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  1. Article: Relationship of the Difficulty of

    Ozeki, Kayoko / Furuta, Takahisa / Hada, Kazuhiro / Wakiya, Yoshifumi / Ojima, Toshiyuki

    Microorganisms

    2022  Volume 10, Issue 5

    Abstract: Eradication ... ...

    Abstract Eradication of
    Language English
    Publishing date 2022-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10051029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association Between Patients' Immunoglobulin E Levels and Difficulty Eradicating

    Ozeki, Kayoko / Furuta, Takahisa / Ojima, Toshiyuki

    Clinical and experimental gastroenterology

    2021  Volume 14, Page(s) 311–316

    Abstract: Background: Helicobacter pylori: Aim: Because allergy status may be a factor and considering research linking hay fever with eradication failure, the purpose of this study was to examine blood immunoglobulin E levels as a contributing factor in ... ...

    Abstract Background: Helicobacter pylori
    Aim: Because allergy status may be a factor and considering research linking hay fever with eradication failure, the purpose of this study was to examine blood immunoglobulin E levels as a contributing factor in patients who were unable to eradicate
    Methods: Questionnaire data were collected from 250 patients who visited the Department of Gastroenterology, Hamamatsu University School of Medicine, for
    Results: The mean IgE values were 188.4, 211.9, and 744.0 IU/mL in patients with one, two, and three or more eradication attempts, respectively (P < 0.05). The results of multinomial logistic regression analysis showed that attempting eradication three or more times was significantly associated with high levels of IgE, even after consideration of antibiotic sensitivity.
    Conclusion: H. pylori
    Language English
    Publishing date 2021-07-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520690-4
    ISSN 1178-7023
    ISSN 1178-7023
    DOI 10.2147/CEG.S322512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alopecia areata with autoimmune polyglandular syndrome type 3 showing type 1/Tc1 immunological inflammation.

    Hanai, Shiho / Ito, Taisuke / Furuta, Takahisa / Tokura, Yoshiki

    European journal of dermatology : EJD

    2020  Volume 30, Issue 4, Page(s) 425–427

    MeSH term(s) Adult ; Alopecia Areata/complications ; Alopecia Areata/immunology ; Female ; Gastritis, Atrophic/complications ; Gastritis, Atrophic/immunology ; Humans ; Polyendocrinopathies, Autoimmune/complications ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Thyroid Diseases/complications ; Thyroid Diseases/immunology
    Language English
    Publishing date 2020-10-27
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2020.3811
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3484: Show issues Location:
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  4. Article ; Online: Relationship of the Difficulty of Helicobacter pylori Eradication with Drinking Habits and Allergic Disease

    Kayoko Ozeki / Takahisa Furuta / Kazuhiro Hada / Yoshifumi Wakiya / Toshiyuki Ojima

    Microorganisms, Vol 10, Iss 1029, p

    2022  Volume 1029

    Abstract: Eradication of Helicobacter pylori ( H. pylori ) is crucial to reduce the risk of developing gastric ulcers and gastric cancer. Although immunoglobulin E (IgE) levels and alcohol consumption have been shown to influence the failure of H. pylori ... ...

    Abstract Eradication of Helicobacter pylori ( H. pylori ) is crucial to reduce the risk of developing gastric ulcers and gastric cancer. Although immunoglobulin E (IgE) levels and alcohol consumption have been shown to influence the failure of H. pylori eradication, the relationship between these factors and the mechanism of failure has not been clarified. Because high IgE levels are associated with eradication failure, the purpose of this study was to clarify the factors leading to high IgE levels. Completed questionnaires and blood test data were collected from patients who visited a university hospital for H. pylori eradication. Logistic regression analysis was per-formed to examine the relationship between high IgE levels and allergic diseases. We also examined the relationship between alcohol intake and high IgE levels. Linear regression analysis was performed on the relationship between the amount of alcohol consumed and IgE measurements. The results showed that patients with allergic diseases and those with high alcohol intake had significantly higher IgE levels. High IgE levels are a risk factor for failure of H. pylori eradication that is associated with drinking habits and alcohol consumption, and our results suggest that daily alcohol consumption should be avoided even in non-allergic patients.
    Keywords Helicobacter pylori ; eradication ; immunoglobulin E levels ; alcohol ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Response to "CYP-Mediated Drug-Drug Interaction Is Not a Major Determinant of Attenuation of Antiplatelet Function of Clopidogrel by Vonoprazan".

    Kagami, Takuma / Furuta, Takahisa

    Clinical pharmacology and therapeutics

    2018  Volume 104, Issue 1, Page(s) 33–34

    MeSH term(s) Clopidogrel ; Cytochrome P-450 CYP2C19/genetics ; Drug Interactions ; Esomeprazole ; Genotype ; Prasugrel Hydrochloride ; Pyrroles ; Sulfonamides
    Chemical Substances 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Pyrroles ; Sulfonamides ; Clopidogrel (A74586SNO7) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; Prasugrel Hydrochloride (G89JQ59I13) ; Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2018-04-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.1059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 20: Show issues Location:
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  6. Article ; Online: Diagnostic criteria and endoscopic and histological findings of autoimmune gastritis in Japan.

    Kamada, Tomoari / Watanabe, Hidenobu / Furuta, Takahisa / Terao, Shuichi / Maruyama, Yasuhiko / Kawachi, Hiroshi / Kushima, Ryoji / Chiba, Tsutomu / Haruma, Ken

    Journal of gastroenterology

    2023  Volume 58, Issue 3, Page(s) 185–195

    Abstract: The Japanese diagnostic criteria for autoimmune gastritis (AIG) were established by the "Study Group on the establishment of diagnostic criteria for type A gastritis," which is related to a workshop associated with the Japan Gastroenterological Endoscopy ...

    Abstract The Japanese diagnostic criteria for autoimmune gastritis (AIG) were established by the "Study Group on the establishment of diagnostic criteria for type A gastritis," which is related to a workshop associated with the Japan Gastroenterological Endoscopy Society (JGES) and the Committee of AIG Research Group (CARP). The criteria were set as follows: the cases of confirmed diagnosis are patients in whom either the endoscopic or histological findings, or both, meet the requirements for AIG and who are confirmed to be positive for gastric autoantibodies (either anti-parietal cell or anti-intrinsic factor antibodies, or both). The presentation of endoscopic findings of early-stage AIG in the diagnostic criteria was withheld owing to the need for further accumulation and characterization of endoscopic clinical data. Therefore, diagnosis of early-stage AIG only requires histological confirmation and gastric autoantibody positivity. Suspected cases are patients in whom either the endoscopic or histological findings, or both, meet only the requirements for AIG. Histological findings only meet the requirements for early stage. AIG has been underdiagnosed in the past, but our study group's newly proposed diagnostic criteria will enable a more accurate and early diagnosis of AIG. The criteria can be used to stratify patients into various high-risk groups for gastric tumors and pernicious anemia. They would allow the establishment of an appropriate surveillance system in the coming years. Nevertheless, issues such as establishing the endoscopic findings of early-stage AIG and obtaining Japanese insurance coverage for gastric autoantibody tests require attention.
    MeSH term(s) Humans ; Autoimmune Diseases/diagnosis ; Japan ; Gastritis/diagnosis ; Gastritis/pathology ; Autoantibodies ; Endoscopy
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-03-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-022-01954-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 620: Show issues Location:
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  7. Article ; Online: Ustekinumab effectiveness in Crohn's disease with lesions in the intestines.

    Tamura, Satoshi / Asai, Yusuke / Ishida, Natsuki / Miyazu, Takahiro / Tani, Shinya / Yamade, Mihoko / Hamaya, Yasushi / Iwaizumi, Moriya / Osawa, Satoshi / Furuta, Takahisa / Sugimoto, Ken

    Medicine

    2024  Volume 103, Issue 15, Page(s) e35647

    Abstract: Ustekinumab is prescribed for the treatment of patients with steroid-resistant moderate to severe Crohn's disease. We investigated its clinical outcome in patients with small and large intestinal lesions. Patients who were newly administered ustekinumab ... ...

    Abstract Ustekinumab is prescribed for the treatment of patients with steroid-resistant moderate to severe Crohn's disease. We investigated its clinical outcome in patients with small and large intestinal lesions. Patients who were newly administered ustekinumab between March 2014 and December 2020 at Hamamatsu University Hospital were included in the study. The primary endpoint was Crohn's disease activity index score at baseline and weeks 8, 24, and 48 after the initiation of treatment, and secondary endpoints were albumin, hemoglobin, and C-reactive protein at these time points. Ustekinumab treatment retention was examined in both groups; the 2 groups were compared using the Friedman test, Mann-Whitney U test, or Fisher exact test. Overall, Crohn's disease activity index scores improved between baseline and 48 weeks, but the difference was not significant. However, there was a significant improvement between baseline and 48 weeks in patients with lesions in the small intestine only. Overall, patients showed significant improvement in albumin levels between baseline and 48 weeks but not in C-reactive protein or hemoglobin levels. When limited to patients with lesions in the small intestine, albumin and hemoglobin levels showed significant improvement. Both types showed high rates of treatment retention, although there was no significant difference. Ustekinumab appears to be a safe and effective treatment option that may be particularly effective in patients with lesions in the small intestine only.
    MeSH term(s) Humans ; Crohn Disease/drug therapy ; Ustekinumab/therapeutic use ; C-Reactive Protein ; Intestines ; Albumins ; Hemoglobins
    Chemical Substances Ustekinumab (FU77B4U5Z0) ; C-Reactive Protein (9007-41-4) ; Albumins ; Hemoglobins
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000035647
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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Expectations for the Dual Therapy with Vonoprazan and Amoxicillin for the Eradication of

    Furuta, Takahisa / Yamade, Mihoko / Higuchi, Tomohiro / Takahashi, Satoru / Ishida, Natsuki / Tani, Shinya / Tamura, Satoshi / Iwaizumi, Moriya / Hamaya, Yasushi / Osawa, Satoshi / Sugimoto, Ken

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: Vonoprazan (VPZ) inhibits gastric acid secretion more potently than proton pump inhibitors. Recently, attention has been focused on the dual therapy with VPZ and amoxicillin (AMOX) for the eradication ... ...

    Abstract Vonoprazan (VPZ) inhibits gastric acid secretion more potently than proton pump inhibitors. Recently, attention has been focused on the dual therapy with VPZ and amoxicillin (AMOX) for the eradication of
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093110
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  9. Article: Rapid Sintering of Li₂O-Nb₂O₅-TiO₂ Solid Solution by Air Pressure Control and Clarification of Its Mechanism.

    Nakano, Hiromi / Kamimoto, Konatsu / Yamamoto, Takahisa / Furuta, Yoshio

    Materials (Basel, Switzerland)

    2018  Volume 11, Issue 6

    Abstract: We first successfully synthesized ... ...

    Abstract We first successfully synthesized Li
    Language English
    Publishing date 2018-06-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma11060987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Relationship between primary eradication of

    Ozeki, Kayoko / Asano, Michio / Furuta, Takahisa / Ojima, Toshiyuki

    Epidemiology and infection

    2019  Volume 147, Page(s) e292

    Abstract: Helicobacter pylori is a cause of stomach cancer and peptic ulcer. For prevention, improving the eradication rate of H. pylori is crucial. However, the association between eradication and lifestyle of infected patients, including alcohol consumption, ... ...

    Abstract Helicobacter pylori is a cause of stomach cancer and peptic ulcer. For prevention, improving the eradication rate of H. pylori is crucial. However, the association between eradication and lifestyle of infected patients, including alcohol consumption, remains unclear. We explored associations between failed primary eradication therapy and drinking status by sex. This study involved 356 patients who visited a pharmacy with prescriptions for primary H. pylori eradication therapy. We assessed drinking habits using a questionnaire. Data on patients with failed primary eradication were provided by the nearby local clinic. We performed logistic regression analysis to examine the effect of drinking habit and frequency of drinking on failed primary eradication by sex. The odds ratio of primary eradication failure in female patients with a drinking habit was 3.75 (P = 0.001), but that in male patients was not significant. The odds ratio tended to increase in relation to drinking frequency in women. Frequent consumption of alcohol is not only likely to affect eradication, but also has a large impact on the bodies of women, who are more susceptible than men to the effects of alcohol. Thus, women should take greater care in alcohol consumption.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/physiopathology ; Alcohol Drinking/psychology ; Anti-Bacterial Agents/therapeutic use ; Female ; Helicobacter Infections/drug therapy ; Helicobacter Infections/psychology ; Helicobacter pylori ; Humans ; Logistic Models ; Male ; Middle Aged ; Sex Factors ; Surveys and Questionnaires ; Treatment Failure
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-10-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268819001730
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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.271: Show issues Location:
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