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  1. Article ; Online: Please Wait for the Host to Start This Meeting: A Push for H.R. 3235 Amid COVID-19.

    Anderson, Katherine / Terry, Sharon F

    Genetic testing and molecular biomarkers

    2020  Volume 24, Issue 11, Page(s) 689–691

    MeSH term(s) COVID-19 ; Coronavirus Infections ; Genetic Counseling/economics ; Genetic Counseling/legislation & jurisprudence ; Genetic Counseling/trends ; Health Services Accessibility/legislation & jurisprudence ; Humans ; Medicare ; Pandemics ; Pneumonia, Viral ; Telemedicine ; United States
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2486664-7
    ISSN 1945-0257 ; 1945-0265
    ISSN (online) 1945-0257
    ISSN 1945-0265
    DOI 10.1089/gtmb.2020.29058.sjt
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5195: Show issues Location:
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  3. Article ; Online: Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic α

    Procopiou, Panayiotis A / Anderson, Niall A / Barrett, John / Barrett, Tim N / Crawford, Matthew H J / Fallon, Brendan J / Hancock, Ashley P / Le, Joelle / Lemma, Seble / Marshall, Richard P / Morrell, Josie / Pritchard, John M / Rowedder, James E / Saklatvala, Paula / Slack, Robert J / Sollis, Steven L / Suckling, Colin J / Thorp, Lee R / Vitulli, Giovanni /
    Macdonald, Simon J F

    Journal of medicinal chemistry

    2018  Volume 61, Issue 18, Page(s) 8417–8443

    Abstract: ... via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of ( R)-BINAP ...

    Abstract A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of ( R)-BINAP to a crotonate ester to provide the ( S) absolute configuration for the major product. A variety of aryl substituents including morpholine, pyrazole, triazole, imidazole, and cyclic ether were screened in cell adhesion assays for affinity against α
    MeSH term(s) Animals ; Antigens, Neoplasm ; Cell Adhesion ; Dogs ; Drug Discovery ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Integrins/antagonists & inhibitors ; Lung/drug effects ; Lung/metabolism ; Male ; Mice ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Pyrazoles/chemistry ; Rats ; Rats, Wistar ; Structure-Activity Relationship ; Tissue Distribution
    Chemical Substances Antigens, Neoplasm ; Integrins ; Pyrazoles ; integrin alphavbeta6
    Language English
    Publishing date 2018-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.8b00959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 151: Show issues Location:
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  4. Article ; Online: Gastroprotective mechanisms of the chloroform and ethyl acetate phases of Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae).

    Falcão, Heloina de Sousa / Maia, Gabriela Lemos de Azevedo / Bonamin, Flávia / Kushima, Hélio / Moraes, Thiago Mello / Hiruma Lima, Clélia Akiko / Takayama, Christiane / Ferreira, Anderson Luiz / Souza Brito, Alba Regina Monteiro / Agra, Maria de Fátima / Barbosa Filho, José Maria / Batista, Leônia Maria

    Journal of natural medicines

    2012  Volume 67, Issue 3, Page(s) 480–491

    Abstract: Flavonoid-rich Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae) is a native plant ...

    Abstract Flavonoid-rich Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae) is a native plant of South America. This study evaluates the gastroprotective activity and possible mechanisms for both the chloroform (CHCl3P) and ethyl acetate phases (AcOEtP) obtained from aerial parts of the plant. The activity was investigated using acute models of gastric ulcer. Gastric secretion biochemical parameters were determined after pylorus ligature. The participation of cytoprotective factors such as mucus, nitric oxide (NO), sulfhydryl (SH) groups, prostaglandin E2 (PGE2), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), reduction of lipid peroxidation (malondialdehyde level), and polymorphonuclear infiltration (myeloperoxidase activity), was also investigated. CHCl3P (125, 250, and 500 mg/kg) and AcOEtP (62.5, 125, and 250 mg/kg) showed significant gastroprotective activity, reducing the ulcerative index by 75, 83, 88% and 66, 66, 81% for ethanol; 67, 67, 56% and 56, 53, 58% for a non-steroidal anti-inflammatory drug (NSAID); and 74, 58, 59% and 64, 65, 61% for stress-induced gastric ulcer, respectively. CHCl3P (125 mg/kg) and AcOEtP (62.5 mg/kg) significantly reduced the ulcerative area by 78 and 83%, respectively, for the ischemia-reperfusion model. They also did not alter the biochemical parameters of gastric secretion, the GSH level or the activities of SOD, GPx or GR. They increased the quantity of gastric mucus, not dependent on NO, yet dependent on SH groups, and maintained PGE2 levels. The P. clematidea phases demonstrated gastroprotective activity related to cytoprotective factors.
    MeSH term(s) Acetates/chemistry ; Animals ; Anti-Ulcer Agents/isolation & purification ; Anti-Ulcer Agents/pharmacology ; Asteraceae/chemistry ; Biomarkers/metabolism ; Chloroform/chemistry ; Cytoprotection ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Ethanol ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Male ; Mice ; Mucus/metabolism ; Phytotherapy ; Piroxicam ; Plant Components, Aerial ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plants, Medicinal ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Signal Transduction/drug effects ; Solvents/chemistry ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Stomach Ulcer/prevention & control
    Chemical Substances Acetates ; Anti-Ulcer Agents ; Biomarkers ; Plant Extracts ; Solvents ; Piroxicam (13T4O6VMAM) ; Ethanol (3K9958V90M) ; ethyl acetate (76845O8NMZ) ; Chloroform (7V31YC746X)
    Language English
    Publishing date 2012-09-15
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-012-0705-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2692: Show issues Location:
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  5. Article: A. Kim, k.f. Anderson, j. Berliner, j. Hassan, j. Jensen, h.j. Mertz, h. Pietsch, a. Rao, R. Scherer, and a. Sutterfield.

    Kim, A / Anderson, K F / Berliner, J / Hassan, J / Jensen, J / Mertz, H J / Pietsch, H / Rao, A / Scherer, R / Sutterfield, A

    Stapp car crash journal

    2003  Volume 47, Page(s) 489–523

    Abstract: In this study, three dummies were evaluated on the component level and as a whole. Their responses were compared with available volunteer and embalmed Post Mortem Human Subject (PMHS) data obtained under similar test conditions to evaluate their ... ...

    Abstract In this study, three dummies were evaluated on the component level and as a whole. Their responses were compared with available volunteer and embalmed Post Mortem Human Subject (PMHS) data obtained under similar test conditions to evaluate their biofidelity. The volunteer and PMHS data, used as comparators in this study, were used previously to establish some of the biofidelity requirements of the Hybrid III. The BioRID II, the Hybrid III, and the RID2 were all subjected to rear impact HYGE sled tests with deltaVs of 17 and 28 km/hr to determine their biofidelity in these conditions. A static pull test, where a load was manually applied to the head of each dummy, was used to evaluate the static strength of their necks in flexion and extension. Finally, pendulum tests were conducted with the Hybrid III and RID2 to evaluate the dynamic characteristics of their necks in flexion and extension. The sled test results indicate that out of the three dummies, the overall flexibility of the Hybrid III is comparable to that of the volunteer anticipating the impact. The overall flexibilities of the BioRID II and the RID2 are greater than those of all the comparators used in this study (the tensed volunteer and the two embalmed PMHSs). The responses of the Hybrid III are closer to those of the tensed volunteer than those of the PMHSs. The responses of the BioRID II and the RID2 are closer to those of the PMHSs than to the tensed volunteer.
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2037200-0
    ISSN 1532-8546 ; 0585-086X
    ISSN 1532-8546 ; 0585-086X
    DOI 10.4271/2003-22-0022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1967: Show issues Location:
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  6. Article: Gastroprotective mechanisms of the chloroform and ethyl acetate phases of Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae)

    Falcão, Heloina de Sousa / Maia, Gabriela Lemos de Azevedo / Bonamin, Flávia / Kushima, Hélio / Moraes, Thiago Mello / Hiruma Lima, Clélia Akiko / Takayama, Christiane / Ferreira, Anderson Luiz / Souza Brito, Alba Regina Monteiro / Agra, Maria de Fátima / Barbosa Filho, José Maria / Batista, Leônia Maria

    Natural medicines. 2013 July, v. 67, no. 3

    2013  

    Abstract: Flavonoid-rich Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae) is a native plant ...

    Abstract Flavonoid-rich Praxelis clematidea (Griseb.) R.M.King & H.Robinson (Asteraceae) is a native plant of South America. This study evaluates the gastroprotective activity and possible mechanisms for both the chloroform (CHCl₃P) and ethyl acetate phases (AcOEtP) obtained from aerial parts of the plant. The activity was investigated using acute models of gastric ulcer. Gastric secretion biochemical parameters were determined after pylorus ligature. The participation of cytoprotective factors such as mucus, nitric oxide (NO), sulfhydryl (SH) groups, prostaglandin E₂ (PGE₂), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), reduction of lipid peroxidation (malondialdehyde level), and polymorphonuclear infiltration (myeloperoxidase activity), was also investigated. CHCl₃P (125, 250, and 500� mg/kg) and AcOEtP (62.5, 125, and 250� mg/kg) showed significant gastroprotective activity, reducing the ulcerative index by 75, 83, 88� % and 66, 66, 81� % for ethanol; 67, 67, 56� % and 56, 53, 58� % for a non-steroidal anti-inflammatory drug (NSAID); and 74, 58, 59� % and 64, 65, 61� % for stress-induced gastric ulcer, respectively. CHCl₃P (125� mg/kg) and AcOEtP (62.5� mg/kg) significantly reduced the ulcerative area by 78 and 83� %, respectively, for the ischemia–reperfusion model. They also did not alter the biochemical parameters of gastric secretion, the GSH level or the activities of SOD, GPx or GR. They increased the quantity of gastric mucus, not dependent on NO, yet dependent on SH groups, and maintained PGE₂ levels. The P. clematidea phases demonstrated gastroprotective activity related to cytoprotective factors.
    Keywords Asteraceae ; aerial parts ; chloroform ; ethanol ; ethyl acetate ; glutathione ; glutathione peroxidase ; glutathione-disulfide reductase ; indigenous species ; lipid peroxidation ; malondialdehyde ; models ; mucus ; myeloperoxidase ; nitric oxide ; nonsteroidal anti-inflammatory agents ; prostaglandins ; pylorus ; secretion ; stomach ulcers ; superoxide dismutase ; South America
    Language English
    Dates of publication 2013-07
    Size p. 480-491.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1201350-x
    ISSN 1340-3443
    ISSN 1340-3443
    DOI 10.1007/s11418-012-0705-4
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2692: Show issues Location:
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  7. Article: A population history of North America. [Review of: Haines, M.R. and Steckel, R.H., ed. A population history of North America. New York: Cambridge U. Pr., 2000].

    Anderson, Margo

    Journal of American history (Bloomington, Ind.)

    2002  Volume 88, Issue 4, Page(s) 1495–1496

    MeSH term(s) Demography ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; North America ; Population
    Language English
    Publishing date 2002
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 2002867-2
    ISSN 1945-2314 ; 1936-0967 ; 0021-8723
    ISSN (online) 1945-2314 ; 1936-0967
    ISSN 0021-8723
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  8. Book ; Article ; Online: Farm Level Comparison of H.R. 2646 and S. 1731

    Richardson, James W. / Outlaw, Joe L. / Anderson, David P. / Schumann, Keith D. / Feldman, Paul A. / Sartwelle, James D., III / Gill, Chope / Kaman, Paul / Houston, Christy M. / Womack, Abner W.

    2002  

    Abstract: The provisions in the House (H.R. 2646) and Senate (S. 1731) farm bills are analyzed with respect ...

    Abstract The provisions in the House (H.R. 2646) and Senate (S. 1731) farm bills are analyzed with respect to their impacts on 94 representative crop, livestock, and dairy farms. The analysis incorporates both historical price and production risk for the farms so the “safety net” aspects of the bills can be compared. Representative crop livestock and dairy farms for major production regions across the county are analyzed. Information to describe and simulate these farms comes from a panel of farmers in each local area. The farm panels are reconvened frequently to update their farm’s data. The representative farm data base has been used for policy analysis for more than 15 years. The simulation model used for the analysis was developed by AFPC scientists.
    Keywords Agribusiness ; Agricultural and Food Policy
    Language English
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Article ; Online: Representative Farm Analysis of the H.R. 2646 Farm Bill Proposal

    Richardson, James W. / Smith, Edward G. / Womack, Abner W. / Anderson, David P. / Outlaw, Joe L. / Klose, Steven L. / Schumann, Keith D. / Feldman, Paul A.

    2001  

    Keywords Agricultural and Food Policy
    Language English
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: Representative farm analysis of the H.R. 2646 Farm Bill Proposal

    Anderson, David P / Feldman, Paul A / Klose, Steven L / Outlaw, Joe L / Richardson, James W / Schumann, Keith D / Smith, Edward G / Womack, Abner W

    (AFPC briefing paper ; 01-10)

    2001  

    Author's details James W. Richardson; Edward G. Smith; Abner W. Womack; David P. Anderson; Joe L. Outlaw; Steven L. Klose; Keith D. Schumann; Paul A. Feldman
    Series title AFPC briefing paper ; 01-10
    Language English
    Size Online-Ressource (39 S.)
    Publisher Agricultural & Food Policy Center
    Publishing place College Station, Tex
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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