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Article ; Online: The association of coffee consumption rate with serum 25-hydroxyvitamin D, non-HDL levels, and TC/HDL ratio in females with vitamin D deficiency.

Habash, Maha / Al-Shakhshir, Sami / Abusamak, Mohammad / Mohammad, Mohammad Yasin / AbuSamak, Mahmoud

2022 Volume 18, Page(s) 17455057221112268

Abstract: Objectives: The purpose of this study was to evaluate the association of coffee consumption rate with serum 25-hydroxyvitamin D, non-high-density lipoprotein cholesterol levels, and total cholesterol to high-density lipoprotein cholesterol ratio in ... ...

Abstract	Objectives: The purpose of this study was to evaluate the association of coffee consumption rate with serum 25-hydroxyvitamin D, non-high-density lipoprotein cholesterol levels, and total cholesterol to high-density lipoprotein cholesterol ratio in females with vitamin D deficiency. Methods: This retrospective cross-sectional study was carried out by studying the records of 270 Jordanian females aged 18-65 years with varying degrees of vitamin D deficiency. Following completion of the questionnaire regarding their anthropometric characteristics and coffee consumption rate during the preceding 3 months, the participants were required to provide blood samples for analysis to measure 25-hydroxyvitamin D and lipid profile levels including non-high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol ratio. Results: The current study demonstrated that coffee consumption rate and vitamin D deficiency were significantly positively connected with the total cholesterol to high-density lipoprotein cholesterol ratio ( Conclusion: Higher coffee consumption rate among women with vitamin D deficiency significantly elevated total cholesterol to high-density lipoprotein cholesterol ratio that may increase woman's risk of hyperlipidemia.
MeSH term(s)	Cholesterol ; Cholesterol, HDL ; Coffee ; Cross-Sectional Studies ; Female ; Humans ; Retrospective Studies ; Vitamin D/analogs & derivatives ; Vitamin D Deficiency/epidemiology
Chemical Substances	Cholesterol, HDL ; Coffee ; Vitamin D (1406-16-2) ; Cholesterol (97C5T2UQ7J) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2022-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274503-8
ISSN	1745-5065 ; 1745-5057
ISSN (online)	1745-5065
ISSN	1745-5057
DOI	10.1177/17455057221112268
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Zs.A 6629: Show issues

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Article ; Online: The Effect of Weekly 50,000 IU Vitamin D

Bader, Dana A / Abed, Anas / Mohammad, Beisan A / Aljaberi, Ahmad / Sundookah, Ahmad / Habash, Maha / Alsayed, Ahmad R / Abusamak, Mohammad / Al-Shakhshir, Sami / Abu-Samak, Mahmoud

Nutrients

2023 Volume 15, Issue 5

Abstract: This research aimed to evaluate the effects of high-dose cholecalciferol ( ... ...

Abstract	This research aimed to evaluate the effects of high-dose cholecalciferol (VD
MeSH term(s)	Adult ; Humans ; Cholecalciferol ; Interleukin-10 ; Cytokines ; Leptin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Cytokine Release Syndrome ; Dietary Supplements ; Vitamin D Deficiency ; Vitamin D ; Double-Blind Method
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Interleukin-10 (130068-27-8) ; Cytokines ; Leptin ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Vitamin D (1406-16-2)
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15051188
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Article: Improved Reptile Search Algorithm by Salp Swarm Algorithm for Medical Image Segmentation.

Abualigah, Laith / Habash, Mahmoud / Hanandeh, Essam Said / Hussein, Ahmad MohdAziz / Shinwan, Mohammad Al / Zitar, Raed Abu / Jia, Heming

Journal of bionic engineering

2023 , Page(s) 1–25

Abstract: This study proposes a novel nature-inspired meta-heuristic optimizer based on the Reptile Search Algorithm combed with Salp Swarm Algorithm for image segmentation using gray-scale multi-level thresholding, called RSA-SSA. The proposed method introduces a ...

Abstract	This study proposes a novel nature-inspired meta-heuristic optimizer based on the Reptile Search Algorithm combed with Salp Swarm Algorithm for image segmentation using gray-scale multi-level thresholding, called RSA-SSA. The proposed method introduces a better search space to find the optimal solution at each iteration. However, we proposed RSA-SSA to avoid the searching problem in the same area and determine the optimal multi-level thresholds. The obtained solutions by the proposed method are represented using the image histogram. The proposed RSA-SSA employed Otsu's variance class function to get the best threshold values at each level. The performance measure for the proposed method is valid by detecting fitness function, structural similarity index, peak signal-to-noise ratio, and Friedman ranking test. Several benchmark images of COVID-19 validate the performance of the proposed RSA-SSA. The results showed that the proposed RSA-SSA outperformed other metaheuristics optimization algorithms published in the literature.
Language	English
Publishing date	2023-02-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2233712-X
ISSN	2543-2141 ; 1672-6529
ISSN (online)	2543-2141
ISSN	1672-6529
DOI	10.1007/s42235-023-00332-2
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Article ; Online: Pathogenicity of Two Nematodes Tetramerese sp. and Microtetramerese Spiralis in Proventriculus of Some Aquatic Birds from Al-Sanaf Marshes in Thi-Qar Province, South of Iraq

Zainab Abd-Ali Mohammad / Abdul-Hussein Habash Awad

مجلة علوم ذي قار, Vol 7, Iss

2020 Volume 2

Abstract: The present study was carried out to investigate the prevalence and mean of intensity of two nematodes Tetramerese sp. and Microtetrameresespiralis isolated from some of aquatic birds collected from Al-Sanaf marshes, Thi-Qar province.The pathological ... ...

Abstract	The present study was carried out to investigate the prevalence and mean of intensity of two nematodes Tetramerese sp. and Microtetrameresespiralis isolated from some of aquatic birds collected from Al-Sanaf marshes, Thi-Qar province.The pathological effects of these parasites on the tissues of the infected aquatic birds were recorded.TheTetramerese sp. females were embedded in glands of proventriculus of the some aquatic birds including: Ardea ralloides, Egretta garazeta, Nycticorax nycticorax, Himantopus himantopus, Larus genei, Bubulicus ibis, Aredea purpurea and Anas clypeata with prevalence 12.57% and mean of intensity 3.00, while the Microtetrameresespiralis embedded in gastric glands of proventriculus of Bubulicusibis with prevalence 10% and mean of intensity 25.00.Histopathological examination of infected tissues showed dilation of the proventericular gland lumen, atrophy, necrosis and degeneration of the glandular cells of proventriculus
Keywords	Tetramerese sp. ; Microtetramereses spiralis ; Aquatic birds ; Proventriculus ; Pathogenicity ; Iraq ; Physics ; QC1-999 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	590
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	University of Thi-Qar
Document type	Article ; Online
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Article ; Online: Combined Effect of Omega-3 Fatty Acid and Vitamin D 3 on Oxidized LDL-C and Non-HDL-C Levels in People With Vitamin D Deficiency: A Randomized Controlled Trial.

Mehdawi, Amani / Mohammad, Beisan A / Mosleh, Ibrahim / Khader, Heba A / Habash, Maha / Nassar, Razan I / Awwad, Shady / Hasoun, Luai / Abu-Samak, Mahmoud S

Journal of cardiovascular pharmacology

2023 Volume 81, Issue 4, Page(s) 251–258

Abstract: Abstract: The present randomized clinical trial (RCT) was conducted on Jordanian participants with vitamin D deficiency (VDD) with no other medical conditions, to evaluate the combined effect of 1,25-dihydroxy vitamin D 3 (Vit.D 3 ) and omega-3 fatty ... ...

Abstract	Abstract: The present randomized clinical trial (RCT) was conducted on Jordanian participants with vitamin D deficiency (VDD) with no other medical conditions, to evaluate the combined effect of 1,25-dihydroxy vitamin D 3 (Vit.D 3 ) and omega-3 fatty acid (n-3FA) supplements (D+) on oxidized low-density lipoprotein (Ox-LDL) and non-high-density lipoprotein cholesterol (non-HDL-C) levels as common predictors of cardiovascular diseases (CVDs). Participants were randomized into 4 groups as follows: a control group (C) that received no supplementations, a Vit.D 3 group that received 50,000 IU of Vit.D 3 every week, an n-3FA group that received 300 mg of omega-3 fatty acid every day, and a D+ group that received a combination of both supplements, with the same dosage administered by the previous groups but with a 4-6-hour time interval between Vit.D 3 and n-3FA administration to avoid any possible interaction. All supplementations were administered orally for 8 weeks. Forty-seven participants were allocated to each group. Twenty-six in the control group, 37 participants in the Vit.D 3 group, 37 participants in the n-3FA group, and 46 participants in the D+ group completed the study to the end. The D+ supplementations significantly increased non-HDL-C (118.99 ± 60.98 to 155.26 ± 43.36 mg/dL, P << 0.05) but decreased Ox-LDL-C levels (69.29 ± 37.69 to 52.81 ± 17.30 pg/mL, P = 0.03). The stepwise regression showed that the serum LDL-C level was the main independent variable involved in the elevation of non-HDL levels (R 2 = 0.837) observed at the end of the trial in the D+ group. The groups that were supplemented with either Vit.D 3 alone or n-3FA alone had an insignificant decrease in the level of Ox-LDL-C. In conclusion, despite the observed hyperlipidemic effect, the combination treatment is recommended by the research team because the decrease in Ox-LDL may offset the hyperlipidemic effect.
MeSH term(s)	Humans ; Fatty Acids, Omega-3/adverse effects ; Cholecalciferol ; Lipoproteins, LDL ; Cholesterol ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy
Chemical Substances	oxidized low density lipoprotein ; Fatty Acids, Omega-3 ; Cholecalciferol (1C6V77QF41) ; Lipoproteins, LDL ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001398
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Article: The effect of omega-3 supplements on the serum levels of ACE/ACE2 ratio as a potential key in cardiovascular disease: A randomized clinical trial in participants with vitamin D deficiency.

Daboul, Sara M / Abusamak, Mohammad / Mohammad, Beisan A / Alsayed, Ahmad R / Habash, Maha / Mosleh, Ibrahim / Al-Shakhshir, Sami / Issa, Reem / Abu-Samak, Mahmoud

Pharmacy practice

2022 Volume 21, Issue 1, Page(s) 2761

Abstract: Objective: The aim of this randomized controlled clinical trial was to determine the effect of the omega-3 fatty acid supplementations 300 mg per day for 8 weeks on the serum levels of ACE/ACE2 ratio in Jordanian participants with vitamin D deficiency ( ... ...

Abstract	Objective: The aim of this randomized controlled clinical trial was to determine the effect of the omega-3 fatty acid supplementations 300 mg per day for 8 weeks on the serum levels of ACE/ACE2 ratio in Jordanian participants with vitamin D deficiency (VDD). Methods: The physical and clinical characteristic of individuals in both intervention and control randomized controlled clinical trial were measured and analyzed. The comparisons between the two groups and the changes in each group before and after taking omega-3 doses were studied through independent t test and paired t test, respectively. Possible factors that have a role in the changes were determined by multivariate stepwise regression. Follow-up period lasted 10 weeks. Results: The sample consisted of 82 participants with VDD and a mean age of 37.85 ± 9.85 years. Omega-3 Supplements resulted in a significant decrease in serum ACE levels, ACE/ACE2 ratio and serum 25-hydroxy vitamin D (25OHD). While the change in serum ACE2 levels and serum triglycerides levels were insignificant. Also, a significant increase in serum LDL levels were observed. Conclusion: It is possible that taking high doses of omega-3 fatty acid supplementations have positive effects on the heart and circulatory system and could protect from COVID-19 or decrease disease severity, in connection with a decrease in the ACE/ACE 2 ratio. On the other hand, omega-3 supplement may have negative effect on cardiovascular system due to the significant increase in serum LDL levels.
Language	English
Publishing date	2022-12-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2414565-8
ISSN	1886-3655 ; 1885-642X
ISSN (online)	1886-3655
ISSN	1885-642X
DOI	10.18549/PharmPract.2023.1.2761
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Article ; Online: Accuracy of noninvasive fibrosis scores in predicting advanced fibrosis in pediatric patients after liver transplantation.

Habash, Nawras / Ezaizi, Yamen / Kak, Ibrahim / Conjeevaram Selvakumar, Praveen Kumar / Lopez, Rocio / Alkhouri, Naim / Kabbany, Mohammad Nasser

Pediatric transplantation

2022 Volume 26, Issue 5, Page(s) e14279

Abstract: Background: Liver biopsy is the gold standard to stage fibrosis in liver disease. Several scoring systems have been studied to predict advanced fibrosis in liver disease. Those scores have not been validated in pediatric liver transplant patients.: ... ...

Abstract	Background: Liver biopsy is the gold standard to stage fibrosis in liver disease. Several scoring systems have been studied to predict advanced fibrosis in liver disease. Those scores have not been validated in pediatric liver transplant patients. Aim: Evaluate the performance of three fibrosis scores (FSc) in assessing the presence of advanced fibrosis (AF) in children after orthotopic liver transplantation (OLT). Methods: Patients < 20 years of age who underwent liver biopsy post-OLT with laboratory values within 1 month of the biopsy were included. Fibrosis was determined by an experienced pathologist (F0-4). We defined AF as F3-4. The following FSc were calculated: AST/ALT ratio, APRI, and FIB-4 index. Receiver operating characteristic curve analysis was done to assess the FSc performance in predicting AF. Results: A total of 232 biopsies were analyzed, of those 42 (18.1%) showed AF (F3-4). FIB-4 was significantly higher in patients with AF compared to those without AF [median value of 1.1 [0.7, 3.0] and 0.6 [0.2, 1.4], respectively (p = .02)]; however, FIB-4 had satisfactory accuracy to diagnose AF with significant overlap and AUC of 0.68 (CI 0.56-0.81). Cutoff points of 0.2 and 3.03 were used to rule in and rule out AF, respectively. AST/ALT and APRI were not significantly different between patients with and without AF. Conclusion: Even though FIB-4 had satisfactory accuracy in detecting AF in pediatric transplant patients, noninvasive hepatic FSc developed in adults still performed poorly. Our results highlight the need to develop a reliable pediatric FSc.
MeSH term(s)	Adult ; Aspartate Aminotransferases ; Biomarkers ; Biopsy ; Child ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Liver Cirrhosis/surgery ; Liver Transplantation ; Platelet Count/methods ; ROC Curve ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2022-04-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14279
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Zs.A 4947: Show issues

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Article ; Online: Vancomycin therapeutic monitoring by measured trough concentration versus Bayesian-derived area under the curve in critically ill patients with cancer.

AbuSara, Aseel K / Abdelrahman, Deema H / Habash, Khader I / Al-Shaer, Mohammad H / Le, Jennifer / Nazer, Lama H

Pharmacology research & perspectives

2022 Volume 10, Issue 1, Page(s) e00912

Abstract: The updated vancomycin guideline and recent studies suggested that trough concentrations may result in underestimation of the actual area under the curve (AUC), leading to excessive dosing and nephrotoxicity. With limited data available on critically ill ...

Abstract	The updated vancomycin guideline and recent studies suggested that trough concentrations may result in underestimation of the actual area under the curve (AUC), leading to excessive dosing and nephrotoxicity. With limited data available on critically ill cancer patients, this study aimed to compare the two methods in this patient population. This was a 5-year retrospective study on patients treated with vancomycin in the intensive care unit (ICU) of a comprehensive cancer center. The measured trough concentration was compared to Bayesian-derived AUC/minimum-inhibitory-concentration (MIC), considering MIC as 1. Trough concentrations of 15-20 mg/L and AUC of 400-600 mg h/L were considered the targeted goal. Multivariate analysis was performed to identify factors associated with an AUC below the targeted goal. During the study period, 316 patients were included. The mean age was 54 years ±16 (SD); most patients had solid tumors (75%), and 11% had neutropenia. A targeted goal AUC and trough were recorded in 128 (41%) patients and in 64 (20%) patients, respectively. Of the 128 patients with targeted goal AUC, 31 (24%) had targeted goal trough concentrations and 91 (71%) had trough concentrations below 15 mg/L. Furthermore, among the patients with targeted goal trough concentration (n = 64), 33 (52%) had higher than targeted goal AUC. Augmented renal clearance (ARC), defined as a calculated creatinine-clearance ≥130 ml/min, was associated with an AUC below the targeted goal. In a cohort of critically ill patients with cancer, over two-thirds of the patients with a targeted goal Bayesian AUC/MIC had trough concentrations below the targeted goal. ARC was associated with AUC below the targeted goal.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Area Under Curve ; Bayes Theorem ; Cohort Studies ; Critical Illness ; Drug Monitoring/methods ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Neoplasms/pathology ; Retrospective Studies ; Vancomycin/administration & dosage ; Vancomycin/pharmacokinetics
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.912
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Article: Epidemiology of Sepsis Syndrome among Intensive Care Unit Patients at a Tertiary University Hospital in Palestine in 2019.

Rabee, Hadi A / Tanbour, Raghad / Nazzal, Zaher / Hamshari, Yousef / Habash, Yousef / Anaya, Ahmad / Iter, Abbas / Gharbeyah, Mohammad / Abugaber, Dina

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2020 Volume 24, Issue 7, Page(s) 551–556

Abstract: ... Tanbour R, Nazzal Z, Hamshari Y, Habash Y, Anaya A, ...

Abstract	Background: Sepsis syndrome is an emerging healthcare problem, especially in critically ill patients, regardless whether it's community- or hospital-acquired sepsis. This study evaluates the characteristics of these patients, in addition to the type, source, and outcome of sepsis and septic shock, in a university tertiary hospital in Palestine. It also studies the most common organisms encountered in these patients. Materials and methods: This is retrospective observational chart review study of all adult admissions to the intensive care unit over a period of 2 years. The presence of sepsis and septic shock was assessed and documented based on the Third International Consensus Definitions (Sepsis-3). Data regarding demographics, severity, comorbidities, source of infection, microbiology, length of stay, and outcomes (dead/alive at discharge from ICU) were recorded. Results: A total number of 174 patients were included. The mean age was 57.4 years, with cardiovascular diseases and diabetes being the leading comorbidities encountered in them. Respiratory infections were the most common site of sepsis, found in around 71% of patients, followed by urinary tract infections. More than 70% of cases were due to hospital-acquired infections (HAIs). Conclusion: Both sepsis and septic shock carry high morbidity and mortality rates, and they are very frequent among critically ill patients. Special care and developing management bundles are crucial in controlling and preventing this threat. How to cite this article: Rabee HA, Tanbour R, Nazzal Z, Hamshari Y, Habash Y, Anaya A,
Language	English
Publishing date	2020-09-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-23474
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Article ; Online: Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling.

Khanfar, Mohammad A / Al-Qtaishat, Saja / Habash, Maha / Taha, Mutasem O

Chemico-biological interactions

2016 Volume 254, Page(s) 93–101

Abstract: Adenosine A2A receptor antagonists are of great interest in the treatment for Parkinson's disease. In this study, we combined extensive pharmacophore modeling and quantitative structure-activity relationship (QSAR) analysis to explore the structural ... ...

Abstract	Adenosine A2A receptor antagonists are of great interest in the treatment for Parkinson's disease. In this study, we combined extensive pharmacophore modeling and quantitative structure-activity relationship (QSAR) analysis to explore the structural requirements for potent Adenosine A2A antagonists. Genetic function algorithm (GFA) joined with k nearest neighbor (kNN) analyses were applied to build predictive QSAR models. Successful pharmacophores were complemented with exclusion spheres to improve their receiver operating characteristic curve (ROC) profiles. Best QSAR models and their associated pharmacophore hypotheses were validated by identification of several novel Adenosine A2A antagonist leads retrieved from the National Cancer Institute (NCI) structural database. The most potent hit illustrated IC50 value of 545.7 nM.
MeSH term(s)	Adenosine A2 Receptor Antagonists/chemistry ; Adenosine A2 Receptor Antagonists/metabolism ; Adenosine A2 Receptor Antagonists/therapeutic use ; Algorithms ; Antiparkinson Agents/chemistry ; Antiparkinson Agents/metabolism ; Antiparkinson Agents/therapeutic use ; Drug Design ; Humans ; Models, Molecular ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology ; Quantitative Structure-Activity Relationship ; ROC Curve ; Receptor, Adenosine A2A/chemistry ; Receptor, Adenosine A2A/metabolism
Chemical Substances	Adenosine A2 Receptor Antagonists ; Antiparkinson Agents ; Receptor, Adenosine A2A
Language	English
Publishing date	2016-07-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2016.05.023
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