVID-19 can be complicated by subsequent cardiac injury and/or coagulopathy is important. As more people recover from this viral illness and return to normal activity levels, discussion among cardiac experts has begun regarding screening for occult myocardial injury in those who plan to resume competitive athletic activity. This case highlights the need for investigation regarding (i) the duration of thrombophilia after recovery from illness; (ii) the population that should receive thromboprophylaxis; and (iii) the duration of thromboprophylaxis therapy for COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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