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  1. Article ; Online: Clinical efficacy and safety of canagliflozin combined with valsartan in the treatment of early and mid-stage diabetic nephropathy.

    Ma, Dongmei / Cao, Tong

    Minerva surgery

    2023  

    Language English
    Publishing date 2023-12-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.23.10172-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association Between Baseline Echocardiographic Parameters and Acute Coronavirus Disease 2019 Infection in Hospitalized Patients.

    Wang, Jin / Yang, Dongmei / Cao, Cheng

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55432

    Abstract: Background The current study aimed to examine the association between baseline clinical and echocardiographic parameters with new-onset coronavirus disease 2019 (COVID-19) infection. Methodology We retrospectively enrolled consecutive hospitalized ... ...

    Abstract Background The current study aimed to examine the association between baseline clinical and echocardiographic parameters with new-onset coronavirus disease 2019 (COVID-19) infection. Methodology We retrospectively enrolled consecutive hospitalized patients from our center during the national outbreak of the COVID-19 pandemic in China. Overall, 100 patients were enrolled, including 38 patients with COVID-19 infection. Results Compared with those without infection, patients with COVID-19 infection were more likely male (63.2% vs. 35.5%, p = 0.008), were older (59.08 vs. 52.35 years, p = 0.022), had higher heart failure (31.6% vs. 11.3%, p = 0.018) and hypertension (52.6% vs. 30.6%, p = 0.036) rates, had lower left ventricular ejection fraction (LVEF) (61.16% vs. 65.76%, p = 0.018), had higher A-wave velocity (86.84 vs. 73.63 cm/s, p = 0.003), and had and lower E/A ratio (0.85 vs 1.04, p = 0.015). On univariate and multivariate analysis, baseline echocardiographic parameters (LVEF and A-wave velocity) were independent risk factors for COVID-19 infection. There were no significant changes in echocardiographic parameters during the one-month follow-up period in patients infected and not infected with COVID-19. Conclusions In conclusion, baseline echocardiographic parameters were significantly associated with acute COVID-19 infection.
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders.

    Cao, Dongmei / Zhang, Pei / Wang, Sheng

    Neuron

    2024  Volume 112, Issue 4, Page(s) 526–538

    Abstract: Over the years, the field of GPCR drug design has undergone a remarkable evolution, fueled by advancements in science and technology. This evolution has given rise to a diverse range of ideas and approaches in structure-based drug design, bolstering the ... ...

    Abstract Over the years, the field of GPCR drug design has undergone a remarkable evolution, fueled by advancements in science and technology. This evolution has given rise to a diverse range of ideas and approaches in structure-based drug design, bolstering the versatility and strength of the GPCR drug design toolbox. This review encapsulates the iterative development process, navigating challenges and opportunities in structure-based drug design within GPCRs. With a focused emphasis on its impact on psychiatric disorders, the review accentuates recent advancements and delves into the potentials unlocked by emerging technologies. The review explores the intricate interplay between scientific progress and iterative refinement, offering profound insights into the potential pathways that lie ahead for GPCR drug design.
    MeSH term(s) Humans ; Receptors, G-Protein-Coupled/metabolism ; Drug Design ; Mental Disorders/drug therapy
    Chemical Substances Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Investigation of high-dose radiotherapy's effect on brain structure aggravated cognitive impairment and deteriorated patient psychological status in brain tumor treatment.

    Ma, Jianpeng / Cao, Hetao / Hou, Dongmei / Wang, Weiqi / Liu, Tingting

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 10149

    Abstract: This study aims to investigate the potential impact of high-dose radiotherapy (RT) on brain structure, cognitive impairment, and the psychological status of patients undergoing brain tumor treatment. We recruited and grouped 144 RT-treated patients with ... ...

    Abstract This study aims to investigate the potential impact of high-dose radiotherapy (RT) on brain structure, cognitive impairment, and the psychological status of patients undergoing brain tumor treatment. We recruited and grouped 144 RT-treated patients with brain tumors into the Low dose group (N = 72) and the High dose group (N = 72) according to the RT dose applied. Patient data were collected by using the HADS and QLQ-BN20 system for subsequent analysis and comparison. Our analysis showed no significant correlation between the RT doses and the clinicopathological characteristics. We found that a high dose of RT could aggravate cognitive impairment and deteriorate patient role functioning, indicated by a higher MMSE and worsened role functioning in the High dose group. However, the depression status, social functioning, and global health status were comparable between the High dose group and the Low dose group at Month 0 and Month 1, while being worsened in the High dose group at Month 3, indicating the potential long-term deterioration of depression status in brain tumor patients induced by high-dose RT. By comparing patient data at Month 0, Month 1, Month 3, Month 6, and Month 9 after RT, we found that during RT treatment, RT at a high dose could aggravate cognitive impairment in the short term and lead to worsened patient role functioning, and even deteriorate the overall psychological health status of patients in the long term.
    MeSH term(s) Humans ; Male ; Female ; Cognitive Dysfunction/etiology ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/psychology ; Middle Aged ; Aged ; Brain/radiation effects ; Brain/pathology ; Adult ; Radiotherapy Dosage ; Depression/etiology ; Quality of Life
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59694-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Serotonin 2A Receptor (5-HT

    Duan, Wenwen / Cao, Dongmei / Wang, Sheng / Cheng, Jianjun

    Chemical reviews

    2023  Volume 124, Issue 1, Page(s) 124–163

    Abstract: Psychedelics make up a group of psychoactive compounds that induce hallucinogenic effects by activating the serotonin 2A receptor (5- ... ...

    Abstract Psychedelics make up a group of psychoactive compounds that induce hallucinogenic effects by activating the serotonin 2A receptor (5-HT
    MeSH term(s) Hallucinogens/pharmacology ; Serotonin ; Receptor, Serotonin, 5-HT2A ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use
    Chemical Substances Hallucinogens ; Serotonin (333DO1RDJY) ; Receptor, Serotonin, 5-HT2A ; Antidepressive Agents
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.3c00375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Global, regional, and national burdens of interpersonal violence in young women aged 10-24 years from 1990 to 2019: a trend analysis based on the global burden of disease study 2019.

    Cao, Yu / Lu, Hao / Duan, Pengqian / Wang, Dongmei / Wei, Guojun

    Frontiers in psychology

    2024  Volume 14, Page(s) 1241862

    Abstract: Background: Interpersonal violence (IPV) against young women, including physical and sexual violence, poses a major threat to public health. We analyzed global, regional and national trends in violence against females aged 10-24 years from 1990 to 2019.! ...

    Abstract Background: Interpersonal violence (IPV) against young women, including physical and sexual violence, poses a major threat to public health. We analyzed global, regional and national trends in violence against females aged 10-24 years from 1990 to 2019.
    Methods: We extracted age-standardized prevalence rates (ASPRs) of physical violence by firearm (PVF), physical violence by other means (PVOM), physical violence by sharp object (PVSO), and sexual violence (SV) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. Joinpoint regression analysis calculated annual and average annual percentage changes (AAPCs) in ASPRs.
    Results: Globally, the ASPRs of the four measures of IPV decreased between 1990 and 2019, with the steepest declines between 2000 and 2009, except for SV, which increased slightly. However, the ASPRs of PVF and PVOM increased slightly between 2010 and 2019. Regionally, PVF prevalence declined most in East Asia (-0.9505, -1.0011 to -0.8975), South Asia (-0.277, -0.3089 to -0.244) and Latin America but PVOM prevalence increased in Oceania (0.6275, 0.6036 to 0.6498) and SV prevalence increased in Caribbean (0.4267, 0.4069 to 0.4495). Nationally, PVF prevalence decreased most in Thailand (-2.4031, -2.4634 to -2.3328) but increased most in Libya (6.8143, 6.6194 to 7.0113). SV prevalence increased most in Oman (0.4561, 0.4338 to 0.478) and the largest increase in Disability-adjusted life years (DALYs) from PVOM was observed in Botswana (6.2725, 6.0951 to 6.4082). DALYs showed similar trends.
    Conclusion: While global declines over 30 years are encouraging, IPV against young women persists. Urgent, tailored approaches across sectors are critical to curb drivers of violence against young women, including poverty, inequality and sociocultural attitudes. High-quality data and in-depth analyses can inform locally-relevant solutions. Overall, intensified political will and resource investment are needed to overcome this pervasive human rights violation.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1241862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association between body mass index and mental health among nurses: a cross-sectional study in China.

    Luan, Bonan / Tian, Xueyan / Wang, Chao / Cao, Ming / Liu, Dongmei

    BMC health services research

    2024  Volume 24, Issue 1, Page(s) 506

    Abstract: Purpose: To examine the correlation between body mass index (BMI) and mental well-being in Chinese nurses during the COVID-19 epidemic.: Method: This study was conducted in a tertiary hospital using a cross-sectional design. A total of 2,811 nurses ... ...

    Abstract Purpose: To examine the correlation between body mass index (BMI) and mental well-being in Chinese nurses during the COVID-19 epidemic.
    Method: This study was conducted in a tertiary hospital using a cross-sectional design. A total of 2,811 nurses were enlisted at Shengjing Hospital in China during the period from March to April, 2022. Information was gathered through a questionnaire that individuals completed themselves. The mental health of the participants was assessed using the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder Assessment-7. Binary logistic regression was used to calculate adjusted odds ratios (ORs) and their corresponding 95% confidence intervals.
    Results: The prevalence of nurses experiencing depression and anxiety was 7.8% (219) and 6.7% (189), respectively. Regarding depression after adjustment, the odds ratios (ORs) for each quartile, compared to the lowest quartile, were as follows: 0.91 (95% confidence interval [CI]: 0.53, 1.56), 2.28 (95% CI: 0.98, 3.77), and 2.32 (95% CI: 1.41, 3.83). The p-value for trend was found to be 0.001. The odds ratios (ORs) for anxiety after adjustment were 2.39 (0.83, 4.36), 4.46 (0.51, 7.93), and 2.81 (1.56, 5.08) when comparing the highest quartiles to the lowest quartile. The p-value for trend was 0.009.
    Conclusion: This study found a positive association between BMI and poor mental health among nurses during the COVID-19 pandemic, particularly in those who were overweight or obesity. The findings could assist in developing interventions and help policy-makers establish appropriate strategies to support the mental health of frontline nurses, especially those who are overweight or obesity.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Body Mass Index ; China/epidemiology ; Female ; Adult ; COVID-19/epidemiology ; COVID-19/psychology ; Male ; Depression/epidemiology ; Mental Health/statistics & numerical data ; Anxiety/epidemiology ; SARS-CoV-2 ; Middle Aged ; Prevalence ; Nurses/psychology ; Nurses/statistics & numerical data ; Surveys and Questionnaires ; Obesity/epidemiology ; Obesity/psychology
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-024-11006-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Etiological and clinical characteristics of severe pneumonia in pediatric intensive care unit (PICU).

    Chen, Dongmei / Cao, Lu / Li, Wenjing

    BMC pediatrics

    2023  Volume 23, Issue 1, Page(s) 362

    Abstract: Objective: To analyze the etiological distribution characteristics of pediatric patients with severe pneumonia admitted to the Pediatric Intensive Care Unit (PICU), in order to provide a reference for the rational use of clinical antimicrobial drugs.: ...

    Abstract Objective: To analyze the etiological distribution characteristics of pediatric patients with severe pneumonia admitted to the Pediatric Intensive Care Unit (PICU), in order to provide a reference for the rational use of clinical antimicrobial drugs.
    Methods: A retrospective analysis of pediatric patients admitted to PICU with a diagnosis of severe pneumonia from January 2018 to December 2021 was performed and statistical analysis of pathogenic characteristics was performed.
    Results: A total of 649 pathogens were detected in 515 children, with a positive detection rate of 77.48%. Bacteria were detected at the highest rate (40.52%), followed by viruses (34.35%), atypical pathogens (19.72%) and fungal (4.31%). Gram-positive infections were dominated by Staphylococcus aureus (39.56%) and Streptococcus pneumoniae (32.97%), and Gram-negative infections were dominated by Acinetobacter Bahmani (16.28%) and Haemophilus influenzae (15.12%), followed by Klebsiella pneumoniae (13.95%) and Pseudomonas aeruginosa (12.21%). Viral infections were dominated by respiratory syncytial virus (25.65%) and EB virus (20.43%), fungal infections were dominated by Candida albicans (50.0%). The proportion of children infected with single pathogen (49.62%) was comparable to that of those with mixed infections (50.38%). There were statistically significant differences in the distribution of children with single pathogen infection by gender (P < 0.05). The age distribution of children with single bacterial, single viral and single fungal infections was statistically different (P < 0.05). There was no significant difference in the distribution of onset season in children with single pathogen infections (P > 0.05), but the number of children with single viral infections was significantly higher in winter and spring than that in summer and autumn, and the difference was statistically significant (P < 0.05). A mixture of 2 pathogens (77.61%) accounted for the majority of mixed infections, there were statistical differences in the distribution of bacterial + viral infection in terms of gender, age, and onset season (P < 0.05), children with viral + mycoplasma infection in terms of gender and age (P < 0.05), and children with viral + fungal infection in terms of gender (P < 0.05), and children with bacterial + mycoplasma infection in terms of age and onset season (P < 0.05). Among the children infected with 3 pathogens, there were statistically significant differences in the distribution of bacterial + viral + fungal and viral + mycoplasma + fungal infections in terms of gender (P < 0.05), and children with bacterial + viral + mycoplasma infection in terms of age (P < 0.05), while there was no significant difference in the distribution of onset season (P > 0.05). There were no significant differences in the distribution of children infected with 4 pathogens in terms of gender, age and onset season (P > 0.05).
    Conclusion: The pathogens of pediatric patients with severe pneumonia in PICU commonly involves bacteria and viruses. As the age of children grows, the detection rate of bacteria shows a decreasing trend, and the pathogenic spectrum gradually changes from bacteria to mycoplasma and viruses, and the number of mixed infections gradually increase. Rational selection of antimicrobial drugs needs to consider pathogenic characteristics of different age, gender, and onset season in clinical practice.
    MeSH term(s) Child ; Humans ; Retrospective Studies ; Coinfection ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Pneumonia/etiology ; Bacteria ; Virus Diseases/diagnosis ; Staphylococcal Infections ; Intensive Care Units, Pediatric ; Mycoplasma Infections
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-023-04175-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How and when can job-insecure employees prevent psychological distress against the COVID-19 pandemic? The role of cognitive appraisal and reappraisal.

    Wang, Dan / Cao, Dongmei / Kiani, Ataullah

    Current psychology (New Brunswick, N.J.)

    2023  , Page(s) 1–13

    Abstract: The COVID-19 pandemic has greatly affected economies around the world, causing record unemployment rates that have exacerbated the already prevalent job insecurity, thereby leading to psychological distress among many individuals. The present study aims ... ...

    Abstract The COVID-19 pandemic has greatly affected economies around the world, causing record unemployment rates that have exacerbated the already prevalent job insecurity, thereby leading to psychological distress among many individuals. The present study aims to reveal the underlying mechanisms of psychological distress induced by the COVID-19 pandemic among job-insecure employees and to identify one of the emotion regulation strategies (i.e., cognitive reappraisal) as a protective factor that mitigates psychological distress. Drawing upon transactional theory, we proposed and tested a moderated mediation model, wherein cognitive reappraisal serves as a moderator of the direct and indirect relationship between job insecurity and psychological distress via stress appraisals (i.e., threat appraisal and challenge appraisal) based on data from 922 employees. Results show that threat appraisal and challenge appraisal positively and negatively mediate the relationship between job insecurity and psychological distress, respectively. Furthermore, as an emotion regulation strategy, cognitive reappraisal mitigates psychological distress among job-insecure employees, weakens the positive indirect effect of threat appraisal, but intensifies the negative indirect effect of challenge appraisal. Our findings suggest that cognition plays an important role in individuals' emotional reactions to COVID-19-related stress, and cognition reappraisal is an effective emotion regulation strategy in mitigating psychological distress. Therefore, cognition reappraisal skills should be improved to reduce psychological distress induced by COVID-19 pandemic.
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-023-04331-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy.

    Li, Fangling / Cao, Dongdong / Gu, Wenyi / Li, Dongmei / Liu, Zhiyong / Cui, Lin

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) can cause a variety of malignancies. Ganciclovir (GCV) is one of the most efficient drugs against KSHV, but its non-specificity can cause other side effects in patients. Nucleic acid miR-34a-5p can inhibit ... ...

    Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) can cause a variety of malignancies. Ganciclovir (GCV) is one of the most efficient drugs against KSHV, but its non-specificity can cause other side effects in patients. Nucleic acid miR-34a-5p can inhibit the transcription of KSHV RNA and has great potential in anti-KSHV therapy, but there are still problems such as easy degradation and low delivery efficiency. Here, we constructed a co-loaded dual-drug nanocomplex (GCV@ZIF-8/PEI-FA+miR-34a-5p) that contains
    MeSH term(s) Humans ; Herpesvirus 8, Human/genetics ; Ganciclovir/pharmacology ; MicroRNAs/genetics ; Sarcoma, Kaposi/genetics
    Chemical Substances Ganciclovir (P9G3CKZ4P5) ; MicroRNAs
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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