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Article ; Online: A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant.

Zhao, Yuan-Yuan / Hwang, Bokyeong / Lee, Yeju / Yoon, Juyoung

2024 Volume 11, Issue 4, Page(s) nwae048

Language	English
Publishing date	2024-02-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwae048
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Article ; Online: Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma.

Hwang, Juyoung / Jin, Jun-O

Biomolecules

2020 Volume 10, Issue 8

Abstract: Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the ... ...

Abstract	Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.
MeSH term(s)	Acrylic Resins/chemistry ; Allyl Compounds/chemistry ; Animals ; Drug Carriers/chemistry ; Drug Delivery Systems ; Hydrogels/chemistry ; Indocyanine Green/administration & dosage ; Indocyanine Green/therapeutic use ; Melanoma/pathology ; Melanoma/therapy ; Mice, Inbred C57BL ; Photothermal Therapy/methods ; Quaternary Ammonium Compounds/chemistry ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
Chemical Substances	Acrylic Resins ; Allyl Compounds ; Drug Carriers ; Hydrogels ; Quaternary Ammonium Compounds ; poly(acrylamide-co-diallyldimethylammonium chloride) ; Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2020-07-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom10081124
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Article ; Online: Escherichia coli

Hwang, Juyoung / An, Eun-Koung / Kim, So-Jung / Zhang, Wei / Jin, Jun-O

ACS nano

2022 Volume 16, Issue 5, Page(s) 8472–8483

Abstract: Most cancer-related deaths are due to metastasis or recurrence. Therefore, the ultimate goal of cancer therapy will be to treat metastatic and recurrent cancers. Combination therapy for cancer will be one of trial for effective treating metastasis and ... ...

Abstract	Most cancer-related deaths are due to metastasis or recurrence. Therefore, the ultimate goal of cancer therapy will be to treat metastatic and recurrent cancers. Combination therapy for cancer will be one of trial for effective treating metastasis and recurrence. In this study,
MeSH term(s)	Mice ; Animals ; Gold/chemistry ; Escherichia coli ; Cell Line, Tumor ; Nanotubes/chemistry ; Immunotherapy ; Immunologic Factors ; Phototherapy ; Neoplasms
Chemical Substances	Gold (7440-57-5) ; Immunologic Factors
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c03379
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Article: Immunomodulatory effects of polysaccharides from marine algae for treating cancer, infectious disease, and inflammation

Hwang, Juyoung / Yadav, Dhananjay / Lee, Peter CW / Jin, Jun‐O

Phytotherapy research. 2022 Feb., v. 36, no. 2

2022

Abstract: A significant rise in the occurrence and severity of adverse reactions to several synthetic drugs has fueled considerable interest in natural product‐based therapeutics. In humans and animals, polysaccharides from marine microalgae and seaweeds have ... ...

Abstract	A significant rise in the occurrence and severity of adverse reactions to several synthetic drugs has fueled considerable interest in natural product‐based therapeutics. In humans and animals, polysaccharides from marine microalgae and seaweeds have immunomodulatory effects. In addition, these polysaccharides may possess antiviral, anticancer, hypoglycemic, anticoagulant, and antioxidant properties. During inflammatory diseases, such as autoimmune diseases and sepsis, immunosuppressive molecules can serve as therapeutic agents. Similarly, molecules that participate in immune activation can induce immune responses against cancer and infectious diseases. We aim to discuss the chemical composition of the algal polysaccharides, namely alginate, fucoidan, ascophyllan, and porphyran. We also summarize their applications in the treatment of cancer, infectious disease, and inflammation. Recent applications of nanoparticles that are based on algal polysaccharides for the treatment of cancer and inflammatory diseases have also been addressed. In conclusion, these applications of marine algal polysaccharides could provide novel therapeutic alternatives for several diseases.
Keywords	alginates ; anticoagulants ; antioxidants ; chemical composition ; fucoidan ; immunosuppression ; infectious diseases ; inflammation ; microalgae ; phytotherapy ; research
Language	English
Dates of publication	2022-02
Size	p. 761-777.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7348
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunomodulatory effects of polysaccharides from marine algae for treating cancer, infectious disease, and inflammation.

Hwang, Juyoung / Yadav, Dhananjay / Lee, Peter Cw / Jin, Jun-O

Phytotherapy research : PTR

2021 Volume 36, Issue 2, Page(s) 761–777

Abstract: A significant rise in the occurrence and severity of adverse reactions to several synthetic drugs has fueled considerable interest in natural product-based therapeutics. In humans and animals, polysaccharides from marine microalgae and seaweeds have ... ...

Abstract	A significant rise in the occurrence and severity of adverse reactions to several synthetic drugs has fueled considerable interest in natural product-based therapeutics. In humans and animals, polysaccharides from marine microalgae and seaweeds have immunomodulatory effects. In addition, these polysaccharides may possess antiviral, anticancer, hypoglycemic, anticoagulant, and antioxidant properties. During inflammatory diseases, such as autoimmune diseases and sepsis, immunosuppressive molecules can serve as therapeutic agents. Similarly, molecules that participate in immune activation can induce immune responses against cancer and infectious diseases. We aim to discuss the chemical composition of the algal polysaccharides, namely alginate, fucoidan, ascophyllan, and porphyran. We also summarize their applications in the treatment of cancer, infectious disease, and inflammation. Recent applications of nanoparticles that are based on algal polysaccharides for the treatment of cancer and inflammatory diseases have also been addressed. In conclusion, these applications of marine algal polysaccharides could provide novel therapeutic alternatives for several diseases.
MeSH term(s)	Animals ; Communicable Diseases/drug therapy ; Humans ; Immunity ; Inflammation/drug therapy ; Neoplasms/drug therapy ; Polysaccharides/therapeutic use ; Seaweed/chemistry
Chemical Substances	Polysaccharides
Language	English
Publishing date	2021-12-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7348
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Article ; Online: Dual-functional alginate and collagen-based injectable hydrogel for the treatment of cancer and its metastasis.

Hwang, Juyoung / An, Eun-Koung / Zhang, Wei / Kim, Hyo Jeong / Eom, Youngho / Jin, Jun-O

Journal of nanobiotechnology

2022 Volume 20, Issue 1, Page(s) 245

Abstract: Background: Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill cancer cells. However, there are ... ...

Abstract	Background: Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill cancer cells. However, there are difficulties in inducing cancer antigen-specific immunity due to limited knowledge regarding cancer antigens. In this study, we synthesized a dual-functional hydrogel to induce antigen generation and immune activation. Results: To elicit a cancer self-antigen-specific immune response, we synthesized an alginate-collagen-based injectable hydrogel, called thermally responsive hydrogel (pTRG), which was incorporated with indocyanine green and the immune stimulator polyinosinic:polycytidylic acid (poly I:C). pTRG was evaluated for its anticancer and anti-metastatic effects against CT-26 carcinoma and 4T1 breast tumor in mice by combining photothermal therapy (PTT) and immunotherapy. Near-infrared (NIR) irradiation promoted temperature elevation in pTRG, consequently exerting a therapeutic effect on mouse tumors. Lung metastasis was prevented in cured CT-26 tumor-injected mice following pTRG treatment via cancer antigen-specific T cell immunity. Moreover, pTRG successfully eliminated the original tumor in 4T1 tumor-bearing mice via PTT and protected them from lung metastasis. To further evaluate the carrier function of TRGs, different types of immunotherapeutic molecules were incorporated into TRGs, which led to the effective elimination of the first CT-26 tumor and the prevention of lung metastasis. Conclusions: Our data demonstrate that TRG is a efficient material not only for treating primary tumors but also for preventing metastasis and recurrence.
MeSH term(s)	Alginates ; Animals ; Collagen ; Hydrogels ; Immunotherapy ; Lung Neoplasms ; Mice
Chemical Substances	Alginates ; Hydrogels ; Collagen (9007-34-5)
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-022-01458-x
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Article ; Online: Mice Plasmacytoid Dendritic Cells Were Activated by Lipopolysaccharides Through Toll-Like Receptor 4/Myeloid Differentiation Factor 2.

Zhang, Wei / An, Eun-Koung / Hwang, Juyoung / Jin, Jun-O

Frontiers in immunology

2021 Volume 12, Page(s) 727161

Abstract: Plasmacytoid dendritic cells (pDCs) are known to respond to viral infections. However, the activation of pDCs by bacterial components such as lipopolysaccharides (LPS) has not been well studied. Here, we found that pDCs, conventional dendritic cells ( ... ...

Abstract	Plasmacytoid dendritic cells (pDCs) are known to respond to viral infections. However, the activation of pDCs by bacterial components such as lipopolysaccharides (LPS) has not been well studied. Here, we found that pDCs, conventional dendritic cells (cDCs), and B cells express high levels of toll-like receptor 4 (TLR4), a receptor for LPS. Moreover, LPS could effectively bind to not only cDCs but also pDCs and B cells. Intraperitoneal administration of LPS promoted activation of splenic pDCs and cDCs. LPS treatment led to upregulation of interferon regulatory factor 7 (IRF7) and induced production of interferon-alpha (IFN-α) in splenic pDCs. Furthermore, LPS-dependent upregulation of co-stimulatory molecules in pDCs did not require the assistance of other immune cells, such as cDCs. However, the production levels of IFN-α were decreased in cDC-depleted splenocytes, indicating that cDCs may contribute to the enhancement of IFN-α production in pDCs. Finally, we showed that activation of pDCs by LPS requires the TLR4 and myeloid differentiation factor 2 (MD2) signaling pathways. Thus, these results demonstrate that the gram-negative component LPS can directly stimulate pDCs
MeSH term(s)	Animals ; Dendritic Cells/immunology ; Female ; Interferon Regulatory Factor-7/immunology ; Interferon-alpha/immunology ; Lipopolysaccharides ; Lymphocyte Antigen 96/genetics ; Lymphocyte Antigen 96/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Spleen/cytology ; Spleen/immunology ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology ; Mice
Chemical Substances	Interferon Regulatory Factor-7 ; Interferon-alpha ; Irf7 protein, mouse ; Lipopolysaccharides ; Ly96 protein, mouse ; Lymphocyte Antigen 96 ; Tlr2 protein, mouse ; Tlr4 protein, mouse ; Toll-Like Receptor 2 ; Toll-Like Receptor 4
Language	English
Publishing date	2021-09-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.727161
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Article ; Online: Effects of Prostaglandin E1 on Mastectomy Flap Necrosis in Immediate Implant-based Breast Reconstruction.

Hwang, Ji Won / Lim, Woo Sung / Kim, Hyun Goo / Park, Jin-Woo / Bae, Juyoung / Park, Seyeon / Jeon, Byung-Joon / Woo, Kyong-Je

Plastic and reconstructive surgery

2023

Abstract: Purpose: Necrosis of a cutaneous flap including the nipple-areolar complex is a common complication in immediate implant-based breast reconstruction following nipple/skin-sparing mastectomy (NSM/SSM). This study aimed to evaluate the efficacy of ... ...

Abstract	Purpose: Necrosis of a cutaneous flap including the nipple-areolar complex is a common complication in immediate implant-based breast reconstruction following nipple/skin-sparing mastectomy (NSM/SSM). This study aimed to evaluate the efficacy of prostaglandin E1 (PGE1) in reducing such complications. Methods: A retrospective analysis of prospectively collected data was conducted at two centers, and the cohort consisted of patients undergoing NSM/SSM followed by immediate reconstruction with a prosthesis. Patients who were randomly allocated to the treatment group were administered daily intravenous PGE1 (10 mcg/2 mL) beginning intraoperatively through postoperative day 6. Skin flap complications including nipple/skin necrosis, delayed wound healing, and postoperative wound revision were recorded. Complication rates were compared between the PGE1 and control groups. Results: A total of 276 breasts in 259 patients were included for analysis (139 breasts to the treatment group and 137 breasts to the control group). There was no difference in patient demographics between the control and treatment group. Reconstructed breasts receiving PGE1 had significantly lower rates for overall skin complications (21.6% vs. 34.3%, p=0.022) and wound revision (2.9% vs. 9.5%, p=0.025). Among NSM cases, the PGE1 group showed a significantly lower rate of nipple necrosis (15.5% vs. 29.4%, p=0.027). In the multivariate analysis, the use of PGE1 significantly reduced the risk of overall skin flap complications (odds=0.491, p=0.018), wound revision (odds=0.213, p=0.018) in NSM/SSM cases, and nipple necrosis (odds=0.357 p=0.008) in NSM cases. Conclusion: PGE1 can be effective in reducing risk of mastectomy flap complications in immediate implant-based breast reconstructions.
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010991
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Article: Cancer immunotherapy using a polysaccharide from

Park, Hae-Bin / Lim, Seong-Min / Hwang, Juyoung / Zhang, Wei / You, SangGuan / Jin, Jun-O

Oncoimmunology

2020 Volume 9, Issue 1, Page(s) 1772663

Abstract: Natural polysaccharides have shown immune modulatory effects with low toxicity in both animal and human models. A previous study has shown that the polysaccharide from : Abbreviations: CFP: ...

Abstract	Natural polysaccharides have shown immune modulatory effects with low toxicity in both animal and human models. A previous study has shown that the polysaccharide from Abbreviations: CFP:
MeSH term(s)	Animals ; China ; Disease Models, Animal ; Immunotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neoplasms/drug therapy ; Polysaccharides/pharmacology
Chemical Substances	Polysaccharides
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-4011
ISSN (online)	2162-402X
ISSN	2162-4011
DOI	10.1080/2162402X.2020.1772663
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Article ; Online: Novel Animal Model of Spontaneous Cerebral Petechial Hemorrhage Using Focused Ultrasound in Rats.

Yoon, Sang-Youl / Han, Mun / Lee, Chaejin / Lee, Eun-Hee / Kim, Moonsik / Kim, Kyoung-Tae / Hwang, Jeong-Hyun / Na, Sungdae / Park, Juyoung / Park, Ki-Su

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 7

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Animals ; Blood-Brain Barrier/diagnostic imaging ; Blood-Brain Barrier/physiology ; Cerebral Hemorrhage/diagnostic imaging ; Disease Models, Animal ; Endothelial Cells ; Microbubbles ; Rats
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58070881
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