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  1. Article ; Online: Mitochondrial cargo export in exosomes: Possible pathways and implication in disease biology.

    Sharma, Aman

    Journal of cellular physiology

    2023  Volume 238, Issue 4, Page(s) 687–697

    Abstract: Exosome biogenesis occurs parallel to multiple endocytic traffic routes. These coexisting routes drive cargo loading in exosomes via overlapping of exosome biogenesis with endosomal pathways. One such pathway is autophagy which captures damaged ... ...

    Abstract Exosome biogenesis occurs parallel to multiple endocytic traffic routes. These coexisting routes drive cargo loading in exosomes via overlapping of exosome biogenesis with endosomal pathways. One such pathway is autophagy which captures damaged intracellular organelles or their components in an autophagosome vesicle and route them for lysosomal degradation. However, in case of a noncanonical fusion event between autophagosome and maturing multivesicular body (MVB)-a site for exosome biogenesis, the autophagic cargo is putatively loaded in exosomes and subsequent released out of the cell via formation of an "amphisome" like structure. Similarly, during "mitophagy" or mitochondrial (mt) autophagy, amphisome formation routes mitophagy cargo to exosomes. These mt-cargo enriched exosomes or mt-enREXO are often positive for LC3 protein-an autophagic flux marker, and potent regulators of paracrine signaling with both homeostatic and pathological roles. Here, I review this emerging concept and discuss how intracellular autophagic routes helps in generation of mt-enREXO and utility of these vesicles in paracrine cellular signaling and diagnostic areas.
    MeSH term(s) Autophagy ; Endosomes/metabolism ; Exosomes/metabolism ; Lysosomes/metabolism ; Mitochondria/metabolism
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30967
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  2. Article ; Online: Vasculitis in the 21st century: From prayers to progress.

    Kermani, Tanaz A / Sharma, Aman

    Best practice & research. Clinical rheumatology

    2023  Volume 37, Issue 1, Page(s) 101863

    MeSH term(s) Humans ; Vasculitis/therapy
    Language English
    Publishing date 2023-08-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2023.101863
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  3. Article ; Online: A Case of Morphea After COVID-19 Vaccination.

    Sharma, Aishwarya / Sandhu, Aman

    Dermatitis : contact, atopic, occupational, drug

    2023  Volume 35, Issue 2, Page(s) 187–188

    MeSH term(s) Humans ; Scleroderma, Localized/etiology ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1089/derm.2023.0120
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    Zs.A 3680: Show issues Location:
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  4. Article ; Online: General dermatology & dermatology in primary health care.

    Mehta, Hitaishi / Vinay, Keshavamurthy / Chatterjee, Debajyoti / Sharma, Aman / Dogra, Sunil

    Clinical and experimental dermatology

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae103
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    Zs.A 1278: Show issues Location:
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  5. Article ; Online: Insight into physico-chemical properties and microbial community structure of biogas slurry from household biogas plants of sub-Himalaya for its implications in improved biogas production.

    Kumar, Aman / Sharma, Sonia / Dindhoria, Kiran / Thakur, Aman / Kumar, Rakshak

    International microbiology : the official journal of the Spanish Society for Microbiology

    2024  

    Abstract: Numerous metagenomics studies, conducted in both full-scale anaerobic digesters and household biogas plants, have shed light on the composition and activity of microbial flora essential for optimizing the performance of biogas reactors, underscoring the ... ...

    Abstract Numerous metagenomics studies, conducted in both full-scale anaerobic digesters and household biogas plants, have shed light on the composition and activity of microbial flora essential for optimizing the performance of biogas reactors, underscoring the significance of microbial community composition in biogas plant efficiency. Although the efficiency of household biogas plants in the sub-Himalayan region has been reported, there is no literature evidence on the microbial community structure of such household biogas plants in the sub-Himalayan region. The current study evaluated the physico-chemical properties and bacterial community structure from the slurry samples of household biogas plants prevalent in the sub-Himalayan region. The slurry samples were observed to be rich in nutrients; however, their carbon and nitrogen contents were higher than the recommended standard values of liquid-fermented organic manure. The species richness and diversity indices (Chao1, Shannon, and Simpson) of household biogas plants were quite similar to the advanced biogas reactors operating at mesophilic conditions. 16S rRNA gene amplicon sequencing reveals microbial diversity, showing a higher abundance of Firmicutes (70.9%) and Euryarchaeota (9.52%) in advanced biogas reactors compared to household biogas plants. Microbial analysis shows a lack of beneficial microbes for anaerobic digestion, which might be the reason for inefficient biogas production in household biogas plants of the sub-Himalayan region. The lack of efficient bacterial biomass may also be attributed to the digester design, feedstock, and ambient temperatures. This study emphasized the establishment of efficient microbial consortia for enhanced degradation rates that may increase the methane yield in biogas plants.
    Language English
    Publishing date 2024-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-024-00530-w
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    Zs.A 4964: Show issues Location:
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  6. Article: Yellowish discolouration of palms: Think beyond jaundice!

    Mohan Kumar, H / Sharma, Aman

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S100

    MeSH term(s) Humans ; Jaundice/diagnosis
    Language English
    Publishing date 2022-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2166_19
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    Ua VI Zs.143: Show issues Location:
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  7. Article ; Online: Vasculitis research: Moving east.

    Sharma, Aman

    International journal of rheumatic diseases

    2019  Volume 22 Suppl 1, Page(s) 6–7

    MeSH term(s) Animals ; Biomedical Research ; Humans ; Prognosis ; Rheumatology ; Vasculitis/diagnosis ; Vasculitis/immunology ; Vasculitis/therapy
    Language English
    Publishing date 2019-02-20
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13368
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    Zs.A 6098: Show issues Location:
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  8. Article ; Online: Quinolone scaffolds as potential drug candidates against infectious microbes: a review.

    Sharma, Vishal / Das, Rina / Mehta, Dinesh Kumar / Sharma, Diksha / Aman, Shahbaz / Khan, M U

    Molecular diversity

    2024  

    Abstract: Prevalence of microbial infections and new rising pathogens are signified as causative agent for variety of serious and lethal health crisis in past years. Despite medical advances, bacterial and fungal infections continue to be a rising problem in the ... ...

    Abstract Prevalence of microbial infections and new rising pathogens are signified as causative agent for variety of serious and lethal health crisis in past years. Despite medical advances, bacterial and fungal infections continue to be a rising problem in the health care system. As more bacteria develop resistance to antibiotics used in therapy, and as more invasive microbial species develop resistance to conventional antimicrobial drugs. Relevant published publications from the last two decades, up to 2024, were systematically retrieved from the MEDLINE/PubMed, SCOPUS, EMBASE, and WOS databases using keywords such as quinolones, anti-infective, antibacterial, antimicrobial resistance and patents on quinolone derivatives. With an approach of considerable interest towards novel heterocyclic derivatives as novel anti-infective agents, researchers have explored these as essential tools in vistas of drug design and development. Among heterocycles, quinolones have been regarded extremely essential for the development of novel derivatives, even able to tackle the associated resistance issues. The quinolone scaffold with its bicyclic structure and specific functional groups such as the carbonyl and acidic groups, is indeed considered a valuable functionalities for further lead generation and optimization in drug discovery. Besides, the substitution at N-1, C-3 and C-7 positions also subjected to be having a significant role in anti-infective potential. In this article, we intend to highlight recent quinolone derivatives based on the SAR approach and anti-infective potential such as antibacterial, antifungal, antimalarial, antitubercular, antitrypanosomal and antiviral activities. Moreover, some recent patents granted on quinolone-containing derivatives as anti-infective agents have also been highlighted in tabular form. Due consideration of this, future research in this scaffold is expected to be useful for aspiring scientists to get pharmacologically significant leads.
    Language English
    Publishing date 2024-04-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-024-10862-4
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    Zs.A 4946: Show issues Location:
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  9. Article ; Online: Diagnosing osteoarticular tuberculosis and detecting rifampicin resistance: A comparative analysis of Truenat MTB Plus vs GeneXpert Ultra.

    Sharma, Kusum / Sharma, Megha / Sharma, Aman / Dhillon, Mandeep Singh

    Tuberculosis (Edinburgh, Scotland)

    2024  Volume 145, Page(s) 102483

    Abstract: Setting: Diagnosing osteoarticular tuberculosis (OATB) and detecting drug resistance is a challenge in an endemic country like India.: Objective: Truenat MTB Plus assay (TruPlus), a chip-based portable machine, was compared with GeneXpert Ultra ( ... ...

    Abstract Setting: Diagnosing osteoarticular tuberculosis (OATB) and detecting drug resistance is a challenge in an endemic country like India.
    Objective: Truenat MTB Plus assay (TruPlus), a chip-based portable machine, was compared with GeneXpert Ultra (GxUltra) for diagnosing drug-resistant OATB.
    Design: 115 synovial fluid and pus specimens [22 culture-positive confirmed, 58 culture-negative clinically-suspected, 35 non-TB controls] processed between 2017 and 2023 were subjected to TruPlus, GxUltra and multiplex-PCR for diagnosing OATB. They were further screened for rifampicin resistance using TruRif chip. The performance was evaluated against composite reference standard, phenotypic drug susceptibility testing and rpoB gene sequencing.
    Results: TruPlus, GxUltra and MPCR detected 77.5 %, 71.25 %, and 83.75 %, cases of OATB, respectively. TruPlus detected five additional cases missed by GxUltra. The performance of TruPlus was comparable to GxUltra (p = 0.074) and to MPCR (p = 0.074), while performance of GxUltra was significantly inferior to MPCR (p = 0.004). The overall agreement with reference standard was substantial for TruPlus and MPCR and moderate for GxUltra. Both TruRif and GxUltra reported 4 cases as rifampicin resistant.
    Conclusion: TruPlus along with TruRif offers better sensitivity than GxUltra. Its compact and portable platform allows wider application in peripheral settings, thus making it a pragmatic solution for diagnosing OATB and its drug resistance.
    MeSH term(s) Humans ; Rifampin/pharmacology ; Mycobacterium tuberculosis/genetics ; Microbial Sensitivity Tests ; Sensitivity and Specificity ; Tuberculosis, Osteoarticular/diagnosis ; Tuberculosis, Osteoarticular/drug therapy ; Tuberculosis, Osteoarticular/genetics ; Drug Resistance, Bacterial/genetics
    Chemical Substances Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2024-02-01
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2046804-0
    ISSN 1873-281X ; 1472-9792
    ISSN (online) 1873-281X
    ISSN 1472-9792
    DOI 10.1016/j.tube.2024.102483
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  10. Article ; Online: Enhancing proton mobility and thermal stability in phosphate glasses with WO

    Sharma, Aman / Suzuki, Issei / Ishiyama, Tomohiro / Omata, Takahisa

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 28, Page(s) 18766–18774

    Abstract: This study aimed to investigate the impact of ... ...

    Abstract This study aimed to investigate the impact of WO
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp01453c
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