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  1. Article ; Online: Mother and neonate suffering from COVID-19 infection. Is there any risk of vertical transmission? A case report.

    Urban, Agnieszka / Dyrda, Michal

    Ginekologia polska

    2021  Volume 92, Issue 10, Page(s) 701–703

    Abstract: Objectives: This study was carried out to visualize possible infection of the fetus during pregnancy through vertical transmission.: Material and methods: A descriptive observational study was conducted on a 39th week pregnant woman who was suspected ...

    Abstract Objectives: This study was carried out to visualize possible infection of the fetus during pregnancy through vertical transmission.
    Material and methods: A descriptive observational study was conducted on a 39th week pregnant woman who was suspected COVID-19. Pregnancy was ended with a caesarean section due to epidemiological reasons. The mother and newborn were examined for COVID-19 infection using PCR swabs.
    Results: At first there were discrepancies between SARS-CoV-2 test results from the nasopharyngeal swabs of the mother and the neonate. The mother tested positive, whereas the newborn tested negative. However, neonate's control swab was repeated within the following 48 hours and revealed a positive test result.
    Conclusions: The risk of vertical transmission with SARS-CoV2 is possible, therefore it is very important to isolate pregnant women from infected people to protect mothers and newborns.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/transmission ; Cesarean Section ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Mothers ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis
    Language English
    Publishing date 2021-09-20
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 130894-4
    ISSN 2543-6767 ; 0017-0011
    ISSN (online) 2543-6767
    ISSN 0017-0011
    DOI 10.5603/GP.a2021.0033
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    Zs.B 118: Show issues Location:
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  2. Article: Ca

    Campiglio, Marta / Dyrda, Agnieszka / Tuinte, Wietske E / Török, Enikő

    Handbook of experimental pharmacology

    2023  Volume 279, Page(s) 3–39

    Abstract: In skeletal muscle, excitation-contraction (EC) coupling relies on the mechanical coupling between two ion channels: the L-type voltage-gated calcium channel ( ... ...

    Abstract In skeletal muscle, excitation-contraction (EC) coupling relies on the mechanical coupling between two ion channels: the L-type voltage-gated calcium channel (Ca
    MeSH term(s) Humans ; Ryanodine Receptor Calcium Release Channel/genetics ; Ryanodine Receptor Calcium Release Channel/metabolism ; Muscle Fibers, Skeletal/metabolism ; Channelopathies/genetics ; Adaptor Proteins, Signal Transducing ; Excitation Contraction Coupling/physiology ; Muscle, Skeletal/physiology ; Muscular Diseases/genetics ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Calcium/metabolism ; Calcium Signaling
    Chemical Substances Ryanodine Receptor Calcium Release Channel ; Adaptor Proteins, Signal Transducing ; Calcium Channels, L-Type ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-01-02
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2022_627
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  3. Article ; Online: Annexin A3: a newly identified player in store‑operated calcium entry.

    Dyrda, Agnieszka / Kuznicki, Jacek / Majewski, Lukasz

    Acta neurobiologiae experimentalis

    2022  Volume 81, Issue 4, Page(s) 307–313

    Abstract: Store‑operated calcium entry (SOCE) is important for refilling endoplasmic reticulum (ER) Ca2+ stores and Ca2+ signaling. Extracellular Ca2+ is conducted by highly Ca2+‑selective Orai channels that are activated by stromal interaction molecule proteins ( ... ...

    Abstract Store‑operated calcium entry (SOCE) is important for refilling endoplasmic reticulum (ER) Ca2+ stores and Ca2+ signaling. Extracellular Ca2+ is conducted by highly Ca2+‑selective Orai channels that are activated by stromal interaction molecule proteins (STIMs), which are sensitive ER Ca2+ sensors. We found an approximately five‑fold increase in annexin A3a (anxa3a) expression levels in stim2b knockout zebrafish. The present study investigated whether annexin A3 protein is involved in SOCE. We used Ca2+ imaging and electrophysiological recordings to determine the effect of annexin A2, A3, and A6 overexpression on SOCE and Orai-dependent Ca2+ currents (ICRAC) in cultured cells. Annexin A3 increased SOCE amplitude and potentiated Ca2+ ICRAC currents. These results suggest that annexin A3 is a positive modulator of SOCE.
    MeSH term(s) Animals ; Annexin A3/metabolism ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium Signaling ; ORAI1 Protein ; Stromal Interaction Molecule 1/genetics ; Zebrafish/metabolism
    Chemical Substances Calcium Channels ; ORAI1 Protein ; Stromal Interaction Molecule 1 ; Annexin A3 (EC 3.1.4.43) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-01-11
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 184409-x
    ISSN 1689-0035 ; 0065-1400
    ISSN (online) 1689-0035
    ISSN 0065-1400
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    Zs.B 479: Show issues Location:
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  4. Article ; Online: Endoscope-Assisted Carlevale Lens Implantation in Patients Without Capsular Support: A Novel Surgical Approach to Ensure Correct Lens Positioning.

    Dyrda, Agnieszka / Pighin, Maria S / Jürgens, Ignasi

    Retina (Philadelphia, Pa.)

    2022  Volume 43, Issue 12, Page(s) 2084–2088

    Abstract: Purpose: To describe endoscope-assisted Carlevale intraocular lens (IOL) implantation.: Methods: Twelve eyes underwent posterior vitrectomy combined with Carlevale IOL implantation and endoscopy in a single procedure, using a technique developed by ... ...

    Abstract Purpose: To describe endoscope-assisted Carlevale intraocular lens (IOL) implantation.
    Methods: Twelve eyes underwent posterior vitrectomy combined with Carlevale IOL implantation and endoscopy in a single procedure, using a technique developed by the authors. Transscleral incisions were performed under direct visualization of the sulcus using the endoscope, and the final lens position was checked at the end of each intervention. The main outcome was to determine the exact position of all lens fixation points.
    Results: All plugs were correctly placed in the sulcus, but in seven eyes (58.3%), at least one of the closed-loop haptics was folded over the ciliary body. Repositioning was performed during the same procedure. Given that each IOL has four closed-loop haptics, the incidence of this complication was 23% (11/48).
    Conclusion: Blind implantation of Carlevale IOL may cause a high incidence of haptic malpositioning. Because the sulcus and the ciliary body are not visible under the microscope, endoscopy is the only way to ensure correct lens implantation. This new technique ensures that all lens fixation points are correctly placed by the end of surgery, avoiding complications such as decentration or tilting of the IOL, damage to the iris or the ciliary body, and uveitis.
    MeSH term(s) Humans ; Lens Implantation, Intraocular/methods ; Lenses, Intraocular ; Lenses ; Lens, Crystalline ; Endoscopes ; Suture Techniques
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003496
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    Zs.A 1724: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Comment on: In vivo evaluation of a 1-piece foldable sutureless intrascleral fixation lens using ultrasound biomicroscopy and anterior segment optical coherence tomography.

    Dyrda, Agnieszka / Pighin, Maria S / Rey, Amanda / Jürgens, Ignasi

    Journal of cataract and refractive surgery

    2021  Volume 47, Issue 2, Page(s) 284–285

    MeSH term(s) Cataract ; Humans ; Lens Implantation, Intraocular ; Microscopy, Acoustic ; Silicone Oils ; Tomography, Optical Coherence
    Chemical Substances Silicone Oils
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632744-8
    ISSN 1873-4502 ; 0886-3350
    ISSN (online) 1873-4502
    ISSN 0886-3350
    DOI 10.1097/j.jcrs.0000000000000570
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    Zs.A 1806: Show issues Location:
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  6. Article ; Online: STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry.

    Dyrda, Agnieszka / Koenig, Stéphane / Frieden, Maud

    Cell calcium

    2019  Volume 86, Page(s) 102134

    Abstract: During myogenesis, a long splice variant of STIM1, called STIM1L is getting expressed, while the level of STIM1 remains constant. Previous work demonstrated that STIM1L is more efficient in eliciting store-operated ... ...

    Abstract During myogenesis, a long splice variant of STIM1, called STIM1L is getting expressed, while the level of STIM1 remains constant. Previous work demonstrated that STIM1L is more efficient in eliciting store-operated Ca
    MeSH term(s) Alternative Splicing/genetics ; Calcium/metabolism ; Calcium Signaling ; Egtazic Acid/analogs & derivatives ; Egtazic Acid/metabolism ; HEK293 Cells ; Humans ; Ion Channel Gating ; Neoplasm Proteins/metabolism ; Protein Binding ; Stromal Interaction Molecule 1/metabolism ; TRPC Cation Channels/metabolism
    Chemical Substances Neoplasm Proteins ; STIM1 protein, human ; Stromal Interaction Molecule 1 ; TRPC Cation Channels ; transient receptor potential cation channel, subfamily C, member 1 ; Egtazic Acid (526U7A2651) ; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (K22DDW77C0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-12-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.102134
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    Zs.A 1596: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Swept source optical coherence tomography angiography in patients treated with hydroxychloroquine: correlation with morphological and functional tests.

    Forte, Raimondo / Haulani, Hanan / Dyrda, Agnieszka / Jürgens, Ignasi

    The British journal of ophthalmology

    2019  Volume 105, Issue 9, Page(s) 1297–1301

    Abstract: Purpose: To evaluate swept source optical coherence tomography angiography (SS-OCTA) in patients treated with hydroxychloroquine (HCQ) for more than 5 years and to compare results with the tests currently recommended for screening of HCQ retinopathy.: ...

    Abstract Purpose: To evaluate swept source optical coherence tomography angiography (SS-OCTA) in patients treated with hydroxychloroquine (HCQ) for more than 5 years and to compare results with the tests currently recommended for screening of HCQ retinopathy.
    Methods: In this controlled pilot study, consecutive patients treated with HCQ for more than 5 years underwent SS-OCTA, SS-OCT B-scan and en-face C-scan, fundus autofluorescence (FAF), 10-2 automated visual field (AVF) testing and multifocal electroretinography (mfERG). On SS-OCTA, evaluation of the retinal superficial capillary plexus, middle capillary plexus, and deep capillary plexus (DCP) and the choriocapillaris (CC) was obtained.
    Results: We included 10 patients under HCQ treatment (20 eyes, mean age 38.91±11.73 years) and 18 healthy control patients (36 eyes, mean age 38.87±8.6 years). Mean duration of HCQ treatment was 10.0±3.25 (5-15) years and HCQ cumulative dose/body weight was 15.86±5.56 g/kg. The HCQ group showed a reduction of the vessel density in the 1 mm central, in the nasal and temporal subfields of DCP and in the 1 mm central subfield of CC, an increased foveal avascular zone in the three capillary plexuses, a greater frequency of CC flow voids and a reduced foveal choroidal thickness (p<0.05). Best-corrected visual acuity (BCVA), mfERG, SS-OCT B-scan and C-scan, AVF and FAF were normal in 20/20 eyes (100%).
    Conclusions: In patients treated with HCQ for more than 5 years, choroidal thinning and flow abnormalities at SS-OCTA in the retinal capillary plexuses and CC may be observed even if BCVA, FAF, mfERG, AVF and SS-OCT are normal.
    MeSH term(s) Adult ; Antirheumatic Agents ; Cross-Sectional Studies ; Electroretinography/methods ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Forecasting ; Humans ; Hydroxychloroquine/therapeutic use ; Macula Lutea/blood supply ; Macula Lutea/pathology ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Retinal Diseases/diagnosis ; Retinal Diseases/drug therapy ; Retinal Diseases/physiopathology ; Retinal Vessels/pathology ; Retinal Vessels/physiopathology ; Tomography, Optical Coherence/methods ; Treatment Outcome ; Visual Acuity ; Young Adult
    Chemical Substances Antirheumatic Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2019-03-06
    Publishing country England
    Document type Comparative Study ; Controlled Clinical Trial ; Journal Article
    ZDB-ID 80078-8
    ISSN 1468-2079 ; 0007-1161
    ISSN (online) 1468-2079
    ISSN 0007-1161
    DOI 10.1136/bjophthalmol-2018-313679
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    Ul I Zs.83: Show issues Location:
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  8. Article ; Online: Reply.

    Pazos, Marta / Dyrda, Agnieszka / Biarnés, Marc / Antón, Alfonso

    Ophthalmology

    2017  Volume 125, Issue 3, Page(s) e21–e22

    Language English
    Publishing date 2017-12-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2017.10.018
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    Ul II Zs.83: Show issues Location:
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    Zs.MO 533: Show issues

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  9. Article: Surgical Management for Refractory Bleb Dysesthesia.

    Dyrda, Agnieszka / Anton, Alfonso / Figueroa-Vercellino, Juan Pablo / Pazos, Marta

    Journal of ophthalmology

    2020  Volume 2020, Page(s) 7570454

    Abstract: Purpose: To present long-term results of modified bleb-limiting conjunctivoplasty as a successful treatment for intractable bleb dysesthesia and to review the literature on the surgical management of dysesthetic bleb.: Methods: Consecutive case ... ...

    Abstract Purpose: To present long-term results of modified bleb-limiting conjunctivoplasty as a successful treatment for intractable bleb dysesthesia and to review the literature on the surgical management of dysesthetic bleb.
    Methods: Consecutive case series and literature review. We present four cases of surgically reduced painful blebs. Our technique consisted of the following steps: (1) conjunctival, radial incision to the bare sclera in the desired limit of the bleb; (2) suturing with buried, interrupted sutures at the nearest edge of the filtering bleb; (3) lower limbal peritomy including unwanted area of the extended bleb; (4) dissection and removal of the underlying fibrous tissue when present; (5) conjunctival and resorbable sutures. In addition, a systematic literature review was performed. Only reports presenting outcomes of surgical treatment of bleb dysesthesia after filtering procedure were included in review.
    Results: Four eyes were included consecutively in the study in a period of 4 years. On average, they developed circumferential bleb dysesthesia 9.3 ± 4.7 months after uneventful combined phacotrabeculectomy with Mitomycin C as primary procedure. Surgical reduction was decided after failure of lubricants in controlling ocular discomfort. Two cases showed a dense fibrous tissue beneath the conjunctiva that was excised to ensure filtration. In all cases, a rapid disappearance of symptoms with very good aesthetic and functional outcome was observed. After 12-month follow-up, patients remained asymptomatic and maintained intraocular pressure of 10.7 ± 1.2 mmHg without treatment. A systematic review of the literature obtained 15 eligible case series (
    Conclusion: Bleb dysesthesia is a rare complication of filtering glaucoma surgery. This modified bleb-limiting conjunctivoplasty technique (with removal of subjacent fibrous tissue if present) is able to target the underlying etiology providing ocular discomfort relief while maintaining bleb function and may be considered as first-choice surgical treatment.
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2020/7570454
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  10. Article ; Online: Bleb revision for resolution of hypotony maculopathy following primary trabeculectomy.

    Pazos, Marta / Dyrda, Agnieszka / Antón, Alfonso

    American journal of ophthalmology

    2015  Volume 159, Issue 2, Page(s) 410

    MeSH term(s) Forecasting ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; Ocular Hypotension/surgery ; Retinal Diseases/surgery ; Trabeculectomy/adverse effects
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2014.11.015
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