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  1. Article ; Online: Metabolic dysregulation of lymphocytes in autoimmune diseases.

    Wang, Shuyi / Yang, Niansheng / Zhang, Hui

    Trends in endocrinology and metabolism: TEM

    2024  

    Abstract: Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls ... ...

    Abstract Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Bleomycin overdose in a patient with stage II Hodgkin lymphoma: A case report of a medication error.

    Jieting, Zhang / Shuyi, Xue / Xiaolin, Chen / Hai, Yang

    British journal of clinical pharmacology

    2023  

    Abstract: Bleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of ... ...

    Abstract Bleomycin is an antibiotic with cytotoxic properties that is commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency in the dosage nomenclature of bleomycin appears universally, which increases the risk of medication errors. However, to the best of our knowledge, no such cases have been reported. Herein, we present a rare case report of a medication error caused by a bleomycin overdose. At the third cycle of chemotherapy, a 25-year-old patient with stage II Hodgkin lymphoma received a 10 times higher dose of bleomycin (150 USP) than that usually used as part of the doxorubicin, bleomycin, vindesine and dacarbazine protocol (ABVD). After the medication error was discovered, the patient was immediately treated with intravenous rehydration and furosemide to promote drug clearance. Additionally, methylprednisone and acetylcysteine were administered to prevent lung injury. However, the patient developed slight nausea and mild rash, which gradually improved after treatment. After evaluation with positron emission spectrometry-computed tomography (PET-CT), the patient received four cycles of AVD chemotherapy. No other obvious abnormalities were observed during the treatment and 1-year follow-up period. Hence, the toxicities, clinical management and selection of further chemotherapy after bleomycin overdose in such cases deserved serious attention. More importantly, management measures after this error may be used as a reference in other hospitals.
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 93 risk genes for Alzheimer's disease dementia.

    Guo, Shuyi / Yang, Jingjing

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Transcriptome-wide association study (TWAS) is an influential tool for identifying novel genes associated with complex diseases, where their genetic effects may be mediated through transcriptome. TWAS utilizes reference genetic and ... ...

    Abstract Background: Transcriptome-wide association study (TWAS) is an influential tool for identifying novel genes associated with complex diseases, where their genetic effects may be mediated through transcriptome. TWAS utilizes reference genetic and transcriptomic data to estimate genetic effect sizes on expression quantitative traits of target genes (i.e., effect sizes of a broad sense of expression quantitative trait loci, eQTL). These estimated effect sizes are then employed as variant weights in burden gene-based association test statistics, facilitating the mapping of risk genes for complex diseases with genome-wide association study (GWAS) data. However, most existing TWAS of Alzheimer's disease (AD) dementia have primarily focused on
    Methods: We first applied BGW-TWAS to the Genotype-Tissue Expression (GTEx) V8 dataset to estimate
    Results: We identified 37 genes in prefrontal cortex, 55 in cortex, and 51 in whole blood that were significantly associated with AD dementia. By combining BGW-TWAS p-values across these three tissues, we obtained 93 significant risk genes including 29 genes primarily due to
    Conclusion: We applied BGW-TWAS and aggregated Cauchy test methods to integrate both
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.06.23292336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transition-state defect structure: A new strategy for TiO

    Zhang, Jingyang / E, Tao / Zhou, Ruifeng / Li, Na / Wang, Yuanfei / Li, Yun / Yang, Shuyi

    Journal of environmental management

    2024  Volume 356, Page(s) 120599

    Abstract: The aim of this paper is to investigate the derived structure and properties of Zeolitic Imidazolate Framework-8 (ZIF-8), and the effect of residual structural on the catalytic properties after loading with Titanium Dioxide ( ... ...

    Abstract The aim of this paper is to investigate the derived structure and properties of Zeolitic Imidazolate Framework-8 (ZIF-8), and the effect of residual structural on the catalytic properties after loading with Titanium Dioxide (TiO
    MeSH term(s) Photolysis ; Environmental Pollutants ; Porosity ; Wastewater ; Catalysis
    Chemical Substances Environmental Pollutants ; Wastewater
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  5. Article ; Online: Biomacromolecular and Toxicity Responses of Bacteria upon the Nano-Bio Interfacial Interactions with Ti

    Shen, Shuyi / Yang, Kun / Lin, Daohui

    Environmental science & technology

    2023  Volume 57, Issue 35, Page(s) 12991–13003

    Abstract: The biomolecular responses of bacteria to 2D nanosheets that result from nano-bio interfacial interactions remain to be thoroughly examined. Herein, Fourier transform infrared (FTIR) multivariate and 2D correlation analyses were performed to assess the ... ...

    Abstract The biomolecular responses of bacteria to 2D nanosheets that result from nano-bio interfacial interactions remain to be thoroughly examined. Herein, Fourier transform infrared (FTIR) multivariate and 2D correlation analyses were performed to assess the composition and conformational changes in bacterial biomacromolecules (lipids, polysaccharides, and carbohydrates) upon exposure to Ti
    MeSH term(s) Titanium ; Bacterial Proteins ; Antioxidants ; Bacillus subtilis ; Escherichia coli
    Chemical Substances Titanium (D1JT611TNE) ; Bacterial Proteins ; Antioxidants
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c02397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The spatiotemporal variation of PM

    Chen, Chenru / Gao, Bingbo / Xu, Miaoqing / Liu, Shuyi / Zhu, Dehai / Yang, Jianyu / Chen, Ziyue

    The Science of the total environment

    2023  Volume 880, Page(s) 163346

    Abstract: In recent years, ... ...

    Abstract In recent years, PM
    Language English
    Publishing date 2023-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.163346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Alginate-based adsorbents with adjustable slit-shaped pore structure for selective removal of copper ions.

    Li, Suya / Hao, Jie / Yang, Shuyi / Wang, Yuanfei / Li, Yun / E, Tao

    International journal of biological macromolecules

    2024  Volume 267, Issue Pt 2, Page(s) 131484

    Abstract: Adopting effective and efficient techniques for the treatment of heavy metal pollution in water bodies plays an important role in guaranteeing the quality of water and the sustainable development of water resources. In this study, GO, MMT and SA were ... ...

    Abstract Adopting effective and efficient techniques for the treatment of heavy metal pollution in water bodies plays an important role in guaranteeing the quality of water and the sustainable development of water resources. In this study, GO, MMT and SA were used as raw materials to compare the adsorption behaviors of three alginate-based adsorbents crosslinked with different valence metal ions (Ca
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Securing Dynamic Service Function Chain Orchestration in EC-IoT Using Federated Learning.

    Wang, Shuyi / Yang, Longxiang

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 23

    Abstract: Dynamic service orchestration is becoming more and more necessary as IoT and edge computing technologies continue to advance due to the flexibility and diversity of services. With the surge in the number of edge devices and the increase in data volume of ...

    Abstract Dynamic service orchestration is becoming more and more necessary as IoT and edge computing technologies continue to advance due to the flexibility and diversity of services. With the surge in the number of edge devices and the increase in data volume of IoT scenarios, there are higher requirements for the transmission security of privacy information from each edge device and the processing efficiency of SFC orchestration. This paper proposes a kind of dynamic SFC orchestration security algorithm applicable to EC-IoT scenarios based on the federated learning framework, combined with a block coordinated descent approach and the quadratic penalty algorithm to achieve communication efficiency and data privacy protection. A deep reinforcement learning algorithm is used to simultaneously adapt the SFC orchestration method in order to dynamically observe environmental changes and decrease end-to-end delay. The experimental results show that compared with the existing dynamic SFC orchestration algorithms, the proposed algorithm can achieve better convergence and latency performance under the condition of privacy protection; the overall latency is reduced by about 33%, and the overall convergence speed is improved by about 9%, which not only achieves the security of data privacy protection of edge computing nodes, but also meets the requirements of dynamic SFC orchestration.
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22239041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coronavirus-like Core–Shell-Structured Co@C for Hydrogen Evolution via Hydrolysis of Sodium Borohydride

    Shuyi Su / Kailei Chen / Xu Yang / Dai Dang

    Molecules, Vol 28, Iss 1440, p

    2023  Volume 1440

    Abstract: Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by the metal leaching and re-oxidization of metallic cobalt. A unique core– ... ...

    Abstract Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by the metal leaching and re-oxidization of metallic cobalt. A unique core–shell-structured coronavirus-like Co@C microsphere was prepared via pyrolysis of Co-MOF. This special Co@C had a microporous carbon coating to retain the reduced state of cobalt and resist the metal leaching. Furthermore, several nano-bumps grown discretely on the surface afforded enriched active centers. Applied in the pyrolysis of NaBH 4 , the Co@C-650, carbonized at 650 °C, exhibited the best activity and reliable recyclability. This comparable performance is ascribed to the increased metallic active sites and robust stability.
    Keywords cobalt catalysts ; sodium borohydride ; hydrogen evolution ; core–shell ; metal–organic-framework ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Coronavirus-like Core-Shell-Structured Co@C for Hydrogen Evolution via Hydrolysis of Sodium Borohydride.

    Su, Shuyi / Chen, Kailei / Yang, Xu / Dang, Dai

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 3

    Abstract: Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by the metal leaching and re-oxidization of metallic cobalt. A unique core- ... ...

    Abstract Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by the metal leaching and re-oxidization of metallic cobalt. A unique core-shell-structured coronavirus-like Co@C microsphere was prepared via pyrolysis of Co-MOF. This special Co@C had a microporous carbon coating to retain the reduced state of cobalt and resist the metal leaching. Furthermore, several nano-bumps grown discretely on the surface afforded enriched active centers. Applied in the pyrolysis of NaBH
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28031440
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    Zs.MO 81: Show issues

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