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  1. Article ; Online: Need Assessment Of Teaching Qualitative Research In Undergraduate Medical Education: A Mixed Method Study.

    Adeeb, Humera / Qamar Naqvi, Syeda Saima / Ullah, Ihsan

    Journal of Ayub Medical College, Abbottabad : JAMC

    2024  Volume 35, Issue 4, Page(s) 570–573

    Abstract: Background: Accreditation bodies of medical education globally value competency in research that facilitates evidence-based practice of medicine. Physician-scientists need awareness of qualitative research methods for in-depth exploration of ... ...

    Abstract Background: Accreditation bodies of medical education globally value competency in research that facilitates evidence-based practice of medicine. Physician-scientists need awareness of qualitative research methods for in-depth exploration of sociocultural, gender, behavioural, emotional, and religious factors affecting health that cannot be gauged by quantitative research methods. The introduction of qualitative research at the undergraduate level can enhance understanding of local populations' unique health needs and strengthen evidence-based practice.
    Methods: This was a mixed-method study conducted from July to October 2021. Four journals with dedicated student's corner/student journals were hand-searched for qualitative research articles published by students, over the past five years. Quantitative data was collected at four medical colleges of Khyber-Pakhtunkhwa for several qualitative research projects being conducted by students. Quantitative data was collected from the faculty of these colleges about the facilities of research departments. After analysing quantitative data, five semi-structured interviews via email were conducted about factors limiting qualitative research at medical colleges. Written responses were analysed for themes.
    Results: There was not a single qualitative research article published by students in local journals in five years. Out of 39 research projects by undergraduates at four medical colleges only one was qualitative. Two themes developed from qualitative data were underdeveloped research departments and a lack of attitude toward qualitative research.
    Conclusions: There is a felt need and gap to include qualitative research objectives at the undergraduate level, but before that emphasis needs to be placed on providing infrastructure, resources, and trained faculty to facilitate implementation. It will facilitate future doctors to find answers to problems impalpable by quantitative methods.
    MeSH term(s) Humans ; Education, Medical, Undergraduate/methods ; Qualitative Research ; Education, Medical ; Faculty ; Attitude
    Language English
    Publishing date 2024-02-26
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    DOI 10.55519/JAMC-04-11711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Recurrent Graves' Disease Following Near-Total Thyroidectomy: A Case Report and Literature Review.

    Menon, Lakshmi P / Naqvi, Syeda / Maradana, Jhansi / Edem, Dinesh

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52260

    Abstract: Recurrent Graves' disease due to regrowth of thyroid tissue is a rare complication of near-total thyroidectomy, which can be challenging to recognize and manage. Here, we present the case of a 30-year-old woman with Graves' disease and thyroid eye ... ...

    Abstract Recurrent Graves' disease due to regrowth of thyroid tissue is a rare complication of near-total thyroidectomy, which can be challenging to recognize and manage. Here, we present the case of a 30-year-old woman with Graves' disease and thyroid eye disease who underwent near-total thyroidectomy with resultant hypothyroidism. Her levothyroxine dose requirement gradually decreased and thyroglobulin level increased, which led to the diagnosis of recurrent Graves' disease. A neck ultrasound showed regrowth of thyroid tissue. The treatment options in such cases are repeat thyroid surgery and radioactive iodine ablation. The patient had moderate-severe active thyroid eye disease, so radioactive iodine ablation was contraindicated. Repeat surgery was deemed high risk due to the location of the residual thyroid tissue near the recurrent laryngeal nerve. Watchful waiting with serial thyrotropin (TSH) receptor antibody monitoring was chosen, and her levothyroxine dose was adjusted based on her thyroid function tests. There was a normalization of her TSH receptor antibody level over the next two and half years and stabilization of levothyroxine dose requirement. Recurrent Graves' disease must be considered when there is an ongoing decrease in the levothyroxine dose requirement associated with a rise in the serum thyroglobulin level following near-total thyroidectomy. Conservative management with medical therapy can induce remission in the case of recurrent Graves' disease following near-total thyroidectomy, without the need for radioactive iodine ablation or repeat thyroid surgery.
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Survival in general surgery: The female surgeons' perspective.

    Naqvi, Syeda Saima Qamar / Adeeb, Humera / Sethi, Ahsan

    Pakistan journal of medical sciences

    2023  Volume 39, Issue 4, Page(s) 926–930

    Abstract: Objective: Specialty choices in health profession has long been influenced by gender. The field of General Surgery remains the least preferred specialty by females, especially in Pakistan. The objective of this study was to identify the factors leading ... ...

    Abstract Objective: Specialty choices in health profession has long been influenced by gender. The field of General Surgery remains the least preferred specialty by females, especially in Pakistan. The objective of this study was to identify the factors leading to success and retention of females in General Surgery in Pakistan.
    Methods: Qualitative case study was conducted from February to May 2020 at Khyber Medical University, Peshawar. Ten semi-structured interviews were conducted with purposive sample of female surgeons at various academic position in different tertiary care hospitals of Pakistan. Data were thematically analyzed.
    Results: Participants were driven by their passion for surgery, which led them to choose this specialty in the beginning. Their survival in male dominant workplace was made possible by their own personality traits and conducive environment provided by the supervisors and peers. However, a structured mentorship program for females was found lacking.
    Conclusion: The necessary ingredients for success are passion and personality traits in any field but attention to nurturing and supportive environment for females in the General Surgery is paramount in determining success. Due consideration to the factors identified in the current study will enhance the retention and success of females in General Surgery.
    Language English
    Publishing date 2023-08-08
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.39.4.7528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells.

    Kumar, Vatsal / Naqvi, Syeda M / Verbruggen, Anneke / McEvoy, Eoin / McNamara, Laoise M

    Cell reports

    2024  Volume 43, Issue 5, Page(s) 114043

    Abstract: Bone is highly susceptible to cancer metastasis, and both tumor and bone cells enable tumor invasion through a "vicious cycle" of biochemical signaling. Tumor metastasis into bone also alters biophysical cues to both tumor and bone cells, which are ... ...

    Abstract Bone is highly susceptible to cancer metastasis, and both tumor and bone cells enable tumor invasion through a "vicious cycle" of biochemical signaling. Tumor metastasis into bone also alters biophysical cues to both tumor and bone cells, which are highly sensitive to their mechanical environment. However, the mechanobiological feedback between these cells that perpetuate this cycle has not been studied. Here, we develop highly advanced in vitro and computational models to provide an advanced understanding of how tumor growth is regulated by the synergistic influence of tumor-bone cell signaling and mechanobiological cues. In particular, we develop a multicellular healthy and metastatic bone model that can account for physiological mechanical signals within a custom bioreactor. These models successfully recapitulated mineralization, mechanobiological responses, osteolysis, and metastatic activity. Ultimately, we demonstrate that mechanical stimulus provided protective effects against tumor-induced osteolysis, confirming the importance of mechanobiological factors in bone metastasis development.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Fungicidal activity of stem extract of Chenopodium murale L. against the pathogen of Fusarium wilt of tomato

    Naqvi, Syeda Fakehha / Javaid, Arshad / Khan, Iqra Haider

    Allelopathy journal

    2023  Volume 58, Issue 1, Page(s) 69

    Document type Article
    ZDB-ID 1232515-6
    ISSN 0971-4693
    Database Current Contents Nutrition, Environment, Agriculture

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  6. Article: The effect of turmeric and black pepper powder incorporated in breakfast on postprandial glycemia, appetite, palatability, and gastrointestinal well-being in normal-weight adults.

    Khan, Safarat / Arif, Muhammad / Laraib, Hafza / Naqvi, Syeda Nimra / Shah, Omair Ali / Farooq, Umar / Sami-Ullah, Muhammad / Khan, Gul Asghar

    Food science & nutrition

    2024  Volume 12, Issue 4, Page(s) 2846–2854

    Abstract: Culinary herbs and spices are primarily known as flavor enhancers, research suggests that black pepper ( ...

    Abstract Culinary herbs and spices are primarily known as flavor enhancers, research suggests that black pepper (
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tonsillitis as a Rare Manifestation of COVID-19.

    Fatima, Kainat / Naqvi, Syeda Ghadeer Zehra

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2020  Volume 30, Issue 10, Page(s) 178–179

    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/epidemiology ; Female ; Humans ; Pandemics ; Rare Diseases ; SARS-CoV-2 ; Tonsillitis/diagnosis ; Tonsillitis/etiology
    Language English
    Publishing date 2020-12-08
    Publishing country Pakistan
    Document type Case Reports ; Letter
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.supp2.S178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Conformal Tri-Band Antenna for Flexible Devices and Body-Centric Wireless Communications.

    Awan, Wahaj Abbas / Abbas, Anees / Naqvi, Syeda Iffat / Elkamchouchi, Dalia H / Aslam, Muhammad / Hussain, Niamat

    Micromachines

    2023  Volume 14, Issue 10

    Abstract: A conformal tri-band antenna tailored for flexible devices and body-centric wireless communications operating at the key frequency bands is proposed. The antenna is printed on a thin Rogers RT 5880 substrate, merely 0.254 mm thick, with an overall ... ...

    Abstract A conformal tri-band antenna tailored for flexible devices and body-centric wireless communications operating at the key frequency bands is proposed. The antenna is printed on a thin Rogers RT 5880 substrate, merely 0.254 mm thick, with an overall geometrical dimension of 15 × 20 × 0.254 mm
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14101842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cost-utility of Initial Management of High-grade T1 Bladder Cancer With Intravesical BCG vs Immediate Radical Cystectomy.

    Huelster, Heather L / Mason, Neil T / Davaro, Facundo / Naqvi, Syeda Mahrukh Hussain / Kim, Youngchul / Gilbert, Scott M

    Urology

    2024  

    Abstract: Objective: To compare the cost-utility of initial management of high-grade T1 non-muscle invasive bladder cancer (HGT1 NMIBC) with intravesical BCG vs immediate radical cystectomy. High-risk NMIBC patients may climb a costly ladder of treatments, ... ...

    Abstract Objective: To compare the cost-utility of initial management of high-grade T1 non-muscle invasive bladder cancer (HGT1 NMIBC) with intravesical BCG vs immediate radical cystectomy. High-risk NMIBC patients may climb a costly ladder of treatments, culminating in radical cystectomy for oncologic or symptomatic benefit in up to one-third. This high healthcare resource utilization presents a challenging dilemma in balancing sufficiently aggressive management with cost, toxicity, and quality-of-life.
    Methods: Cost-utility of initially managing HGT1 with intravesical BCG and early radical cystectomy with ileal conduit urinary diversion was compared using decision-analytic Markov models. Five-year oncologic outcomes, adverse event rates, and published utility values were extracted from literature. Costs were calculated from a US Medicare perspective in 2021 US dollars. Sensitivity analysis identified drivers of cost and break-even points for recurrence and progression.
    Results: Mean costs were $26,093 for intravesical BCG and $39,720 for immediate radical cystectomy, though cystectomy generated a gain of 2.2 quality-adjusted life years (QALYs) compared to intravesical BCG. Immediate cystectomy was a more cost-effective management strategy for HGT1 NMIBC with an incremental CE ratios (ICER) of $7120/QALY. The costs associated with cystectomy, TURBT, and BCG toxicity had the greatest impact on ICER. One-way sensitivity analysis demonstrated that intravesical BCG became a cost-effective management strategy if the 5-year recurrence rate of HG T1 was less than 56% or the 5-year progression rate to MIBC was less than 4%.
    Conclusion: At current prices, treatment of high-grade T1 NMIBC with early radical cystectomy is more cost-effective management strategy than initial treatment with intravesical BCG.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2024.02.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Experimental trials of predicted CD4

    Qousain Naqvi, Syeda Tahira / Muhammad, Syed Aun / Guo, Jinlei / Zafar, Sidra / Ali, Amjad / Anderson, Larry J / Rostad, Christina A / Bai, Baogang

    Frontiers in immunology

    2024  Volume 15, Page(s) 1349749

    Abstract: Background: Respiratory syncytial virus (RSV) is the most common cause of viral lower respiratory tract infections (LRTIs) in young children around the world and an important cause of LRTI in the elderly. The available treatments and FDA-approved ... ...

    Abstract Background: Respiratory syncytial virus (RSV) is the most common cause of viral lower respiratory tract infections (LRTIs) in young children around the world and an important cause of LRTI in the elderly. The available treatments and FDA-approved vaccines for RSV only lessen the severity of the infection and are recommended for infants and elderly people.
    Methods: We focused on developing a broad-spectrum vaccine that activates the immune system to directly combat RSV. The objective of this study is to identify CD4
    Results: For each major histocompatibility complex (MHC) class-I and II, we found three epitopes of RSV proteins including F, G, and SH with an antigenic score of >0.5 and a projected SVM score of <5. Experimental validation of these peptides on female BALB/c mice was conducted before and after infection with the RSV A2 line 19f. We found that the 3RVMHCI (CD8
    Conclusion: In conclusion, epitopes of the F protein showed considerable immune response and are suitable for further validation.
    MeSH term(s) Infant ; Child ; Female ; Humans ; Mice ; Animals ; Aged ; Child, Preschool ; Epitopes, T-Lymphocyte/metabolism ; Granzymes ; Respiratory Syncytial Virus Infections ; Antibodies, Viral ; Respiratory Syncytial Virus, Human ; CD8-Positive T-Lymphocytes ; CD4-Positive T-Lymphocytes ; Immunoglobulin G ; Peptides
    Chemical Substances Epitopes, T-Lymphocyte ; Granzymes (EC 3.4.21.-) ; Antibodies, Viral ; Immunoglobulin G ; Peptides
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1349749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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