LIVIVO - Search results -

Search results

Result 1 - 10 of total 1893

Search options

Article: [Genetic Analysis of Thalassemia in 22 940 Pregnant Women in Xiangxi Tujia and Miao Autonomous Prefecture].

Yu, Hui / Yang, Qing-Xiang / Liu, Chun / Peng, La-Ying / Zhou, Xiao-Bo / Shao, Lu / Huang, Nan

2022 Volume 30, Issue 1, Page(s) 206–210

Abstract: Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao ... ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were ...

Abstract	Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao Autonomous Prefecture. Methods: Automatic capillary electrophoresis was used to screen the thalassemia phenotypes of 22 940 blood samples of pregnant women and puerperants collected in our hospital and some other medical institutions in the prefecture during 2017-2019, among which there were 3 356 cases of Tujia ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were indicated. The samples with positive result would undergo further genetic testing. Results: There were 2 314 cases of suspicious thalassemia were screened from 22 940 cases by the electrophoresis, thus the positive rate was 10.1% (hematological phenotypes from some other institutions were not included). Specifically, there were 1 706 cases with HBA Conclusion: The positive rate of thalassemia screening in Xiangxi Autonomous Prefecture is roughly the same as that in other regions of Hunan. The positive predictive value of β-thalassemia screening is as high as 86%. Compared with the missed screening data, it is recommended to use hematology (MCV, MCH) method combined with capillary hemoglobin electrophoresis for thalassemia screening.
MeSH term(s)	Ethnicity ; Female ; Genetic Testing ; Hemoglobin A2/analysis ; Humans ; Pregnancy ; Pregnant Women ; alpha-Thalassemia/genetics ; beta-Thalassemia/genetics
Chemical Substances	Hemoglobin A2 (9034-53-1)
Language	Chinese
Publishing date	2022-02-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2022.01.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Book: T'u mien tseng wen chi tsai shu mu yū miao shang ti ying yung

Shao, Chen-sheng

1989

Title translation	Application of soil heating chemicals on tree seedlings.
Author's details	Shao Chen-sheng chu
Keywords	Plant-soil relationships. ; Soil heating.
Language	Chinese
Size	31 p. :, ill. ;, 19 cm.
Edition	Ti 1 pan.
Publisher	Tung pei lin yeh ta hsuüeh ch'u pan she
Publishing place	Ha-erh-pin shih
Document type	Book
ISBN	7810080482 ; 9787810080484
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Chung shu miao

Shao, Chün

(Kung nung sheng ch'an chi shu pien lan)

1950

Title translation	Growing saplings.
Author's details	Shao Chün chu. --
Series title	Kung nung sheng ch'an chi shu pien lan
Keywords	Trees/Seedlings. ; Seedlings.
Language	Chinese
Size	16 p. ;, 17 cm. --
Edition	Ch'u pan. --
Publisher	Chung hua shu chü
Publishing place	Shang-hai
Document type	Book
Note	Cover title.
Database	NAL-Catalogue (AGRICOLA)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: Yang shu miao

Shao, Chün

(Kung nung sheng ch'an ch'i shu pien lan)

1950

Title translation	Growing saplings.
Author's details	Shao Chün pien chu. --
Series title	Kung nung sheng ch'an ch'i shu pien lan
Keywords	Trees/Seedlings. ; Tree farms.
Language	Chinese
Size	56 p. :, ill. ;, 17 cm. --
Edition	Ch'u pan. --
Publisher	Chung-hua shu chü
Publishing place	Shang-hai
Document type	Book
Note	Cover title.
Database	NAL-Catalogue (AGRICOLA)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer.

Yan, Jianing / Yu, Xuan / Li, Qier / Miao, Min / Shao, Yongfu

BMC genomics

2024 Volume 25, Issue 1, Page(s) 319

Abstract: Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide. Nevertheless, GC still lacks effective diagnosed and monitoring method and treating targets. This study used multi omics data to explore novel biomarkers and immune ... ...

Abstract	Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide. Nevertheless, GC still lacks effective diagnosed and monitoring method and treating targets. This study used multi omics data to explore novel biomarkers and immune therapy targets around sphingolipids metabolism genes (SMGs). Method: LASSO regression analysis was performed to filter prognostic and differently expression SMGs among TCGA and GTEx data. Risk score model and Kaplan-Meier were built to validate the prognostic SMG signature and prognostic nomogram was further constructed. The biological functions of SMG signature were annotated via multi omics. The heterogeneity landscape of immune microenvironment in GC was explored. qRT-PCR was performed to validate the expression level of SMG signature. Competing endogenous RNA regulatory network was established to explore the molecular regulatory mechanisms. Result: 3-SMGs prognostic signature (GLA, LAMC1, TRAF2) and related nomogram were constructed combing several clinical characterizes. The expression difference and diagnostic value were validated by PCR data. Multi omics data reveals 3-SMG signature affects cell cycle and death via several signaling pathways to regulate GC progression. Overexpression of 3-SMG signature influenced various immune cell infiltration in GC microenvironment. RBP-SMGs-miRNA-mRNAs/lncRNAs regulatory network was built to annotate regulatory system. Conclusion: Upregulated 3-SMGs signature are excellent predictive diagnosed and prognostic biomarkers, providing a new perspective for future GC immunotherapy.
MeSH term(s)	Humans ; Stomach Neoplasms/genetics ; Prognosis ; Machine Learning ; Biomarkers ; Sphingolipids ; Tumor Microenvironment/genetics
Chemical Substances	Biomarkers ; Sphingolipids
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-024-10243-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs.

Shao, Shengwen / Miao, Huilai / Ma, Wenxue

Frontiers in immunology

2023 Volume 14, Page(s) 1295684

Abstract: Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their ... ...

Abstract	Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While substantial research has explored the fundamentals of TAMs, comprehending their adaptive behavior, and leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, and the complex orchestration of cytokines and chemokines determining their functions. We highlight the complexities of TAM-targeted research focusing on their adaptability and potential variability in therapeutic outcomes. Moreover, we discuss the synergy of integrating TAM-focused strategies with established cancer treatments, such as chemotherapy, and immunotherapy. Emphasis is laid on pioneering methods like TAM reprogramming for cancer immunotherapy and the adoption of single-cell technologies for precision intervention. This synthesis seeks to shed light on TAMs' multifaceted roles in cancer, pinpointing prospective pathways for transformative research and enhancing therapeutic modalities in oncology.
MeSH term(s)	Humans ; Tumor-Associated Macrophages/pathology ; Prospective Studies ; Macrophages/metabolism ; Neoplasms/metabolism ; Immunotherapy ; Tumor Microenvironment
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1295684
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Fangchinoline, an Extract of the

Shao, Yanxiong / Li, Chaoran / Miao, Guojun / Xu, Yubo

Current molecular pharmacology

2023 Volume 17, Issue 1, Page(s) e100223213590

Abstract: Background: Fangchinoline (Fan) is extracted from traditional Chinese medicine (called Fangji), or the root of Stephania tetrandra Moore. Fangji is well-known in Chinese medical literature for treating rheumatic diseases. Sjogren's syndrome (SS) is a ... ...

Abstract	Background: Fangchinoline (Fan) is extracted from traditional Chinese medicine (called Fangji), or the root of Stephania tetrandra Moore. Fangji is well-known in Chinese medical literature for treating rheumatic diseases. Sjogren's syndrome (SS) is a rheumatic disease whose progression can be mediated via CD4+ T cell infiltration. Objective: This study identifies the potential role of Fan in inducing apoptosis in Jurkat T cells. Methods: First, we explored the biological process (BP) associated with SS development by performing a gene ontology analysis of SS salivary gland-related mRNA microarray data. The effect of Fan on Jurkat cells was investigated by analyzing the viability, proliferation, apoptosis, reactive oxygen species (ROS) production, and DNA damage. Results: Biological process analysis showed that T cells played a role in salivary gland lesions in patients with SS, indicating the significance of T cell inhibition in SS treatment. Viability assays revealed that the half-maximal inhibitory concentration of Fan was 2.49 μM in Jurkat T cells, while the proliferation assay revealed that Fan had an inhibitory effect on the proliferation of Jurkat T cells. The results of the apoptotic, ROS, agarose gel electrophoresis, and immunofluorescence assays showed that Fan induced oxidative stress-induced apoptosis and DNA damage in a dosedependent manner. Conclusion: These results indicate that Fan could significantly induce oxidative stress-induced apoptosis and DNA damage and inhibit the proliferation of Jurkat T cells. Moreover, Fan further enhanced the inhibitory effect on DNA damage and apoptosis by inhibiting the pro-survival Akt signal.
MeSH term(s)	Humans ; Jurkat Cells ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-akt ; Stephania tetrandra ; Oxidative Stress ; Apoptosis ; DNA Damage
Chemical Substances	fangchinoline (953592C3ZB) ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-02-20
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1874-4702
ISSN (online)	1874-4702
DOI	10.2174/1874467216666230210152454
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Porous polymer magnetic adsorbents for dye wastewater treatment.

Xue, Tao / Shao, Feifei / Miao, Han / Li, Xinxin

Environmental science and pollution research international

2023 Volume 30, Issue 43, Page(s) 97147–97159

Abstract: Dye wastewater discharged from industries has caused serious environmental problems. The recent decade has witnessed adsorption technology emerging as an advanced dye wastewater treatment method with great potential Therefore, we fabricated two kinds of ... ...

Abstract	Dye wastewater discharged from industries has caused serious environmental problems. The recent decade has witnessed adsorption technology emerging as an advanced dye wastewater treatment method with great potential Therefore, we fabricated two kinds of magnetic porous adsorbents (HSF and HSVF) with different specific surface areas and activity sites. Both of which exhibit excellent performance with remarkable dye adsorption capacities, especially HSVF. We further investigated their adsorption kinetic and isotherm in detail. Therein, HSVF showed a nice desorption capacity, and it could be recycled rapidly by magnetism, which exhibited the advantages of effective, easy operation, and low cost. In addition, their adsorption kinetic and isotherm were further studied and compared in detail. The results revealed that introducing strong active sites could improve both the adsorption capacity and rate effectively even though sacrificing part of specific surface areas, indicating that active sites might play a dominant role during the dye adsorption process.
MeSH term(s)	Polymers ; Porosity ; Wastewater ; Adsorption ; Magnetic Phenomena ; Water Purification/methods ; Water Pollutants, Chemical/analysis ; Kinetics
Chemical Substances	Polymers ; Wastewater ; Water Pollutants, Chemical
Language	English
Publishing date	2023-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29102-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials.

Shao, Y / Miao, J / Wang, Y

International journal of oral and maxillofacial surgery

2023 Volume 53, Issue 3, Page(s) 239–250

Abstract: The objective was to evaluate the efficacy of curcumin in improving mouth opening (MO), burning sensation (BS), and tongue protrusion (TP) symptoms in patients with oral submucous fibrosis (OSF). An electronic search up to November 2022 was conducted in ... ...

Abstract	The objective was to evaluate the efficacy of curcumin in improving mouth opening (MO), burning sensation (BS), and tongue protrusion (TP) symptoms in patients with oral submucous fibrosis (OSF). An electronic search up to November 2022 was conducted in the PubMed, Web of Science, Embase, EBSCO, ProQuest, and Cochrane Library databases to identify studies using curcumin in the treatment of OSF with comparison to control groups (drugs previously proven to be effective for OSF treatment) or placebo. Only randomized controlled trials (RCTs) were considered. RevMan 5.3 software was used for the meta-analysis. Thirteen RCTs met the eligibility criteria and were included in the analysis. The results showed no significant improvement in MO (in millimetres) for curcumin when compared to control at 1 month (P = 0.91), 2 months (P = 0.54), 3 months (P = 0.56), or 6 months (P = 0.17) of treatment. There was no significant difference in BS (assessed using a visual analogue scale) between curcumin and control after 1 month (P = 0.05), 2 months (P = 0.64), 3 months (P = 0.13), or 6 months (P = 0.56) of treatment. Compared with the control groups, treatment with curcumin for 1 month (P = 0.32), 2 months (P = 0.07), and 3 months (P = 0.14) did not significantly improve the TP (in millimetres) of patients. The administration of curcumin, whether topically applied or taken orally, did not confer statistically significant improvements in MO, BS, or TP in comparison to the control treatments, among patients with OSF. The results of this meta-analysis showed that compared to placebo, the application of curcumin for 6 months markedly alleviated BS (P < 0.001). Curcumin treatment in OSF reaches a clinically effective range, but more bioavailability-centred outcomes should be reported. Robust multicentre RCTs are warranted to elucidate the efficacy of curcumin in improving specific outcomes like MO, BS, and TP in patients with this condition. Defining the therapeutic role of this natural compound may provide an effective botanical alternative for managing OSF.
MeSH term(s)	Humans ; Oral Submucous Fibrosis/drug therapy ; Curcumin/therapeutic use ; Randomized Controlled Trials as Topic ; Tongue Diseases
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-12-05
Publishing country	Denmark
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2023.11.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 401: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Undescribed cytotoxic bisabosqual-type meroterpenoids from an endophytic Stachybotryaceae sp. associated with Delphinium yunnanense.

Li, Hongtao / Li, Changyan / Miao, Cuiping / Shao, Yating / Huang, Wenyu / He, Bo / Li, Wei

Phytochemistry

2024 Volume 220, Page(s) 114037

Abstract: Five undescribed bisabosqual-type meroterpenoids, bisabosquals E (1) and F (2), stachybisbins J-L (4-6), together with two known ones, were isolated from a novel endophytic fungus KMU22001 within the Stachybotryaceae family. Their structures with ... ...

Abstract	Five undescribed bisabosqual-type meroterpenoids, bisabosquals E (1) and F (2), stachybisbins J-L (4-6), together with two known ones, were isolated from a novel endophytic fungus KMU22001 within the Stachybotryaceae family. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, single-crystal X-ray diffraction and electronic circular dichroism calculations. Compounds 2, 4 and 6 exhibited significant cytotoxicities against five human cancer cell lines with IC
MeSH term(s)	Humans ; Molecular Structure ; Delphinium ; Antineoplastic Agents/pharmacology ; Crystallography, X-Ray ; Circular Dichroism
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2024.114037
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 1586: Show issues
Z 8.5: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED