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  1. Article ; Online: Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.

    Chen, Zhenjie / Bai, Jiajia / Niu, Liwen

    The New England journal of medicine

    2024  Volume 390, Issue 12, Page(s) 1154

    MeSH term(s) Humans ; Glomerulosclerosis, Focal Segmental/drug therapy ; Irbesartan/therapeutic use ; Spiro Compounds ; Sulfonamides
    Chemical Substances Irbesartan (J0E2756Z7N) ; sparsentan (9242RO5URM) ; Spiro Compounds ; Sulfonamides
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2401126
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: Simultaneous Suppression of p-Doping and Nonradiative Recombination via Barium Incorporation for Highly Efficient Tin Perovskites.

    Zhang, Jiajia / Chen, Lijuan

    The journal of physical chemistry letters

    2023  Volume 14, Issue 17, Page(s) 4058–4062

    Abstract: High p-type self-doping and fast nonradiative recombination severely limit the optoelectronic performance of tin perovskites. Employing first-principles calculations, we show that incorporating barium (Ba) into the prototypical tin perovskite ... ...

    Abstract High p-type self-doping and fast nonradiative recombination severely limit the optoelectronic performance of tin perovskites. Employing first-principles calculations, we show that incorporating barium (Ba) into the prototypical tin perovskite CsSnI
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c00831
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  3. Article ; Online: Nonenzymatic glycation as a tunable technique to modify plant proteins: A comprehensive review on reaction process, mechanism, conjugate structure, and functionality.

    Gao, Kun / Zha, Fengchao / Rao, Jiajia / Chen, Bingcan

    Comprehensive reviews in food science and food safety

    2024  Volume 23, Issue 1, Page(s) e13269

    Abstract: Plant proteins are expected to become a major protein source to replace currently used animal-derived proteins in the coming years. However, there are always challenges when using these proteins due to their low water solubility induced by the high ... ...

    Abstract Plant proteins are expected to become a major protein source to replace currently used animal-derived proteins in the coming years. However, there are always challenges when using these proteins due to their low water solubility induced by the high molecular weight storage proteins. One approach to address this challenge is to modify proteins through Maillard glycation, which involves the reaction between proteins and carbohydrates. In this review, we discuss various chemical methods currently available for determining the indicators of the Maillard reaction in the early stage, including the graft degree of glycation and the available lysine or sugar, which are involved in the very beginning of the reaction. We also provide a detailed description of the most popular methods for determining graft sites and assessing different plant protein structures and functionalities upon non-enzymatic glycation. This review offers valuable insights for researchers and food scientists in order to develop plant-based protein ingredients with improved functionality.
    MeSH term(s) Animals ; Maillard Reaction ; Plant Proteins ; Food
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2185829-9
    ISSN 1541-4337 ; 1541-4337
    ISSN (online) 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.13269
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  4. Article ; Online: What we talk about when we talk about spinal cord aging.

    Ji, Xianhong / Zhang, Jiajia / Tang, Xiaoqiang / Chen, Hou-Zao

    Cell metabolism

    2024  Volume 36, Issue 1, Page(s) 7–9

    Abstract: Spinal cord-associated disorders are common in the elderly population; however, the mechanisms underlying spinal aging remain elusive. In a recent Nature paper, Sun et al. systemically analyzed aged spines in nonhuman primates and identified a new ... ...

    Abstract Spinal cord-associated disorders are common in the elderly population; however, the mechanisms underlying spinal aging remain elusive. In a recent Nature paper, Sun et al. systemically analyzed aged spines in nonhuman primates and identified a new cluster of CHIT1-positive microglia that drives motor neuron senescence and subsequent spine aging.
    MeSH term(s) Animals ; Humans ; Aged ; Spinal Cord ; Motor Neurons ; Aging/physiology ; Microglia
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2023.12.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
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  5. Article ; Online: An interleukin 10 Receptor alpha (IL-10RA) variant with a compound heterozygote mutation shows normal IL-10 signaling activity

    Jiajia Lv / Xiaoyan Chen / Yuan Xiao

    Genes and Diseases, Vol 10, Iss 3, Pp 716-

    2023  Volume 718

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article: Isoquercitrin alleviates pirarubicin-induced cardiotoxicity

    Wang, Lei / Ma, Jiulong / Chen, Chen / Lin, Bin / Xie, Sicong / Yang, Weiwei / Qian, Jiajia / Zhang, Yang

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1315001

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1315001
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  7. Article ; Online: Assessing the causal relationship between immune cell traits and depression by Mendelian randomization analysis.

    Xue, Hua / Chen, Jiajia / Fan, Wenhui

    Journal of affective disorders

    2024  Volume 356, Page(s) 48–53

    Abstract: Background: Observational studies suggested that immune system disorder is associated with depression. However, the causal association has not been fully elucidated. Thus, we aim to assess the causality of the associations of immune cell profiles with ... ...

    Abstract Background: Observational studies suggested that immune system disorder is associated with depression. However, the causal association has not been fully elucidated. Thus, we aim to assess the causality of the associations of immune cell profiles with risk of depression through Mendelian randomization analysis.
    Methods: We extracted genetic variances of immune cell traits from a large publicly available genome-wide association study (GWAS) involving 3757 participants and depression from a GWAS containing 246,363 cases and 561,190 controls of European ancestry. Inverse variance weighting (IVW) was performed as the MR primary analysis. Simultaneously apply MR-Egger and weighted median as supplementary enhancements to the final result. We further performed heterogeneity and horizontal pleiotropy test to validate the main MR results.
    Results: Five immunophenotypes were identified to be significantly associated with depression risk: CD27 on IgD
    Conclusion: Our findings shed light on the intricate interaction pattern between the immune system and depression, offering a novel direction for researchers to investigate the underlying biological mechanisms of depression.
    Language English
    Publishing date 2024-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.04.006
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    Zs.A 1485: Show issues Location:
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  8. Book ; Online: Continuously Evolving Graph Neural Controlled Differential Equations for Traffic Forecasting

    Wu, Jiajia / Chen, Ling

    2024  

    Abstract: As a crucial technique for developing a smart city, traffic forecasting has become a popular research focus in academic and industrial communities for decades. This task is highly challenging due to complex and dynamic spatial-temporal dependencies in ... ...

    Abstract As a crucial technique for developing a smart city, traffic forecasting has become a popular research focus in academic and industrial communities for decades. This task is highly challenging due to complex and dynamic spatial-temporal dependencies in traffic networks. Existing works ignore continuous temporal dependencies and spatial dependencies evolving over time. In this paper, we propose Continuously Evolving Graph Neural Controlled Differential Equations (CEGNCDE) to capture continuous temporal dependencies and spatial dependencies over time simultaneously. Specifically, a continuously evolving graph generator (CEGG) based on NCDE is introduced to generate the spatial dependencies graph that continuously evolves over time from discrete historical observations. Then, a graph neural controlled differential equations (GNCDE) framework is introduced to capture continuous temporal dependencies and spatial dependencies over time simultaneously. Extensive experiments demonstrate that CEGNCDE outperforms the SOTA methods by average 2.34% relative MAE reduction, 0.97% relative RMSE reduction, and 3.17% relative MAPE reduction.

    Comment: 9 pages, 4 figures
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2024-01-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Sandwich-like voltametric immunosensing of interleukin-8 based on β-cyclodextrin/carbon nanotubes and methylthionine chloride@UIO-66 framework.

    Zhou, Zhihua / Lin, Jiajia / Yue, Daoping / Chen, Huaiyu / Chen, Sheng

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2024  

    Abstract: The level of interleukin-8 (IL-8) in the body is an effective factor for the early diagnosis of acute tubular necrosis and oral tumor. In this work, a novel sandwich-like voltametric immunosensor (SVS) of IL-8 was constructed by preparing β-cyclodextrin/ ... ...

    Abstract The level of interleukin-8 (IL-8) in the body is an effective factor for the early diagnosis of acute tubular necrosis and oral tumor. In this work, a novel sandwich-like voltametric immunosensor (SVS) of IL-8 was constructed by preparing β-cyclodextrin/carbon nanotube (CD/CNT) to immobilize primary antibody (PAb) of IL-8 and UIO-66-NH
    Language English
    Publishing date 2024-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-024-00574-y
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  10. Article ; Online: Heating performance of dual-source microwave heating using different frequency shifting strategies in a solid-state system.

    Yang, Ran / Chen, Jiajia

    Food research international (Ottawa, Ont.)

    2023  Volume 175, Page(s) 113781

    Abstract: Solid-state microwave heating holds potential in mitigating the issue of nonuniform heating commonly observed in magnetron-based microwave ovens. Previous work on solid-state application primarily focused on single-source microwave heating and modeling ... ...

    Abstract Solid-state microwave heating holds potential in mitigating the issue of nonuniform heating commonly observed in magnetron-based microwave ovens. Previous work on solid-state application primarily focused on single-source microwave heating and modeling of dual-source heating with fixed frequency combinations. This study experimentally investigated the port interactions and heating performance of four different frequency shifting approaches (in range of 2.4 and 2.5 GHz, at an interval of 0.01 GHz), i.e., Fixed-frequency without shifting, Synchronized-shifting, Inverse-shifting and Distinct-shifting, in a dual-source microwave system under both stationary and rotatory conditions. Results showed that port interactions were dependent on the microwave frequency and load position, both of which significantly affected the microwave power efficiency. All three shifting strategies significantly improved heating performance compared to the Fixed-frequency heating. Additionally, the use of a turntable in our dual-source microwave configuration did not improve the heating uniformity in the context of various frequency shifting processes, suggesting that the inclusion of a turntable might be dispensable in solid-state microwave systems if proper multi-port frequency shifting strategy could deliver more uniform heating.
    MeSH term(s) Microwaves ; Heating
    Language English
    Publishing date 2023-11-24
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.113781
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    Z 2972: Show issues

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