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  1. Article: Correction: Yu et al. Rare-Earth-Metal (Nd

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Yu et al. Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by

    Yu, Zhihao / Jiang, Tingting / Xu, Fangfang / Zhang, Jing / Hu, Yuan / Cao, Jianping

    Tropical medicine and infectious disease

    2024  Volume 9, Issue 3

    Abstract: In the published publication [ ... ]. ...

    Abstract In the published publication [...].
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Published Erratum
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed9030062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Correction: Yu et al. Achieving Effective Multimodal Imaging with Rare-Earth Ion-Doped CaF

    Yu, Zhenfeng / He, Yuanyuan / Schomann, Timo / Wu, Kefan / Hao, Yang / Suidgeest, Ernst / Zhang, Hong / Eich, Christina / Cruz, Luis J

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: There was an error in the original publication [ ... ]. ...

    Abstract There was an error in the original publication [...].
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [The works of Zhang Wenzhong as the Shang Yao Feng Yu in the early Tang Dynasty].

    Yu, Y L / Zhang, B R

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2022  Volume 52, Issue 5, Page(s) 276–281

    Abstract: ... position as Shang Yao Feng Yu, for the Empress Wu Ze Tian dealing with medication. He was good at dealing ... Zhang Wenzhong, a famous Chinese medical doctor in the early Tang Dynasty, was granted a particular ...

    Abstract Zhang Wenzhong, a famous Chinese medical doctor in the early Tang Dynasty, was granted a particular position as Shang Yao Feng Yu, for the Empress Wu Ze Tian dealing with medication. He was good at dealing with stroke in particular. He also had unique viewpoints towards medical prescriptions and skills. He wrote medical books and developed his own medical theories. All these were recorded in both the
    MeSH term(s) Male ; Humans ; Books ; Prescriptions ; Writing ; Physicians ; China ; Medicine, Chinese Traditional
    Language Chinese
    Publishing date 2022-10-20
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.cn112155-20210301-00032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

    Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9110704

    Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

    Abstract Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW.
    Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms.
    Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our
    Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9110704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Spin-orbital Yu-Shiba-Rusinov states in single Kondo molecular magnet.

    Xia, Hui-Nan / Minamitani, Emi / Žitko, Rok / Liu, Zhen-Yu / Liao, Xin / Cai, Min / Ling, Zi-Heng / Zhang, Wen-Hao / Klyatskaya, Svetlana / Ruben, Mario / Fu, Ying-Shuang

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6388

    Abstract: Studies of single-spin objects are essential for designing emergent quantum states. We investigate a molecular magnet ... ...

    Abstract Studies of single-spin objects are essential for designing emergent quantum states. We investigate a molecular magnet Tb
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34187-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

    Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

    Journal of ethnopharmacology

    2023  Volume 321, Page(s) 117480

    Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

    Abstract Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated.
    Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism.
    Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments.
    Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry.
    Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
    MeSH term(s) Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-11-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117480
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

    Lv, Shuquan / Fan, Lirong / Chen, Xiaoting / Su, Xiuhai / Dong, Li / Wang, Qinghai / Wang, Yuansong / Zhang, Hui / Cui, Huantian / Zhang, Shufang / Wang, Lixin

    Journal of diabetes research

    2024  Volume 2024, Page(s) 9990304

    Abstract: ... effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment ...

    Abstract Background: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet.
    Purpose: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis.
    Materials and methods: We established a DN mouse model to investigate the therapeutic effect of JPGS in a DN mouse model. Subsequently, we examined the effects of JPGS on ferroptosis- and glutathione peroxidase 4 (GPX4) pathway-related indices. Finally, we validated whether JPGS inhibited ferroptosis in DN mice via the GPX4 pathway using GPX4 inhibitor and ferroptosis inhibitors.
    Results: The results indicate that JPGS has a therapeutic effect on DN mice by improving kidney function and reducing inflammation. Additionally, JPGS treatment decreased iron overload and oxidative stress levels while upregulating the expression of GPX4 pathway-related proteins. Moreover, JPGS demonstrated a similar therapeutic effect as Fer-1 in the context of DN treatment, and RSL3 was able to counteract the therapeutic effect of JPGS and antiferroptotic effect.
    Conclusion: JPGS has significant therapeutic and anti-inflammatory effects on DN mice, and its mechanism is mainly achieved by upregulating the expression of GPX4 pathway-related proteins, thereby alleviating iron overload and ultimately reducing ferroptosis.
    MeSH term(s) Animals ; Mice ; Diabetic Nephropathies/drug therapy ; Ferroptosis ; Disease Models, Animal ; Inflammation ; Iron Overload/complications ; Iron Overload/drug therapy ; Diabetes Mellitus
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2024/9990304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mode of Action of Shan-Zhu-Yu (

    Liu, Ping / Yang, Ping / Zhang, Lan

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 8838888

    Abstract: Background: Although the traditional Chinese medicine Shan-Zhu-Yu may be efficacious against ... of action of Shan-Zhu-Yu in the treatment of depression using network pharmacology.: Methods ... The active ingredients and targets of Shan-Zhu-Yu were obtained from the Traditional Chinese Medicine System Pharmacology ...

    Abstract Background: Although the traditional Chinese medicine Shan-Zhu-Yu may be efficacious against depression, its mechanism of action is unknown. In this study, we aimed to explore the possible mechanisms of action of Shan-Zhu-Yu in the treatment of depression using network pharmacology.
    Methods: The active ingredients and targets of Shan-Zhu-Yu were obtained from the Traditional Chinese Medicine System Pharmacology Database (TCMSP) database and converted into gene names using UniProt. Then, the target genes of depression were collected using GeneCards and OMIM. Drug disease intersection genes were obtained using a Venn tool, and a protein-protein interaction network was constructed using STRING. Cytoscape was used to construct an active ingredients-targets-drug-disease network. GO and KEGG pathway enrichment analyses were performed using DAVID. Furthermore, Autodock was used to evaluate drug and target binding and explore possible molecular mechanisms.
    Results: We identified 9721 disease genes, 13 active ingredients, 50 target genes, and 48 drug disease intersecting genes. The results of the GO enrichment analysis suggested that Shan-Zhu-Yu affects the activity of G protein-coupled amine, neurotransmitter, steroid hormone, nuclear, and G protein-coupled neurotransmitter receptors in the treatment of depression by acting on hormone and nuclear receptor binding. The main signaling pathways were associated with neuroactive ligand-receptor interaction, calcium, cGMP-PKG, apoptosis, estrogen, p53, and AGE-RAGE. Molecular docking confirmed that the active components of Shan-Zhu-Yu (e.g., telocinobufagin and
    Conclusions: The present study elucidates that Shan-Zhu-Yu suppresses the expression of
    Language English
    Publishing date 2020-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/8838888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Spin-orbital Yu-Shiba-Rusinov states in single Kondo molecular magnet

    Hui-Nan Xia / Emi Minamitani / Rok Žitko / Zhen-Yu Liu / Xin Liao / Min Cai / Zi-Heng Ling / Wen-Hao Zhang / Svetlana Klyatskaya / Mario Ruben / Ying-Shuang Fu

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 7

    Abstract: Yu-Shiba-Rusinov (YSR) states result from the exchange coupling between a localized magnetic moment ...

    Abstract Yu-Shiba-Rusinov (YSR) states result from the exchange coupling between a localized magnetic moment and a superconductor. Traditionally, the YSR states have been studied for magnetic atoms. For molecular magnets with extended ligand spin, the entanglement of spin and ligand orbital gives rise to new forms of YSR excitations. Here, Xia et al uncovered spin-orbital YSR states in an unpaired ligand spin in the molecular magnet Tb2Pc3 on Pb.
    Keywords Science ; Q
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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