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  1. Article ; Online: The role of high dose vitamin d and glutathione supplementation in COVID-19 treatment: A case series.

    Burhan, Erlina / Wijaya, Indra

    Journal of infection in developing countries

    2023  Volume 17, Issue 2, Page(s) 188–193

    Abstract: COVID-19 has been affecting millions of people worldwide and becoming a global public health burden. Therefore, exploring treatment options is essential to help flatten the curve and reduce hospitalization time. This is a case series of ten COVID-19 ... ...

    Abstract COVID-19 has been affecting millions of people worldwide and becoming a global public health burden. Therefore, exploring treatment options is essential to help flatten the curve and reduce hospitalization time. This is a case series of ten COVID-19 patients in Jakarta and Tangerang, Indonesia, who received a high dose of vitamin D and glutathione supplementation daily. Within 5-7 days of treatment, all patients were confirmed COVID-19 negative. To date, this is the first report from Indonesia describing the potential benefit of supplementing vitamin D and glutathione concurrently in improving clinical conditions and expediting the recovery time of COVID-19 patients.
    MeSH term(s) Humans ; Vitamin D ; COVID-19 ; SARS-CoV-2 ; Dietary Supplements ; Vitamins ; Glutathione
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2023-02-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.17109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Omicron surge and the future of COVID-19 vaccinations

    Erlina Burhan / Rizky Abi Rachmadi

    Medical Journal of Indonesia, Vol 31, Iss

    2022  Volume 1

    Abstract: The global surge of Omicron has caused significant concern. Omicron has caused new wave of infections in nations with adequate vaccine coverage. Omicron has around 30 mutations that are similar to the previous variant of concerns, possibly decreasing ... ...

    Abstract The global surge of Omicron has caused significant concern. Omicron has caused new wave of infections in nations with adequate vaccine coverage. Omicron has around 30 mutations that are similar to the previous variant of concerns, possibly decreasing vaccine effectiveness (VE). Hence, the emergence of Omicron is predicted to be a significant public health challenge and may alter the future of COVID-19 vaccinations. Furthermore, other issues may affect vaccine policy in the future such as the never-ending vaccine inequity, waning immunity of current COVID-19 vaccines, decreasing VE against new emerging strains, and new findings regarding hybrid immunity. This literature review aimed to explore the possible steps forward using the most updated knowledge on COVID-19 vaccines and Omicron.
    Keywords COVID-19 vaccine ; Omicron ; SARS-CoV-2 vaccine ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Faculty of Medicine Universitas Indonesia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Characteristics and outcomes of endobronchial tuberculosis therapy.

    Aniwidyaningsih, Wahju / Elhidsi, Mia / Sari, Adistya / Burhan, Erlina

    Lung India : official organ of Indian Chest Society

    2021  Volume 38, Issue 1, Page(s) 101–103

    Language English
    Publishing date 2021-01-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_132_20
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  4. Article ; Online: A systematic review of respiratory infection due to air pollution during natural disasters

    Erlina Burhan / Ummul Mukminin

    Medical Journal of Indonesia, Vol 29, Iss

    2020  Volume 1

    Abstract: BACKGROUND Wildfire and volcano eruption occurred in Indonesia due to its geographical location, climate change, global warming, and human behavior. Various substances produced an increased risk of experiencing health problems, including respiratory ... ...

    Abstract BACKGROUND Wildfire and volcano eruption occurred in Indonesia due to its geographical location, climate change, global warming, and human behavior. Various substances produced an increased risk of experiencing health problems, including respiratory infection. Evidence about the effect of pulmonary infection during natural disasters is still limited. This study was aimed to review and elaborate on previous studies to determine the effect of air pollution exposure during natural disasters and respiratory infection. METHODS Literature searches were conducted on PubMed, EBSCOhost, and Google Scholar, and was limited to the 10 last years, human studies, and the English language. Inclusion criteria were articles with representation for clinical questions, review articles, population studies, and the full-text article was available. Exclusion criteria were articles that only discussed the exposure to and not the association with the effect of the respiratory infection. The Oxford Center for Evidence-Based Medicine tools appraised six relevant articles. RESULTS Air pollution during a natural disaster enhances particulate matter to 10–70 μg/m3 and more than 5 times the aerosol optical depth measurement compared with the tolerated air concentration. The air level was consistently related to acute respiratory infection, pneumonia, bronchitis, and bronchiolitis admissions in wildfire smoke and volcanic eruption in this review. Nevertheless, there was a diverse result for upper respiratory infection cases. CONCLUSIONS Natural disasters increased the level of ambient air pollution that exceeded the levels recommended by the World Health Organization air quality guideline. Air pollution may play an important role in respiratory tract infection, especially among population with high exposure.
    Keywords air pollution ; disasters ; respiratory tract infections ; volcanic eruptions ; wildfires ; Medicine (General) ; R5-920
    Subject code 333
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Faculty of Medicine Universitas Indonesia
    Document type Article ; Online
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  5. Article: The Role of TB-LAMP Method in Detecting Mycobacterium tuberculosis from Sputum of Patients Suspected of Having Pulmonary Tuberculosis.

    Wahid, Mardiastuti H / Sjahrurachman, Agus / Sitorus, Ardath H / Burhan, Erlina

    Acta medica Indonesiana

    2021  Volume 52, Issue 4, Page(s) 352–359

    Abstract: Background: Indonesia is one of the countries with the highest incidence of tuberculosis (TB) in the world. Appropriate diagnosis is an effort to control TB. The World Health Organization has recommended loop-mediated isothermal amplification (LAMP). In ...

    Abstract Background: Indonesia is one of the countries with the highest incidence of tuberculosis (TB) in the world. Appropriate diagnosis is an effort to control TB. The World Health Organization has recommended loop-mediated isothermal amplification (LAMP). In order to be applied routinely, it is necessary to do research to evaluate the LAMP method.
    Methods: the research was a cross-sectional study and was carried out at the Clinical Microbiology Laboratory of the Faculty of Medicine, Universitas Indonesia, for 100 patients suspected of having pulmonary TB. Each patient handed over two direct sputum specimens. For each direct sputum specimen, an acid-fast bacilli (AFB) smear was carried out. Two direct sputum specimens from each patient were combined to produce mixed sputum. For each mixed sputum specimen, an AFB smear, Lowenstein-Jensen culture, and TB-LAMP were carried out.
    Results: the percentage of LAMP (+) cells in mixed sputum that was AFB (-) was 32.78%. The TB-LAMP showed a sensitivity of 100% (95% CI 89.56-100%), a specificity of 69.64% (95% CI 55.74-80.84%), positive predictive value of 71.19% (95% CI 57.73-81.86%), and negative predictive value of 100% (95% CI 88.83-100%).
    Conclusion: TB-LAMP has both high sensitivity and negative predictive value.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Indonesia ; Male ; Microscopy, Fluorescence/methods ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Mycobacterium tuberculosis/genetics ; Nucleic Acid Amplification Techniques/methods ; Sensitivity and Specificity ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnosis
    Language English
    Publishing date 2021-01-23
    Publishing country Indonesia
    Document type Journal Article
    ZDB-ID 2474707-5
    ISSN 2338-2732 ; 0125-9326
    ISSN (online) 2338-2732
    ISSN 0125-9326
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6834: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Factors affecting time to treatment initiation after diagnosis for multidrug-resistant/rifampicin-resistant tuberculosis patients: A mixed-methods study in Jakarta, Indonesia.

    Silitonga, Permata / Jiang, Weixi / Wyatt, Sage / Burhan, Erlina / Kes, Esty Febriani M / Long, Qian

    Tropical medicine & international health : TM & IH

    2022  Volume 28, Issue 1, Page(s) 43–52

    Abstract: Objective: To investigate the time to treatment initiation (TTI) for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) patients after diagnosis in Indonesia and biological, psychological and social factors associated with the time ... ...

    Abstract Objective: To investigate the time to treatment initiation (TTI) for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) patients after diagnosis in Indonesia and biological, psychological and social factors associated with the time interval.
    Methods: This study was conducted in Persahabatan Hospital, Jakarta using a mixed-methods approach. Registry data and medical records of MDR/RR-TB patients were collected and matched (hospital dataset), and linked with psychosocial assessment results (linked dataset). Descriptive analysis was conducted to understand patient characteristics and the distribution of TTI after RR-TB diagnosis by GeneXpert. Generalised linear regression was used to analyse factors associated with delay duration, and logistic regression to explore factors associated with the delay longer than the median duration for both datasets (basic vs. extended model). In-depth interviews were conducted with patients and healthcare workers to understand the procedure of treatment initiation and how different factors led to delay.
    Results: The hospital dataset included 275 patient-matched cases, and 188 were further linked with psychosocial assessment results. The median time interval was 24 days [interquartile range (IQR) 23.5] and 26 days (IQR 21.25), respectively. Regression analysis showed that in the extended model, comorbidities (exp [coefficient]= 1.93), unemployment (exp [coefficient] = 1.80) and poor knowledge of MDR/RR-TB (exp (coefficient) = 1.67) seemed to have the strongest effects on prolonging the time interval (p < 0.05). Unsuccessful TB treatment history was the only factor that significantly increased the risk of delay longer than the median duration (p < 0.05) in the basic model, while none of the factors were significant in the extended model. The qualitative study identified provider-side factors (centralised service provision and insufficient human resources) and patient-side factors (physical weakness, psychological stress and financial concern) associated with treatment delay.
    Conclusion: MDR/RR-TB patients in Persahabatan Hospital, Jakarta, Indonesia waited around 25 days for treatment initiation after RR-TB diagnosis. Health system solutions are needed to address challenges facing both MDR/RR-TB patients and healthcare providers to reduce delay in treatment initiation.
    MeSH term(s) Humans ; Rifampin/therapeutic use ; Rifampin/pharmacology ; Time-to-Treatment ; Indonesia ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/drug therapy ; Outcome Assessment, Health Care ; Mycobacterium tuberculosis ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/pharmacology
    Chemical Substances Rifampin (VJT6J7R4TR) ; Antitubercular Agents
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13838
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4415: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Molecular Diagnosis of Tuberculosis.

    Nurwidya, Fariz / Handayani, Diah / Burhan, Erlina / Yunus, Faisal

    Chonnam medical journal

    2018  Volume 54, Issue 1, Page(s) 1–9

    Abstract: Tuberculosis (TB) is one of the leading causes of adult death in the Asia-Pacific Region, including Indonesia. As an infectious disease caused ... ...

    Abstract Tuberculosis (TB) is one of the leading causes of adult death in the Asia-Pacific Region, including Indonesia. As an infectious disease caused by
    Language English
    Publishing date 2018-01-25
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536217-3
    ISSN 2233-7393 ; 2233-7385 ; 0377-9564
    ISSN (online) 2233-7393
    ISSN 2233-7385 ; 0377-9564
    DOI 10.4068/cmj.2018.54.1.1
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  8. Article: Evaluation of safety and effectiveness of remdesivir in treating COVID-19 patients after emergency use authorization study.

    Burhan, Erlina / Syahruddin, Elisna / Isbaniah, Fathiyah / Desianti, Ginanjar Arum / Fachrucha, Fanny / Sari, Cut Yulia Indah / Ismail, Efriadi / Astuti, Puji / Maruli, Muhammad Farhan / Mubarak, Farhan / Rengganis, Anggit Tresna / Bilqis, Hazia Hanifa / Taslim, Imammurahman / Sastria, Evan / Wiyarta, Elvan

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1205238

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1205238
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  9. Article: Double-Blind, Randomized, Placebo-Controlled Study on hzVSF-v13, a Novel Anti-Vimentin Monoclonal Antibody Drug as Add-on Standard of Care in the Management of Patients with Moderate to Severe COVID-19.

    Prasenohadi, Prasenohadi / Burhan, Erlina / Dhunny, Sri / Suharno, Wahyuningsih / Wabnitz, Paul / Kim, Yoon-Won / Petrosillo, Nicola

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Humanized Virus Suppressing Factor-variant 13 (hzVSF-v13), a monoclonal IgG4 antibody against vimentin, was investigated in moderate to severe COVID-19 pneumonia through a Phase II study. Patients were randomized to two different IV doses of the test ... ...

    Abstract Humanized Virus Suppressing Factor-variant 13 (hzVSF-v13), a monoclonal IgG4 antibody against vimentin, was investigated in moderate to severe COVID-19 pneumonia through a Phase II study. Patients were randomized to two different IV doses of the test drug or saline with standard of care. Overall, 64 patients were recruited, and 62 entered the efficacy assessment in the full analysis set. Primary endpoint: The clinical failure rate at day 28 was 15.8% for placebo, 9.1% for low-dose hzVSF-v13 and 9.5% for high-dose hzVSF-v13 (not significant). A trend toward better efficacy was shown in several secondary endpoints, with statistical significance between low-dose hzVSF-v13 and placebo in terms of the rate of improved patients on the ordinal scale for clinical improvement (OSCI): 90.0% vs. 52.63% (
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11112961
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  10. Article ; Online: The Role of TB-LAMP Method in Detecting Mycobacterium tuberculosis from Sputum of Patients Suspected of Having Pulmonary Tuberculosis

    Mardiastuti H Wahid / Agus Sjahrurachman / Ardath H Sitorus / Erlina Burhan

    Acta Medica Indonesiana, Vol 52, Iss

    2020  Volume 4

    Abstract: Background: Indonesia is one of the countries with the highest incidence of tuberculosis (TB) in the world. Appropriate diagnosis is an effort to control TB. The World Health Organization has recommended loop-mediated isothermal amplification (LAMP). In ... ...

    Abstract Background: Indonesia is one of the countries with the highest incidence of tuberculosis (TB) in the world. Appropriate diagnosis is an effort to control TB. The World Health Organization has recommended loop-mediated isothermal amplification (LAMP). In order to be applied routinely, it is necessary to do research to evaluate the LAMP method. Methods: the research was a cross-sectional study and was carried out at the Clinical Microbiology Laboratory of the Faculty of Medicine, Universitas Indonesia, for 100 patients suspected of having pulmonary TB. Each patient handed over two direct sputum specimens. For each direct sputum specimen, an acid-fast bacilli (AFB) smear was carried out. Two direct sputum specimens from each patient were combined to produce mixed sputum. For each mixed sputum specimen, an AFB smear, Lowenstein-Jensen culture, and TB-LAMP were carried out. Results: the percentage of LAMP (+) cells in mixed sputum that was AFB (-) was 32.78%. The TB-LAMP showed a sensitivity of 100% (95% CI 89.56–100%), a specificity of 69.64% (95% CI 55.74–80.84%), positive predictive value of 71.19% (95% CI 57.73–81.86%), and negative predictive value of 100% (95% CI 88.83–100%). Conclusion: TB-LAMP has both high sensitivity and negative predictive value.
    Keywords sputum ; tb-lamp ; tuberculosis ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Interna Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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