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  1. Article ; Online: [No title information]

    Wolf, Gerhard K / French, Lars E

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 5, Page(s) 744–745

    Title translation Beau-Linien der Fingernägel in Zusammenhang mit kindlichen SARS-CoV-2-Infektionen.
    Language German
    Publishing date 2021-02-10
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14350_g
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Beau-Lines of the fingernails in association with pediatric SARS-CoV-2 infections.

    Wolf, Gerhard K / French, Lars E

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 5, Page(s) 744–745

    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Child, Preschool ; Humans ; Nails, Malformed/etiology ; Nails, Malformed/pathology
    Language English
    Publishing date 2021-03-25
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14350
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: High neutralizing antibody mismatch as a possible reason for vaccine failure in two children with severe tick-borne encephalitis.

    Geißlreiter, Bernd / Kluger, Gerhard / Eschermann, Kirsten / Kiwull, Lorenz / Staudt, Martin / Dobler, Gerhard / Wolf, Gerhard K

    Ticks and tick-borne diseases

    2023  Volume 14, Issue 4, Page(s) 102158

    Abstract: We describe two adolescents (13 and 16 years old) with severe tick-borne encephalitis (TBE) and vaccination breakthrough (VBT). Both suffer from severe persistent neurologic sequelae. Both patients had high TBE-IgG-titers after vaccination at the ... ...

    Abstract We describe two adolescents (13 and 16 years old) with severe tick-borne encephalitis (TBE) and vaccination breakthrough (VBT). Both suffer from severe persistent neurologic sequelae. Both patients had high TBE-IgG-titers after vaccination at the beginning of the infection and a low or missing TBE-IgM response (Type 2 vaccine failure). Neutralization tests show low titers against the respective infecting TBE virus strain and higher titers against the vaccine strain at the beginning of the infection implying an individual weak or impaired immune response to the respective virus as possible cause of TBE vaccine failure. We do not know of any similar observation or explanation for the phenomenon and at the moment can only speculate of a severe course correlated to highly mismatched IgG. This constellation of high TBE IgGs, the lack of immune response and a severe course strongly resembles the severe TBE courses that occurred in the past after TBE immunoglobulin administration. To our knowledge differentiation between structural and functional antibodies by neutralization tests with a) the affecting TBE virus strain and b) the vaccine virus strain in TBE vaccine failures has never been described before. We conclude (1) to consider a TBE virus infection also in vaccinated children presenting with meningoencephalitis, (2) to perform a broad immunological work-up in severe TBE especially after VBT, (3) to further study if high mismatch IgG's are a possible reason for vaccine failure.
    MeSH term(s) Adolescent ; Humans ; Child ; Antibodies, Neutralizing ; Encephalitis, Tick-Borne/prevention & control ; Antibodies, Viral ; Viral Vaccines ; Encephalitis Viruses, Tick-Borne ; Immunoglobulin G
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Viral Vaccines ; Immunoglobulin G
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102158
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  4. Article ; Online: Changes in ventilation distribution during general anesthesia measured with EIT in mechanically ventilated small children.

    Clasen, Dorothea / Winter, Isabel / Rietzler, Stephan / Wolf, Gerhard K

    BMC anesthesiology

    2023  Volume 23, Issue 1, Page(s) 118

    Abstract: Background: Atelectasis during general anesthesia is a risk for perioperative complications. EIT measurements were performed in mechanically ventilated healthy children during elective surgery to demonstrate the changes in ventilation distribution ... ...

    Abstract Background: Atelectasis during general anesthesia is a risk for perioperative complications. EIT measurements were performed in mechanically ventilated healthy children during elective surgery to demonstrate the changes in ventilation distribution during general anesthesia. The ventilation distribution was quantified by calculating the Global Inhomogeneity index (GI).
    Methods: EIT measurements were performed in 23 children (9 weeks-10 years) without lung disease to detect changes in regional ventilation during elective surgery. Three previously defined time points were marked during the measurement: after intubation and start of pressure-controlled ventilation (PCV), change to pressure support ventilation (PSV), and after extubation (spontaneous breathing-SB). Ventilation distribution based on regions of interest (ROI) and changes in end-expiratory volume (∆EELV) were collected at these time points and compared. The Global Inhomogeneity index was calculated at the beginning of pressure-controlled ventilation (PCV).
    Results: With increasing spontaneous breathing, dorsal recruitment of atelectasis occurred. The dorsal ventilation fraction increased over the time of general anesthesia with increasing spontaneous breathing, whereas the ventral fraction decreased relatively (Difference ± 5.5 percentage points respectively; 95% CI; 3.5-7.4; p < 0.001). With the onset of spontaneous breathing, there was a significant reduction in end-expiratory volume (Difference: 105 ml; 95% CI, 75-135; p < 0.001). The GI of the lung-healthy ventilated children is 47% (SD ± 4%).
    Conclusion: Controlled ventilation of healthy children resulted in increased ventilation of the ventral and collapse of the dorsal lung areas. Restart of spontaneous breathing after cessation of surgery resulted in an increase in ventilation in the dorsal with decrease in the ventral lung areas. By calculating the GI, representing the ratio of more to less ventilated lung areas, revealed the presumed homogeneous distribution of ventilation.
    Trial registration: ClinicalTrials.gov Registration ID: NCT04873999. First registration: 05/05/2021.
    MeSH term(s) Child ; Humans ; Anesthesia, General/adverse effects ; Electric Impedance ; Lung ; Pulmonary Atelectasis ; Respiration, Artificial/methods ; Tomography/methods
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-023-02079-z
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  5. Article: Elektrische Impedanztomografie

    Rosemeier, Isabel / Wolf, Gerhard K.

    Neonatologie Scan

    2020  Volume 09, Issue 01, Page(s) 65–77

    Keywords Elektrische Impedanztomografie ; ARDS ; ALI ; lungenprotektive Beatmung
    Language German
    Publishing date 2020-02-27
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2194-5470 ; 2194-5462
    ISSN (online) 2194-5470
    ISSN 2194-5462
    DOI 10.1055/a-0747-9421
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  6. Article: Luft- versus Landrettung bei Kindernotfällen

    Koc, Lisa / Wolf, Gerhard K.

    Der Notarzt

    2020  Volume 36, Issue 03, Page(s) 143–150

    Abstract: In dieser Studie wurden Flug- und Bodenrettungseinsätze bei pädiatrischen Patienten in einer alpinen Region verglichen. Untersucht wurden Diagnosen, Einsatzzeiten, Interventionen, Schweregrade sowie Follow-up-Daten.: Ergebnisse: 1) Beobachtet wurden 2 ...

    Abstract In dieser Studie wurden Flug- und Bodenrettungseinsätze bei pädiatrischen Patienten in einer alpinen Region verglichen. Untersucht wurden Diagnosen, Einsatzzeiten, Interventionen, Schweregrade sowie Follow-up-Daten.
    Ergebnisse: 1) Beobachtet wurden 2 Altersgipfel, 0 – 2 Jahre und 13 – 15 Jahre; 2) chirurgische Notfälle waren häufiger in der Flugrettung, internistische und neurologische Notfälle sowie Intoxikationen zeigten keinen Unterschied; 3) Anfahrt- und Transportzeiten waren in der Bodenrettung signifikant kürzer, die Behandlungsdauer vor Ort war gleich; 4) über 20% aller Patienten hatten NACA-Werte von 1 oder 2, die den Notarzteinsatz nicht rechtfertigen; 5) über 50% der Patienten in der Flugrettung hatten nur einen NACA-Wert (NACA: National Advisory Committee for Aeronautics) von 3; und 6) knapp ein Drittel aller Patienten wurden bereits am Aufnahmetag wieder entlassen. In der retrospektiven Betrachtung erscheint der Anteil der Übertriagierung damit hoch. Möglichkeiten einer verbesserten Triagierung könnten ein genaueres Abfragen des Meldebildes, verbesserte Kommunikation mit den bereits eingetroffenen Rettungskräften und Telemedizin zwischen Leitstelle und Einsatzort sein.
    Keywords pädiatrische Notfallmedizin ; Übertriagierung ; Flugrettung ; Bodenrettung ; Rettungshubschrauber ; Notarzt ; NEF ; pediatric emergency medicine ; unnecessary call-out ; air rescue ; ground rescue ; helicopter transport ; emergency physician
    Language German
    Publishing date 2020-04-15
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2039417-2
    ISSN 1438-8693 ; 0177-2309
    ISSN (online) 1438-8693
    ISSN 0177-2309
    DOI 10.1055/a-1120-8011
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  7. Article: Opportunities for Antibiotic Stewardship Interventions in a Pediatric Hospital

    Grewer-Katona, Gabor / Hüebner, Johannes / Pecar, Alenka / Wolf, Gerhard K.

    Journal of Pediatric Infectious Diseases

    2022  Volume 17, Issue 02, Page(s) 83–89

    Abstract: Objective: This study's objective was to assess an antibiotic stewardship intervention, compare pediatric antibiotic usage in a non-university hospital (Children's Hospital Traunstein [TS]) with a university hospital (Dr. von Hauner Children's Hospital, ...

    Abstract Objective: This study's objective was to assess an antibiotic stewardship intervention, compare pediatric antibiotic usage in a non-university hospital (Children's Hospital Traunstein [TS]) with a university hospital (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich [MUC]), and assess adherence to national guidelines.
    Methods: Antibiotic usage pre- and post-antibiotic stewardship (ABS) intervention was compared, and antibiotic prescriptions over 4 months were prospectively recorded. ABS intervention consisted of weekly teaching sessions, antibiotic pocket cards, and rounds with pediatric infectious disease staff. Medical records were reviewed to describe antibiotic consumption, antibiotic dosages and length of use, and adherence to national guidelines. Pediatric antibiotic usage was compared between hospitals and patient groups.
    Results: After the ABS intervention, the use of second-generation cephalosporins decreased, while penicillin with β-lactamase inhibitors (BLI) increased. Survey of antibiotic prescriptions over the 4 months study period in the non-university hospital showed a high administration rate of second-generation cephalosporins and extended-spectrum penicillins in the non-intensive care units (ICU) wards (48.53 and 38.93 days of therapy [DoT]/1,000 patient days [PD], respectively) and a high rate of third-generation cephalosporins in the ICU ward (110.33 DoT/1,000PD). A high prescriptions rate was seen in the neonatal intensive care unit (NICU) wards (DoT/ length of therapy [LoT] ratio of 2.185). Reserve group antibiotics were only given in the ICU. Adherence to national guidelines was highest in the NICU and pediatric ICU wards. Striking was the relatively high rate of incorrect usage of second-generation cephalosporins. Comparing the pediatric wards of the non-university hospital (TS) and the university hospital (MUC), the prescription ratio was 11.1% (TS) versus 30.6% (MUC), and DoT/1,000PD 198.9 (TS) versus 483.6 (MUC), p  = 0.02. ABS intervention changed the choice of described antibiotics, but not the overall frequency.
    Conclusion: Adherence to national guidelines was highest in fields with standardized therapy recommendations, like in the NICU. In MUC, antibiotics, in particular restricted ones, were prescribed more frequently, probably due to higher severity of illness. These data indicate that the usage of antibiotics and adherence to national guidelines show a wide variety, but ABS interventions were effective in changing prescription behavior.
    Keywords antibiotic prescription ; days of therapy per 1000 patient days ; defined daily dose per 100 patient days ; antibiotic stewardship
    Language English
    Publishing date 2022-02-28
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2236947-8
    ISSN 1305-7693 ; 1305-7707 ; 1871-0336
    ISSN (online) 1305-7693
    ISSN 1305-7707 ; 1871-0336
    DOI 10.1055/s-0042-1744559
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  8. Article ; Online: Mechanical Ventilation Guided by Electrical Impedance Tomography in Children With Acute Lung Injury.

    Rosemeier, Isabel / Reiter, Karl / Obermeier, Viola / Wolf, Gerhard K

    Critical care explorations

    2019  Volume 1, Issue 7, Page(s) e0020

    Abstract: Objectives: To provide proof-of-concept for a protocol applying a strategy of personalized mechanical ventilation in children with acute respiratory distress syndrome. Positive end-expiratory pressure and inspiratory pressure settings were optimized ... ...

    Abstract Objectives: To provide proof-of-concept for a protocol applying a strategy of personalized mechanical ventilation in children with acute respiratory distress syndrome. Positive end-expiratory pressure and inspiratory pressure settings were optimized using real-time electrical impedance tomography aiming to maximize lung recruitment while minimizing lung overdistension.
    Design: Prospective interventional trial.
    Setting: Two PICUs.
    Patients: Eight children with early acute respiratory distress syndrome (< 72 hr).
    Interventions: On 3 consecutive days, electrical impedance tomography-guided positive end-expiratory pressure titration was performed by using regional compliance analysis. The Acute Respiratory Distress Network high/low positive end-expiratory pressure tables were used as patient's safety guardrails. Driving pressure was maintained constant. Algorithm includes the following: 1) recruitment of atelectasis: increasing positive end-expiratory pressure in steps of 4 mbar; 2) reduction of overdistension: decreasing positive end-expiratory pressure in steps of 2 mbar until electrical impedance tomography shows collapse; and 3) maintaining current positive end-expiratory pressure and check regional compliance every hour. In case of derecruitment start at step 1.
    Measurements and main results: Lung areas classified by electrical impedance tomography as collapsed or overdistended were changed on average by -9.1% (95% CI, -13.7 to -4.4;
    Conclusions: Electrical impedance tomography-guided positive end-expiratory pressure titration reduced regional lung collapse without significant increase of overdistension, while improving global compliance and gas exchange in children with acute respiratory distress syndrome.
    Language English
    Publishing date 2019-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000020
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  9. Book ; Thesis: Klinische Forschung mittels verteilungsunabhängiger Methoden

    Wolf, Gerhard K.

    (Medizinische Informatik und Statistik ; 24)

    1980  

    Author's details Gerhard K. Wolf
    Series title Medizinische Informatik und Statistik ; 24
    Collection
    Keywords Klinische Medizin ; Forschung ; Forschungsmethode
    Subject Forschung ; Wissenschaftliche Forschung ; Forschungen
    Language German
    Size X, 141 S. : graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Habil.-Schr., 1978
    HBZ-ID HT001005095
    ISBN 3-540-10268-X ; 0-387-10268-X ; 978-3-540-10268-7 ; 978-0-387-10268-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1981 A 3767 order for loan Magazin

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  10. Book: Klinische Forschung

    Koch, Winfried / Wolf, Gerhard K.

    Hinweise und Checkliste für die Planung von therapeutischen Studien

    1989  

    Author's details Winfried Koch ; Gerhard Karl Wolf
    Keywords Clinical Trials ; Research Design ; Klinische Prüfung ; Planung
    Subject Plan ; Arzneimittel ; Arzneimittelstudie
    Size VII, 63 S.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT003468738
    ISBN 3-540-50936-4 ; 0-387-50936-4 ; 978-3-540-50936-3 ; 978-0-387-50936-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 B 513 order for loan Magazin

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