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  1. Article ; Online: Rituximab-induced gut microbiota changes in Chinese neuromyelitis optica spectrum disorders.

    Chen, Hao / Xu, Zubing / Zhou, Yu / Jiang, Yu-Huan / Chen, Jin / Xiong, Yingqiong / Zhou, Meihong / Wu, Xiaomu / Hong, Daojun

    Multiple sclerosis and related disorders

    2024  Volume 86, Page(s) 105606

    Abstract: Background: Recent evidence shows that immunosuppressive agents can affect the gut microbiota in autoimmune diseases. However, the relationship between the gut microbiome and B-cell depletion immunotherapy in neuromyelitis optica spectrum disorder ( ... ...

    Abstract Background: Recent evidence shows that immunosuppressive agents can affect the gut microbiota in autoimmune diseases. However, the relationship between the gut microbiome and B-cell depletion immunotherapy in neuromyelitis optica spectrum disorder (NMOSD) remains poorly understood.
    Objectives: To evaluate the distinct intestinal microbial patterns and serum cytokine levels after short-term rituximab treatment (three months) in patients with NMOSD.
    Methods: Firstly, we conducted a cross-sectional study involving 46 treatment-naïve NMOSD patients and 48 matched healthy controls. We collected fecal specimens, which were then analyzed using next-generation sequencing, and quantified serum cytokines. Subsequently, fecal and serum samples were re-collected and re-evaluated in 31 of the 46 treatment-naïve NMOSD patients after RTX treatment.
    Results: Comparing the gut microbiome of treatment-naïve NMOSD patients to that of healthy controls revealed low α-diversity and distinct microbial compositions in the former. The microbial composition in NMOSD patients underwent changes following three months of RTX treatment. Specifically, the levels of IL-17F and IL-6 decreased, while those of IL-10 and TNFα increased after RTX treatment. LEfSe analysis identified 27 KEGG categories with significantly differential abundances between NMOSD patients and RTX treatment group.
    Conclusions: Our study provides a comprehensive understanding of the gut microbiota landscape in the context of B-cell depletion immunotherapy. We observed dysbiosis in the gut microbiome of NMOSD patients, which was partially alleviated by three months of RTX treatment. This suggests that B-cell depletion may play a crucial role in driving changes in the gastrointestinal environment.
    Language English
    Publishing date 2024-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2024.105606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Effects of staged acupuncture on endometrial receptivity and anxiety in patients with recurrent implantation failure of thin endometrium based on "thoroughfare vessel is the sea of blood" theory].

    Xing, Li-Wei / He, Zhe / Sun, Yu-Huan / He, Ming / Yu, Shun / Chen, Yang / Xu, Jin-Long / Mei, Rui / Zhao, Rong

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2023  Volume 43, Issue 3, Page(s) 289–293

    Abstract: Objective: To compare the clinical efficacy between staged acupuncture based on "thoroughfare vessel is the sea of blood" theory combined with routine hormone replacement cycle treatment and routine hormone replacement cycle treatment for patients with ... ...

    Abstract Objective: To compare the clinical efficacy between staged acupuncture based on "thoroughfare vessel is the sea of blood" theory combined with routine hormone replacement cycle treatment and routine hormone replacement cycle treatment for patients with recurrent implantation failure (RIF) of thin endometrium.
    Methods: A total of 72 RIF patients with thin endometrium were randomly divided into an observation group and a control group, 36 cases in each group. The patients in the control group were treated with routine hormone replacement cycle treatment. Based on the treatment of the control group, the patients in the observation group were treated with staged acupuncture based on "thoroughfare vessel is the sea of blood" theory. The main acupoints were Neiguan (PC 6) and Gongsun (SP 4), and the supplementary acupoints were selected according to the menstrual cycle and syndrome differentiation; the acupuncture was given once every other day, 3 times a week, for 3 consecutive menstrual cycles. The thickness and shape of endometrium, and Hamilton anxiety scale (HAMA) score were observed at implantation window before and after treatment; the clinical pregnancy rate, live birth rate and cycle cancellation rate were compared between the two groups; the correlation between endometrial thickness and HAMA score was analyzed.
    Results: Compared before treatment, the endometrial thickness in the two groups and the proportion of type A+B endometrium in the observation group were increased (
    Conclusion: Based on the routine hormone replacement cycle treatment, the addition use of staged acupuncture based on "thoroughfare vessel is the sea of blood" theory could improve the thickness and shape of endometrium, relieve anxiety, increase the clinical pregnancy rate and live birth rate, and reduce the cycle cancellation rate in RIF patients with thin endometrium. The curative effect is superior to the routine hormone replacement cycle treatment alone.
    MeSH term(s) Female ; Pregnancy ; Humans ; Anxiety ; Anxiety Disorders ; Acupuncture Therapy ; Endometrium ; Hormones
    Chemical Substances Hormones
    Language Chinese
    Publishing date 2023-02-28
    Publishing country China
    Document type Randomized Controlled Trial ; English Abstract ; Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20220523-k0007
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  3. Article ; Online: MobileSal: Extremely Efficient RGB-D Salient Object Detection.

    Wu, Yu-Huan / Liu, Yun / Xu, Jun / Bian, Jia-Wang / Gu, Yu-Chao / Cheng, Ming-Ming

    IEEE transactions on pattern analysis and machine intelligence

    2022  Volume 44, Issue 12, Page(s) 10261–10269

    Abstract: The high computational cost of neural networks has prevented recent successes in RGB-D salient object detection (SOD) from benefiting real-world applications. Hence, this article introduces a novel network, MobileSal, which focuses on efficient RGB-D SOD ...

    Abstract The high computational cost of neural networks has prevented recent successes in RGB-D salient object detection (SOD) from benefiting real-world applications. Hence, this article introduces a novel network, MobileSal, which focuses on efficient RGB-D SOD using mobile networks for deep feature extraction. However, mobile networks are less powerful in feature representation than cumbersome networks. To this end, we observe that the depth information of color images can strengthen the feature representation related to SOD if leveraged properly. Therefore, we propose an implicit depth restoration (IDR) technique to strengthen the mobile networks' feature representation capability for RGB-D SOD. IDR is only adopted in the training phase and is omitted during testing, so it is computationally free. Besides, we propose compact pyramid refinement (CPR) for efficient multi-level feature aggregation to derive salient objects with clear boundaries. With IDR and CPR incorporated, MobileSal performs favorably against state-of-the-art methods on six challenging RGB-D SOD datasets with much faster speed (450fps for the input size of 320×320) and fewer parameters (6.5M). The code is released at https://mmcheng.net/mobilesal.
    MeSH term(s) Image Processing, Computer-Assisted/methods ; Algorithms ; Neural Networks, Computer
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2021.3134684
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  4. Article: Some sufficient conditions on hamilton graphs with toughness.

    Cai, Gaixiang / Yu, Tao / Xu, Huan / Yu, Guidong

    Frontiers in computational neuroscience

    2022  Volume 16, Page(s) 1019039

    Abstract: ... ...

    Abstract Let
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452964-3
    ISSN 1662-5188
    ISSN 1662-5188
    DOI 10.3389/fncom.2022.1019039
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  5. Article ; Online: Correction: Excitatory neurons in the lateral parabrachial nucleus mediate the interruptive effect of inflammatory pain on a sustained attention task.

    Zheng, Huan-Yu / Chen, Yu-Meng / Xu, Yao / Cen, Cheng / Wang, Yun

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 217

    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04935-z
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  6. Article ; Online: To identify important MRI features to differentiate hepatic mucinous cystic neoplasms from septated hepatic cysts based on random forest.

    Xiao, Si-Yu / Xu, Jian-Xia / Shao, Yi-Huan / Yu, Ri-Sheng

    Japanese journal of radiology

    2024  

    Abstract: Objective: To identify important MRI features to differentiate hepatic mucinous cystic neoplasms (MCN) from septated hepatic cysts (HC) using random forest and compared with logistic regression algorithm.: Methods: Pathologically diagnosed hepatic ... ...

    Abstract Objective: To identify important MRI features to differentiate hepatic mucinous cystic neoplasms (MCN) from septated hepatic cysts (HC) using random forest and compared with logistic regression algorithm.
    Methods: Pathologically diagnosed hepatic cysts and hepatic MCNs with pre-operative contrast-enhanced MRI in our hospital from 2010 to 2023 were collected and only septated lesions on enhanced MRI were enrolled. A total of 21 septated HC and 18 MCNs were included in this study. Eighteen MRI features were analyzed and top important features were identified based on random forest (RF) algorithm. The results were evaluated by the prediction performance of a RF model combining the important features and compared with the performance of the logistic regression (LR) algorithm. Finally, for each identified feature, diagnostic probability, sensitivity, and specificity were calculated and compared.
    Results: Four variables, i.e., the septation arising from wall without indentation, multiseptate, intracapsular cyst sign, and solitary lesion were extracted as top important features with significance for MCNs by the random forest algorithm. The RF model using these variables had an AUC of 0.982 (0.95CI, 0.950-1.000), compared with the LR model based on two identified features with AUC of 0.931 (0.95CI, 0.846-1.000), p = 0.202. Among the four important features, multiseptate had the highest specificity (95.2%) and good sensitivity (72.2%, lower than the septation from wall without indentation, 94.4%) to diagnose MCNs.
    Conclusion: Four out of 18 MRI features were extracted as reliably important factors to differ hepatic MCNs from septated HC. The combination of these four features in a RF model could achieve satisfactory diagnostic efficacy.
    Language English
    Publishing date 2024-04-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2488907-6
    ISSN 1867-108X ; 1867-1071
    ISSN (online) 1867-108X
    ISSN 1867-1071
    DOI 10.1007/s11604-024-01562-y
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    Zs.A 2249: Show issues Location:
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  7. Article ; Online: Hepatitis D virus dual-infection among Chinese hepatitis B patient related to hepatitis B surface antigen, hepatitis B virus DNA and age.

    Zi, Jun / Li, Yu-Huan / Wang, Xiao-Mei / Xu, Hong-Qin / Liu, Wen-Hui / Cui, Jia-Yue / Niu, Jun-Qi / Chi, Xiu-Mei

    World journal of gastroenterology

    2023  Volume 29, Issue 38, Page(s) 5395–5405

    Abstract: Background: The screening practices for hepatitis D virus (HDV) are diverse and non-standardized worldwide, and the exact prevalence of HDV is uncertain.: Aim: To estimate HDV prevalence and investigate viral marker quantity trends in patients with ... ...

    Abstract Background: The screening practices for hepatitis D virus (HDV) are diverse and non-standardized worldwide, and the exact prevalence of HDV is uncertain.
    Aim: To estimate HDV prevalence and investigate viral marker quantity trends in patients with hepatitis D.
    Methods: We collected 5594 serum samples from patients with hepatitis B in Jilin Province, China (3293 males and 2301 females, age range of 2 to 89 years). We then conducted tests for hepatitis B surface antigen (HBsAg), hepatitis B Virus (HBV) DNA, anti-hepatitis D antigen (HDAg), and HDV RNA.
    Results: We found that the prevalence of anti-HDAg and HDV RNA among hepatitis B patient were 3.6% (3.2-4.2%) and 1.2% (0.9-1.5%), respectively, 87.69% of hepatitis D patients were 51-70 years old. HDV infection screening positive rate of patients with HBV DNA levels below 2000 IU/mL (2.0%) was higher than those above 2000 IU/mL (0.2%). Among anti-HDAg positive patients, the HDV RNA positive rate was positively correlated with the HBsAg level and anti-HDAg level. There was a weak correlation between HBsAg and anti-HDAg levels among hepatitis D patients.
    Conclusion: Our study highlights the importance of considering multiple factors when assessing the severity of HDV infection, comprehensive evaluation of patients' clinical and laboratory parameters is necessary for proper diagnosis and treatment.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; DNA ; East Asian People ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B Surface Antigens ; Hepatitis B virus/genetics ; Hepatitis D/diagnosis ; Hepatitis D/epidemiology ; Hepatitis delta Antigens ; Hepatitis Delta Virus/genetics ; RNA ; Coinfection/diagnosis ; Coinfection/epidemiology ; Coinfection/virology
    Chemical Substances DNA (9007-49-2) ; Hepatitis B Surface Antigens ; Hepatitis delta Antigens ; RNA (63231-63-0)
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i38.5395
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  8. Article: [Identification, biological characteristics, and control of pathogen causing southern blight of Pinellia ternata].

    Zhou, Jia / Chen, Qiao-Huan / Xu, Jia-Wei / Chen, Hong / Huang, Bi-Sheng / Miao, Yu-Huan / Liu, Da-Hui

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 19, Page(s) 5209–5216

    Abstract: In summer in 2020, Pinellia ternata in many planting areas in Hubei suffered from serious southern blight, as manifested by the yellowing and wilted leaves and rotten tubers. This study aims to identify the pathogen, clarify the biological ... ...

    Abstract In summer in 2020, Pinellia ternata in many planting areas in Hubei suffered from serious southern blight, as manifested by the yellowing and wilted leaves and rotten tubers. This study aims to identify the pathogen, clarify the biological characteristics of the pathogen, and screen fungicides. To be specific, the pathogen was isolated, purified, and identified, and the pathogenicity was detected according to the Koch's postulates. Moreover, the biological characteristics of the pathogen were analyzed. Furthermore, PDA plates and seedlings were used to determine the most effective fungicides. The results showed that the mycelia of the pathogen were white and villous with silk luster, which produced a large number of white to black brown sclerotia. The pathogen was identified as Athelia rolfsii by morphological observation and molecular identification based on LSU and TEF gene sequences. The optimum growth conditions for A. rolfsii were 30 ℃ and pH 5-8, and the optimum conditions for the germination of sclerotia were 25 ℃ and pH 7-9. Bacillus subtilis, difenoconazole, and flusilazole were identified as effective fungicides with PDA, and their half maximal effective concentration(EC_(50)) was all less than 5 mg·L~(-1). The effective fungicides screened with the seedlings were hymexazol and difenoconazole. Based on the screening experiments, difenoconazole can be used as the main agent for the prevention and treatment of southern blight.
    Language Chinese
    Publishing date 2022-12-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20220615.103
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  9. Article: Alteration of brain nuclei in obese children with and without Prader-Willi syndrome.

    Wu, Ning / Yu, Huan / Xu, Mingze

    Frontiers in neuroinformatics

    2022  Volume 16, Page(s) 1032636

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2022.1032636
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  10. Article ; Online: Author Response to Letter to the Editor Regarding "Risk Assessment of Falls Among Older Adults Based on Probe Reaction Time During Water-Carrying Walking" [Response to Letter].

    Liu, Fan / Yu, Huan / Xu, Qing / Gong, Jianwei / Huo, Ming / Huang, Fei

    Clinical interventions in aging

    2024  Volume 19, Page(s) 121–122

    MeSH term(s) Humans ; Aged ; Reaction Time ; Accidental Falls/prevention & control ; Walking/physiology ; Risk Assessment
    Language English
    Publishing date 2024-01-21
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S460426
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